BGC0000240 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000240 (Salinispora pacifica)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	75,641	High	lomaiviticin A/lomaiviticin C/lomaiviticin D/lomaiviticin E	PKS:Type II+saccharide:hybrid/tailoring

BGC0000240 - Region 1 - T2PKS

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Location: 1 - 75,641 nt. (total: 75,641 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 75,642
Label		BGC0000240

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

lom13: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

lom16: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

lom17: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

lom18: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

lom22: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

lom24: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

lom26: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

lom27: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

lom53: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: acylase aminotransferase glycosyltransferase methyltransferase sulfotransferase transferase

lom10: Sulfotransferase domain

extras: Sulfotransfer_4: Sulfotransferase domain

lom23: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

lom36: aminotransferase

smcogs: SMCOG1019: aminotransferase

lom48: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

lom49: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

lom55: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

lom56: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

lom61: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

lom65: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Hydrolases: amidase dehalogenase

lom33: amidase

smcogs: SMCOG1105: amidase

lom6: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

Lyases: cyclase dehydratase lyase

lom21: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

lom25: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

lom34: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

lom51: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

lom57: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

lom42: 2-isopropylmalate synthase

smcogs: SMCOG1271: 2-isopropylmalate synthase

lom58: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

lom59: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000240.5	0.89	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora pacifica
BGC0000241.5	0.70	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora tropica CNB-440
BGC0001693.3	0.68	PKS	nenestatin	Micromonospora echinospora
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001817.5	0.64	other (other)	vancosamine	Streptomyces sp. WAC2288
BGC0001257.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0001160.5	0.63	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.62	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001258.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis
BGC0000231.5	0.62	PKS	griseusin A, griseusin B	Streptomyces griseus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000240.5	1.00	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora pacifica
BGC0000241.5	0.85	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora tropica CNB-440
BGC0001693.3	0.80	PKS	nenestatin	Micromonospora echinospora
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001160.5	0.65	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001257.3	0.63	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0000231.5	0.63	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001258.3	0.62	PKS	1,3,6,8-tetrahydroxynaphthalene	Glarea lozoyensis

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

lom61: mal

PKS_AT (13..292): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Methylmalonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 63.7
Methylmalonyl-CoA: 33.4
Propionyl-CoA: 31.8
Methoxymalonyl-CoA: 31.0
Acetyl-CoA: 18.5
inactive: 16.4
Ethylmalonyl-CoA: 11.6
2-Methylbutyryl-CoA: 9.5
Isobutyryl-CoA: 9.1
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 27999 to 75641
Starter unit(s):: propionyl-CoA (Score: 954.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 685.6; E-value: 4.2e-209)
Product class(es):: angucycline
anthracycline
aureolic acid
tetracenomycin
tetracycline
Product molecular weight(s):: propionyl-CoA_8: 799 Da
propionyl-CoA_9: 841 Da

lom27: OXY (Score: 523.1; E-value: 1.7e-159)
lom37: MET (Score: 53.6; E-value: 4.3e-17)
lom48: GT (Score: 355.4; E-value: 1.2e-108)
lom49: MET (Score: 221.0; E-value: 5.2e-68)
lom55: GT (Score: 283.3; E-value: 9.1e-87)
lom58: KS (Score: 746.1; E-value: 2.3e-227)
lom59: CLF 8|9 (Score: 685.6; E-value: 4.2e-209)
lom60: ACP (Score: 106.3; E-value: 1.5e-33)
lom61: AT (Score: 379.6; E-value: 3e-116); AT AAF70110.1_Aclacinomycin_propionyl-CoA (Score: 294.0; E-value: 7.62e-102)
lom62: AT (Score: 185.9; E-value: 2.3e-57); AT AHZ61896.1_Lomaiviticin_propionyl-CoA (Score: 660.0; E-value: 0.0)
lom63: ACP (Score: 80.7; E-value: 1.4e-25)