LOCUS       BGC0000243             15833 bp    DNA     linear   BCT 07-JUL-2000
DEFINITION  Streptomyces griseus subsp. griseus macrotetrolide biosynthesis gene
            cluster, upstream region.
ACCESSION   BGC0000243
VERSION     BGC0000243
KEYWORDS    .
SOURCE      Streptomyces griseus subsp. griseus
  ORGANISM  Streptomyces griseus subsp. griseus
            Bacteria; Actinobacteria; Streptomycetales; Streptomycetaceae;
            Streptomyces.
COMMENT     [WARNING] On Jun 10, 2016 this sequence was replaced by AH009582.2.
            ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 13:15:02
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 15833
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..15833
                     /db_xref="taxon:67263"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces griseus subsp. griseus"
                     /strain="DSM 40695"
                     /sub_species="griseus"
     subregion       1..15833
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000243"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..15833
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     CDS             complement(339..872)
                     /codon_start=1
                     /note="orf1; similar to hypothetical protein SC9B5.17 from
                     Streptomyces coelicolor A3(2)"
                     /product="unknown"
                     /protein_id="AAF81228.1"
                     /transl_table=11
                     /translation="MSTSVSPVVRLVRGDITDQSVDVIVNAANSSLLGGGGVDGAIHRR
                     GGPDILAACRELRASRYGKGLPTGQAVATTAGRLDARWIVHTVGPVFSGAQDRSALLAS
                     CYRESLRLAAELGARSIAFPAISTGIYGWPMDDGARIAVRTVLAETVEPVEEVRFVLFD
                     AHAYVEFEEVLAMR"
     CDS             complement(918..2387)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DAO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1222:dehydrogenase (Score: 87.6; E-value: 1.6e-26)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf2; similar to putative dehydrogenase from
                     Streptomyces coelicolor A3(2)"
                     /product="unknown"
                     /protein_id="AAF81229.1"
                     /sec_met_domain="DAO (E-value: 6.8e-11, bitscore: 31.9,
                     seeds: 521, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAANILGVRLPADEWSPKVPSMLDAVVVGAGPNGLTAAVELARRG
                     CSVEVHEAHDTIGGGARTEELTLPGFRHDPCSAVHPLAIGSPAFRGMPLDRHGLQWLHP
                     EIDLAHPFPDGTAATLTRSVGESAMSLGAADAGAYRRLMAPFVGRWDTLAADFLRTPWD
                     GLPRDPYRLARFGLLGLQPATWLSRRFSGEKAPGLFAGLAAHAIAPTSGFATAAIALVF
                     ALAAHENGWPVPRGGSQSISDALASYLREQGGTIRTGSEVKRLDDLPPARAYIFDTSPS
                     ALARIAGLGSAYHRYRYGASAFKIDYALSGPVPWTAPQARRAGTVHIGPDAGTIDAALT
                     AAVAGRDPDVPFLITAQPSVIDPSRAPEGRHVFWAYGHVPAGWEGDATDVIERQLERFA
                     PGFRDLVLARALAGPPQLAARNANYVGGDIACGAFAGLQTLIRPKLARVPYATAHPAVF
                     LCSSATPPGPGVHGMSGHHAAKAVWRRLRAS"
     CDS             complement(2430..3275)
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1207:inositol monophosphatase (Score: 180.4; E-value:
                     9.2e-55)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf3"
                     /product="inositol monophosphatase-like protein"
                     /protein_id="AAF81230.1"
                     /transl_table=11
                     /translation="MIDDFLYGTAGHTGPPAEVEAAVRAAAAAEIMPRHRKLAAHEIIE
                     KSGPHDLVTAADRLAEEHLTAALTKLLPGSVVVGEESVHADPAVYEALDGDAPVWIVDP
                     VDGTRQFVRGEAGFCTLVALALHGEVHASWTYAPVRGEMAIAVRGRGATLNGAPIRSGA
                     PAPGAVLKVAMSHPDYTTEAQKRALLGLRTESIAARPCGSAGLEYLAVARGSLDAVAFN
                     WEYAWDHAAGLLLVTEAGGAQSTLSGAPFRIAGGNDLPFTAARDEATAQRVLAALRTGG
                     "
     CDS             4678..5466
                     /NRPS_PKS="Domain: ECH (16-218). E-value: 2.6e-45. Score:
                     146.5. Matches aSDomain: nrpspksdomains_AAF81231.1_ECH.1"
                     /codon_start=1
                     /function="may catalyze formation of the furan ring of (+)
                     nactic acids"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023:enoyl-CoA hydratase (Score: 182.9; E-value:
                     9.7e-56)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf4"
                     /product="enoyl-CoA hydratase-like protein"
                     /protein_id="AAF81231.1"
                     /transl_table=11
                     /translation="MTPQETAPEGEPSPLLVERHGRVATLTLNRPHRRNAMSTAMLARL
