BGC0000233: hedamycin biosynthetic gene cluster from Streptomyces griseoruber
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Location: 1 - 45,603 nt. (total: 45,603 nt).
This entry is originally from NCBI GenBank AY196994.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
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NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000233
Short description hedamycin biosynthetic gene cluster from Streptomyces griseoruber
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: AY196994.1
Compounds
  • hedamycin
Species Streptomyces griseoruber [taxonomy]
References
Chemical products information
hedamycin
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C41H50N2O11
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAP85335.1
 1 - 6378 (-) type I PKS
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  • AAP85336.1
 6375 - 9332 (-) type I PKS
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  • AAP85337.1
 9388 - 10434 (-) putative 3-oxoacyl-ACP synthase
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  • AAP85338.1
 10511 - 11740 (-) cytochrome P450
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  • AAP85339.1
 11885 - 14167 (-) UvrA-like drug resistance protein
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  • AAP85340.1
 14164 - 14511 (-) anthrone oxygenase
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  • AAP85341.1
 14549 - 15991 (-) 2,3-hexose dehydratase
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  • AAP85342.1
 16172 - 16993 (-) putative hydroxylase
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  • AAP85343.1
 17084 - 18130 (+) transcription repressor
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  • AAP85344.1
 18085 - 18771 (-) ACP-phosphodiesterase
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  • AAP85345.1
 18843 - 19562 (-) putative N,N-dimethyltransferase
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  • AAP85346.1
 19783 - 20748 (+) diphospho-4-keto-2,3,6-trideoxyhexulose reductase
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  • AAP85347.1
 20750 - 21868 (+) aminotransferase
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  • AAP85348.1
 21967 - 23109 (-) glycosyltransferase
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  • AAP85349.1
 23172 - 23954 (-) ABC transporter
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  • AAP85350.1
 23972 - 24976 (-) ATP-binding protein
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  • AAP85351.1
 26379 - 27197 (-) putative regulatory protein
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  • AAP85352.1
 27493 - 28587 (-) hypothetical protein
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  • AAP85353.1
 28743 - 29423 (+) putative 3-5-epimerase
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  • AAP85354.1
 29467 - 30606 (+) glycosyltransferase
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  • AAP85355.1
 30644 - 31621 (+) probable dTDP-4-keto-6-deoxyhexose reductase
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  • AAP85356.1
 31640 - 32368 (-) N,N-dimethyltransferase
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  • AAP85357.1
 32374 - 33609 (-) putative monooxygenase
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  • AAP85358.1
 33606 - 35231 (-) putative secreted tripeptidylaminopeptidase
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  • AAP85359.1
 35293 - 36270 (+) putative acyltransferase
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  • AAP85360.1
 36538 - 37497 (+) putative bifunctional cyclase dehydratase and ACP fusion
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  • AAP85361.1
 37469 - 38734 (-) keto synthase beta
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  • AAP85362.1
 38731 - 39999 (-) putative keto synthase alpha
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  • AAP85363.1
 40439 - 41404 (+) cyclase
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  • AAP85364.1
 41609 - 42388 (+) keto reductase
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  • AAP85365.1
 43426 - 44094 (-) putative TetR-family regulatory protein
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  • AAP85366.1
 44086 - 45603 (+) membrane transport protein
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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