{"accession":"BGC0000247","version":5,"changelog":{"releases":[{"version":"1","entries":[{"contributors":["IROSGRAECON7XFWB774QFHDN"],"reviewers":["AAAAAAAAAAAAAAAAAAAAAAAA"],"date":"2015-06-12","comment":"Submitted"}],"date":"2015-06-12"},{"version":"2","entries":[{"contributors":["AAAAAAAAAAAAAAAAAAAAAAAA"],"reviewers":["AAAAAAAAAAAAAAAAAAAAAAAA"],"date":"2019-10-16","comment":"Migrated from v1.4"}],"date":"2019-10-16"},{"version":"3","entries":[{"contributors":["3UOU7PODQJXIM6BEPUHHRRA5"],"reviewers":["AAAAAAAAAAAAAAAAAAAAAAAA"],"date":"2022-09-15","comment":"Remove duplicated citations"},{"contributors":["AAAAAAAAAAAAAAAAAAAAAAAA"],"reviewers":["AAAAAAAAAAAAAAAAAAAAAAAA"],"date":"2022-09-15","comment":"Updated bioactivity data"}],"date":"2022-09-15"},{"version":"4","entries":[{"contributors":["AAAAAAAAAAAAAAAAAAAAAAAA"],"reviewers":["AAAAAAAAAAAAAAAAAAAAAAAA"],"date":"2022-10-07","comment":"Update chemical activity to schema version 2.11"}],"date":"2022-10-07"},{"version":"5","entries":[{"contributors":["P75FRHHCFPTCPYSP65VDVPHW","MGLE5JJ3S32DQA3YR5WPYH4W"],"reviewers":["AAAAAAAAAAAAAAAAAAAAAAAA"],"date":"2024-06-04","comment":"MIBiG v4 annotathon"}],"date":"2024-11-15"}]},"quality":"questionable","status":"active","completeness":"complete","loci":[{"accession":"X89899.2","location":{"from":0,"to":0},"evidence":[{"method":"Knock-out studies"},{"method":"Enzymatic assays"}]}],"biosynthesis":{"classes":[{"class":"PKS","subclass":"Type II","cyclases":[]},{"class":"saccharide","glycosyltransferases":[{"gene":"CAK50788.1","evidence":[{"method":"Activity assay","references":[]}],"specificity":"[To][Do]"},{"gene":"CAK50788.1","evidence":[{"method":"Activity assay","references":[]}],"specificity":"[To][Do]"},{"gene":"CAK50789.1","evidence":[{"method":"Knock-out construct","references":[]}],"specificity":"[To][Do]"},{"gene":"CAK50792.1","evidence":[{"method":"Knock-out construct","references":[]}],"specificity":"[To][Do]"},{"gene":"CAK50793.1","evidence":[{"method":"Knock-out construct","references":[]}],"specificity":"[To][Do]"}],"subclass":"oligosaccharide"}]},"compounds":[{"name":"mithramycin","evidence":[],"bioactivities":[{"name":"antibacterial","observed":true,"references":[]},{"name":"cytotoxic","observed":true,"references":[]}],"structure":"C[C@@H]1[C@H]([C@@H](C[C@@H](O1)O[C@@H]2C[C@@H](O[C@@H]([C@H]2O)C)OC3=CC4=CC5=C(C(=O)[C@H]([C@@H](C5)[C@@H](C(=O)[C@H]([C@@H](C)O)O)OC)O[C@H]6C[C@H]([C@@H]([C@H](O6)C)O)O[C@H]7C[C@H]([C@H]([C@H](O7)C)O)O[C@H]8C[C@]([C@@H]([C@H](O8)C)O)(C)O)C(=C4C(=C3C)O)O)O)O","synonyms":["Mitramycin","Plicamycin","Aureolic Acid"],"mass":1084.4726533120004,"formula":"C52H76O24"}],"taxonomy":{"name":"Streptomyces argillaceus","ncbiTaxId":41951},"genes":{"annotations":[{"id":"CAK50770.1","name":"mtmR"},{"id":"CAK50774.1","name":"mtmD"},{"id":"CAK50777.1","name":"mtmOII"},{"id":"CAA61989.1","name":"mtmP"},{"id":"CAK50783.1","name":"mtmTIII"},{"id":"CAK50784.1","name":"mtmC","product":"D-mycarose 3-C-methyltransferase and 4-D-olivosyl-ketoreductase"},{"id":"CAK50785.1","name":"mtmU"},{"id":"CAK50786.1","name":"mtmV"},{"id":"CAK50787.1","name":"mtmW","tailoring":[{"function":"Reduction","references":["doi:10.1002/anie.201910241"],"db_reference":"mite:MITE0000017","details":"Reductase"}]},{"id":"CAK50788.1","name":"mtmGIV","tailoring":[{"function":"Glycosylation","references":["doi:10.1007/pl00008667"],"db_reference":"mite:MITE0000018","details":"Glycosyltransferase"}]},{"id":"CAK50789.1","name":"mtmGIII","tailoring":[{"function":"Glycosylation","references":["doi:10.1007/pl00008667"],"db_reference":"mite:MITE0000019","details":"Glycosyltransferase"}]},{"id":"CAK50790.1","name":"mtmMII","tailoring":[{"function":"Methylation","references":["doi:10.1074/jbc.275.5.3065"],"db_reference":"mite:MITE0000015","details":"Methyltransferase"}]},{"id":"CAK50791.1","name":"mtmMI","tailoring":[{"function":"Methylation","references":["doi:10.1074/jbc.275.5.3065","doi:10.1186/s12934-020-01368-3"],"db_reference":"mite:MITE0000014","details":"Methyltransferase"}]},{"id":"CAK50792.1","name":"mtmGII","tailoring":[{"function":"Glycosylation","references":["doi:10.1002/cbic.200400309"],"db_reference":"mite:MITE0000020","details":"Glycosyltransferase"}]},{"id":"CAK50793.1","name":"mtmGI"},{"id":"CAK50794.2","name":"mtmOIV","tailoring":[{"function":"Decarboxylation","references":["doi:10.1021/ja055750t"],"db_reference":"mite:MITE0000016","details":"Decarboxylase"},{"function":"Oxidation","references":["doi:10.1021/ja055750t"],"db_reference":"mite:MITE0000016","details":"Oxidase"}]}]},"legacy_references":["pubmed:8654997","pubmed:9150235","pubmed:10102355","pubmed:11254130","pubmed:8807845","pubmed:8757400","pubmed:9375253","pubmed:9733697","pubmed:9882681","pubmed:9889148","pubmed:9917296","pubmed:10660060","pubmed:10760873","pubmed:10652287","pubmed:10779713","pubmed:11853433","pubmed:12022840","pubmed:12733914","pubmed:12813091","pubmed:14660589","pubmed:15712316"]}