Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000246.1:
Cluster 1Polyketide118977

BGC0000246, mithramycin biosynthetic gene cluster from Streptomyces argillaceus. Locus 1. Partial MIBiG entry.

Chemical compounds

Compound: mithramycin
PubChem ID: 163659
SMILES string: Copy to clipboard
Molecular formula: C52H76O24
Average molecular mass: 1085.156 Da

Class-specific details

Biosynthetic class(es):
Polyketide synthase subclass:
Type II

Gene cluster description

mithramycin (BGC0000246). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank AJ007932. Click on genes for more information.


biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

Literature references

1. Lombo F et al. (1996) Characterization of Streptomyces argillaceus genes encoding a polyketide synthase involved in the biosynthesis of the antitumor mithramycin. Gene 172(1):87-91.
2. Lombo F et al. (1997) Cloning and insertional inactivation of Streptomyces argillaceus genes involved in the earliest steps of biosynthesis of the sugar moieties of the antitumor polyketide mithramycin. J Bacteriol 179(10):3354-7.
3. Prado L et al. (1999) Analysis of two chromosomal regions adjacent to genes for a type II polyketide synthase involved in the biosynthesis of the antitumor polyketide mithramycin in Streptomyces argillaceus. Mol Gen Genet 261(2):216-25.
4. Gonzalez A et al. (2001) The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties. Mol Gen Genet 264(6):827-35.