                     DHALGKLTDQGGEAPGALVLTGAGGTFSSGADTREPDWRDLSRRAVRRAHFRTVFAMLH
                     EAPFPVVAAVEGYALGGGLELALACDLVVAGEGALFGLPELGVGAVPGGGAVHSLVRRA
                     GRGVAARMLLIPGERVRADELARLGAVERTVPDGGALAEAQALAASVAAGDPALLEAGV
                     RLLRDSGHLDRTAALGVENGYWWQAASAANRDPSPSSGRP"
     aSDomain        4726..5331
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AAF81231.1_ECH.1"
                     /evalue="2.60E-45"
                     /label="AAF81231.1_ECH.1"
                     /locus_tag="AAF81231.1"
                     /protein_end="218"
                     /protein_start="16"
                     /score="146.5"
                     /tool="antismash"
                     /translation="VERHGRVATLTLNRPHRRNAMSTAMLARLDHALGKLTDQGGEAPG
                     ALVLTGAGGTFSSGADTREPDWRDLSRRAVRRAHFRTVFAMLHEAPFPVVAAVEGYALG
                     GGLELALACDLVVAGEGALFGLPELGVGAVPGGGAVHSLVRRAGRGVAARMLLIPGERV
                     RADELARLGAVERTVPDGGALAEAQALAASVAAGDPALL"
     CDS             5904..6860
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1000:ABC
                     transporter ATP-binding protein (Score: 164.1; E-value:
                     7.1e-50)"
                     /gene_kind="transport"
                     /note="orf5"
                     /product="ABC transporter ATP binding protein"
                     /protein_id="AAF81232.1"
                     /transl_table=11
                     /translation="MTPLIECTDVTKKFGDFTALSRLNLTVPQGVVYGYLGPNGAGKST
                     TIRMLMGLSRPTSGQVRVLGQDPTDPEVRRRIGYLPGELRLDERLTIGQTLASWGRLRG
                     LTDTAYRDELVQRFGIDPSRRVRGLSTGNRRKVGLVGAFMAKPELLILDEPTNGLDPLM
                     QQVFLATVEEARDNGQSVLLSSHILSEVERVADVVAVLQGGRLAASGPTQELRRRAAQR
                     FHITFAEGEDVPLAALAGLEGASDVERRSPEGQVVSLAWAGSPDALLKFLAGRRITTLT
                     APEPDLEEAFLEYYQRDVPGSRDAEAEEPSAAAGPVR"
     CDS             6934..7740
                     /codon_start=1
                     /note="orf6"
                     /product="ABC transporter membrane protein"
                     /protein_id="AAF81233.1"
                     /transl_table=11
                     /translation="MSSPSSEIFRRGVQIQKRTLIAWSAALVLLALSVVGAWPSMEESG
                     ALEDFSSGISPEMAAAFGIDQISSASGYLKGNLYAVLLPLLLGLMAVTATAALTGGDEE
                     AGRLELLLALPVARRTVFLVRFLCVTFGLALTSILVWLSVYGSVVSFDMDVSGGGVAAV
                     TLTVGLLAVLHAGVAYAVVGFGFGRGPALGVAAGVLVVGYLLHAIAPMSDSLEPLANIS
                     PWEWALGSDPLLNGVPWGGVALLVVLSAAIVAAGTYAVDRRDVKNA"
     CDS             7986..9233
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (2-383). E-value:
                     3.5e-40. Score: 130.0. Matches aSDomain:
                     nrpspksdomains_AAF81234.1_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) t2fas"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 255.9; E-value:
                     1.2e-77)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf7"
                     /product="type II beta-ketoacyl synthase"
                     /protein_id="AAF81234.1"
                     /sec_met_domain="t2fas (E-value: 1.1e-77, bitscore: 251.1,
                     seeds: 8, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MLTGIGCVLPGTPDVHSFWSHVSTGTSQVSRLESPAFAAAGLPVH
                     AAAQLGAFDTGARLPDLLPAHAAKYNRDILATMAAVGDALEDAGIARGQIAPERMSIVQ
                     SSSRGPLSWWAETIAADPEQNPYGGRATAMFRGLAGCPATLAAIGVGAKGLVTTVSSAC
                     VGGHHAIGLALRELRSGSADVVLAGGHEFPIAPEVARCYLALGDGVLSPESDAPATAVR
                     PYDRDRRGFALGEGAMTLCLERESSARARGARIYARILGHRALNEANHATSMDLVGDVT
                     ASVVAGVLDDAGRKPEEIGYVCGHGTATRYNDIAESRALRRLLPRHDDADLPPHGSNKP
                     IYGHTFGMAGIINVAATSLMLHHQRLAPTANHVTPDPECDYDHVAGGPRDTEIDLAVSL
                     SFAFGSQTSVMALEHA"
     aSDomain        7992..9134
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AAF81234.1_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="3.50E-40"
                     /label="AAF81234.1_PKS_KS.1"
                     /locus_tag="AAF81234.1"
                     /protein_end="383"
                     /protein_start="2"
                     /score="130.0"
                     /tool="antismash"
                     /translation="TGIGCVLPGTPDVHSFWSHVSTGTSQVSRLESPAFAAAGLPVHAA
                     AQLGAFDTGARLPDLLPAHAAKYNRDILATMAAVGDALEDAGIARGQIAPERMSIVQSS
                     SRGPLSWWAETIAADPEQNPYGGRATAMFRGLAGCPATLAAIGVGAKGLVTTVSSACVG
                     GHHAIGLALRELRSGSADVVLAGGHEFPIAPEVARCYLALGDGVLSPESDAPATAVRPY
