Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000240.1:
Cluster 1Polyketide / Saccharide175641

BGC0000240, lomaiviticin biosynthetic gene cluster from Salinispora pacifica. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: lomaiviticin A
PubChem ID: 56841540
SMILES string: Copy to clipboard
Molecular formula: C68H80N6O24
Average molecular mass: 1365.406 Da
Molecular activity: Cytotoxic
Molecular target: DNA

Class-specific details

Biosynthetic class(es):
Polyketide / Saccharide
Polyketide subclass:
Angucycline (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
Propionyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
AHZ61892
Genes involved in folding/cyclization:
AHZ61855,AHZ61859

Saccharide subclass:
hybrid/tailoring
Glycosyltransferases:
AHZ61889:
Specificity: Unknown
Evidence for specificity: Unknown
AHZ61882:
Specificity: Unknown
Evidence for specificity: Unknown

Gene cluster description

lomaiviticin (BGC0000240). Gene Cluster 1. Biosynthetic class = Polyketide/Saccharide. GenBank KF731828. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?unknown
Evidence for cluster-compound connection:Knock-out studies, Enzymatic assays, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Emily Balskus (Harvard University)

Literature references

1. Kersten RD et al. (2013) Bioactivity-guided genome mining reveals the lomaiviticin biosynthetic gene cluster in Salinispora tropica. Chembiochem 14(8):955-62. doi: 10.1002/cbic.201300147. Epub 2013 May
2. Janso JE et al. (2014) Discovery of the lomaiviticin biosynthetic gene cluster in Salinispora pacifica. Tetrahedron 70(27-28):4156-4164. doi: 10.1016/j.tet.2014.03.009.
3. Waldman AJ, Balskus EP. (2014) Lomaiviticin biosynthesis employs a new strategy for starter unit generation. Org Lett 16(2):640-3. doi: 10.1021/ol403714g. Epub 2014 Jan 2.