BGC0000240

BGC0000240: lomaiviticin A biosynthetic gene cluster from Salinispora pacifica

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Location: 1 - 75,641 nt. (total: 75,641 nt).
This entry is originally from NCBI GenBank KF731828.1.

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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General

Compounds

Genes

Biosynthesis

History

NRPS/PKS domains

KnownClusterBlast

General information about the BGC

MIBiG accession	BGC0000240
Short description	lomaiviticin A biosynthetic gene cluster from Salinispora pacifica
Status	Quality: questionable The quality level of this entry. Status: active The status of this entry. Completeness: unknown Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)	PKS (Type II) saccharide (hybrid/tailoring)
Loci	KF731828.1 via Knock-out studies, Enzymatic assays
Compounds	lomaiviticin A lomaiviticin C lomaiviticin D lomaiviticin E
Species	Salinispora pacifica [taxonomy]
References	[1] Bioactivity-guided genome mining reveals the lomaiviticin biosynthetic gene cluster in Salinispora tropica. Kersten RD et al., Chembiochem (2013) PMID:23649992 [2] Lomaiviticin biosynthesis employs a new strategy for starter unit generation. Waldman AJ et al., Org Lett (2014) PMID:24383813 [3] Discovery of the lomaiviticin biosynthetic gene cluster in . Janso JE et al., Tetrahedron (2014) PMID:25045187

Chemical products information

lomaiviticin A Evidence:

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C₆₈H₈₀N₆O₂₄

Chemical database entries
NPAtlas
PubCHEM

lomaiviticin C Evidence:

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C₆₈H₈₂N₄O₂₄

lomaiviticin D Evidence:

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C₆₉H₈₄N₄O₂₄

lomaiviticin E Evidence:

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C₇₀H₈₆N₄O₂₄

Chemical database entries
NPAtlas

List of genes involved in compound(s) production

Identifiers	Position	Product	Functions	Evidence	Extra
AHZ61835.1 lom1	45 - 1619 (+)	EmrB/QacA family drug resistance transporter	Transport		copy AA seq copy Nt seq
AHZ61836.1 lom2	1820 - 2305 (+)	hypothetical protein			copy AA seq copy Nt seq
AHZ61837.1 lom3	2462 - 3292 (-)	ABC transporter-like protein	Transport		copy AA seq copy Nt seq
AHZ61838.1 lom4	3289 - 4239 (-)	ABC transporter-like protein	Transport		copy AA seq copy Nt seq
AHZ61839.1 lom5	4199 - 4729 (-)	glyoxalase/bleomycin resistance protein			copy AA seq copy Nt seq
AHZ61840.1 lom6	4873 - 5649 (-)	alpha,beta-hydrolase family protein			copy AA seq copy Nt seq
AHZ61841.1 lom7	5892 - 6728 (-)	SARP family regulatory protein	Regulation		copy AA seq copy Nt seq
AHZ61842.1 lom8	7477 - 8310 (+)	AraC transcriptional regulator	Regulation		copy AA seq copy Nt seq
AHZ61843.1 lom9	8610 - 10004 (+)	NDP-hexose 2,3-dehydratase	Precursor biosynthesis		copy AA seq copy Nt seq
AHZ61844.1 lom10	10094 - 10759 (-)	hypothetical protein			copy AA seq copy Nt seq
AHZ61845.1 lom11	10801 - 11247 (-)	carboxymuconolactone decarboxylase/alkylhydroperoxidase			copy AA seq copy Nt seq
AHZ61846.1 lom12	11177 - 12004 (-)	peptidase C26, glutamine amidotransferase			copy AA seq copy Nt seq
AHZ61847.1 lom13	12470 - 14242 (+)	FAD-binding monooxygenase aromatic ring hydroxylase	Tailoring		copy AA seq copy Nt seq
AHZ61848.1 lom14	14410 - 15876 (-)	protoporphyrinogen oxidase, amine oxidase			copy AA seq copy Nt seq
AHZ61849.1 lom15	15998 - 17104 (-)	nuclease, transcriptional regulation	Regulation		copy AA seq copy Nt seq
AHZ61850.1 lom16	17156 - 18655 (-)	FAD-binding monooxygenase	Tailoring		copy AA seq copy Nt seq
AHZ61851.1 lom17	18664 - 20136 (-)	FAD-binding monooxygenase	Tailoring		copy AA seq copy Nt seq
AHZ61852.1 lom18	20353 - 21081 (+)	short-chain dehydrogenase	Tailoring		copy AA seq copy Nt seq
AHZ61853.1 lom19	21167 - 22039 (+)	NAD-dependent epimerase/dehydratase	Tailoring		copy AA seq copy Nt seq
AHZ61854.1 lom20	22098 - 22715 (-)	DSBA oxidoreductase			copy AA seq copy Nt seq
AHZ61855.1 lom21	22729 - 23058 (-)	polyketide synthesis, cyclase	Scaffold biosynthesis		copy AA seq copy Nt seq
AHZ61856.1 lom22	23087 - 23872 (-)	short-chain dehydrogenase/reductase	Scaffold biosynthesis		copy AA seq copy Nt seq
AHZ61857.1 lom23	24063 - 25100 (+)	O-methyltransferase	Tailoring		copy AA seq copy Nt seq
AHZ61858.1 lom24	25154 - 26665 (+)	FAD-binding monooxygenase	Tailoring		copy AA seq copy Nt seq
AHZ61859.1 lom25	26687 - 27649 (+)	cyclase/dehydratase/aromatase	Scaffold biosynthesis		copy AA seq copy Nt seq
AHZ61860.1 lom26	27646 - 29085 (+)	FAD-binding monooxygenase	Tailoring		copy AA seq copy Nt seq
AHZ61861.1 lom27	29072 - 30550 (+)	FAD-binding monooxygenase	Tailoring		copy AA seq copy Nt seq
AHZ61862.1 lom28	30621 - 31364 (+)	antibiotic biosynthesis monooxygenase	Tailoring		copy AA seq copy Nt seq
AHZ61863.1 lom29	31429 - 33312 (-)	hypothetical protein	Tailoring		copy AA seq copy Nt seq
AHZ61864.1 lom30	33287 - 33643 (-)	4Fe-4S ferrodoxin	Tailoring		copy AA seq copy Nt seq
AHZ61865.1 lom31	33712 - 34506 (-)	hypothetical protein			copy AA seq copy Nt seq
AHZ61866.1 lom32	34556 - 36058 (-)	glutamine synthetase	Tailoring		copy AA seq copy Nt seq
AHZ61867.1 lom33	36055 - 37473 (-)	amidase	Tailoring		copy AA seq copy Nt seq
AHZ61868.1 lom34	37714 - 39000 (+)	adenylosuccinate lyase	Tailoring		copy AA seq copy Nt seq
AHZ61869.1 lom35	38984 - 39385 (+)	N-acetyltransferase GCN5	Tailoring		copy AA seq copy Nt seq
AHZ61870.1 lom36	39515 - 40717 (-)	aminotransferase			copy AA seq copy Nt seq
AHZ61871.1 lom37	40714 - 41841 (-)	methyltransferase			copy AA seq copy Nt seq
AHZ61872.1 lom38	41865 - 42890 (-)	3-isopropylmalate dehydrogenase			copy AA seq copy Nt seq
AHZ61873.1 lom39	42887 - 43363 (-)	aminotransferase			copy AA seq copy Nt seq
