LOCUS       BGC0000237             12707 bp    DNA     linear   BCT 05-FEB-2008
DEFINITION  Streptomyces sanglieri strain AK 623 lactonamycin Z biosynthetic
            gene cluster, partial sequence.
ACCESSION   BGC0000237
VERSION     BGC0000237
KEYWORDS    .
SOURCE      Streptomyces sanglieri
  ORGANISM  Streptomyces sanglieri
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 13:14:20
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            1..282
                     /gene="lcz24"
     CDS             1..282
                     /NRPS_PKS="Domain: ACP (14-78). E-value: 2.1e-11. Score:
                     35.8. Matches aSDomain: nrpspksdomains_lcz24_ACP.1"
                     /codon_start=1
                     /gene="lcz24"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1129:acyl carrier protein (Score: 100.1; E-value:
                     9e-31)"
                     /gene_functions="biosynthetic-additional (t2pks) ACP
                     (Score: 108.9; E-value: 2.2e-34)"
                     /gene_kind="biosynthetic-additional"
                     /note="acyl carrier protein"
                     /product="Lcz24"
                     /protein_id="ABX71141.1"
                     /sec_met_domain="PP-binding (E-value: 3.3e-11, bitscore:
                     33.6, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MQKFTLDDLVDLTRTYAGESEEGALDGDIVDVLFTHLGYDSVALM
                     EVLSQIKHQYGIDLSDDSVDALRTPRAVIEKVNAVISSQGDNRKKVSS"
     source          1..12707
                     /db_xref="taxon:193460"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces sanglieri"
                     /strain="AK 623"
     misc_feature    <1..>12707
                     /note="lactonamycin Z biosynthetic gene cluster"
     protocluster    1..12707
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[4474:6957]"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="8|9 (Score: 657.9; E-value:
                     1.1e-200)"
                     /t2pks_molecular_weights="acetyl-CoA_8 (Da): 525.567"
                     /t2pks_molecular_weights="acetyl-CoA_9 (Da): 567.603"
                     /t2pks_product_classes="tetracenomycin"
                     /t2pks_starter_units="acetyl-CoA (Score: 0.0; E-value: 0)"
                     /tool="antismash"
     proto_core      4475..6957
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="8|9 (Score: 657.9; E-value:
                     1.1e-200)"
                     /t2pks_molecular_weights="acetyl-CoA_8 (Da): 525.567"
                     /t2pks_molecular_weights="acetyl-CoA_9 (Da): 567.603"
                     /t2pks_product_classes="tetracenomycin"
                     /t2pks_starter_units="acetyl-CoA (Score: 0.0; E-value: 0)"
     cand_cluster    1..12707
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(t2ks and t2clf)"
                     /kind="single"
                     /product="T2PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..12707
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000237"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..12707
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T2PKS"
                     /region_number="1"
                     /rules="(t2ks and t2clf)"
                     /subregion_numbers="1"
                     /tool="antismash"
     aSDomain        43..234
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_lcz24_ACP.1"
                     /evalue="2.10E-11"
                     /label="lcz24_ACP.1"
                     /locus_tag="lcz24"
                     /protein_end="78"
                     /protein_start="14"
                     /score="35.8"
                     /tool="antismash"
                     /translation="TYAGESEEGALDGDIVDVLFTHLGYDSVALMEVLSQIKHQYGIDL
                     SDDSVDALRTPRAVIEKVN"
     gene            283..1290
                     /gene="lcz25"
     CDS             283..1290
                     /codon_start=1
                     /gene="lcz25"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 272; E-value:
                     1.2e-82)"
                     /gene_functions="biosynthetic-additional (t2pks) MET C11O
                     (Score: 532.7; E-value: 7.6e-163)"
                     /gene_kind="biosynthetic-additional"
                     /note="O-methyltransferase"
                     /product="Lcz25"
                     /protein_id="ABX71142.1"
                     /transl_table=11
                     /translation="MRPKRLQLVLLASGGRLFQLVNALAELGIADILEGGPLPIAELAK
                     RAGAHEQALQRVLRATAMLGIFAEGPTGIFRSTPVTKALTQDNPHGVFPLIRYNHMELT
                     SRPFEHTLHSLRTGESAFKEAFGTAFNDHLEQNPEADRFCDEFQTYWAKQFAEEELDEW
                     DLGRFSSIADLGGGDGYFLAQALRRYPQMRAYLFDLPWMAKKGEQIFANHGVGDRAEII
                     GGDLLTDPLPRGAECYFVKAVFMRFSDDEAVAALRNIRESIGDDTKARLLIVDSVLKPG
                     NEWDHGKLLDVDMLVLHGGRKRTLEDWNELFSRTGFKLLNKPVYHWDLLECKPV"
     gene            1323..1574
                     /gene="lcz26"
     CDS             1323..1574
                     /NRPS_PKS="Domain: PP-binding (10-62). E-value: 1.4e-10.
                     Score: 33.4. Matches aSDomain:
                     nrpspksdomains_lcz26_PP-binding.1"
                     /codon_start=1
                     /gene="lcz26"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (t2pks) ACP
                     (Score: 32.0; E-value: 2.1e-10)"
                     /gene_kind="biosynthetic-additional"
                     /note="acyl carrier protein"
                     /product="Lcz26"
                     /protein_id="ABX71143.1"
                     /sec_met_domain="PP-binding (E-value: 3.8e-11, bitscore:
                     33.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MASAGISRSVLRDILTTHIGLDPETIDGAGGASLADLGVDSIGFI
                     ELQKAVEEQYGTELPDDAQAWSLDGILDHLNSSLRRAS"
     aSDomain        1353..1508
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_lcz26_PP-binding.1"
                     /evalue="1.40E-10"
                     /label="lcz26_PP-binding.1"
                     /locus_tag="lcz26"
                     /protein_end="62"
                     /protein_start="10"
                     /score="33.4"
                     /tool="antismash"
                     /translation="LRDILTTHIGLDPETIDGAGGASLADLGVDSIGFIELQKAVEEQY
                     GTELPDD"
     gene            1574..2035
                     /gene="lcz27"
     CDS             1574..2035
                     /NRPS_PKS="Domain: Polyketide_cyc2 (5-145). E-value:
                     1.3e-21. Score: 69.3. Matches aSDomain:
                     nrpspksdomains_lcz27_Polyketide_cyc2.1"
                     /codon_start=1
                     /gene="lcz27"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1128:cyclase/dehydrase (Score: 200.5; E-value:
                     6.5e-61)"
                     /gene_functions="biosynthetic-additional (t2pks) CYC C9-C14
                     (Score: 237.3; E-value: 1.2e-73)"
                     /gene_kind="biosynthetic-additional"
                     /note="polyketide cyclase"
                     /product="Lcz27"
                     /protein_id="ABX71144.1"
                     /transl_table=11
                     /translation="MASSTDNSVHIAAPLDVVWRLTNDVRTWPDLFTEYASVEVLHEDG
                     PTVRFRLTMVPDDDGTVWSWVSERTTDVAAHSVRAHRIETGPFVYMRIRWSYEPDGEGT
                     KMRWRQEFEAKPDAPFDDEAITKRINENTRIQMDVIKKKVEAAAPAPHS"
     aSDomain        1589..2008
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_lcz27_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="1.30E-21"
                     /label="lcz27_Polyketide_cyc2.1"
                     /locus_tag="lcz27"
                     /protein_end="145"
                     /protein_start="5"
                     /score="69.3"
                     /tool="antismash"
                     /translation="DNSVHIAAPLDVVWRLTNDVRTWPDLFTEYASVEVLHEDGPTVRF
                     RLTMVPDDDGTVWSWVSERTTDVAAHSVRAHRIETGPFVYMRIRWSYEPDGEGTKMRWR
                     QEFEAKPDAPFDDEAITKRINENTRIQMDVIKKKVE"
     gene            2084..3658
                     /gene="lcz28"
     CDS             2084..3658
                     /NRPS_PKS="Domain: AMP-binding (11-419). E-value: 6.6e-77.
