BGC0000233 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000233 (Streptomyces griseoruber)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	PKS-like,T1PKS,T2PKS	1	45,603	hedamycin	PKS	100%

BGC0000233 - Region 1 - PKS-like,T1PKS,T2PKS

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Location: 1 - 45,603 nt. (total: 45,603 nt) Show pHMM detection rules used

Region on contig edge.

PKS-like: (t2pks2 or ksIII)
T1PKS: cds(PKS_AT and (PKS_KS or ene_KS or mod_KS or hyb_KS or itr_KS or tra_KS))
T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 45,604
Label		BGC0000233

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000233	2.15	Polyketide	hedamycin	Streptomyces griseoruber
BGC0000844	1.05	Other	clavulanic acid	Streptomyces clavuligerus
BGC0001219	0.89	Polyketide	shanorellin	Chaetomium globosum CBS 148.51
BGC0000278	0.81	Polyketide	urdamycin	Streptomyces fradiae
BGC0001264	0.79	Polyketide	betaenone A, betaenone B, betaenone C	Phoma betae
BGC0002597	0.78	NRP, Polyketide	nocuolactylates	Nodularia sp. LEGE 06071
BGC0001704	0.78	Other	nocuolin A	Nodularia sp. HBU26
BGC0000041	0.77	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0000996	0.74	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0000170	0.73	Polyketide	yanuthone D	Aspergillus niger ATCC 1015

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000233	1.00	Polyketide	hedamycin	Streptomyces griseoruber
BGC0000844	0.68	Other	clavulanic acid	Streptomyces clavuligerus
BGC0000866	0.67	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0002733	0.65	Other	sinapigladioside	Burkholderia gladioli
BGC0000278	0.65	Polyketide	urdamycin	Streptomyces fradiae
BGC0000041	0.64	Polyketide	oronofacic acid	Pseudomonas syringae
BGC0001219	0.63	Polyketide	shanorellin	Chaetomium globosum CBS 148.51
BGC0001273	0.62	Polyketide	asperlactone	Aspergillus ochraceus
BGC0000996	0.62	NRP, Polyketide	frontalamide B, frontalamide A	Streptomyces sp. SPB78
BGC0001244	0.62	Polyketide	(-)-Mellein	Parastagonospora nodorum

Similar known gene clusters from MIBiG 4.0

Module view

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NRPS/PKS products

NRPS/PKS substrates

Type II PKS

Predicted core structure(s)

For candidate cluster 1, location 0 - 45603:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (ccmal)
Non-colinear ordering:: AAP85336.1 + AAP85335.1

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 2, location 0 - 30434:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (ccmal)
Non-colinear ordering:: AAP85336.1 + AAP85335.1

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 3, location 0 - 29332:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (ccmal)
Non-colinear ordering:: AAP85336.1 + AAP85335.1

Direct lookup in NORINE database: strict or relaxed

For candidate cluster 4, location 2468 - 45603:

Rough prediction of core scaffold based on assumed PKS linker matching; tailoring reactions not taken into account

Polymer prediction:: (mal) + (ccmal)
Non-colinear ordering:: AAP85336.1 + AAP85335.1

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

AAP85335.1

PKS_AT (573..862): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 79.2%; Propionyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 198.3
inactive: 103.3
Methoxymalonyl-CoA: 61.5
Methylmalonyl-CoA: 57.8
Propionyl-CoA: 34.6
Isobutyryl-CoA: 32.2
Acetyl-CoA: 19.0
fatty_acid: 11.3
Ethylmalonyl-CoA: 11.3
Benzoyl-CoA: 8.0
CHC-CoA: 7.9
3-Methylbutyryl-CoA: 6.3
2-Methylbutyryl-CoA: 0.3
trans-1,2-CPDA: 0.0

AAP85336.1

PKS_AT (541..835): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 100.0%; inactive: 70.8%; Methylmalonyl-CoA: 62.5%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 179.8
inactive: 76.9
Methoxymalonyl-CoA: 64.4
Methylmalonyl-CoA: 53.2
Isobutyryl-CoA: 27.6
Propionyl-CoA: 25.6
Ethylmalonyl-CoA: 25.0
Acetyl-CoA: 18.2
Benzoyl-CoA: 16.2
3-Methylbutyryl-CoA: 12.6
CHC-CoA: 8.0
fatty_acid: 5.0
2-Methylbutyryl-CoA: 1.6
trans-1,2-CPDA: 0.0

AAP85359.1

PKS_AT (4..286): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%; Methylmalonyl-CoA: 58.3%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 50.9
Methoxymalonyl-CoA: 37.6
Methylmalonyl-CoA: 34.6
Isobutyryl-CoA: 19.9
Propionyl-CoA: 17.9
inactive: 15.5
fatty_acid: 14.9
2-Methylbutyryl-CoA: 8.2
Ethylmalonyl-CoA: 4.0
CHC-CoA: 3.2
trans-1,2-CPDA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 2468 to 45603
Starter unit(s):: hexadienyl-CoA (Score: 1331.0; E-value: 0)
propionyl-CoA (Score: 150.0; E-value: 9.82e-43)
Product class(es):: benzoisochromanequinone

AAP85336.1: AT (Score: 187.8; E-value: 6.1e-58); AT BAB72049.1_Aklavinone_propionyl-CoA (Score: 150.0; E-value: 9.82e-43)
AAP85337.1: KSIII (Score: 533.1; E-value: 6.3e-163); KSIII AAP85337.1_Hedamycin_hexadienyl-CoA (Score: 695.0; E-value: 0.0)
AAP85348.1: GT (Score: 394.2; E-value: 1.9e-120)
AAP85354.1: GT (Score: 387.5; E-value: 2.1e-118)
AAP85357.1: OXY (Score: 49.3; E-value: 9.1e-16)
AAP85359.1: AT (Score: 424.1; E-value: 8.8e-130); AT AAP85359.1_Hedamycin_hexadienyl-CoA (Score: 636.0; E-value: 0.0)
AAP85360.1: CYC C7-C12 (Score: 318.4; E-value: 8.8e-98); ACP (Score: 94.6; E-value: 6.3e-30)
AAP85361.1: CLF (Score: 545.3; E-value: 1.9e-166)
AAP85362.1: KS (Score: 727.3; E-value: 1.1e-221)
AAP85363.1: CYC C5-C14 (Score: 319.4; E-value: 4.5e-98)
AAP85364.1: KR C9 (Score: 446.5; E-value: 6.5e-137)