                     DRDRRGFALGEGAMTLCLERESSARARGARIYARILGHRALNEANHATSMDLVGDVTAS
                     VVAGVLDDAGRKPEEIGYVCGHGTATRYNDIAESRALRRLLPRHDDADLPPHGSNKPIY
                     GHTFGMAGIINVAATSLMLHHQRLAPTANHVTPDPECDYDH"
     CDS             9230..11005
                     /codon_start=1
                     /note="orf8"
                     /product="glutaconate CoA-transferase-like protein"
                     /protein_id="AAF81235.1"
                     /transl_table=11
                     /translation="MTTALERPSTTGPYLATGPDDLIRRFVREGDHVHAAATMSRPNAL
                     LNAVCRTFAGSGSMTVSTTAVHSSAHALALSGAVRKVITGFVGDTYPSPRPNRLYRELA
                     EGRPFEVEMWSLLSYTQRLMAAALGQPFATTGSMLAETDLRHGKEGKLHLVPHPEDPER
                     TVTLLSPLRPRFTLFHGVAADRRGNVVACPPLGEGAWAAYAATEGVLASVEAIVDDEVI
                     AAMPDRVVIPAARVLGLCEAPLGAHPQSLRTGGLAGVDGYLDDYDFLTDIVAACKDPES
                     AAAWYEKWVGGAGSHADYLERLGGTRRAALVFPAPPGVPVAVEKDRSPADGSAAPTEQE
                     QLIVLGARAIVDLVRERGYDTLLAGIGTSHMSAWLAARLLGRDGVQVQVAAELGLQSMD
                     PEPGDVFLFSQRHAERSQMLAGVAETLGGAVAANPRCLGVLSAAEIDPDANINTTLLPD
                     GRWITGSGGANDIASSVDCVVIAVASARRYVPRLTHLTSPGLRVRDVVSQFGRFTRAGA
                     GDAFELASWLPPVPGRGRAGKDLPDGPEAAVRDLTGWEFPAASTGVSGFLTDEKAVTTE
                     ELVLLRTMDPEGFYR"
     CDS             11002..12045
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 252.9; E-value: 6.6e-77)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf9"
                     /product="type III beta-ketoacyl synthase-like protein"
                     /protein_id="AAF81236.1"
                     /sec_met_domain="fabH (E-value: 6.1e-69, bitscore: 222.2,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTTADTVPDPATAHLRPLPPTAIAPVRLAGIGHYFPGEPITNAH
                     FEQIEALGIDDAWIRENTGIVSRHWPADEKERAVEMAAKAVDDALNAAGLGPDDIDLVI
                     GTTSTTRPRVNPSSATNNYMDISLPLQKQVGLRHATCFDVTSVACAGFMYGTATAAAML
                     PALGMRNALVVCAENPRPILNFDYRYSALFGAGAAAAVWSADTEEHGLLDVALHADGSY
                     FDAFDIDENDKMLMRGREVGAVGPKLLSHVGLEILERNGLTVDDIDWFVPHQGNLNMIN
                     QVCRTLEIPREKLLTNIQERGNTSSVSIPSCLSENLGSGKIRSGDLVATIGIGRGFSWG
                     AMLLRIP"
     CDS             12042..13079
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) fabH"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1084:3-oxoacyl-(acyl carrier protein) synthase III
                     (Score: 231.9; E-value: 1.7e-70)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf10"
                     /product="type III beta-ketoacyl synthase-like protein"
                     /protein_id="AAF81237.1"
                     /sec_met_domain="fabH (E-value: 8e-55, bitscore: 175.8,
                     seeds: 7, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSPADSPAAGRPPAPPHSTGRREMHDETSLWRESGLRLSGFGHYY
                     PRLQVENESAEDPAGNAVDEAVIGRLDVRSRHVADEEETPAYMGVRAARAAMEQAGITA
                     DEVDLLILSNWTDRQFVPEWAPHTAHLLGADRALAFDVCGACTGFVHGVQTAAAHLGTH
                     ATWRHALVVSSERFSRRVRPGSKGELIVGDAAGAAVVSRGAGPGAGLWDSLLISDGSGR
                     ETVTVYPPNGWIRSSRELVSIAADSHADLAARMLARSGTKMDEIDWVVPHPGTGQLHTA
                     VRERLGIPEERFVTNYETRANTGSASVPIVLSEMAREGRLKAGDLCYTPTVGSGWYYGG
                     LLFRV"
     CDS             13072..13983
                     /NRPS_PKS="Domain: PKS_KR (15-191). E-value: 1.5e-14.
                     Score: 46.2. Matches aSDomain:
                     nrpspksdomains_AAF81238.1_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     185.9; E-value: 1.5e-56)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf11"
                     /product="putative beta-ketoacyl reductase"
                     /protein_id="AAF81238.1"
                     /transl_table=11
                     /translation="MSEQSSTALPRTSVRGTALVTGGSRGLGAAIARKLAAVGWHTVIC
                     GRDPESLDAGVKAAAEDGLVLHAVRADVTDERSVAALFERLAEDAPPLGLCVNNAGNNF
                     SRRLVSVKERSDGPPLLSPHPLEDFERVVTSLLTGTFLVGRHAAQAMLTAGTPGAIVNI
                     SSTVRHGAYGQSAYCAAKSGVEALTRTWATELGEYGIRVSAVAPGVIDGEALRRRSAAN
                     ERHAAYMTDLRRHVPLRRWCDERDVAEAVAFAADNPSVTGTVLEVDAGGLPARVLPPAD
                     RTTAPRTTAATADLPEKAEKTA"
     aSDomain        13117..13644
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AAF81238.1_PKS_KR.1"
                     /evalue="1.50E-14"
                     /label="AAF81238.1_PKS_KR.1"
                     /locus_tag="AAF81238.1"
                     /protein_end="191"
                     /protein_start="15"