                     Score: 250.6. Matches aSDomain:
                     nrpspksdomains_lcz28_AMP-binding.1"
                     /codon_start=1
                     /gene="lcz28"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score:
                     303.6; E-value: 3.5e-92)"
                     /gene_kind="biosynthetic-additional"
                     /note="carboxylic acid adenylation protein"
                     /product="Lcz28"
                     /protein_id="ABX71145.1"
                     /sec_met_domain="AMP-binding (E-value: 1.1e-82, bitscore:
                     267.7, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTHRTLHDWFAGSAARHGDAVALEVGGYTLTYRHLDRTVDHIARA
                     VLDTCDTTPRRVGLYASRSVAAYAGYLAALRLGATVVPLNPSFPAARNERIVGNAALDV
                     VIAQDADPGLPAPACVVDPSLAQRTALALREPGPASTGRRPDPEAAAYILFTSGSTGAP
                     KGVPVAHRSVDAYLRHVIPRYALGPGARVTQTFDLTFDLSVFDLFCTWGSGAALVVPTR
                     GDLLAPARFVAARGITHWFSVPSAISLAQGLGRLAENSMPNLRWSLFCGEPLTLEQARA
                     WQRAAPGSTMENLYGPTELTLSCAQFRLPVGRAAWPVTANGTVPVGELYPGLEALVVGY
                     DHRPGTTGELCVRGAQRFGGYLDPDDNRGRFVTFDGTRVTVWDQPAAPPEDAWYRTGDR
                     VRDEDGCLVHLGRLDHQVKVQGYRVELGEIEAVLRGHPQVTEAVVVAVRDDDGPMTLHA
                     VCTGTGGGDGDELLTLLRTKLPQHMIPRSLAFWRRFPLNSNGKVDRNAIGAAVMSANNN
                     EADERRE"
     aSDomain        2117..3340
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_lcz28_AMP-binding.1"
                     /evalue="6.60E-77"
                     /label="lcz28_AMP-binding.1"
                     /locus_tag="lcz28"
                     /protein_end="419"
                     /protein_start="11"
                     /score="250.6"
                     /specificity="substrate consensus: Gly"
                     /tool="antismash"
                     /translation="GSAARHGDAVALEVGGYTLTYRHLDRTVDHIARAVLDTCDTTPRR
                     VGLYASRSVAAYAGYLAALRLGATVVPLNPSFPAARNERIVGNAALDVVIAQDADPGLP
                     APACVVDPSLAQRTALALREPGPASTGRRPDPEAAAYILFTSGSTGAPKGVPVAHRSVD
                     AYLRHVIPRYALGPGARVTQTFDLTFDLSVFDLFCTWGSGAALVVPTRGDLLAPARFVA
                     ARGITHWFSVPSAISLAQGLGRLAENSMPNLRWSLFCGEPLTLEQARAWQRAAPGSTME
                     NLYGPTELTLSCAQFRLPVGRAAWPVTANGTVPVGELYPGLEALVVGYDHRPGTTGELC
                     VRGAQRFGGYLDPDDNRGRFVTFDGTRVTVWDQPAAPPEDAWYRTGDRVRDEDGCLVHL
                     GRLDHQVKV"
     CDS_motif       2534..2593
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_lcz28_0001"
                     /evalue="4.40E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="lcz28"
                     /protein_end="170"
                     /protein_start="150"
                     /score="28.4"
                     /tool="antismash"
                     /translation="AYILFTSGSTGAPKGVPVAH"
     CDS_motif       3059..3124
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_lcz28_0002"
                     /evalue="1.80E+00"
                     /label="NRPS-A_a6"
                     /locus_tag="lcz28"
                     /protein_end="347"
                     /protein_start="325"
                     /score="1.2"
                     /tool="antismash"
                     /translation="VGELYPGLEALVVGYDHRPGTT"
     CDS_motif       3113..3196
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_lcz28_0003"
                     /evalue="2.70E-05"
                     /label="NRPS-A_a6"
                     /locus_tag="lcz28"
                     /protein_end="371"
                     /protein_start="343"
                     /score="16.6"
                     /tool="antismash"
                     /translation="PGTTGELCVRGAQRFGGYLDPDDNRGRF"
     CDS_motif       3308..3373
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_lcz28_0004"
                     /evalue="7.70E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="lcz28"
                     /protein_end="430"
                     /protein_start="408"
                     /score="34.0"
                     /tool="antismash"
                     /translation="HLGRLDHQVKVQGYRVELGEIE"
     gene            3661..3990
                     /gene="lcz29"
     CDS             3661..3990
                     /codon_start=1
                     /gene="lcz29"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1225:Polyketide synthesis cyclase (Score: 124.5;
                     E-value: 3e-38)"
                     /gene_functions="biosynthetic-additional (t2pks) CYC
                     C4-C21/C2-C23|C2-C19 (Score: 142.1; E-value: 1.3e-44)"
                     /gene_kind="biosynthetic-additional"
                     /note="polyketide cyclase"
                     /product="Lcz29"
                     /protein_id="ABX71146.1"
                     /transl_table=11
                     /translation="MQRILFIDRMHPQDADEVAKVWRAHDATGLPEEIGVARRHLYRFH
                     GLYVHLVESRDGLDDDLTDRIFAARDAREFVETRDALGRLLTPYSPEFRNLKATRAEEF
                     YRWQA"
     gene            4035..4472
                     /gene="lcz30"
     CDS             4035..4472
                     /codon_start=1
                     /gene="lcz30"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MannoseP_isomer"
                     /gene_functions="biosynthetic-additional (t2pks) CYC C5-C18
                     (Score: 191.0; E-value: 1.6e-59)"
                     /gene_kind="biosynthetic-additional"
                     /note="polyketide cyclase"
                     /product="Lcz30"
                     /protein_id="ABX71147.1"
                     /sec_met_domain="MannoseP_isomer (E-value: 1.5e-08,
                     bitscore: 24.6, seeds: 17, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKKESIPVSGPVKISMADAPVSTRLGGAIRPLLTPKSVGASSGFL
                     GTMTLQPGEFIAEHYHPYSEEFMFVARGEIVVRIDGEEIVARANEAVLVPKFGSHRYEN
                     RGTDLALIVFQMSPLAPSPEEGHVEVEKPPFPTATPPVVGQ"
     gene            4475..5740
                     /gene="lcz31"
     CDS             4475..5740
