BGC0000238 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000238 (Streptomyces rishiriensis)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS,butyrolactone	1	61,508	lactonamycin	PKS	100%

BGC0000238 - Region 1 - T2PKS,butyrolactone

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Location: 1 - 61,508 nt. (total: 61,508 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)
butyrolactone: AfsA

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 61,509
Label		BGC0000238

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000238	1.26	Polyketide	lactonamycin	Streptomyces rishiriensis
BGC0000849	0.78	Other (Butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0002076	0.70	Other	4,5-didehydroacaterin, acaterin	Pseudomonas jessenii
BGC0000848	0.70	Other	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002404	0.66	Other	falcarindiol	Solanum lycopersicum
BGC0000850	0.63	Other	γ-butyrolactone	Streptomyces acidiscabies
BGC0002631	0.63	RiPP	myxarylin	Pyxidicoccus fallax
BGC0000237	0.60	Polyketide	lactonamycin Z	Streptomyces sanglieri
BGC0001928	0.56	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0001458	0.51	Other (Aminocoumarin)	salinipostin G	Salinispora tropica CNB-440

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000238	1.00	Polyketide	lactonamycin	Streptomyces rishiriensis
BGC0000237	0.84	Polyketide	lactonamycin Z	Streptomyces sanglieri
BGC0001817	0.74	Other	vancosamine	Streptomyces sp. WAC2288
BGC0000849	0.71	Other (Butyrolactone)	SCB1, SCB2, SCB3	Streptomyces coelicolor A3(2)
BGC0000278	0.70	Polyketide	urdamycin	Streptomyces fradiae
BGC0002076	0.68	Other	4,5-didehydroacaterin, acaterin	Pseudomonas jessenii
BGC0000848	0.68	Other	A-factor	Streptomyces griseus subsp. griseus NBRC 13350
BGC0002404	0.66	Other	falcarindiol	Solanum lycopersicum
BGC0000850	0.65	Other	γ-butyrolactone	Streptomyces acidiscabies
BGC0002631	0.65	RiPP	myxarylin	Pyxidicoccus fallax

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

lct28

Search NORINE for peptide: strict or relaxed

AMP-binding (9..416): Gly

nrpys: Gly

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: Tiny, hydrophilic, transition to aliphatic (Gly, Ala)
Single AA prediction:: ala (Ala)

Stachelhaus prediction details:

Stachelhaus sequence:: DLFFLCLLSK
Nearest Stachelhaus code(s):: Gly DLFFLCLLSK (91% 8Å match)
Stachelhaus code match:: 100% (strong)

Type II PKS gene cluster prediction details

Cluster section:: 0 to 61508
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 655.2; E-value: 7.4e-200)
Product class(es):: tetracenomycin
Product molecular weight(s):: acetyl-CoA_8: 561 Da
acetyl-CoA_9: 603 Da

lct12: KR (Score: 167.1; E-value: 1.3e-51)
lct16: OXY (Score: 267.9; E-value: 4.2e-82)
lct24: ACP (Score: 104.9; E-value: 3.8e-33)
lct25: MET C11O (Score: 545.7; E-value: 8.4e-167)
lct26: ACP (Score: 35.0; E-value: 2.6e-11)
lct27: CYC C9-C14 (Score: 233.2; E-value: 2.3e-72)
lct29: CYC C4-C21/C2-C23|C2-C19 (Score: 142.7; E-value: 8.2e-45)
lct30: CYC C5-C18 (Score: 191.7; E-value: 1e-59)
lct31: KS (Score: 718.1; E-value: 7e-219)
lct32: CLF 8|9 (Score: 655.2; E-value: 7.4e-200)
lct35: MET C13O|C17O (Score: 510.8; E-value: 3.1e-156)
lct36: GT (Score: 467.7; E-value: 9.2e-143)
lct40: KR (Score: 208.4; E-value: 3.4e-64)
lct41: OXY (Score: 283.0; E-value: 1.2e-86)