BGC0000248 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000248 (Streptomyces arenae)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	72,552	High	α naphtocyclinoic acid/fogacin	PKS

BGC0000248 - Region 1 - T2PKS

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Location: 1 - 72,552 nt. (total: 72,552 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 72,553
Label		BGC0000248

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase

MB828_08075: flavin reductase domain protein FMN-binding

smcogs: SMCOG1160: flavin reductase domain protein FMN-binding

MB828_08095: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

MB828_08100: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

MB828_08105: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

MB828_08115: acyl-CoA dehydrogenase type 2

smcogs: SMCOG1191: acyl-CoA dehydrogenase type 2

MB828_08150: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

Transferases: acyltransferase transferase

MB828_08080: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

MB828_08130: acyltransferase 3

smcogs: SMCOG1088: acyltransferase 3

Hydrolases: hydrolase

MB828_08070: metallo-beta-lactamase family protein

smcogs: SMCOG1170: metallo-beta-lactamase family protein

Lyases: cyclase

MB828_08165: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

MB828_08175: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

MB828_08180: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000248.5	1.00	PKS	α naphtocyclinoic acid, fogacin	Streptomyces arenae DSM 40737
BGC0000231.5	0.65	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0002276.2	0.59	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000234.5	0.59	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001197.5	0.59	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001723.5	0.57	PKS	oviedomycin	Streptomyces antibioticus
BGC0000271.5	0.56	PKS	spore pigment	Streptomyces avermitilis
BGC0001513.3	0.56	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0000275.4	0.54	PKS	tetracenomycin C	Streptomyces glaucescens

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000248.5	1.00	PKS	α naphtocyclinoic acid, fogacin	Streptomyces arenae DSM 40737
BGC0000231.5	0.65	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000272.3	0.61	PKS	spore pigment	Streptomyces collinus
BGC0002276.2	0.59	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0000234.5	0.59	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001197.5	0.59	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0001723.5	0.57	PKS	oviedomycin	Streptomyces antibioticus
BGC0000271.5	0.56	PKS	spore pigment	Streptomyces avermitilis
BGC0001513.3	0.56	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0000275.4	0.54	PKS	tetracenomycin C	Streptomyces glaucescens

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 72552
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 7 (Score: 761.6; E-value: 3.7e-232)
Product class(es):: benzoisochromanequinone
Product molecular weight(s):: acetyl-CoA_7: 309 Da

MB828_08070: CYC C5-C14 (Score: 507.0; E-value: 3.4e-155)
MB828_08095: KR C9 (Score: 451.7; E-value: 1.7e-138)
MB828_08100: KR (Score: 159.7; E-value: 2.4e-49)
MB828_08125: DIMER (Score: 286.0; E-value: 7.3e-88)
MB828_08165: CYC C7-C12 (Score: 432.3; E-value: 1.9e-132)
MB828_08170: ACP (Score: 128.6; E-value: 1.6e-40)
MB828_08175: CLF 7 (Score: 761.6; E-value: 3.7e-232)
MB828_08180: KS (Score: 773.7; E-value: 9.8e-236)