                     /score="46.2"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="GTALVTGGSRGLGAAIARKLAAVGWHTVICGRDPESLDAGVKAAA
                     EDGLVLHAVRADVTDERSVAALFERLAEDAPPLGLCVNNAGNNFSRRLVSVKERSDGPP
                     LLSPHPLEDFERVVTSLLTGTFLVGRHAAQAMLTAGTPGAIVNISSTVRHGAYGQSAYC
                     AAKSGVEALTRTW"
     CDS_motif       13126..13188
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AAF81238.1_0001"
                     /evalue="6.30E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="AAF81238.1"
                     /protein_end="39"
                     /protein_start="18"
                     /score="18.9"
                     /tool="antismash"
                     /translation="LVTGGSRGLGAAIARKLAAVG"
     CDS             13980..14804
                     /NRPS_PKS="Domain: PKS_KR (13-176). E-value: 6.2e-16.
                     Score: 50.7. Matches aSDomain:
                     nrpspksdomains_AAF81239.1_PKS_KR.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     233.6; E-value: 4.2e-71)"
                     /gene_kind="biosynthetic-additional"
                     /note="orf12"
                     /product="putative beta-ketoacyl reductase"
                     /protein_id="AAF81239.1"
                     /sec_met_domain="adh_short (E-value: 8.3e-38, bitscore:
                     119.8, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 2.7e-35, bitscore:
                     112.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSGFAPTLLQGRTTFLTGASSGIGAVLATMLAAHGSSVALMARS
                     EKELRLLAERIEADGGRAVAVPGDLTDGDSVRAAVREAEEQLGPIDRLVHCAGEARNQA
                     FLCDQDEEQWTATLDINLLGAFRVARAVVPGMMERREGNIVMVSSIAGKRGLPANTSYC
                     ASKFGLNGMTQALASELGSFGVRVNAVCPGLTDSPAATDGGRYGDAFMAAIAKHHGPPD
                     LTWERYLRRAVNSTILRRLVRPEEIAAQVLFLLSDLSGGMTGQAVNVDAGAL"
     aSDomain        14019..14507
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AAF81239.1_PKS_KR.1"
                     /evalue="6.20E-16"
                     /label="AAF81239.1_PKS_KR.1"
                     /locus_tag="AAF81239.1"
                     /protein_end="176"
                     /protein_start="13"
                     /score="50.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TTFLTGASSGIGAVLATMLAAHGSSVALMARSEKELRLLAERIEA
                     DGGRAVAVPGDLTDGDSVRAAVREAEEQLGPIDRLVHCAGEARNQAFLCDQDEEQWTAT
                     LDINLLGAFRVARAVVPGMMERREGNIVMVSSIAGKRGLPANTSYCASKFGLNGMTQAL
                     "
     CDS_motif       14028..14114
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_AAF81239.1_0001"
                     /evalue="1.30E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="AAF81239.1"
                     /protein_end="45"
                     /protein_start="16"
                     /score="11.4"
                     /tool="antismash"
                     /translation="LTGASSGIGAVLATMLAAHGSSVALMARS"
ORIGIN
        1 ggatccgggg ctggtgtcgg ggcggcaccg cttgcaggcc cggaatccgg cctgctggca
       61 ggcggcggcg ctcgggtaga aggtcatgtt gcggaccttg ggcggtacga cggggcagct
      121 ggggcggcag tagatccggg tggtgaggac cgcggtgaag aaccagccgt cgaaccgggc
      181 gtccttggac tggacggctc gcacgcagcg ctcggtgtcg gtgtgcatgg ttccaggatg
      241 gtgcaccggt caggggcttg gctggcggaa atccgacagg gccctcgcgc ggaaatccga
      301 caggcgaccg aaccctcccg gtggccgggg gcgcggtctc agcgcatcgc gaggacttcc
      361 tcgaactcca cgtacgcgtg ggcgtcgaag agcacgaagc gcacctcttc gaccggctcc
      421 acggtctccg ccaggaccgt gcgtacggcg atccgggcac cgtcgtccat cggccagccg
      481 tagatgccgg tggagatcgc cgggaacgcg atggacctgg cacccaactc cgctgccagg
      541 cgcagggatt cgcggtagca ggaggcgagc agggcggagc ggtcctgggc gccggagaag
      601 accgggccga ccgtgtgcac gatccaccgg gcgtcgaggc gccccgcggt ggtggcgacg
      661 gcctgcccgg tgggcagtcc ctttccgtag cgcgaggcgc gcagttcacg gcaggcggcg
      721 aggatgtcgg gtccgccgcg ccggtggatg gcgccgtcga ctccgccgcc gccgagcagc
      781 gaggagttcg ccgcgttgac gatgacgtcg acggactggt cggtgatgtc gccgcggacc
      841 agccgtacga cgggggagac agaggtgctc atgcggacat catgccgcgc gccgggggcc
      901 ttcgccgccc ggtccgttca ggaggcccgc agccttcgcc atacggcctt ggcggcgtgg
      961 tggccggaca tgccgtggac cccgggtccg ggcggggtgg ccgaggagca gaggaagacc
     1021 gcggggtgcg cggtggcgta ggggacgcgg gcgagcttgg ggcggatcag cgtctggaga
     1081 ccggcgaaag ccccgcacgc gatgtcgccg ccgacgtaat tggcgttgcg cgcggcgagt
     1141 tggggcgggc ccgcgagggc gcgggcgagc acgagatcgc ggaacccggg ggcgaaacgc
     1201 tccagttggc gttcgatgac gtcggtggcg tcgccctccc agcccgccgg cacgtgcccg
     1261 tacgcccaga agacatggcg tccttcgggg gcccgggagg ggtcgatcac gctgggctgc
