BGC0000241 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000241 (Salinispora tropica CNB-440)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	62,231	lomaiviticin A/lomaiviticin C/lomaiviticin D/lomaiviticin E	PKS:Type II+saccharide:hybrid/tailoring	100%

BGC0000241 - Region 1 - T2PKS

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Location: 1 - 62,231 nt. (total: 62,231 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

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TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 62,232
Label		BGC0000241

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000241	0.80	Polyketide, Saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora tropica CNB-440
BGC0000240	0.47	Polyketide, Saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora pacifica
BGC0001693	0.46	Polyketide	nenestatin	Micromonospora echinospora
BGC0000278	0.39	Polyketide	urdamycin	Streptomyces fradiae
BGC0000866	0.35	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000271	0.34	Polyketide	spore pigment	Streptomyces avermitilis
BGC0000231	0.32	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0002404	0.32	Other	falcarindiol	Solanum lycopersicum
BGC0002733	0.31	Other	sinapigladioside	Burkholderia gladioli
BGC0001817	0.30	Other	vancosamine	Streptomyces sp. WAC2288

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000241	1.00	Polyketide, Saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora tropica CNB-440
BGC0000240	0.82	Polyketide, Saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora pacifica
BGC0001693	0.79	Polyketide	nenestatin	Micromonospora echinospora
BGC0000231	0.69	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000866	0.68	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0002404	0.65	Other	falcarindiol	Solanum lycopersicum
BGC0002435	0.65	Other	coformycin, aristeromycin	Micromonospora haikouensis
BGC0002733	0.64	Other	sinapigladioside	Burkholderia gladioli
BGC0000264	0.64	Polyketide	resistomycin, resistoflavine	Streptomyces resistomycificus
BGC0000019	0.62	Polyketide	angolamycin	Streptomyces eurythermus

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

Strop_2226

PKS_AT (13..292): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 58.3%; Methylmalonyl-CoA: 54.2%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 60.0
Methylmalonyl-CoA: 33.2
Propionyl-CoA: 27.1
Methoxymalonyl-CoA: 22.0
inactive: 16.2
Acetyl-CoA: 11.1
Isobutyryl-CoA: 9.1
Ethylmalonyl-CoA: 8.9
2-Methylbutyryl-CoA: 7.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 20377 to 62231
Starter unit(s):: propionyl-CoA (Score: 951.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 686.6; E-value: 2.1e-209)
Product class(es):: angucycline
Product molecular weight(s):: propionyl-CoA_8: 785 Da
propionyl-CoA_9: 827 Da

Strop_2191: DIMER (Score: 404.3; E-value: 6.5e-124)
Strop_2193: CYC C4-C17/C2-C19 (Score: 190.0; E-value: 9.6e-59)
Strop_2194: KR C9 (Score: 465.3; E-value: 1.2e-142)
Strop_2195: MET (Score: 260.1; E-value: 6.7e-80)
Strop_2196: OXY (Score: 534.0; E-value: 8.1e-163)
Strop_2197: CYC C7-C12 (Score: 459.4; E-value: 1e-140)
Strop_2198: OXY (Score: 436.4; E-value: 3.4e-133)
Strop_2199: OXY (Score: 526.4; E-value: 1.6e-160)
Strop_2213: GT (Score: 358.6; E-value: 1.3e-109)
Strop_2214: MET (Score: 220.4; E-value: 8.1e-68)
Strop_2220: GT (Score: 279.2; E-value: 1.6e-85)
Strop_2223: KS (Score: 743.2; E-value: 1.7e-226)
Strop_2224: CLF 8|9 (Score: 686.6; E-value: 2.1e-209)
Strop_2225: ACP (Score: 108.0; E-value: 4.1e-34)
Strop_2226: AT (Score: 366.2; E-value: 3.6e-112); AT AAF70110.1_Aclacinomycin_propionyl-CoA (Score: 292.0; E-value: 6.92e-101)
Strop_2227: AT (Score: 183.2; E-value: 1.5e-56); AT ABP54678.1_Lomaiviticin_propionyl-CoA (Score: 659.0; E-value: 0.0)