BGC0000234 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000234 (Streptomyces venezuelae ATCC 10712)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	7,064	High	jadomycin	PKS

BGC0000234 - Region 1 - T2PKS

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Location: 1 - 7,064 nt. (total: 7,064 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 7,065
Label		BGC0000234

Tailoring functions

Oxidoreductases: dehydrogenase

AAB36565.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: carboxylase

jadJ: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Lyases: cyclase

AAB36566.1: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

jadI: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

Ligases: synthase

AAB36563.1: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

jadA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000234.5	1.00	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000231.5	0.84	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001723.5	0.77	PKS	oviedomycin	Streptomyces antibioticus
BGC0000253.4	0.71	PKS	oviedomycin	Streptomyces antibioticus
BGC0002369.2	0.69	PKS	maduralactomycin A, maduralactomycin B, actinospirol A, actinospirol B	Actinomadura rubteroloni
BGC0002672.2	0.68	PKS	saccharothrixin D, saccharothrixin E, saccharothrixin F, saccharothrixin G, saccharothrixin H, saccharothrixin I, saccharothrixin J, saccharothrixin K, saccharothrixin L, saccharothrixin M	Saccharothrix sp.
BGC0002477.3	0.67	PKS	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072
BGC0002000.4	0.67	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000235.5	0.66	PKS	kiamycin	Streptomyces sp. W007
BGC0002070.3	0.65	PKS	SEK90, pentangumycin	Saccharothrix espanaensis DSM 44229

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000234.5	1.00	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000231.5	0.84	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001723.5	0.77	PKS	oviedomycin	Streptomyces antibioticus
BGC0000253.4	0.71	PKS	oviedomycin	Streptomyces antibioticus
BGC0002369.2	0.69	PKS	maduralactomycin A, maduralactomycin B, actinospirol A, actinospirol B	Actinomadura rubteroloni
BGC0002672.2	0.68	PKS	saccharothrixin D, saccharothrixin E, saccharothrixin F, saccharothrixin G, saccharothrixin H, saccharothrixin I, saccharothrixin J, saccharothrixin K, saccharothrixin L, saccharothrixin M	Saccharothrix sp.
BGC0002477.3	0.67	PKS	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072
BGC0002000.4	0.67	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000235.5	0.66	PKS	kiamycin	Streptomyces sp. W007
BGC0002070.3	0.65	PKS	SEK90, pentangumycin	Saccharothrix espanaensis DSM 44229

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 7064
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 727.4; E-value: 9e-222)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 333 Da
acetyl-CoA_9: 375 Da

AAB36563.1: CLF 8|9 (Score: 727.4; E-value: 9e-222)
AAB36565.1: KR C9 (Score: 483.4; E-value: 3.6e-148)
AAB36566.1: CYC C7-C12 (Score: 478.3; E-value: 1.9e-146)
acp: ACP (Score: 140.9; E-value: 2.3e-44)
jadA: KS (Score: 768.7; E-value: 3.1e-234)
jadI: CYC C4-C17/C2-C19 (Score: 200.0; E-value: 8.3e-62)