BGC0000240: lomaiviticin A biosynthetic gene cluster from Salinispora pacifica
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Location: 1 - 75,641 nt. (total: 75,641 nt).
This entry is originally from NCBI GenBank KF731828.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000240
Short description lomaiviticin A biosynthetic gene cluster from Salinispora pacifica
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Angucycline)
  • Saccharide (hybrid/tailoring)
Loci NCBI GenBank: KF731828.1
Compounds
  • lomaiviticin A
  • lomaiviticin C
  • lomaiviticin D
  • lomaiviticin E
Species Salinispora pacifica [taxonomy]
References
Chemical products information
lomaiviticin A
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C68H80N6O24
Chemical database entries
NPAtlas
PubCHEM
lomaiviticin C
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C68H82N4O24
lomaiviticin D
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C69H84N4O24
lomaiviticin E
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C70H86N4O24
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AHZ61835.1
  • lom1
 45 - 1619 (+) EmrB/QacA family drug resistance transporter
  • Transport
Sequence-based prediction
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  • AHZ61836.1
  • lom2
 1820 - 2305 (+) hypothetical protein
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  • AHZ61837.1
  • lom3
 2462 - 3292 (-) ABC transporter-like protein
  • Transport
Sequence-based prediction
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  • AHZ61838.1
  • lom4
 3289 - 4239 (-) ABC transporter-like protein
  • Transport
Sequence-based prediction
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  • AHZ61839.1
  • lom5
 4199 - 4729 (-) glyoxalase/bleomycin resistance protein
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  • AHZ61840.1
  • lom6
 4873 - 5649 (-) alpha,beta-hydrolase family protein
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  • AHZ61841.1
  • lom7
 5892 - 6728 (-) SARP family regulatory protein
  • Regulation
Sequence-based prediction
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  • AHZ61842.1
  • lom8
 7477 - 8310 (+) AraC transcriptional regulator
  • Regulation
Sequence-based prediction
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  • AHZ61843.1
  • lom9
 8610 - 10004 (+) NDP-hexose 2,3-dehydratase
  • Precursor biosynthesis
Sequence-based prediction
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  • AHZ61844.1
  • lom10
 10094 - 10759 (-) hypothetical protein
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  • AHZ61845.1
  • lom11
 10801 - 11247 (-) carboxymuconolactone decarboxylase/alkylhydroperoxidase
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  • AHZ61846.1
  • lom12
 11177 - 12004 (-) peptidase C26, glutamine amidotransferase
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  • AHZ61847.1
  • lom13
 12470 - 14242 (+) FAD-binding monooxygenase aromatic ring hydroxylase
  • Tailoring (Hydroxylation)
Sequence-based prediction
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  • AHZ61848.1
  • lom14
 14410 - 15876 (-) protoporphyrinogen oxidase, amine oxidase
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  • AHZ61849.1
  • lom15
 15998 - 17104 (-) nuclease, transcriptional regulation
  • Regulation
Sequence-based prediction
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  • AHZ61850.1
  • lom16
 17156 - 18655 (-) FAD-binding monooxygenase
  • Tailoring (Hydroxylation)
Sequence-based prediction
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  • AHZ61851.1
  • lom17
 18664 - 20136 (-) FAD-binding monooxygenase
  • Tailoring (Hydroxylation)
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  • AHZ61852.1
  • lom18
 20353 - 21081 (+) short-chain dehydrogenase
  • Tailoring (Reduction)
Sequence-based prediction
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  • AHZ61853.1
  • lom19
 21167 - 22039 (+) NAD-dependent epimerase/dehydratase
  • Tailoring (Unknown)
Sequence-based prediction
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  • AHZ61854.1
  • lom20
 22098 - 22715 (-) DSBA oxidoreductase
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  • AHZ61855.1
  • lom21
 22729 - 23058 (-) polyketide synthesis, cyclase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AHZ61856.1
  • lom22
 23087 - 23872 (-) short-chain dehydrogenase/reductase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AHZ61857.1
  • lom23
 24063 - 25100 (+) O-methyltransferase
  • Tailoring (Methylation)
Sequence-based prediction
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  • AHZ61858.1
  • lom24
 25154 - 26665 (+) FAD-binding monooxygenase
  • Tailoring (Oxidation)
Sequence-based prediction
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  • AHZ61859.1
  • lom25
 26687 - 27649 (+) cyclase/dehydratase/aromatase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AHZ61860.1
  • lom26
 27646 - 29085 (+) FAD-binding monooxygenase
  • Tailoring (Oxidation)
Sequence-based prediction
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  • AHZ61861.1
  • lom27
 29072 - 30550 (+) FAD-binding monooxygenase
  • Tailoring (Oxidation)
Sequence-based prediction
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  • AHZ61862.1
  • lom28
 30621 - 31364 (+) antibiotic biosynthesis monooxygenase
  • Tailoring (Hydroxylation)
Sequence-based prediction
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  • AHZ61863.1
  • lom29
 31429 - 33312 (-) hypothetical protein
  • Tailoring (Unknown)
Sequence-based prediction
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  • AHZ61864.1
  • lom30
 33287 - 33643 (-) 4Fe-4S ferrodoxin
  • Tailoring (Unknown)
Sequence-based prediction
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  • AHZ61865.1
  • lom31
 33712 - 34506 (-) hypothetical protein
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  • AHZ61866.1
  • lom32
 34556 - 36058 (-) glutamine synthetase
  • Tailoring (Unknown)
Sequence-based prediction
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  • AHZ61867.1
