BGC0000245: medermycin biosynthetic gene cluster from Streptomyces sp. AM-7161
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Location: 1 - 36,202 nt. (total: 36,202 nt).
This entry is originally from NCBI GenBank AB103463.1.

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core biosynthetic genes
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Gene details
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NRPS/PKS domains
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General information about the BGC
MIBiG accession BGC0000245
Short description medermycin biosynthetic gene cluster from Streptomyces sp. AM-7161
Status Minimal annotation: yes
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: Unknown
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide
Loci NCBI GenBank: AB103463.1
Compounds
  • medermycin
Species Streptomyces sp. AM-7161 [taxonomy]
References
Chemical products information
medermycin
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C24H27N1O7
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAC79013.1
  • ORF_P
 1 - 651 (-) sulfate adenylyltransferase
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  • BAC79014.1
  • ORF_Q
 648 - 1181 (-) adenylylsulfate kinase
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  • BAC79015.1
  • ORF_R
 1211 - 1918 (-) phosphoadenosine phosphosulfate reductase
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  • BAC79016.1
  • ORF_X
 2091 - 3785 (-) nitrite/sulphite reductase
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  • BAC79017.1
  • ORF_Y
 4149 - 4718 (-) acetyltransferase
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  • BAC79018.1
  • med-ORF30
 5000 - 5680 (+) repressor-response regulator
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  • BAC79019.1
  • med-ORF26
 5738 - 6358 (-) putative disulphide-forming protein
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  • BAC79020.1
  • med-ORF25
 6374 - 7951 (-) transmembrane transport protein
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  • BAC79021.1
  • med-ORF29
 7948 - 8973 (-) enoyl reductase
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  • BAC79022.1
  • med-ORF28
 9056 - 9697 (+) Tet-R family transcriptional regulator
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  • BAC79023.1
  • med-ORF27
 9739 - 10785 (-) unknown
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  • BAC79024.1
  • med-ORF23
 11211 - 11486 (+) acyl carrier protein (ACP)
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  • BAC79025.1
  • med-ORF24
 11536 - 12252 (+) phosphopantetheinyl transferase
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  • BAC79026.1
  • med-ORF22
 12287 - 13903 (+) decarboxylase
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  • BAC79027.1
  • med-ORF19
 13942 - 14898 (+) first ring aromatase (ARO)
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  • BAC79028.1
  • med-ORF20
 14936 - 16066 (+) NDP-deoxyhexose 3-aminotransferase
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  • BAC79029.1
  • med-ORF18
 16063 - 17127 (+) NDP-1-glucose synthase
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  • BAC79030.1
  • med-ORF17
 17124 - 18125 (+) NDP-glucose-4,6-dehydratase
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  • BAC79031.1
  • med-ORF16
 18122 - 19561 (+) NDP-deoxyglucose-2,3-dehydratase
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  • BAC79032.1
  • med-ORF15
 19612 - 20334 (+) N-methyl transferase
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  • BAC79033.1
  • med-ORF14
 20331 - 21308 (+) NDP-4-keto-6-deoxyhexose reductase
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  • BAC79034.1
  • med-ORF21
 21350 - 22366 (+) putative carbohydrate kinase
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  • BAC79035.1
  • med-ORF13
 22425 - 22928 (-) NADH:FMN oxidoreductase
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  • BAC79036.1
  • med-ORF12
 22972 - 23946 (-) stereospecific keto reductase
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  • BAC79037.1
  • med-ORF11
 24129 - 24905 (+) pathway-specific transcriptional activator (SARP)
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  • BAC79038.1
  • med-ORF10
 24919 - 25359 (+) unknown (ActVI-A homologue)
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  • BAC79039.1
  • med-ORF9
 25400 - 26419 (+) enoyl reductase
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  • BAC79040.1
  • med-ORF8
 26416 - 27546 (+) C-glycosyl transferase
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  • BAC79041.1
  • med-ORF5
 27628 - 28272 (-) pyran ring cyclase/possible exporter (ActVI-3 homologue)
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  • BAC79042.1
  • med-ORF6
 28556 - 29341 (+) keto reductase (KR)
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  • BAC79043.1
  • med-ORF7
 29375 - 30514 (+) oxygenase/hydroxylase
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  • BAC79044.1
  • med-ORF1
 30657 - 31925 (+) ketosynthase (KS) alpha subunit
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  • BAC79045.1
  • med-ORF2
 31922 - 33148 (+) ketosynthase (KS) beta subunit
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  • BAC79046.1
  • med-ORF3
 33141 - 34049 (+) second ring cyclase (CYC)
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  • BAC79047.1
  • med-ORF4
 34145 - 35374 (-) putative secreted chitosanase
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  • BAC79048.1
  • ORF_Z
 35704 - >36201 (-) putative regulatory protein
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Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
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