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (5-391). E-value:
                     2.1e-56. Score: 183.5. Matches aSDomain:
                     nrpspksdomains_lcz31_PKS_KS.1"
                     /codon_start=1
                     /gene="lcz31"
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2ks"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 450.7; E-value:
                     8.7e-137)"
                     /gene_functions="biosynthetic-additional (t2pks) KS (Score:
                     709.5; E-value: 2.9e-216)"
                     /gene_kind="biosynthetic"
                     /note="ketosynthase alpha subunit"
                     /product="Lcz31"
                     /protein_id="ABX71148.1"
                     /sec_met_domain="t2ks (E-value: 2.2e-216, bitscore: 708.7,
                     seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSRAVITGMGVVAPGGVGTKPFWEQITSGRPATRTVSLFDATGYR
                     SQIAGEVDFDPIAAGLTPQQAGDLDRMVQFALVGLAEAIADSGIELEEADPARIGVSVG
                     TAVGLTMGLEREYAKVSHHGQKWLVDHALAAGTLFDNFIPSSLAREVAWAAGAEGPATV
                     VSTGCTSGLDAVGYALDLIREGSADIVITGATDAPLSPITYACFDALRATSPDNHDPLG
                     ACRPFDRTRNGFALGEGAAIFVLESEEHARRRDAHIYAELAGFATRCNAYHMTGLRPDG
                     AEMAEAIRSAMAQAQVPRDGFQYINAHGSGTRQNDLHETAAFKDALGAAAYDTPISSIK
                     SMIGHALGSVGSIEIAACVLAIEHGVVPPTANLREPDSECDLDYIPVVAREVQVETALT
                     VGSGFGGFQSAAILRRMKDGRA"
     aSDomain        4490..5647
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_lcz31_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.10E-56"
                     /label="lcz31_PKS_KS.1"
                     /locus_tag="lcz31"
                     /protein_end="391"
                     /protein_start="5"
                     /score="183.5"
                     /tool="antismash"
                     /translation="ITGMGVVAPGGVGTKPFWEQITSGRPATRTVSLFDATGYRSQIAG
                     EVDFDPIAAGLTPQQAGDLDRMVQFALVGLAEAIADSGIELEEADPARIGVSVGTAVGL
                     TMGLEREYAKVSHHGQKWLVDHALAAGTLFDNFIPSSLAREVAWAAGAEGPATVVSTGC
                     TSGLDAVGYALDLIREGSADIVITGATDAPLSPITYACFDALRATSPDNHDPLGACRPF
                     DRTRNGFALGEGAAIFVLESEEHARRRDAHIYAELAGFATRCNAYHMTGLRPDGAEMAE
                     AIRSAMAQAQVPRDGFQYINAHGSGTRQNDLHETAAFKDALGAAAYDTPISSIKSMIGH
                     ALGSVGSIEIAACVLAIEHGVVPPTANLREPDSECDLDYIPVVARE"
     gene            5737..6957
                     /gene="lcz32"
     CDS             5737..6957
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (69-404). E-value:
                     7.2e-27. Score: 86.2. Matches aSDomain:
                     nrpspksdomains_lcz32_PKS_KS.1"
                     /codon_start=1
                     /gene="lcz32"
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2clf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 636.9; E-value:
                     1.9e-193)"
                     /gene_functions="biosynthetic-additional (t2pks) CLF 8|9
                     (Score: 657.9; E-value: 1.1e-200)"
                     /gene_kind="biosynthetic"
                     /note="ketosynthase beta subunit"
                     /product="Lcz32"
                     /protein_id="ABX71149.1"
                     /sec_met_domain="t2clf (E-value: 2.1e-194, bitscore: 635.7,
                     seeds: 26, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAKIVVTGIGIVAPNGLGTDAYWKATVATRSGLGVISRFDATLY
                     PVQVAGEVARFTPSEHVPGRLIPQTDRTTQFALAAAQWAIEDAGVDFAELGPYDAGVIT
                     ASGCGGFEFGQRELQKLWSEGPHRVSAYQSFAWFYAVNTGQLSIRHGARGAGSVVVGEQ
                     AGGVDALASARRRLRNGDLAVVLGGGMDAPLSPWGLTAQIPVGLLSTRQDPDRAYLPFD
                     AEATGYVPGEGGAVLVLEELEAARRRGAPAVYGEIAGYAATFDPRPGSGRPPALARAIR
                     GALSDAELGPSDVDVVFADGSGVPCNDTAEAAALREVFGPRGVPVSVPKTMTGRLYAGG
                     APLDVATALLSIRDQVVPAAAHLCEIPEAYGLDVVVDGPRELPVRTALVVARGHGGFNS
                     ALVVRAV"
     aSDomain        5944..6948
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_lcz32_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="7.20E-27"
                     /label="lcz32_PKS_KS.1"
                     /locus_tag="lcz32"
                     /protein_end="404"
                     /protein_start="69"
                     /score="86.2"
                     /tool="antismash"
                     /translation="TDRTTQFALAAAQWAIEDAGVDFAELGPYDAGVITASGCGGFEFG
                     QRELQKLWSEGPHRVSAYQSFAWFYAVNTGQLSIRHGARGAGSVVVGEQAGGVDALASA
                     RRRLRNGDLAVVLGGGMDAPLSPWGLTAQIPVGLLSTRQDPDRAYLPFDAEATGYVPGE
                     GGAVLVLEELEAARRRGAPAVYGEIAGYAATFDPRPGSGRPPALARAIRGALSDAELGP
                     SDVDVVFADGSGVPCNDTAEAAALREVFGPRGVPVSVPKTMTGRLYAGGAPLDVATALL
                     SIRDQVVPAAAHLCEIPEAYGLDVVVDGPRELPVRTALVVARGHGGFNSALVVR"
     misc_feature    6172..6174
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       6397..6435
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_lcz32_0001"
                     /evalue="4.20E-04"
                     /label="PKSI-KS_m4"
                     /locus_tag="lcz32"
                     /protein_end="233"
                     /protein_start="220"
                     /score="13.4"
                     /tool="antismash"
                     /translation="FDAEATGYVPGEG"
     gene            6973..7320
                     /gene="lcz33"
     CDS             6973..7320
                     /codon_start=1
                     /gene="lcz33"
                     /note="monooxygenase"
                     /product="Lcz33"
                     /protein_id="ABX71150.1"
                     /transl_table=11
                     /translation="MATIARENDYYTLINVFTVAPEDQERIYDVIIEATDVIEKFPGFV
                     SANVHKSYDGTRVINYAQWRSKEDFDAMHRHPDVKDHFKACRAITDDIVPIFCEVVHVH
                     RSPSAGADRVS"
     gene            7340..8080
                     /gene="lcz34"
     CDS             7340..8080
                     /NRPS_PKS="Domain: Thioesterase (12-234). E-value: 4.9e-34.