AHZ61874.1 lom40	43360 - 43974 (-)	3-isopropylmalate dehydratase			copy AA seq copy Nt seq
AHZ61875.1 lom41	43984 - 45381 (-)	isopropylmalate isomerase			copy AA seq copy Nt seq
AHZ61876.1 lom42	45378 - 46469 (-)	pyruvate carboxyltransferase			copy AA seq copy Nt seq
AHZ61877.1 lom43	47128 - 48897 (-)	ABC-transporter-like protein	Transport		copy AA seq copy Nt seq
AHZ61878.1 lom44	48994 - 49314 (-)	Rieske (2Fe-2S) domain containing protein			copy AA seq copy Nt seq
AHZ61879.1 lom45	49568 - 49978 (+)	glyoxalase/bleomycin resistance protein/dioxygenase	Resistance/immunity		copy AA seq copy Nt seq
AHZ61880.1 lom46	50046 - 50843 (+)	glyoxalase/bleomycin resistance protein/dioxygenase			copy AA seq copy Nt seq
AHZ61881.1 lom47	50928 - 52490 (-)	TAP-domain containing protein; secreted peptidase			copy AA seq copy Nt seq
AHZ61882.1 lom48	52578 - 53699 (-)	glycosyltransferase	Tailoring		copy AA seq copy Nt seq
AHZ61883.1 lom49	53696 - 54715 (-)	O-methyltransferase	Precursor biosynthesis		copy AA seq copy Nt seq
AHZ61884.1 lom50	54995 - 55921 (+)	N-methyltransferase	Precursor biosynthesis		copy AA seq copy Nt seq
AHZ61885.1 lom51	56026 - 56991 (+)	NAD-dependent epimerase/dehydratase	Precursor biosynthesis		copy AA seq copy Nt seq
AHZ61886.1 lom52	57001 - 57612 (+)	dTDP-4-dehydrorhamnose 3,5 epimerase	Precursor biosynthesis		copy AA seq copy Nt seq
AHZ61887.1 lom53	57661 - 58665 (+)	NDP-hexose-3-ketoreductase;oxidoreductase domain containing protein	Precursor biosynthesis		copy AA seq copy Nt seq
AHZ61888.1 lom54	58694 - 59428 (-)	hypothetical protein			copy AA seq copy Nt seq
AHZ61889.1 lom55	59544 - 60584 (-)	glycosyltransferase	Tailoring		copy AA seq copy Nt seq
AHZ61890.1 lom56	60601 - 61812 (-)	DegT/DnrJ/EryC1/StrS aminotransferase	Precursor biosynthesis		copy AA seq copy Nt seq
AHZ61891.1 lom57	61987 - 63003 (+)	dTDP-glucose 4,6-dehydratase	Precursor biosynthesis		copy AA seq copy Nt seq
AHZ61892.1 lom58	63000 - 64271 (+)	beta-ketoacyl synthase	Scaffold biosynthesis	Knock-out	copy AA seq copy Nt seq
AHZ61893.1 lom59	64268 - 65596 (+)	beta-ketoacyl synthase, chain length factor	Scaffold biosynthesis		copy AA seq copy Nt seq
AHZ61894.1 lom60	65553 - 65807 (+)	phosphopantheine-binding protein; acyl carrier protein	Scaffold biosynthesis	Activity assay	copy AA seq copy Nt seq
AHZ61895.1 lom61	65789 - 66772 (+)	acyl transferase	Scaffold biosynthesis		copy AA seq copy Nt seq
AHZ61896.1 lom62	66835 - 67809 (+)	acyl transferase/decarboxylase, LnmK-like protein	Precursor biosynthesis	Activity assay	copy AA seq copy Nt seq
AHZ61897.1 lom63	67828 - 68076 (-)	phosphopantheine-binding protein; acyl carrier protein	Precursor biosynthesis	Activity assay	copy AA seq copy Nt seq
AHZ61898.1 lom64	68263 - 68724 (+)	AraC transcriptional regulator	Regulation		copy AA seq copy Nt seq
AHZ61899.1 lom65	68906 - 69778 (+)	glucose-1-phosphate thymidylytransferase	Precursor biosynthesis		copy AA seq copy Nt seq

Biosynthesis information

Annotation changelog

Entry version: 4

Date

Changes

Submitters

Reviewers

2022-10-07

Update chemical activity to schema version 2.11

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Entry version: 3

Date

Changes

Submitters

Reviewers

2022-09-15

Corrected gene identifiers

(ID: AAAAAAAAAAAAAAAAAAAAAAAA)

(ID: AAAAAAAAAAAAAAAAAAAAAAAA)

2022-09-15

Updated bioactivity data

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Entry version: 2

Date

Changes

Submitters

Reviewers

2019-10-16

Migrated from v1.4

(ID: AAAAAAAAAAAAAAAAAAAAAAAA)

(ID: AAAAAAAAAAAAAAAAAAAAAAAA)

2019-10-16

Updated compound(s) information (NPAtlas curation)

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Entry version: 1

Date

Changes

Submitters

Reviewers

2015-06-12

Submitted

(ID: AK6U5FV25F7Z3GQ43DVTSAVK)

(ID: AAAAAAAAAAAAAAAAAAAAAAAA)

Detailed domain annotation

Selected features only

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Similar known gene clusters from MIBiG 4.0