Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000241.1:
Cluster 1Polyketide / Saccharide162231

BGC0000241, lomaiviticin biosynthetic gene cluster from Salinispora tropica. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Lomaiviticin A
PubChem ID: 56841540
ChemSpider ID: 10263582
SMILES string: Copy to clipboard
Molecular formula: C68H80N6O24
Average molecular mass: 1365.406 Da
Molecular activity: Antibacterial, Cytotoxic
Molecular target: DNA

Class-specific details

Biosynthetic class(es):
Polyketide / Saccharide
Polyketide subclass:
Other (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
Other
Polyketide synthase / ketosynthase-encoding genes:
ABP54674.1
Genes involved in folding/cyclization:
ABP54644.1, ABP54648.1

Gene cluster description

lomaiviticin (BGC0000241). Gene Cluster 1. Biosynthetic class = Polyketide/Saccharide. GenBank CP000667, positions 2460444-2522674. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Bradley Moore (Scripps Institute of Oceanography, University of California-San Diego)

Literature references

1. Kersten RD et al. (2013) Bioactivity-guided genome mining reveals the lomaiviticin biosynthetic gene cluster in Salinispora tropica. Chembiochem 14(8):955-62. doi: 10.1002/cbic.201300147. Epub 2013 May
2. Colis LC et al. (2014) The cytotoxicity of (-)-lomaiviticin A arises from induction of double-strand breaks in DNA. Nat Chem 6(6):504-10. doi: 10.1038/nchem.1944. Epub 2014 May 11.
3. Janso JE et al. (2014) Discovery of the lomaiviticin biosynthetic gene cluster in Salinispora pacifica. Tetrahedron 70(27-28):4156-4164. doi: 10.1016/j.tet.2014.03.009.
4. Waldman AJ, Balskus EP. (2014) Lomaiviticin biosynthesis employs a new strategy for starter unit generation. Org Lett 16(2):640-3. doi: 10.1021/ol403714g. Epub 2014 Jan 2.
5. Woo CM et al. (2012) Isolation of lomaiviticins C-E, transformation of lomaiviticin C to lomaiviticin A, complete structure elucidation of lomaiviticin A, and structure-activity analyses. J Am Chem Soc 134(37):15285-8. doi: 10.1021/ja3074984. Epub 2012 Sep
6. He H et al. (2001) Lomaiviticins A and B, potent antitumor antibiotics from Micromonospora lomaivitiensis. J Am Chem Soc 123(22):5362-3.