     1321 gcggtgatga ggaaggggac gtcggggtcg cggcccgcga cggccgccgt cagtgcggcg
     1381 tcgatcgttc cggcgtcggg gccgatgtgg acggtgcccg cgcggcgggc ctggggcgcg
     1441 gtccagggga cggggcccga cagcgcgtag tcgatcttga aggcggaggc gccgtagcgg
     1501 tagcggtggt acgcggagcc gaggcccgcg atccgggcca gggcggaggg cgaggtgtcg
     1561 aagatgtagg cgcgggcggg cgggagatcg tccaggcgct tgacctcgct gccggtgcgg
     1621 atcgtgccgc cctgttcgcg gaggtaggag gcgagggcgt ccgagatgga ctgggagccg
     1681 ccgcgcggca ccggccagcc gttctcgtgg gcggcgagcg cgaagacgag ggcgatggcc
     1741 gcggtggcga atccgctggt gggagctatg gcgtgggcgg cgagcccggc gaagaggccg
     1801 ggggccttct caccggagaa gcggcgggag agccaggtgg cgggctggag gccgagcaga
     1861 ccgaagcggg ccagccggta ggggtcgcgg ggcaggccgt cccagggggt gcgcaggaag
     1921 tcggcggcca gggtgtccca gcggccgacg aagggggcca tcaggcggcg gtaggccccg
     1981 gcgtcggcgg cccccagtga catcgcgctc tcccccaccg agcgggtgag cgtggcggcg
     2041 gtgccgtccg ggaaggggtg cgcgaggtcg atctcggggt gcagccactg gaggccgtgg
     2101 cggtccagcg gcatgccccg gaacgcgggc gagccgatcg cgagggggtg cacggcggaa
     2161 caggggtcgt gccggaaccc cgggagggtc agctcctcgg tgcgagctcc cccgccgatg
     2221 gtgtcgtgcg cctcgtggac ctccaccgag cagccccggc gggccagttc gactgcggcg
     2281 gtcagtccgt tgggccccgc gcccaccacg accgcatcga gcatcgacgg caccttggga
     2341 ctccattcgt cggccggcag tcggaccccc aggatattcg ccgccaccga ccgtgtgtac
     2401 gcgggtaccc cgggttcggt cgtggcgggt cagccgcccg tgcgcagggc ggccaggacg
     2461 cgctgggcgg tggcctcgtc gcgggcggcc gtgaacggca ggtcgttgcc gcccgcgatg
     2521 cggaacgggg cgccggacag ggtcgactgg gcgccgcccg cctcggtgac caggagcaag
     2581 cccgcggcgt ggtcccaggc gtactcccag ttgaaggcga cggcgtccag ggagccgcgg
     2641 gcgacggcga ggtactcgag tccggccgag ccgcaggggc gggccgcgat ggattcggtg
     2701 cgcaggccga gcagggcccg cttctgggcc tcggtggtgt agtcggggtg cgacatcgcc
     2761 accttcagca cggcgccggg tgcgggcgcc ccggagcgta tcggcgcccc gttgagcgtg
     2821 gcgccccgtc cgcgtacggc tatggccatc tcgccccgga ccggtgcgta cgtccaggag
     2881 gcgtgcacct cgccgtggag ggcgagggcg accagggtgc agaagccggc ctcgccccgg
     2941 acgaactggc gggtgccgtc gaccgggtcg acgatccaga ccggggcgtc gccgtcgagg
     3001 gcctcgtaga ccgccgggtc ggcatgcacg gactcctcac cgacgacgac cgagccgggc
     3061 agcagtttcg tgagggcggc ggtgaggtgc tcctcggcca gccggtcggc ggcggtgacc
     3121 aggtcgtgcg ggccgctctt ctcgatgatc tcgtgggcgg cgagcttccg atggcgcggc
     3181 atgatctcgg ccgcggcggc ggcgcgcacg gcggcctcga cctcggccgg cggtccggtg
     3241 tgcccggcgg tcccgtacag gaagtcatcg atcatggctc cagctaagca tggccggacg
     3301 agccctcacc ccccgggtga atacggacat ctccggcgca gggtcggatg ccggacagtt
     3361 tccgcgaagt acaaccgtga acaaaggacg cgtcaatttc cggcgcatat tcttgacccc
     3421 ggggaaaaaa ccactacgtg acaagcggag gctctgcggt tactgttggc gtggattcgg
     3481 ggcccgaact ctcgtattgg ttcaccccgc acggccttga acggccaccg ggctggaacg
     3541 cacaaccagg ggggaagccg tgcctcagcc agctaacccc tcggggttac gccatccctg
     3601 ccggaccagg cagtgtttcc cgccgcgcca ccgcgatccg gtccggccgc ggccgccgcg
     3661 tcacggtgca cacacccgga cccactgttc ccatggatgt cacagagcct taacgtgcac
     3721 accgaaacct ggaatcaaag gtacgcgaga gtggaaccga acgtggggcg gatgcgtctt
     3781 gctcggggaa tcccattccc gcgcgggata tctacgctcc agtaataacc gccggtaagg
     3841 aattcctccc ccgcctgaat acacggcggc atcccggcaa caatacgatc gtgcgccgac
     3901 gggcgccgcc atcccgcttt ccgccgcccc gggggccaca ccggagcgga ctcccacctg
     3961 gcgggagggc atcaccccgc gaacgcggtt caacacattc acaacatgcc gaacgacacg
     4021 cggcgccagc cgtcgctgtt ggagtacgag gggttctggt atggccgaga agggcagacg
     4081 cggactgatg gtcctgcact cgtcaccttt gatacgcaag gcgattctcg atctgttccg
     4141 gggcgatccc ggcgtcaccg tactgggcgg ctgtccgcac ccgaccgctg tcggcagcct
     4201 ccccggacgc cggcccgacg tcgcgctcgt ggagtacgag cagtggcagg aggtgctcgg
     4261 caatctggcg tactggagcg gcacccgggt catcctctac agcagggaca acaccccccg
     4321 cagcgtggtg gattgcatca ggggccgggc cgccgggttc gtgcacgagt cgtgcccgcc
     4381 cgagtccatc gtcaaggggc tgcacgatgt gctgagcggg cgcggcttct ggcacctggg
     4441 ggccgacgag cccgagggcg taccggtgac ccggcacgcc gcagcgggcg ggaagtggaa
     4501 actgagcgga cgcgaggagg agatcctcgg gctcttactc cgcagacgct cgaacgagga
     4561 gatcgcggat gagctgtgcc tcacccagca gaccgtcaag aactacgcga gccgggtctt
     4621 ccacaaggtg ggcgtgtccg gacgcaagga gctcttcagg atgctgaggc cctgcggatg
     4681 accccacagg agacggcgcc cgagggggag ccgagccccc tgctggtcga gcggcacggg
     4741 cgggtggcca ccctcaccct gaaccggccg caccgccgca acgcgatgtc caccgcgatg
     4801 ctggcccgac tcgaccacgc gttggggaag ctgacggatc agggcgggga ggcgccgggg
     4861 gcgctggtgc tcaccggcgc cggcgggacc ttctccagcg gcgcggacac ccgcgagccc
     4921 gactggcgcg acctgtcgcg ccgcgcggtg cggcgggccc atttccgtac ggtgttcgcg
