BGC0000239: landomycin A biosynthetic gene cluster from Streptomyces cyanogenus
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Location: 1 - 34,644 nt. (total: 34,644 nt).
This entry is originally from NCBI GenBank AF080235.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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General
Compounds
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Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000239
Short description landomycin A biosynthetic gene cluster from Streptomyces cyanogenus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: partial
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II)
  • saccharide (hybrid/tailoring)
Loci
AF080235.1
via
Compounds
  • landomycin A
Species Streptomyces cyanogenus [taxonomy]
References
Chemical products information
landomycin A Evidence: NMR [1]
Copy SMILES
C55H74O22
Chemical database entries
NPAtlas
ChEBI
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List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAD13534.1
  • lanE
 662 - 2137 (+) oxygenase homolog
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    • AAD13535.1
    • lanF
    		 2220 - 2549 (+) cyclase homolog
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      • AAD13536.1
      • lanA
      		 2584 - 3858 (+) B-ketoacyl-ACP synthase homolog
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        • AAD13537.1
        • lanB
        		 3855 - 5075 (+) chain length factor homolog
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          • AAD13538.1
          • lanC
          		 5135 - 5404 (+) acyl carrier protein homolog
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            • AAD13539.1
            • lanD
            		 5443 - 6228 (+) reductase homolog
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              • AAD13540.1
              • lanL
              		 6276 - 7235 (+) cyclase homolog
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                • AAD13541.1
                • lanM
                		 7238 - 8806 (+) Dehydratase
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                  • AAD13542.1
                  • lanN
                  		 8803 - 9471 (+) reductase homolog
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                    • AAD13543.1
                    • lanO
                    		 9626 - 10207 (+) reductase homolog
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                      • AAD13544.1
                      • lanP1
                      		 10210 - 11784 (+) decarboxylase homolog
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                        • AAD13545.1
                        • lanG
                        		 12086 - 13153 (+) NDP-hexose synthetase homolog
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                          • AAD13546.1
                          • lanH14
                          		 13150 - 14130 (+) NDP-hexose 4,6-dehydratase homolog
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                            • AAD13547.1
                            • lanQ
                            		 14216 - 15520 (+) NDP-hexose 3,4-dehydratase homolog
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                              • AAD13548.1
                              • lanR
                              		 15517 - 16278 (+) 4-keto reductase homolog
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                                • AAD13549.1
                                • lanS
                                		 16318 - 17727 (+) NDP-hexose 2,3-dehydratase homolog
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                                  • AAD13550.1
                                  • lanT
                                  		 17724 - 18689 (+) oxidoreductase homolog
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                                    • AAD13551.1
                                    • lanU
                                    		 18740 - 19387 (+) LanU
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                                      • AAD13552.1
                                      • lanV
                                      		 19517 - 20278 (+) bifunctional reductase + aromatase
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                                        • AAD13553.1
                                        • lanGT2
                                        		 20687 - 21808 (+) D-olivose-transferase
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                                          • AAD13554.1
                                          • lanX
                                          		 21879 - 22322 (+) LanX
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                                            • AAD13555.1
                                            • lanGT1
                                            		 22417 - 23589 (+) glycosyl transferase homolog
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                                              • AAD13556.1
                                              • lanK
                                              		 23647 - 24225 (-) TetR-like regulatory protein
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                                                • AAD13557.1
                                                • lanJ
                                                		 24415 - 25968 (+) LanJ
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                                                  • AAD13558.1
                                                  • lanZ1
                                                  		 26033 - 26611 (+) NDP-hexose 3,5-epimerase homolog
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                                                    • AAD13559.1
                                                    • lanGT3
                                                    		 26719 - 27924 (+) D-olivosyltransferase
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                                                      • AAD13560.1
                                                      • lanZ2
                                                      		 28011 - 28997 (+) impacts the formation of the sugar side chain
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                                                        • AAD13561.1
                                                        • lanZ3
                                                        		 28994 - 29974 (+) NDP-hexose 4-keto reductase homolog
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                                                          • AAD13562.1
                                                          • lanGT4
                                                          		 30061 - 31314 (+) L-rhodinosyltransferase
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                                                            • AAD13563.1
                                                            • lanZ4
                                                            		 31356 - 31958 (+) reductase homolog
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                                                              • AAD13564.1
                                                              • lanZ5
                                                              		 31955 - 33148 (+) bifunctional oxygenase-dehydratase
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                                                                • AAD13565.1
                                                                • lanZ6
                                                                		 33161 - 33877 (+) LanZ6
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                                                                  Biosynthesis information
                                                                  Annotation changelog

                                                                  Entry version: next

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2024-05-15
                                                                  MIBiG v4 annotathon
                                                                  • (ID: LEEWIYEZSPCYOCCY6BHNTE54)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 4

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-10-07
                                                                  Update chemical activity to schema version 2.11
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 3

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2022-09-15
                                                                  Remove duplicated citations
                                                                  • (ID: 3UOU7PODQJXIM6BEPUHHRRA5)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  2022-09-15
                                                                  Remove leading/trailing whitespace in gene identifiers
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  2022-09-15
                                                                  Cleaned up synonym list
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 2

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2019-10-16
                                                                  Migrated from v1.4
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  2019-10-16
                                                                  Updated compound(s) information (NPAtlas curation)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                                  Entry version: 1

                                                                  Date
                                                                  Changes
                                                                  Submitters
                                                                  Reviewers
                                                                  2015-06-12
                                                                  Submitted
                                                                  • (ID: LPHAMZXQ3BT6INJWOLKUYGWU)
                                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                                  Detailed domain annotation
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