BGC0000245 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000245 (Streptomyces sp. AM-7161)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	36,202	High	medermycin	PKS

BGC0000245 - Region 1 - T2PKS

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Location: 1 - 36,202 nt. (total: 36,202 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 36,203
Label		BGC0000245

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

med-ORF12: 3-hydroxybutyryl-CoA dehydrogenase

smcogs: SMCOG1095: 3-hydroxybutyryl-CoA dehydrogenase

med-ORF13: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

med-ORF29: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

med-ORF6: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

med-ORF7: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

med-ORF9: crotonyl-CoA reductase / alcohol dehydrogenase

smcogs: SMCOG1028: crotonyl-CoA reductase / alcohol dehydrogenase

Transferases: PPTase aminotransferase glycosyltransferase kinase methyltransferase transferase

med-ORF15: methyltransferase

smcogs: SMCOG1248: methyltransferase

med-ORF18: glucose-1-phosphate adenylyl/thymidylyltransferase

smcogs: SMCOG1064: glucose-1-phosphate adenylyl/thymidylyltransferase

med-ORF20: DegT/DnrJ/EryC1/StrS aminotransferase

smcogs: SMCOG1056: DegT/DnrJ/EryC1/StrS aminotransferase

med-ORF21: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

med-ORF22: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

med-ORF24: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

med-ORF8: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

Lyases: cyclase dehydratase

med-ORF14: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

med-ORF17: NAD-dependent epimerase/dehydratase

smcogs: SMCOG1010: NAD-dependent epimerase/dehydratase

med-ORF19: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

med-ORF1: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

med-ORF2: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000245.5	1.00	PKS	medermycin	Streptomyces sp. AM-7161
BGC0000231.5	0.65	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002276.2	0.63	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000234.5	0.59	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001197.5	0.57	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000271.5	0.56	PKS	spore pigment	Streptomyces avermitilis
BGC0001513.3	0.55	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0001817.5	0.55	other (other)	vancosamine	Streptomyces sp. WAC2288
BGC0001723.5	0.54	PKS	oviedomycin	Streptomyces antibioticus
BGC0000813.3	0.54	other (other)	K-252a	Nonomuraea longicatena

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000245.5	1.00	PKS	medermycin	Streptomyces sp. AM-7161
BGC0000231.5	0.65	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0002276.2	0.63	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000234.5	0.59	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001197.5	0.57	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000271.5	0.56	PKS	spore pigment	Streptomyces avermitilis
BGC0001513.3	0.55	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0001817.5	0.55	other (other)	vancosamine	Streptomyces sp. WAC2288
BGC0001723.5	0.54	PKS	oviedomycin	Streptomyces antibioticus
BGC0000813.3	0.54	other (other)	K-252a	Nonomuraea longicatena

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 36202
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 7 (Score: 733.6; E-value: 1.2e-223)
Product class(es):: benzoisochromanequinone
Product molecular weight(s):: acetyl-CoA_7: 520 Da

med-ORF1: KS (Score: 761.8; E-value: 4e-232)
med-ORF12: KR (Score: 159.9; E-value: 2.1e-49)
med-ORF15: MET (Score: 20.1; E-value: 6.7e-07)
med-ORF19: CYC C7-C12 (Score: 463.6; E-value: 5.8e-142)
med-ORF2: CLF 7 (Score: 733.6; E-value: 1.2e-223)
med-ORF23: ACP (Score: 124.9; E-value: 2.2e-39)
med-ORF3: CYC C5-C14 (Score: 503.0; E-value: 5.6e-154)
med-ORF6: KR C9 (Score: 446.7; E-value: 5.7e-137)
med-ORF7: OXY (Score: 34.7; E-value: 2.3e-11)
med-ORF8: GT (Score: 408.3; E-value: 1e-124)