  • lom33
 36055 - 37473 (-) amidase
  • Tailoring (Unknown)
Sequence-based prediction
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  • AHZ61868.1
  • lom34
 37714 - 39000 (+) adenylosuccinate lyase
  • Tailoring (Unknown)
Sequence-based prediction
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  • AHZ61869.1
  • lom35
 38984 - 39385 (+) N-acetyltransferase GCN5
  • Tailoring (Unknown)
Sequence-based prediction
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  • AHZ61870.1
  • lom36
 39515 - 40717 (-) aminotransferase
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  • AHZ61871.1
  • lom37
 40714 - 41841 (-) methyltransferase
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  • AHZ61872.1
  • lom38
 41865 - 42890 (-) 3-isopropylmalate dehydrogenase
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  • AHZ61873.1
  • lom39
 42887 - 43363 (-) aminotransferase
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  • AHZ61874.1
  • lom40
 43360 - 43974 (-) 3-isopropylmalate dehydratase
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  • AHZ61875.1
  • lom41
 43984 - 45381 (-) isopropylmalate isomerase
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  • AHZ61876.1
  • lom42
 45378 - 46469 (-) pyruvate carboxyltransferase
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  • AHZ61877.1
  • lom43
 47128 - 48897 (-) ABC-transporter-like protein
  • Transport
Sequence-based prediction
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  • AHZ61878.1
  • lom44
 48994 - 49314 (-) Rieske (2Fe-2S) domain containing protein
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  • AHZ61879.1
  • lom45
 49568 - 49978 (+) glyoxalase/bleomycin resistance protein/dioxygenase
  • Resistance/immunity
Sequence-based prediction
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  • AHZ61880.1
  • lom46
 50046 - 50843 (+) glyoxalase/bleomycin resistance protein/dioxygenase
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  • AHZ61881.1
  • lom47
 50928 - 52490 (-) TAP-domain containing protein; secreted peptidase
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  • AHZ61882.1
  • lom48
 52578 - 53699 (-) glycosyltransferase
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • AHZ61883.1
  • lom49
 53696 - 54715 (-) O-methyltransferase
  • Precursor biosynthesis
Sequence-based prediction
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  • AHZ61884.1
  • lom50
 54995 - 55921 (+) N-methyltransferase
  • Precursor biosynthesis
Sequence-based prediction
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  • AHZ61885.1
  • lom51
 56026 - 56991 (+) NAD-dependent epimerase/dehydratase
  • Precursor biosynthesis
Sequence-based prediction
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  • AHZ61886.1
  • lom52
 57001 - 57612 (+) dTDP-4-dehydrorhamnose 3,5 epimerase
  • Precursor biosynthesis
Sequence-based prediction
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  • AHZ61887.1
  • lom53
 57661 - 58665 (+) NDP-hexose-3-ketoreductase;oxidoreductase domain containing protein
  • Precursor biosynthesis
Sequence-based prediction
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  • AHZ61888.1
  • lom54
 58694 - 59428 (-) hypothetical protein
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  • AHZ61889.1
  • lom55
 59544 - 60584 (-) glycosyltransferase
  • Tailoring (Glycosylation)
Sequence-based prediction
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  • AHZ61890.1
  • lom56
 60601 - 61812 (-) DegT/DnrJ/EryC1/StrS aminotransferase
  • Precursor biosynthesis
Sequence-based prediction
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  • AHZ61891.1
  • lom57
 61987 - 63003 (+) dTDP-glucose 4,6-dehydratase
  • Precursor biosynthesis
Sequence-based prediction
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  • AHZ61892.1
  • lom58
 63000 - 64271 (+) beta-ketoacyl synthase
  • Scaffold biosynthesis
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Sequence-based prediction
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  • AHZ61893.1
  • lom59
 64268 - 65596 (+) beta-ketoacyl synthase, chain length factor
  • Scaffold biosynthesis
Sequence-based prediction
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  • AHZ61894.1
  • lom60
 65553 - 65807 (+) phosphopantheine-binding protein; acyl carrier protein
  • Scaffold biosynthesis
Activity assay
Sequence-based prediction
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  • AHZ61895.1
  • lom61
 65789 - 66772 (+) acyl transferase
  • Scaffold biosynthesis
Sequence-based prediction
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  • AHZ61896.1
  • lom62
 66835 - 67809 (+) acyl transferase/decarboxylase, LnmK-like protein
  • Precursor biosynthesis
Activity assay
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  • AHZ61897.1
  • lom63
 67828 - 68076 (-) phosphopantheine-binding protein; acyl carrier protein
  • Precursor biosynthesis
Activity assay
Sequence-based prediction
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  • AHZ61898.1
  • lom64
 68263 - 68724 (+) AraC transcriptional regulator
  • Regulation
Sequence-based prediction
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  • AHZ61899.1
  • lom65
 68906 - 69778 (+) glucose-1-phosphate thymidylytransferase
  • Precursor biosynthesis
Sequence-based prediction
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Polyketide-specific information
Subclass Angucycline
Starter unit Propionyl-CoA
Ketide length 10
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
lom21
+
lom58
+
lom25 		Synthase subclass: Type II
Saccharide-specific information
Subclass hybrid/tailoring
Glycosyltransferases
lom55
Evidence:
  • Sequence-based prediction
lom48
Evidence:
  • Sequence-based prediction
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AK6U5FV25F7Z3GQ43DVTSAVK, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Corrected gene identifiers
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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