BGC0000242 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000242 (Streptomyces tendae)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	43,202	High	lysolipin I	PKS

BGC0000242 - Region 1 - T2PKS

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Location: 1 - 43,202 nt. (total: 43,202 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 43,203
Label		BGC0000242

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

llpOIV: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

llpOVI: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

llpOVII: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

llpOVIII: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

llpS: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

llpU: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

llpZI: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

llpZII: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

llpZIII: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

llpZIV: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: glycosyltransferase halogenase methyltransferase

llpG: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

llpH: conventional flavin-dependent halogenase

halogenases: conventional flavin-dependent halogenase
MITE: MITE0000024Halogenation (identity: 70.40%)
smcogs: SMCOG1119: halogenase

llpMI: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

llpMII: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

llpMIII: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

llpMIV: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

llpMVI: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Hydrolases: hydrolase

llpA: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: cyclase

llpCI: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

llpCIII: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

Ligases: synthase

llpE: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

llpF: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000242.5	1.00	PKS	lysolipin I	Streptomyces tendae
BGC0002608.2	0.77	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0002341.2	0.76	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0000231.5	0.70	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.63	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001197.5	0.61	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001723.5	0.57	PKS	oviedomycin	Streptomyces antibioticus
BGC0002084.4	0.57	ribosomal	biarylitide YYH	Planomonospora sp. ID82291
BGC0002099.3	0.57	ribosomal	biarylitide YFH	Planomonospora sp. ID107089

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000242.5	1.00	PKS	lysolipin I	Streptomyces tendae
BGC0002608.2	0.77	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0002341.2	0.76	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0000231.5	0.70	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.63	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001197.5	0.61	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0002276.2	0.58	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001723.5	0.57	PKS	oviedomycin	Streptomyces antibioticus
BGC0002084.4	0.57	ribosomal	biarylitide YYH	Planomonospora sp. ID82291
BGC0002099.3	0.57	ribosomal	biarylitide YFH	Planomonospora sp. ID107089

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 43202
Starter unit(s):: malonamyl-CoA (Score: 1222.0; E-value: 0)
Malonyl elongations:: 11|12 (Score: 714.2; E-value: 8.3e-218)
Product class(es):: pentangular polyphenol
Product molecular weight(s):: malonamyl-CoA_11: 846 Da
malonamyl-CoA_12: 888 Da

llpA: AMID (Score: 1133.6; E-value: 0.0); AMID CAM34350.1_Lysolipin_malonamyl-CoA (Score: 1222.0; E-value: 0.0)
llpCI: CYC C9-C14 (Score: 241.0; E-value: 8.8e-75)
llpCII: CYC C5-C18 (Score: 221.5; E-value: 6.4e-69)
llpCIII: CYC C4-C21/C2-C23|C2-C19 (Score: 176.6; E-value: 2.4e-55)
llpD: ACP (Score: 109.0; E-value: 2e-34)
llpE: CLF 11|12 (Score: 714.2; E-value: 8.3e-218)
llpF: KS (Score: 759.1; E-value: 2.6e-231)
llpG: GT (Score: 365.1; E-value: 1.3e-111)
llpH: HAL (Score: 724.9; E-value: 8.7e-221)
llpMI: MET C11O (Score: 513.6; E-value: 4.9e-157)
llpMII: MET C13O|C17O (Score: 507.8; E-value: 2.6e-155)
llpMIII: MET C13O|C17O (Score: 501.1; E-value: 2.9e-153)
llpMIV: MET C13O|C17O (Score: 489.6; E-value: 8.9e-150)
llpMV: MET C9O (Score: 220.2; E-value: 5.1e-68)
llpMVI: MET C13O|C17O (Score: 491.3; E-value: 2.6e-150)
llpOI: OXY (Score: 24.6; E-value: 2.8e-08)
llpOV: OXY (Score: 34.4; E-value: 2.9e-11)
llpOVIII: OXY (Score: 327.9; E-value: 2.7e-100)
llpU: KR (Score: 115.9; E-value: 5.7e-36)
llpZI: KR C19 (Score: 433.0; E-value: 7.7e-133)
llpZIII: KR C11 (Score: 454.3; E-value: 2.2e-139)
llpZIV: KR (Score: 183.9; E-value: 1.1e-56)