                     Score: 110.6. Matches aSDomain:
                     nrpspksdomains_lcz34_Thioesterase.1"
                     /codon_start=1
                     /gene="lcz34"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1004:thioesterase (Score: 187.3; E-value: 4e-57)"
                     /gene_kind="biosynthetic-additional"
                     /note="thioesterase"
                     /product="Lcz34"
                     /protein_id="ABX71151.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 7.9e-14, bitscore:
                     42.7, seeds: 455, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGGGPPPHAETVLYCLPNAGGGGTHYLSWRRLLPDTLWVQPVQLP
                     GRENRLLEDPRFDVAEVARALAEHVDRPYVLYGHSMGGVLAWKAAVALAHRGVPLPERL
                     VVAASPAPREYTPWARRWAALSEAELLGEVAALGGVPPQVLDHPRLSQRIATVLAADVG
                     WLAERSAGIRDDPLPVPVLALAGQEDPLVRPEHMAGWAECTSQDFQLHVIAGGHLFHTN
                     HAEAVTSAILQTIVAEKGNLHEVR"
     aSDomain        7376..8041
                     /aSDomain="Thioesterase"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_lcz34_Thioesterase.1"
                     /evalue="4.90E-34"
                     /label="lcz34_Thioesterase.1"
                     /locus_tag="lcz34"
                     /protein_end="234"
                     /protein_start="12"
                     /score="110.6"
                     /tool="antismash"
                     /translation="LYCLPNAGGGGTHYLSWRRLLPDTLWVQPVQLPGRENRLLEDPRF
                     DVAEVARALAEHVDRPYVLYGHSMGGVLAWKAAVALAHRGVPLPERLVVAASPAPREYT
                     PWARRWAALSEAELLGEVAALGGVPPQVLDHPRLSQRIATVLAADVGWLAERSAGIRDD
                     PLPVPVLALAGQEDPLVRPEHMAGWAECTSQDFQLHVIAGGHLFHTNHAEAVTSAILQT
                     "
     misc_feature    7433..7435
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     CDS_motif       7550..7618
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_lcz34_0001"
                     /evalue="3.10E-09"
                     /label="NRPS-te1"
                     /locus_tag="lcz34"
                     /protein_end="93"
                     /protein_start="70"
                     /score="29.2"
                     /tool="antismash"
                     /translation="DRPYVLYGHSMGGVLAWKAAVAL"
     gene            8106..9077
                     /gene="lcz35"
     CDS             8106..9077
                     /codon_start=1
                     /gene="lcz35"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 273.3; E-value:
                     5e-83)"
                     /gene_functions="biosynthetic-additional (t2pks) MET
                     C13O|C17O (Score: 520.6; E-value: 3.3e-159)"
                     /gene_kind="biosynthetic-additional"
                     /note="O-methyltransferase"
                     /product="Lcz35"
                     /protein_id="ABX71152.1"
                     /transl_table=11
                     /translation="MDIASGFWRARALFSAVDLDLFTHLAKGPATREELQDSLGLHPSP
                     AEDFLDALVALGLLQREDGRYANARAAERYLDRAKDSYVGGFFTFMSYSLYPAWGRLTG
                     LLRSGGRQEGLDDFGEWYKDLDQVRGFMHAMDSVSAPVTEELVRRFDWSAYRTFADLGG
                     ARGNLAGHLVKAHTHLRGTTFDVPAVKPLFEEHVAKLGVADKVDFQGGDFRIDPLPETD
                     VLIFGHVLHDWDADTRELLVKRAYDALRPGGALLIYEELLDDDRRGPARSLLMSLNMRL
                     VRSDGSEYTAAESRGWLREAGFAEVSVEDLTATERLVVARKK"
     gene            complement(9261..10544)
                     /gene="lcz36"
     CDS             complement(9261..10544)
                     /codon_start=1
                     /gene="lcz36"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062:glycosyltransferase, MGT family (Score: 379.5;
                     E-value: 3.7e-115)"
                     /gene_functions="biosynthetic-additional (t2pks) GT (Score:
                     468.4; E-value: 5.7e-143)"
                     /gene_kind="biosynthetic-additional"
                     /note="glycosyltransferase"
                     /product="Lcz36"
                     /protein_id="ABX71153.1"
                     /sec_met_domain="MGT (E-value: 2.6e-136, bitscore: 444.8,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRVLFAVMPSPTHLHPFVPLAWALQGAGHDVCVASHPDMVPTITE
                     AGLTAVGLGDPVDLAGSVDDCAADERLDPIISPLADPAEPGLWKVIRNILMSPFWLHYH
                     AEAPSPGEHPYTDALVSFARNWEPDLVLWDPMCFAGAVAARACGAAHARLLWAPDYFAW
                     TRKKYRTWLADPAAQPREDGMAALMAPTLERFGLAFDEDLLVGQWSLDPMPSQMRLPVD
                     LEYVPVRRVPYTGAQAVPAWLHERPRRTRVCLTLGVSTRTFFGKDSKLPMTEIFDAVAD
