Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000230.1:
Cluster 1Polyketide136905

BGC0000230, griseorhodin biosynthetic gene cluster from Streptomyces sp. JP95. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: griseorhodin A
PubChem ID: 5458191
SMILES string: Copy to clipboard
Molecular formula: C25H16O10
Average molecular mass: 476.393 Da
Molecular activity: Antibacterial, Cytotoxic, Inhibitor, Other
Molecular target: HIV reverse transcriptase, human telomerase

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Polyphenol (linear)
Polyketide synthase subclass:
Type II
Starter unit:
Unknown
Polyketide synthase / ketosynthase-encoding genes:
AAM33653.1,AAM33655.1
Genes involved in folding/cyclization:
AAM33657.1, AAM33678.1, AAM33685.1,

Gene cluster description

griseorhodin (BGC0000230). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank AF509565. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Eric J. N. Helfrich (Institute of Microbiology, Eidgenoessische Technische Hochschule (ETH) Zurich, Piel lab)

Literature references

1. Li A, Piel J. (2002) A gene cluster from a marine Streptomyces encoding the biosynthesis of the aromatic spiroketal polyketide griseorhodin A. Chem Biol 9(9):1017-26.
2. Yunt Z et al. (2009) Cleavage of four carbon-carbon bonds during biosynthesis of the griseorhodin a spiroketal pharmacophore. J Am Chem Soc 131(6):2297-305. doi: 10.1021/ja807827k.
3. Lackner G et al. (2007) Biosynthesis of pentangular polyphenols: deductions from the benastatin and griseorhodin pathways. J Am Chem Soc 129(30):9306-12. doi: 10.1021/ja0718624. Epub 2007 Jul