BGC0000236 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000236 (combined with 2 others) (Streptomyces murayamaensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	37,227	High	kinamycin	PKS

BGC0000236 (combined with 2 others) - Region 1 - T2PKS

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Location: 1 - 37,227 nt. (total: 37,227 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 37,228
Label		BGC0000236

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase synthase

AAO65325.1: Antibiotic biosynthesis monooxygenase

smcogs: SMCOG1258: Antibiotic biosynthesis monooxygenase

AAO65334.1: alcohol dehydrogenase

smcogs: SMCOG1040: alcohol dehydrogenase

AAO65336.1: riboflavin biosynthesis protein RibD

smcogs: SMCOG1240: riboflavin biosynthesis protein RibD

kinE: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

kinO1: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

kinO2: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

kinOR: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: PPTase transferase

kinM: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

kinN: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

Hydrolases: synthase

AAO65336.1: riboflavin biosynthesis protein RibD

smcogs: SMCOG1240: riboflavin biosynthesis protein RibD

Lyases: cyclase

kinD: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

kinI: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

Isomerases: mutase

AAO65326.1: phosphoglycerate mutase

smcogs: SMCOG1101: phosphoglycerate mutase

Ligases: synthase

kinA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

kinB: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000236.5	1.00	PKS	kinamycin	Streptomyces murayamaensis
BGC0000231.5	0.84	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.79	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002047.2	0.69	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0001723.5	0.66	PKS	oviedomycin	Streptomyces antibioticus
BGC0001904.2	0.60	PKS	fluostatin L, fluostatin D, difluostatin A, fluostatin C, fluostatin F, fluostatin G/H, fluostatin J, fluostatin K, rabelomycin	Micromonospora rosaria
BGC0002000.4	0.60	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000253.4	0.58	PKS	oviedomycin	Streptomyces antibioticus
BGC0001661.5	0.57	PKS	mayamycin	Streptomyces sp.

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000236.5	1.00	PKS	kinamycin	Streptomyces murayamaensis
BGC0000231.5	0.84	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.79	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002047.2	0.69	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0001723.5	0.66	PKS	oviedomycin	Streptomyces antibioticus
BGC0001904.2	0.60	PKS	fluostatin L, fluostatin D, difluostatin A, fluostatin C, fluostatin F, fluostatin G/H, fluostatin J, fluostatin K, rabelomycin	Micromonospora rosaria
BGC0002000.4	0.60	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000253.4	0.58	PKS	oviedomycin	Streptomyces antibioticus
BGC0001661.5	0.57	PKS	mayamycin	Streptomyces sp.

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 37227
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 717.5; E-value: 9.1e-219)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 381 Da
acetyl-CoA_9: 423 Da

kinA: KS (Score: 780.7; E-value: 7e-238)
kinB: CLF 8|9 (Score: 717.5; E-value: 9.1e-219)
kinC: ACP (Score: 140.1; E-value: 3.9e-44)
kinD: CYC C7-C12 (Score: 494.0; E-value: 3.2e-151)
kinE: KR C9 (Score: 481.8; E-value: 1.1e-147)
kinI: CYC C4-C17/C2-C19 (Score: 200.5; E-value: 5.6e-62)
kinO1: OXY (Score: 508.6; E-value: 4.2e-155)
kinO2: OXY (Score: 569.5; E-value: 1.4e-173)
kinOR: OXY (Score: 580.7; E-value: 5.6e-177)