                     MDIEMVATLNADQLASVQRIPDNIRTVDYVPLNQLLPSCSAIIHHGSGGTFAAAVAHRT
                     PQLIASRPTGQSFDIARFTEKRGAGLVATDIESEDFSATEMRAQLERILREPSFQEGAD
                     ALRDEIARMPSPNDVVLTLEKLTARHRS"
     gene            10719..11132
                     /gene="lcz37"
     CDS             10719..11132
                     /codon_start=1
                     /gene="lcz37"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /note="hypothetical protein, ester cyclase"
                     /product="Lcz37"
                     /protein_id="ABX71154.1"
                     /sec_met_domain="PF07366 (E-value: 3.7e-35, bitscore:
                     110.5, seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSSSENRNAILRLYDEALNQGNYEQVIDELVADGAVMHHAPYHD
                     QTGPEVLKSTWRALHDAFSDLHFEVEELLVENDFIAVRGTTSGTHTGTFAGTGPTGQRV
                     SERAHVFYRLRDAKVTEIWPMVDRAGLLQQLHA"
     gene            complement(11232..12707)
                     /gene="lcz38"
     CDS             complement(11232..12707)
                     /codon_start=1
                     /gene="lcz38"
                     /gene_functions="transport (smcogs) SMCOG1005:Drug
                     resistance transporter, EmrB/QacA (Score: 399.4; E-value:
                     2.7e-121)"
                     /gene_kind="transport"
                     /note="membrane efflux protein"
                     /product="Lcz38"
                     /protein_id="ABX71155.1"
                     /transl_table=11
                     /translation="MRKWLPLVAVCLGSFMLIVDTTVVTVALPEIGTGLHASLSSLQWV
                     MNIYTLVLAALTLSAGSLGDLLGRRRVYLLSLTVFGGASLLCALANSPAMLVAARGVQG
                     IGGAAMFVTSMALLGTTYEGEERGTAMGVWSATIGVAAAVGPIFGGLLTQSMSWRAIFY
                     VNIPISLVTMLLTKICFAADTPQQRPRLDIPGIVTFALASGALTFGLILADDKGWTSNA
                     TLGLFALALLGVVLFIVAERRHPNPMLDLSLMRNASFAAIMLSTIAAAWGFSSLVFTSL
                     WLQSVVGLTPIKAGLALLPLAGATFVASTVTGKRLHNVSPRVTITTSLLLIGTGCAING
                     LLIHGGSSWAAAVPGLLVIGVGVGVGMPATGSAIFASLPPQRAGMGSGAMATFRQFGQA
                     LGVAVLGVIFSDVIHDHLVGKVADPQSAEDALTGGRRTTLGVLHDAGAHGLTSVYLATA
                     GLALVAALVTSSFVRKKAPSVPPAAPKEAAEVH"
ORIGIN
        1 gtgcagaaat tcacccttga tgacctggtg gatctcacgc gaacctatgc cggtgagtcg
       61 gaggaaggcg cactcgacgg tgacatcgtc gacgtcctct tcacgcatct cggctatgac
      121 tcggttgcgt tgatggaggt cctgagccag atcaagcatc aatacggcat cgacctatcc
      181 gatgattccg tggatgcact gagaaccccc cgtgcggtca tcgagaaggt caacgcagta
      241 atcagttccc aaggtgacaa ccgaaagaag gtttcgtcgt gagtgaggcc gaaaagactg
      301 cagctggtcc tgctcgcctc gggcggccgg ctgttccagc tcgtcaacgc gctcgcggag
      361 ctgggcatcg ccgacattct tgaaggcggc cccctgccga tcgcggagct cgcgaagcgg
      421 gccggtgccc acgagcaggc tttgcagagg gtgctgcggg ccaccgccat gctcggcatc
      481 ttcgccgagg ggccaaccgg catcttccgt tctacgccgg tcaccaaggc gctgacccag
      541 gacaacccgc acggtgtgtt cccgctgatc cgctacaacc acatggaact cacctcccgc
      601 cccttcgagc acacgctgca cagcctcagg acgggcgagt cggccttcaa agaggccttc
      661 ggcaccgcgt tcaacgacca cctggagcag aacccggagg ccgaccgctt ctgcgacgag
      721 ttccagacct actgggccaa gcagttcgcc gaggaagagc tcgacgagtg ggacctgggc
      781 cgcttctcca gcatcgccga cctgggcggc ggtgacggct acttcctggc gcaggccctg
      841 cgacgctatc cgcagatgcg ggcgtatctg ttcgacctgc cctggatggc gaagaagggg
      901 gagcagatct tcgcgaacca tggcgtcggc gaccgtgccg agatcatcgg cggcgacctg
      961 ctgacggacc cgctgccccg gggcgccgag tgctatttcg tcaaggccgt gttcatgcgc
     1021 ttctccgacg acgaggccgt cgcggcactg cgcaacatcc gcgagtcaat cggcgacgac
     1081 accaaggcgc gcctgctaat cgtcgactcc gtgctcaagc ccggcaacga gtgggaccac
     1141 ggcaaactgc tcgatgtcga catgctcgtg ctccacggcg ggcgcaagcg cactctcgag
     1201 gactggaacg agctgttctc acgcaccggg ttcaagctgc tgaataagcc cgtctaccac
     1261 tgggacctgc ttgagtgcaa gccggtctga ggccccggac agtccagccc aaggaggaaa
     1321 gcatggcatc cgccggcata tcgcgctcgg tcctgcgcga catcctgacc acccacatcg
     1381 gcctcgaccc ggagaccatc gacggggcgg gcggcgcctc gctggccgac ctcggcgtcg
     1441 actccatcgg cttcatcgag ttgcagaagg ccgtggagga gcagtacggc acggagctcc
     1501 ccgacgacgc ccaggcatgg agcctcgacg ggatcctcga ccacctgaac tcaagcctga
     1561 ggagggcaag ctgatggcga gcagcacgga caactcggtt cacatcgcgg caccgctgga
     1621 cgtggtgtgg cggctgacca acgacgtcag gacctggccg gacctcttta ccgagtacgc
     1681 ctcggtggag gtgctccacg aggacgggcc caccgtccgc ttccggctca cgatggtgcc
     1741 ggacgacgac ggcaccgtat ggagctgggt cagcgagcgc accacggacg tggcggcgca
     1801 ctccgtgcgc gcccacagga tcgagactgg ccccttcgtg tacatgcgca tccgctggag