     4981 atgttgcacg aggccccctt cccggtggtc gcggccgtcg aggggtacgc gctcggcggc
     5041 ggcctcgaac tggccctggc ctgcgacctg gtggtggcgg gcgagggtgc gctgttcggc
     5101 cttcccgagc tgggggtcgg cgccgttccg ggcggcggcg cggtccactc actggtgcgc
     5161 cgggccggtc gcggagtggc cgcccggatg ctgctgatcc ccggggagcg cgtgcgggcg
     5221 gacgaactcg cccgactggg cgcggtggag cgcaccgtgc ccgacggcgg tgcgctcgcc
     5281 gaggcgcagg cgctggcggc ttccgtggcc gccggggatc cggcgctcct ggaggcgggc
     5341 gtccggctgt tgcgggactc cgggcacctg gaccgcacgg cggcgctcgg cgtggagaac
     5401 ggctactggt ggcaggccgc gtccgccgcg aaccgggacc cctcgccctc ctccggacga
     5461 ccctaggggc gatgccttcg cgccacggat ggcaggcgct tcgttgcagc gggtgagctg
     5521 cgccgttagg cttgttgatc cggcgctcct ggaggcgggc gtccggctgt tgcgggactc
     5581 cgggcacctg gaccgcacgg cggcgctcgg cgtggagaac ggctactggt ggcaggccgc
     5641 gtccgccgcg aaccgggacc cctcgccctc ctccggacga ccctaggggc gatgccttcg
     5701 cgccacggat ggcaggcgct tcgttgcagc gggtgagctg cgccgttagg cttgttgatc
     5761 agattcagta atcactgaat ctactgtccg tgccgtacgg cggacctgac gccccatccc
     5821 ccccaccccc gatgcccgcc ggacgacccc ggccgaccgt ggacgcacga gccgtggacg
     5881 caagaggaga gagcagaaga gacgtgaccc ctctcatcga atgtaccgac gtcaccaaga
     5941 agttcggtga cttcaccgcg ctgagccggc tgaacctgac cgtcccccag ggcgtggtct
     6001 acggatatct gggccccaac ggagcgggca agagcaccac gatccgtatg ctcatgggcc
     6061 tctcccggcc cacatccggc caggtccggg tgctcggcca ggacccgacc gaccccgagg
     6121 tccggcggcg catcggctat ctgccgggtg aactgcgcct ggacgagcgg ctgaccatcg
     6181 gtcagacgct ggcctcctgg gggcggctgc gaggactgac ggacaccgcc taccgggacg
     6241 agctggtcca gcggttcggc atcgacccgt cccggcgggt gcgcgggctc tccaccggca
     6301 accgccgcaa ggtcggcctg gtcggcgcct tcatggccaa gccggagctg ctgatcctcg
     6361 acgaaccgac caacgggctc gacccgttga tgcaacaggt gttcctcgcc accgtcgagg
     6421 aggcccggga caacgggcag agcgtgctgc tctcctcgca catcctctcc gaggtcgagc
     6481 gggtcgccga cgtggtcgcg gtgctccagg gcggcaggct cgccgcctcc ggtccgacac
     6541 aggaactgcg ccgccgggcc gcacagcgtt tccacatcac cttcgcggag ggcgaggacg
     6601 tcccgctcgc cgcactggcc ggcctggagg gcgcgtcgga cgtggagcgg cgcagtccgg
     6661 agggccaggt ggtctccctg gcctgggccg gctcgcccga cgcactgctg aagttcctgg
     6721 cgggccgccg gatcacgacg ctcaccgcgc ccgaaccgga cctggaggag gcgttcctgg
     6781 agtactacca gagggatgtc ccgggcagcc gcgacgccga ggccgaagag ccctccgcgg
     6841 ccgcaggccc ggtgcggtag cgaccgccgg acaccaccgc cacgggtctc agtcatcaag
     6901 gccgttcccc cgggccggcc ggaagggata catatgtcat cgcccagctc ggagatcttc
     6961 cggcgcggag tacagatcca gaagcgcacc ctgatcgcct ggtcggccgc gctggtcctg
     7021 ctcgcactct ccgtcgtcgg cgcctggccc tcgatggagg agtccggcgc cctggaggac
     7081 ttctcctccg gcatatcgcc ggagatggcc gccgccttcg gaatcgacca gatcagcagc
     7141 gcgagcggct acctgaaggg gaacctgtac gcggtactgc tgccgctgct cctcggcctg
     7201 atggccgtga ccgcgaccgc cgccctgacc ggcggcgacg aggaggccgg gcggctcgaa
     7261 ctgctgctcg cgctgccggt cgcccgccgc acggtctttc tggtgcgctt cctctgcgtg
     7321 accttcggcc tggccctcac cagcatcctg gtctggctgt cggtgtacgg ctcggtcgtc
     7381 tccttcgaca tggacgtctc cggaggcggg gtcgccgccg tgacgctgac cgtcggtctg
     7441 ctggccgtgc tgcacgcggg tgtcgcgtac gccgtcgtcg ggttcggctt cgggcgcggt
     7501 cccgcactcg gcgtggcggc cggtgtgctc gtcgtcgggt atctgctgca cgccatcgcg
     7561 ccgatgtccg actccctgga accgctggcg aacatctccc cgtgggagtg ggcgctgggc
     7621 agcgacccgc tgctcaacgg cgttccctgg ggcggggtcg cgctgctggt ggtcctctcg
     7681 gccgcgatcg tcgccgccgg tacgtacgcc gtggaccgac gcgacgtcaa gaacgcctga
     7741 gccccacgcc cgcgcctacg ccgagcggcc cggcgcctcc ctcacggagg cggcgggccg
     7801 cttccgtgcg tgcgggcgcg gataccgtac ggcgttgacg cccggtgctc atattcgagt
     7861 actggtagtc accaaataag acgcgcatga gtacttgacg gccatatcga ggctcatgta
     7921 agggcagcta gcttcgatcc atggacagca gccgatcccc ttccccggac ccctccgatc
     7981 ccatcgtgct gaccggcatc ggatgcgtgc tgcccggcac ccccgatgtc cattccttct
     8041 ggagccatgt ctccaccggt acctcacagg tgagccggct ggagtcgccg gcgttcgccg
     8101 ccgccgggct gccggtccac gcggccgcgc agctcggcgc cttcgacacc ggggcccggc
     8161 tgccggacct cctgccggcg cacgccgcga agtacaaccg cgacatcctg gcgaccatgg
     8221 ccgccgtggg cgacgccctg gaggacgccg ggatcgcccg gggccagatc gccccggagc
     8281 gcatgagcat cgtccagtcc tcgtcccgcg gcccgctgtc ctggtgggcc gagaccatcg
     8341 cggcggaccc ggagcagaac ccgtacgggg gcagggcgac ggccatgttc cgcggtctgg
     8401 ccggctgtcc ggccaccctc gccgccatcg gcgtcggcgc gaagggcctg gtcaccacgg
     8461 tcagcagtgc ctgtgtcggt ggccaccacg cgatcggtct cgctctgcgc gagctgcgtt
     8521 cgggcagtgc cgacgtggtc ctcgccggtg ggcacgagtt cccgatcgcc cccgaggtcg
