BGC0000235 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000235 (Streptomyces sp. W007)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	44,428	High	kiamycin	PKS

BGC0000235 - Region 1 - T2PKS

Download region GenBank file

Download region SVG

Location: 1 - 44,428 nt. (total: 44,428 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 44,429
Label		BGC0000235

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

SPW_4220: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

SPW_4222: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

SPW_4226: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

SPW_4231: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

SPW_4233: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

SPW_4234: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: methyltransferase transferase

SPW_4217: methyltransferase

smcogs: SMCOG1089: methyltransferase

SPW_4225: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

SPW_4235: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Lyases: cyclase

SPW_4227: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

SPW_4232: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

SPW_4228: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

SPW_4229: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000235.5	1.00	PKS	kiamycin	Streptomyces sp. W007
BGC0000231.5	0.83	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002477.3	0.83	PKS	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072
BGC0001723.5	0.77	PKS	oviedomycin	Streptomyces antibioticus
BGC0000234.5	0.77	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002047.2	0.63	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0002000.4	0.61	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000253.4	0.61	PKS	oviedomycin	Streptomyces antibioticus
BGC0002369.2	0.60	PKS	maduralactomycin A, maduralactomycin B, actinospirol A, actinospirol B	Actinomadura rubteroloni
BGC0001596.3	0.59	PKS	fluostatin M, fluostatin N, fluostatin O, fluostatin P, fluostatin Q	Streptomyces albus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000235.5	1.00	PKS	kiamycin	Streptomyces sp. W007
BGC0000231.5	0.83	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002477.3	0.83	PKS	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072
BGC0001723.5	0.77	PKS	oviedomycin	Streptomyces antibioticus
BGC0000234.5	0.77	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002047.2	0.63	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0002000.4	0.61	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0000253.4	0.61	PKS	oviedomycin	Streptomyces antibioticus
BGC0002369.2	0.60	PKS	maduralactomycin A, maduralactomycin B, actinospirol A, actinospirol B	Actinomadura rubteroloni
BGC0001596.3	0.59	PKS	fluostatin M, fluostatin N, fluostatin O, fluostatin P, fluostatin Q	Streptomyces albus

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 44428
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 702.0; E-value: 4.5e-214)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 386 Da
acetyl-CoA_9: 428 Da

SPW_4220: KR (Score: 137.9; E-value: 1.1e-42)
SPW_4222: KR (Score: 101.5; E-value: 1.4e-31)
SPW_4225: MET (Score: 255.7; E-value: 1.5e-78)
SPW_4226: OXY (Score: 562.3; E-value: 2.1e-171)
SPW_4227: CYC C4-C17/C2-C19 (Score: 174.3; E-value: 5.7e-54)
SPW_4228: KS (Score: 772.4; E-value: 2.4e-235)
SPW_4229: CLF 8|9 (Score: 702.0; E-value: 4.5e-214)
SPW_4230: ACP (Score: 132.4; E-value: 1.1e-41)
SPW_4231: KR C9 (Score: 472.9; E-value: 5.7e-145)
SPW_4232: CYC C7-C12 (Score: 498.2; E-value: 1.6e-152)
SPW_4233: OXY (Score: 538.2; E-value: 4.3e-164)
SPW_4234: KR (Score: 134.6; E-value: 1.1e-41)