     1861 ctacgagccc gacggtgagg gcacgaagat gcgttggcgc caggagttcg aggcgaagcc
     1921 cgacgctccc ttcgacgacg aggccatcac caagcgcatc aacgagaaca cccggatcca
     1981 gatggacgtg atcaagaaga aggtcgaggc ggccgcgccc gcgccgcaca gctgagtcgc
     2041 agcaacgtac tgcgcacccc cgacggcgtc tggatgggaa gagatgacac atcgaacgct
     2101 gcacgactgg ttcgctgggt ccgcggcccg gcacggtgac gcggtcgctc ttgaggtcgg
     2161 cggatatacc ctgacgtatc gtcaccttga ccggaccgtg gaccacatcg cccgcgcggt
     2221 cctggacaca tgcgacacca cgccccggcg cgtcggcctg tacgcgtccc ggtctgtggc
     2281 ggcgtacgcc ggctacctgg cggcattgcg tctgggcgcc accgtcgtac cgctcaaccc
     2341 gtcctttcct gcggcccgca acgaacggat cgtgggcaat gccgcgctgg acgtggtgat
     2401 cgcgcaggac gcggatccgg gactgcctgc gcccgcctgc gtggtggacc cctcactcgc
     2461 gcagcggacg gcgctagccc tgcgggaacc cggcccggcc agtacgggac gccgaccgga
     2521 tccggaggcg gcagcgtaca tcctcttcac atcagggtcg actggcgctc ccaagggtgt
     2581 accggtcgcg caccgcagcg tcgatgccta tctgcggcac gtcattccgc gctatgcgtt
     2641 ggggcccggt gcacgggtga cacagacctt cgacctgacc ttcgacctgt cggttttcga
     2701 cctgttctgc acgtggggat cgggggcagc ccttgtggtg cccacccgcg gcgacctgct
     2761 tgcgccagcg cggttcgtcg cagcgcgcgg catcacccat tggttctccg tgccctcggc
     2821 gatatcgctc gcgcagggcc tgggccgact ggccgagaac tcgatgccga atctgcgctg
     2881 gagcctgttc tgcggcgagc cattgaccct tgaacaggcc cgcgcttggc agcgggcggc
     2941 gcccggaagc accatggaga acctctacgg gcccaccgaa ctcacactca gctgcgcgca
     3001 gttccggctc ccggtaggcc gggcggcatg gccggtgacc gcgaacggca ccgtgcctgt
     3061 gggcgagctg tatcccggct tggaggcgct tgtcgtcggg tacgaccacc gtccgggcac
     3121 cactggcgaa ctgtgcgtgc gaggcgccca gcggttcggc ggctacctcg acccggacga
     3181 caaccgaggc cgcttcgtca ccttcgacgg cacccgggtg accgtctggg accagcctgc
     3241 ggctccgccc gaggacgcct ggtaccgcac cggcgaccgg gtccgcgacg aggacggctg
     3301 cctcgtccac ctcggccgcc tcgaccacca ggtcaaggtg cagggctacc gggtcgagct
     3361 cggcgagatc gaggccgttc tgcgcggtca tccgcaggtg accgaggccg tcgtagtcgc
     3421 cgtacgtgac gacgacggtc cgatgacgct gcacgcggtg tgcaccggca ccggcggggg
     3481 cgacggcgac gaactcctca ccttgctacg gacaaaactc ccgcagcaca tgattccccg
     3541 gtctctcgcg ttctggcgcc gctttccgct gaactccaac ggaaaggtcg accgcaatgc
     3601 gatcggagcg gccgtcatgt cagcgaacaa caacgaggca gacgaacgga gagagtgaga
     3661 atgcagcgaa tcctcttcat cgaccgcatg catccgcagg atgcagacga ggtggcgaag
     3721 gtatggcggg cgcacgacgc cacgggcctg cccgaagaga tcggtgtcgc gcgcagacac
     3781 ctctatcggt tccacggact gtacgtacac ctggtcgagt cccgggacgg cctggacgac
     3841 gacctcaccg atcgcatctt cgccgctcgc gacgcccgag agttcgtcga gacccgtgac
     3901 gcgctgggcc gtctcctgac gccctactcg cccgagttcc ggaacctcaa ggccaccagg
     3961 gcggaggagt tctaccgctg gcaggcgtga cccatctctt ccgcagcccg ttcgaagccc
     4021 gcaatgaagc ccgtatgaag aaggagagca tccctgtgtc gggtccggtc aagatttcca
     4081 tggcagatgc gccggtgagc acgcggctgg gcggggcaat ccgcccgctg ctcacgccga
     4141 agtcggtcgg ggcgagttcg ggattcctcg gaacaatgac cctgcagccc ggcgagttca
     4201 tcgccgagca ctaccacccc tactcggaag agttcatgtt cgtggcccgg ggcgagatcg
     4261 tcgtgcgaat cgacggcgag gagatagtgg cccgcgccaa tgaggcggtg ctggtgccca
     4321 agttcggctc gcaccgctac gagaaccggg gcaccgatct cgcgctgatc gtcttccaga
     4381 tgtcaccgct cgctcccagc cccgaagagg ggcatgtcga ggtggagaag ccgccgttcc
     4441 cgacggcgac ccctccggtc gtggggcagt gaccatgtcc cgagccgtca tcacggggat
     4501 gggtgtcgtc gctccgggcg gagtcggcac caagcctttc tgggaacaga taacttccgg
     4561 gcggcccgcg acccgcacgg tgtctctctt cgacgccacg ggataccggt cgcagatcgc
     4621 tggcgaggtc gacttcgatc cgatcgccgc cggactgacc ccgcagcagg ccggagatct
     4681 cgaccggatg gtgcagttcg cgctggtggg cctcgccgag gcgatcgccg acagcggcat
     4741 cgaactggag gaggccgacc ctgcgcgcat cggcgtcagc gtcggcacgg cggtcggcct
     4801 gacgatgggc ctggagcgcg agtatgccaa ggtcagccac catggccaga agtggctcgt
     4861 ggatcacgcc ctagcggccg gcactctctt cgacaacttc atcccctcct cgctcgcccg
     4921 cgaggtggcc tgggcggccg gggcggaagg ccccgccaca gtggtgtcca ccggctgcac
     4981 ctccggtctg gacgcagtcg gttacgcact agacctgatc cgcgagggat ccgccgacat
     5041 cgtaatcacc ggtgcgaccg acgcgcccct gtcaccgatc acctatgcgt gcttcgacgc
     5101 gctgagggcc acgtccccgg acaaccacga ccccctcggc gcgtgccggc ctttcgaccg
     5161 gacccgcaac ggattcgccc tcggcgaggg cgccgcgatc ttcgtcctgg agagcgagga
     5221 acacgcccgt cggcgcgatg cgcacatcta cgccgagttg gcggggttcg ccacgcgctg
     5281 caatgcctac cacatgaccg gcctgcgccc ggacggggcc gaaatggccg aggccatccg
     5341 ctccgccatg gcccaggctc aggtcccccg cgacgggttc cagtacatca acgcccacgg
     5401 ctccggtacc cggcagaacg acctgcacga gacggccgcg ttcaaggacg ccctcggcgc
     5461 cgccgcctac gacaccccga tcagctccat caagtcgatg atcggtcacg cgctcgggtc