     8581 cccgctgcta cctggcgctc ggggacgggg tgctctcgcc cgagagcgac gcccccgcca
     8641 ccgccgtacg cccctacgac cgggaccggc gcggattcgc cctgggcgag ggcgccatga
     8701 cgctctgcct ggagcgcgag tcgtcggccc gggcgcgcgg cgcccggatc tacgcacgga
     8761 tcctgggcca ccgcgccctc aacgaggcca accacgccac cagcatggac ctggtcgggg
     8821 acgtcaccgc ctcggtcgtc gcgggcgtgc tcgacgacgc cgggcgcaag ccggaggaga
     8881 tcggctacgt ctgcggccac ggcaccgcca cccggtacaa cgacatcgcc gagagccggg
     8941 ccctgcgccg cctgctgccg cgccacgacg acgcggacct gccgccgcac ggctccaaca
     9001 aacccatcta cggccacacg ttcggcatgg ccgggatcat caacgtcgcc gccacctcgc
     9061 tgatgctcca tcaccagcgg ctggccccga ccgccaacca cgtcacgccg gaccccgagt
     9121 gcgactacga ccacgtcgcc ggggggccgc gcgacaccga gatcgacctc gcggtctcgc
     9181 tgtccttcgc cttcggctcg cagacctccg tcatggccct ggagcacgca tgaccacagc
     9241 cctcgaacgc ccctccacca ccggccccta cctggccacc ggccccgacg acctgatacg
     9301 ccgcttcgtc cgcgagggcg accacgtgca cgccgcggcg acgatgtcgc ggcccaacgc
     9361 cctgctgaac gcggtgtgcc ggaccttcgc cgggagcggc agcatgacgg tgagcaccac
     9421 cgccgtgcac tccagcgccc atgcgctggc cctctccggc gccgtacgca aggtgatcac
     9481 cgggttcgtc ggcgacacct acccctcacc gcgccccaac cgcctctacc gcgagctggc
     9541 cgagggccgg ccgttcgagg tggagatgtg gtcgctgctg agctacacgc agcggctgat
     9601 ggccgcggcg ctcggccagc ccttcgccac caccggctcg atgctcgccg agaccgacct
     9661 ccggcacggc aaggagggca agctccacct ggtgccgcac cccgaggacc cggagcgcac
     9721 cgtcaccctg ctcagcccgc tgcgcccgcg cttcaccctc ttccacggtg tcgccgccga
     9781 ccgccggggc aacgtcgtgg cctgcccccc gctgggcgag ggcgcctggg ccgcgtacgc
     9841 cgccaccgag ggggtcctcg cctccgtgga ggcgatcgtc gacgacgagg tgatcgccgc
     9901 gatgccggac cgggtggtga tccccgccgc ccgcgtcctc ggcctgtgcg aggcgccgct
     9961 cggcgcccac ccgcagtcac tgcgcacggg tggactggcc ggagtcgacg gctacctgga
    10021 cgactacgac ttcctcaccg acatcgtggc cgcctgcaag gacccggagt ccgccgccgc
    10081 ctggtacgag aagtgggtcg gcggggcggg cagccacgcc gactacctgg agcggctggg
    10141 tgggacccgc cgcgccgcgc tggtgttccc cgctcccccg ggcgtcccgg tcgccgtgga
    10201 gaaggaccgg agcccggcgg acgggtccgc cgcccccacc gagcaggagc agctcatcgt
    10261 gctcggcgcc cgcgcgatcg tcgacctggt ccgggagcgc ggctacgaca cgctgctcgc
    10321 cgggatcggc acctcgcaca tgtccgcgtg gctggcggcc cggctgctgg gacgcgacgg
    10381 cgtccaggtg caggtggccg ccgagctggg cctccagtcg atggaccccg aacccggcga
    10441 cgtcttcctc ttcagccaac ggcacgccga gcgctcgcag atgctggcgg gcgtcgcgga
    10501 gacgctgggc ggcgcggtcg ccgccaaccc gcgctgcctg ggcgtgctct ccgccgcgga
    10561 gatcgacccg gacgccaaca tcaacacgac gctgctgccc gacggccgtt ggatcaccgg
    10621 ctccggcggg gccaacgaca tcgcctcgtc cgtggactgc gtcgtgatcg cggtcgcctc
    10681 ggcccgccgc tacgtacccc ggctgaccca cctcaccagt ccgggcctgc gggtccgcga
    10741 cgtggtcagc cagttcgggc gcttcacccg cgccggggcc ggcgacgcct tcgagctggc
    10801 gagctggctg ccgcccgttc cgggccgcgg ccgcgccggg aaggacctcc ccgacgggcc
    10861 ggaggcggcg gtgcgcgacc tcaccggctg ggagttcccc gcggcctcca ccggggtcag
    10921 cggcttcctg accgacgaga aggccgtcac caccgaagaa ctcgtcctcc tgcgcaccat
    10981 ggacccggaa ggtttctacc gatgaccacc accgccgaca ccgtccccga cccggcgacg
    11041 gcacatctgc gcccgctgcc gcccaccgcg atcgcccccg tgcggctcgc cgggatcggc
    11101 cactacttcc ccggcgagcc gatcaccaac gcccacttcg agcagatcga ggcgctgggc
    11161 atcgacgacg cctggatccg cgagaacacc gggatcgtca gccgccactg gccggccgac
    11221 gagaaggaac gcgcggtgga gatggcggcc aaggcggtgg acgacgccct gaacgccgcc
    11281 ggtctggggc ccgacgacat cgatctcgtc atcggcacga cgtccaccac ccggccgcgg
    11341 gtcaacccct ccagcgccac caacaactac atggacatct cgctgccgct ccagaagcag
    11401 gtcgggctgc gccacgccac ctgcttcgac gtcacctcgg tggcctgcgc cggcttcatg
    11461 tacggcaccg cgacggccgc cgcgatgctt ccggcgctcg gcatgcgcaa cgcgctggtc
    11521 gtctgcgcgg agaacccgcg cccgatcctg aacttcgact accgctactc ggcgctgttc
    11581 ggggcggggg ccgccgcggc ggtctggtcg gcggacaccg aggagcacgg gctgctggac
    11641 gtggcgctgc acgcggacgg ctcgtacttc gacgccttcg acatcgacga gaacgacaag
    11701 atgctgatgc gcggccggga ggtcggcgcg gtcggtccga agctgctctc ccacgtgggc
    11761 ctggagatcc tggagcgcaa cggcctgacg gtggacgaca tcgactggtt cgtgccgcac
    11821 cagggcaacc tgaacatgat caaccaggtg tgccggacgc tggagatccc gcgcgagaag
    11881 ctcctcacca acatccagga acgcggcaac acctccagcg tctccatccc cagctgcctc
    11941 tccgagaacc tcggttccgg gaagatccgc tccggcgatc tcgtcgcgac gatcggcatc
    12001 ggccgcggct tcagctgggg cgcgatgctc ctgcggattc cgtgagcccg gccgattccc
    12061 cagccgccgg gcgtcccccg gccccaccgc acagtacggg aagacgagag atgcacgacg
    12121 agacctccct gtggcgcgag agcggactgc gcctgtccgg attcgggcac tactacccac
    12181 gtctccaggt ggagaacgag agcgccgagg accccgcggg caacgcggtg gacgaggccg
