BGC0000241 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000241 (Salinispora tropica CNB-440)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	92,932	High	lomaiviticin A/lomaiviticin C/lomaiviticin D/lomaiviticin E	PKS:Type II+saccharide:hybrid/tailoring

BGC0000241 - Region 1 - T2PKS

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Location: 1 - 92,932 nt. (total: 92,932 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 92,933
Label		BGC0000241

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

Strop_2185: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Strop_2188: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Strop_2189: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Strop_2190: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Strop_2194: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Strop_2196: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Strop_2198: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Strop_2199: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Strop_2218: oxidoreductase

smcogs: SMCOG1079: oxidoreductase

Transferases: acylase aminotransferase glycosyltransferase methyltransferase sulfotransferase transferase

Strop_2182: Sulfotransferase domain

extras: Sulfotransfer_4: Sulfotransferase domain

Strop_2195: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Strop_2213: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

Strop_2214: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Strop_2220: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

Strop_2221: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

Strop_2226: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

Strop_2230: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

Hydrolases: amidase dehalogenase

Strop_2177: haloalkane dehalogenase

smcogs: SMCOG1262: haloalkane dehalogenase

Strop_2205: amidase

smcogs: SMCOG1105: amidase

Lyases: cyclase dehydratase lyase

Strop_2193: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

Strop_2197: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Strop_2206: argininosuccinate lyase/adenylosuccinate lyase

smcogs: SMCOG1063: argininosuccinate lyase/adenylosuccinate lyase

Strop_2216: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Strop_2222: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

Ligases: synthase

Strop_2223: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Strop_2224: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000241.5	0.92	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora tropica CNB-440
BGC0000240.5	0.76	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora pacifica
BGC0001693.3	0.75	PKS	nenestatin	Micromonospora echinospora
BGC0000231.5	0.66	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001817.5	0.64	other (other)	vancosamine	Streptomyces sp. WAC2288
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001197.5	0.56	PKS	frankiamicin	Frankia sp. EAN1pec

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000241.5	1.00	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora tropica CNB-440
BGC0000240.5	0.82	PKS, saccharide	lomaiviticin A, lomaiviticin C, lomaiviticin D, lomaiviticin E	Salinispora pacifica
BGC0001693.3	0.79	PKS	nenestatin	Micromonospora echinospora
BGC0000231.5	0.69	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001284.4	0.65	PKS	alternariol	Parastagonospora nodorum SN15
BGC0001160.5	0.64	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.64	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0001275.3	0.63	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0001817.5	0.61	other (other)	vancosamine	Streptomyces sp. WAC2288
BGC0000278.3	0.56	PKS	urdamycin	Streptomyces fradiae

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

Strop_2226: mal

PKS_AT (13..292): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 58.3%; Methylmalonyl-CoA: 54.2%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 60.0
Methylmalonyl-CoA: 33.2
Propionyl-CoA: 27.1
Methoxymalonyl-CoA: 22.0
inactive: 16.2
Acetyl-CoA: 11.1
Isobutyryl-CoA: 9.1
Ethylmalonyl-CoA: 8.9
2-Methylbutyryl-CoA: 7.6
trans-1,2-CPDA: 0.0
fatty_acid: 0.0
CHC-CoA: 0.0
Benzoyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 20377 to 92932
Starter unit(s):: propionyl-CoA (Score: 951.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 686.6; E-value: 2.1e-209)
Product class(es):: angucycline
Product molecular weight(s):: propionyl-CoA_8: 785 Da
propionyl-CoA_9: 827 Da

Strop_2191: DIMER (Score: 404.3; E-value: 6.5e-124)
Strop_2193: CYC C4-C17/C2-C19 (Score: 190.0; E-value: 9.6e-59)
Strop_2194: KR C9 (Score: 465.3; E-value: 1.2e-142)
Strop_2195: MET (Score: 260.1; E-value: 6.7e-80)
Strop_2196: OXY (Score: 534.0; E-value: 8.1e-163)
Strop_2197: CYC C7-C12 (Score: 459.4; E-value: 1e-140)
Strop_2198: OXY (Score: 436.4; E-value: 3.4e-133)
Strop_2199: OXY (Score: 526.4; E-value: 1.6e-160)
Strop_2213: GT (Score: 358.6; E-value: 1.3e-109)
Strop_2214: MET (Score: 220.4; E-value: 8.1e-68)
Strop_2220: GT (Score: 279.2; E-value: 1.6e-85)
Strop_2223: KS (Score: 743.2; E-value: 1.7e-226)
Strop_2224: CLF 8|9 (Score: 686.6; E-value: 2.1e-209)
Strop_2225: ACP (Score: 108.0; E-value: 4.1e-34)
Strop_2226: AT (Score: 366.2; E-value: 3.6e-112); AT AAF70110.1_Aclacinomycin_propionyl-CoA (Score: 292.0; E-value: 6.92e-101)
Strop_2227: AT (Score: 183.2; E-value: 1.5e-56); AT ABP54678.1_Lomaiviticin_propionyl-CoA (Score: 659.0; E-value: 0.0)