     5521 ggtgggttcc atcgagatcg cggcctgtgt gctggcgatt gagcacggag tggttccgcc
     5581 gacggccaac ctccgtgagc cggactccga gtgcgacctg gactacatcc ccgtggtcgc
     5641 acgggaggtg caggtggaaa ccgccctcac ggtcggcagc ggcttcggcg gattccagag
     5701 cgcggcaatc ctgcgccgga tgaaggacgg tcgggcatga cagcaaagat cgtcgtcaca
     5761 ggcatcggca tcgtggcacc gaacggcctg ggcaccgacg cgtactggaa ggctaccgtc
     5821 gccacgcgca gcggcctggg cgtcatctcc cgcttcgatg ccaccctgta cccggtccaa
     5881 gtagccggcg aggtcgccag gttcacaccg tccgagcacg tgcccggacg gctgatcccg
     5941 cagaccgacc ggaccacgca gttcgcgctc gccgccgccc agtgggcgat cgaggacgcg
     6001 ggcgtcgact tcgcagaact gggaccgtac gacgccgggg tgatcaccgc gagcggatgc
     6061 ggcggcttcg agttcggcca gcgcgaactg cagaagctgt ggagcgaggg tccgcatcgg
     6121 gtcagcgcct accagtcgtt cgcctggttc tacgcggtca acaccggcca gttatccatc
     6181 cggcacggcg cccgcggcgc cggatcggtg gtggtcggcg agcaggccgg cggcgttgac
     6241 gcactcgcga gcgcacggcg tcggctccgc aacggcgacc tcgcggtggt cctcggcggc
     6301 gggatggacg cgccgctgtc tccatggggc ctcaccgcgc agatcccggt cgggctgctc
     6361 agcacccggc aggacccgga ccgcgcgtac ctgcccttcg acgccgaagc cacgggctac
     6421 gttccgggcg agggcggagc cgttctcgtg ctggaggaac tggaggccgc acgtcgccgt
     6481 ggtgcaccgg ccgtgtacgg cgagattgcg ggctacgcgg cgacgttcga cccccgcccc
     6541 ggctccgggc ggcccccggc cctggcccgg gcgatccgcg gcgccctgtc ggacgcggag
     6601 ctcgggccgt cggacgtcga tgtcgtcttc gccgacggga gcggagttcc ctgcaatgac
     6661 accgcagaag cggctgcgct ccgggaggtc ttcgggccgc gaggcgtccc agtgtccgtt
     6721 cccaagacaa tgaccggccg actctacgcg ggcggcgccc ctctcgacgt ggccacggct
     6781 ctgctgagca tccgggacca ggtcgtgcca gccgctgccc acctgtgcga gatcccggag
     6841 gcctacggcc tcgacgtcgt ggtggacgga cctcgcgaac tgcccgttcg cacggccctc
     6901 gtcgtggcca ggggccacgg cggcttcaac tcagcacttg tcgtgcgcgc cgtctgaagg
     6961 agacagcacc cgatggccac catcgcccgc gagaacgact actacacgct catcaacgtc
     7021 ttcacggtcg cacccgagga ccaggagcgc atctacgacg tcatcatcga ggccaccgac
     7081 gtcatcgaga agttccccgg cttcgtctcg gcgaacgtcc acaagagcta cgacggcacc
     7141 cgcgtaatca attacgcgca gtggcgcagc aaagaggact tcgacgcgat gcatcgtcac
     7201 ccggacgtca aggaccactt caaggcctgc cgggccatca cggacgacat cgtgcccatc
     7261 ttctgcgagg tcgtgcatgt ccaccggtct ccctctgcgg gagcggaccg tgtcagctga
     7321 cgcccacgaa cggtggttcc tgggcggcgg gccgcccccg cacgccgaga ccgtcctgta
     7381 ctgcctgccg aacgcgggcg gcggcggcac ccactacctc tcgtggcggc gcttactgcc
     7441 cgacactctg tgggtccagc cggtgcagct tcccggccgg gagaaccggc tcctggagga
     7501 tccgcgcttc gacgtggcgg aggtggccag agccctggcg gagcacgtgg accgaccgta
     7561 cgtcctctac ggccacagca tgggcggcgt cctcgcctgg aaggcggccg tagcactggc
     7621 ccaccgggga gtccccctgc ccgaacggct cgtcgtcgcg gcgagcccgg caccgcggga
     7681 gtacacgccg tgggcccgtc gctgggcggc gctcagcgag gcggaactgc tcggcgaggt
     7741 cgcagccctg ggcggagtgc cgccccaggt gctggaccac cctcggctga gccagcgcat
     7801 cgccacggtc ctcgccgcgg acgtgggctg gctcgccgag cggtcggccg gtatccgcga
     7861 cgacccgctg cccgtaccgg tcctcgccct ggccgggcag gaggacccct tggtccggcc
     7921 cgagcacatg gcgggctggg ccgagtgcac gtcccaggac ttccaactgc acgtgatcgc
     7981 gggcggccac ctcttccaca cgaaccatgc agaggccgtc acgtcagcga ttctgcagac
     8041 cattgtcgcc gagaaaggaa acctccatga ggtccgttga cgcagatgcc cagcttcagt
     8101 ccgtgatgga catcgccagt ggattctggc gggcccgcgc gctcttcagc gccgtggacc
     8161 tggacctgtt cacccatctg gccaaggggc ccgccacccg tgaggaactc caggactccc
     8221 tcggcctgca cccgagcccg gccgaagact tcctcgacgc gctcgtcgcc ctgggcctgc
     8281 tgcagcgcga agacggccgg tacgctaacg ccagggccgc cgagcgttac ctggaccggg
     8341 ccaaggattc ctatgtcggc gggttcttca ccttcatgag ctactccctc tacccggcct
     8401 ggggccgcct gaccggtctg ctgcgcagtg gcggccggca ggagggcctg gacgacttcg
     8461 gcgagtggta taaggacctg gatcaagttc gcggattcat gcacgccatg gacagcgtct
     8521 ccgcgccggt gactgaggaa ctcgtccgcc gcttcgactg gtccgcgtac cggacattcg
     8581 ccgacctcgg gggggctcgt ggcaacctcg ctggccacct ggtcaaggcc cacacgcacc
     8641 tgcggggcac cacgttcgac gtgcccgccg tcaagccgct gttcgaggaa cacgtcgcga
     8701 agctgggcgt cgccgacaag gtcgacttcc agggcggcga cttccgcatc gacccgctgc
     8761 ccgagaccga cgtcctcatc ttcggccacg tcctgcacga ctgggatgcc gacacccggg
     8821 agctgctcgt caagcgggcc tacgacgcgc tccgcccggg gggcgccctg ctgatctacg
     8881 aggagctcct cgacgacgac cggcgcggtc cggcccgctc gctgctgatg agcctcaaca
     8941 tgcggctcgt gcgcagtgac ggatcggagt acacggcggc cgagagccgg ggctggctgc
     9001 gggaggccgg gttcgcggag gtctccgtgg aggatctcac cgcgaccgaa cgcctcgtcg
     9061 tggcccgcaa gaagtagaaa ggccccgcac cactgctcgc ggcccggccc gcgtgcctcg