    12241 tcatcggccg gctcgacgtc cgcagccgcc atgtggcgga cgaggaggag acccccgcgt
    12301 acatgggggt gcgcgccgcc cgtgcggcca tggagcaggc gggcatcacc gccgacgagg
    12361 tggacctgct gatcctcagc aactggacgg accgtcagtt cgtccccgag tgggccccgc
    12421 acaccgcgca cctgctgggt gcggaccggg cgctcgcctt cgacgtgtgc ggcgcctgca
    12481 cggggttcgt gcacggggtc cagacggcgg cggcgcatct cgggacacac gccacctggc
    12541 gccacgcgct ggtcgtctcc agcgagcggt tctcgcgccg ggtgcgcccg ggcagcaagg
    12601 gcgagctgat cgtgggcgac gcggccggcg cggccgtggt gtcgcgcggc gccgggccgg
    12661 gcgccggcct gtgggactcg ctgctgatca gcgacggctc cggccgggag acggtcaccg
    12721 tgtacccgcc caacggatgg atcaggagca gccgcgagct ggtctccatc gccgccgact
    12781 cccacgccga tctggccgcc cggatgctgg cccgctcggg cacgaagatg gacgagatcg
    12841 actgggtggt gccgcacccc ggaacgggcc agctgcacac cgccgtacgg gaacgtctcg
    12901 gcatcccgga ggaacgcttc gtcaccaact acgagacccg ggcgaacacc ggcagcgcct
    12961 cggtgccgat cgtgctctcc gagatggcgc gcgagggccg gctgaaggcc ggggacctct
    13021 gctacacgcc cacggtgggt tcgggctggt actacggggg gctgctcttc cgtgtctgag
    13081 cagtcatcaa cagcgttgcc gcgcacgagt gttcgcggca ccgccctggt caccggcggc
    13141 agccggggac tcggcgccgc catcgcccga aagctggccg ccgtcggctg gcacaccgtg
    13201 atctgcgggc gcgacccgga gagcctggac gccggggtga aggcggcggc cgaggacggg
    13261 ctcgtcctgc acgccgtgcg ggcggacgtc accgacgagc ggtcggtggc cgccctcttc
    13321 gagcggctgg ccgaggacgc cccgccgctc gggctctgcg tcaacaacgc ggggaacaac
    13381 ttctcccgcc gcctggtgag cgtcaaggaa cggagcgacg gcccgccgct gctctcccca
    13441 cacccgctgg aggacttcga gcgggtggtg acgtccctgc tcaccggcac cttcctcgtc
    13501 ggccgccacg cggcgcaggc gatgctgacc gccggcacgc ccggggcgat cgtcaacatc
    13561 tcctccacgg tccggcacgg cgcgtacggg cagtcggcgt actgcgcggc caagtccggg
    13621 gtggaggcgc tgacccgcac ctgggcgacc gagctgggcg agtacggcat ccgggtcagc
    13681 gcggtggcgc ccggagtcat tgacggcgag gcgctgcgcc gccgttcggc ggcgaacgag
    13741 cggcacgcgg cctatatgac cgacctccgg cgccatgtgc cgctgcgccg ctggtgcgac
    13801 gagagggacg tggccgaggc ggtcgccttc gccgccgaca acccctcggt gaccggcacc
    13861 gtgctggagg tcgacgcggg cggactgccc gcccgcgtcc tgcccccggc cgaccggacc
    13921 accgcaccac gtacgacagc cgcgacggcg gacctccccg agaaagcgga gaaaacagca
    13981 tgaccagcgg cttcgcaccc accctgctcc agggcaggac cacctttctg accggcgcca
    14041 gcagcgggat cggcgcggtc ctggcgacga tgctcgccgc ccacggctcc agcgtggcgc
    14101 tcatggcccg cagcgagaag gagctccggc tgctggccga gcggatcgag gcggacggcg
    14161 ggcgggcggt ggcggtcccc ggtgacctca ccgacggcga cagtgtgcgc gccgccgtcc
    14221 gcgaggccga ggaacagctc ggcccgatcg accggctggt gcactgcgcg ggcgaggccc
    14281 gcaaccaggc gttcctgtgc gaccaggacg aggagcagtg gacggccacc ctcgacatca
    14341 acctgctggg ggccttccgg gtcgcccgtg cggtggtgcc ggggatgatg gagcgccgcg
    14401 agggcaacat cgtgatggtc tcctccatcg ccgggaagcg cgggctgccc gccaacacct
    14461 cgtactgcgc ctcgaagttc gggctcaacg gcatgacgca ggcgctcgcc tccgagctgg
    14521 gctccttcgg cgtgcgggtc aacgcggtct gccccgggct caccgacagc cccgccgcca
    14581 cggacggcgg acggtacggc gacgccttca tggccgccat cgccaagcac cacggccccc
    14641 cggacctgac ctgggagcgg tacctcaggc gcgcggtcaa cagcaccatc ctgcggcgcc
    14701 tggtgcgccc cgaggagatc gccgcccagg tcctgttcct gctctccgac ctctccggcg
    14761 ggatgaccgg acaggccgtc aacgtggacg cgggggctct gtgagcaagg agcacggccc
    14821 ggggaagggc gaaccgcccc tgccggaaca gctgctcgcc cccgcggcgc gcccctgggc
    14881 ccccggcccc cgggacgcgc tggtcaccgg gatggggttc tgcctgcccg gtgcgggcga
    14941 cgagccggtg cgcacggccg agcaggtctg ggcggccgcc tccaccggga ccagtcatgt
    15001 cgaacgcgac ggcttccacc acgggaccgt acgcggtgcc cgcgaggcgt tcggagagct
    15061 gctgccggac ataccggccc gctatctgcg cagctacgcc gacgtccacc tctacgggct
    15121 gatctcgctg gccgaggcct gccgggacgc cggactcgat tacgggaaag gcgagttgag
    15181 aggggcggac gtgctgaccg cccgggccgg ggtggacagc aactacgaca gctaccgcgc
    15241 ctggcacgac gccgatccgg cgacggtcac tccctcggac gccaagtccc tcttcgtacg
    15301 gctcctggtg gcgggcacct ccagcgacgt cggccccgtc caggccgcgc tgctcggttc
    15361 caccggcgcc aactacacgg tgagctgcgg ctgcgcctcc tcctcggtgc tgctcggcat
    15421 cgcccgcatg atgatcgcct ccggccagag cgacctggtc gtggtcaccg gggtggaccg
    15481 cttcgacacc gaacgggtgc tgcacggaca ccggttgcgc gaggtcgtcg agcgcgaggg
    15541 cgtgacggtg cggcacaaca gcgatccgcc ggcagcaccc cgtcacgacc ggccgatgcg
    15601 cccgtacgac gcggcgggcg actgcatgaa ctacggcgac gggtcggtga ccctgatcct
    15661 ggagagccgc gaacacgccg ccgcgcgggg cgcccggacg cacggggcgg tcctcggcca
    15721 ggccaccacg cgcgggggcc tgaacagcgc cgtcgccatc gacaccggcg gtacggggct
    15781 ggccgaggcg gcccgccgcg ccctgggcga ccatacctcg ctggggcgga tcc
//