     9121 cgaagatggg cgaggcacgc gggccgggcc gttcgcgctg tgcggcgagc ccggtcgggt
     9181 acccgcggcc agtacggcag tatgcgcaac gggccggccc ccgagggacc ggcccgccga
     9241 cgcagatgcc tgacgatttg tcaggaccgg tgccgggcgg tgagcttctc cagcgtcaga
     9301 acaacgtcgt tggggctcgg catccgcgcg atctcgtcgc gcagcgcgtc cgctccctcc
     9361 tggaaggagg gctcccgcag gatccgctcc aactgagccc gcatctcggt cgccgagaag
     9421 tcctcgctct cgatgtcggt ggcgaccaga cccgcaccgc gcttctccgt gaagcgggcg
     9481 atgtcgaagg actgtcccgt gggacgggag gcgatgagct gcggggtgcg gtgtgccacc
     9541 gcggccgcga aggtgccgcc gctgccgtgg tggatgatcg ccgagcagga cggcagcaac
     9601 tggttcagcg gtacatagtc caccgtacgg atgttgtcgg gtatgcgctg aacagaggcc
     9661 agctggtcgg cgttgagtgt ggccaccatc tcgatgtcca tgtcggcgac ggcgtcgaag
     9721 atctcagtca tgggcagttt gctgtccttg ccgaagaacg tccgtgtact cacccccagc
     9781 gtcaggcaca cacgcgtgcg ccgcggccgt tcgtggagcc acgctggaac ggcctgggcg
     9841 cccgtgtagg gcacccggcg gaccggaacg tactccaggt cgaccggcag acgcatttgg
     9901 gacggcatcg ggtcgaggct ccactggccg acgagcaggt cctcgtcgaa ggcgagaccg
     9961 aagcgctcaa gagtgggggc catgagggcc gccataccgt cctcgcgcgg ctgcgcggcc
    10021 ggatcagcga gccacgtacg gtatttcttc ctggtccacg cgaagtagtc gggggcccac
    10081 agcagacggg cgtgcgcggc gccacacgcc cgggccgcga cggcgccggc gaagcacatg
    10141 gggtcccaca gaaccaggtc gggctcccag ttgcgggcga aggacaccag ggcgtcggta
    10201 taggggtgct cgccggggct tggcgcctcg gcgtggtaat gcagccagaa cggcgacatc
    10261 agtatgttcc ggatcacctt ccacagcccg ggttcggccg ggtcggcgag gggggagatg
    10321 atcgggtcca gccgctcgtc cgcggcgcag tcgtccaccg agcccgcgag atccaccggg
    10381 tcgcccagac cgaccgctgt caggccggcc tcggtgatgg tgggcaccat gtcagggtgg
    10441 ctggccacgc acacgtcgtg tcctgcgccc tgcagtgccc atgccagtgg cacgaaggga
    10501 tgcagatgcg taggggacgg catgacagca aacagaactc tcatccatgc tctccaatcc
    10561 ttttcccgga gcgaacacat catttttgtc gccgcagctt tcccgataca agaccaggag
    10621 aagctggagt ccttttcttc agtgcttttc gagcgattct tcaacagagc tcggagagaa
    10681 tcctgctgcc tgtcggaccg ggaaaatgga gagaacacat gtcaagctcc agcgagaaca
    10741 ggaacgccat cctccgcctc tatgacgagg cgctcaacca gggcaattac gagcaggtca
    10801 tcgatgaact ggtggcggac ggcgcggtca tgcaccatgc gccttaccac gaccagaccg
    10861 gtcccgaggt tctcaagtcg acctggcgcg cgctgcacga tgccttcagc gaccttcact
    10921 tcgaggtcga ggagcttctc gtggagaacg acttcatcgc ggtgcgcggc accacctccg
    10981 gcacacacac cggcaccttc gcgggcaccg gccccacggg gcagcgggtg tcggagcggg
    11041 ctcacgtgtt ctaccggctg cgggacgcga aggtgaccga gatctggccc atggtcgacc
    11101 gggccggcct gctgcagcag ctgcacgctt gacccggcgc ggggacgaaa gtgagccgcc
    11161 gaccccaagg ggtcggcggc tcgtccgcgt accggcgacg ggggacacac ccgcacacgg
    11221 agttcggtgt gtcagtgcac ttccgcggcc tccttcggtg ccgcaggcgg caccgaagga
    11281 gccttcttgc ggacgaacga ggacgtcacc agggcggcca ccaaggcgag ccccgcggtg
    11341 gcgaggtata cggaggtcag accgtgcgcg cccgcgtcgt gaagcacacc gagggtggtg
    11401 cgccggccgc cggtcagggc gtcctcggcg gactggggat cggccacctt gcccaccagg
    11461 tgatcgtgga tcacatcgct gaagatcacg ccgaggacgg cgacgcccag tgcctgcccg
    11521 aattgacgga aggtggccat ggcgccggat cccatgccgg cccgctgtgg aggaagggag
    11581 gcgaagatcg cggaccccgt ggcgggcatc ccgacgccga cgccgacgcc gataacgagc
    11641 agccccggca ctgcggccgc ccacgatgag ccgccgtgga tcaacaagcc gttgatcgcg
    11701 cagccagtgc cgatgagcag cagcgacgtc gtgatggtca cccgcggtga gacgttgtgc
    11761 aggcgcttac cagtgaccgt ggaagcgacg aatgtggctc cggcgagcgg caacaaggcc
    11821 aggcccgcct tgatcggcgt gagtccgacg actgactgca gccacagcga ggtgaagacc
    11881 aggctggaga agccccaggc tgccgcgatc gtgctcagca tgatcgccgc gaacgacgcg
    11941 ttgcgcatca gcgacaggtc gagcatcggg ttcgggtgcc gccgctcagc gacaatgaac
    12001 agcaccaccc ctagcagggc gagcgcgaac agacccaggg tagcgttcga cgtccagccc
    12061 ttgtcgtcgg ccaggatcag cccaaaggtc agggcaccgg aggccagggc gaacgtgacg
    12121 atcccgggaa tgtcgaggcg cggacgctgc tgcggcgtat ccgcggcgaa gcagatcttg
    12181 gtcagcagca tcgtcaccag actgatcggg atgttgacgt agaagatggc ccgccagctc
    12241 atgctctggg tcagcaggcc gccgaagatc gggccgacgg ccgcagcaac accgatggtg
    12301 gccgaccaca cacccatggc ggtgccgcgt tcctcgccct cataggtggt gccgagcagg
    12361 gccatgctgg tgacgaacat ggcggcgccg ccgatgccct ggacaccgcg ggcggcgacg
    12421 agcatcgccg ggctgttggc caaggcgcac agcagggagg ctccaccgaa gacagtcagg
    12481 gacagcaggt acaccctgcg ccgccccagc agatcaccca gggaaccagc gctcagggtg
    12541 agggccgcca gcaccagggt gtaaatgttc atcacccact gcaggctgga gagcgaggcg
    12601 tgcaggccgg tgccgatctc gggcagcgcc acggtcacca ccgtggtgtc cacgatgagc
    12661 atgaacgacc ccaggcacac cgctacaagg ggcaaccact tgcgcat
//
