BGC0000248: α naphtocyclinoic acid biosynthetic gene cluster from Streptomyces arenae DSM 40737
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Location: 94,867 - 120,787 nt. (total: 25,921 nt).
This entry is originally from NCBI GenBank JAKQYH010000014.1.

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core biosynthetic genes
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General
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Polyketide
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General information about the BGC
MIBiG accession BGC0000248
Short description α naphtocyclinoic acid biosynthetic gene cluster from Streptomyces arenae DSM 40737
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Type II, Benzoisochromanequinone)
Loci NCBI GenBank: JAKQYH010000014.1
Compounds
  • α naphtocyclinoic acid
  • fogacin
Species Streptomyces arenae DSM 40737 [taxonomy]
References
Chemical products information
α naphtocyclinoic acid
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C32H28O15
fogacin
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C16H16O6
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • MB828_08060
 95425 - 95547 (+) histidine kinase dimerization/phosphoacceptor domain-containing protein
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  • MB828_08065
  • MCG7203797.1
 95998 - 96606 (-) response regulator transcription factor
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  • MB828_08070
  • MCG7203798.1
 96957 - 97889 (+) MBL fold metallo-hydrolase
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  • MB828_08075
  • MCG7203799.1
 97859 - 98371 (-) flavin reductase family protein
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  • MB828_08080
  • MCG7203800.1
 98658 - 100190 (+) acyl-CoA carboxylase subunit beta
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  • MB828_08085
  • MCG7203801.1
 100370 - 101179 (+) AfsR/SARP family transcriptional regulator
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  • MB828_08090
  • MCG7203802.1
 101409 - 101837 (-) nuclear transport factor 2 family protein
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  • MB828_08095
  • MCG7203803.1
 102086 - 102871 (+) 3-oxoacyl-ACP reductase
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  • MB828_08100
  • MCG7203804.1
 102871 - 103608 (+) SDR family oxidoreductase
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  • MB828_08105
  • MCG7203805.1
 103668 - 104702 (+) LLM class flavin-dependent oxidoreductase
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  • MB828_08110
  • MCG7203806.1
 104906 - 105709 (+) DUF6081 family protein
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  • MB828_08115
  • MCG7203807.1
 105816 - 107033 (-) flavin-dependent monooxygenase
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  • MB828_08120
  • MCG7203808.1
 107033 - 107443 (-) DoxX family protein
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  • MB828_08125
  • MCG7203809.1
 107663 - 108541 (+) NmrA/HSCARG family protein
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  • MB828_08130
  • MCG7203810.1
 108553 - 109758 (+) acyltransferase
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  • MB828_08135
  • MCG7203811.1
 109883 - 111379 (-) DHA2 family efflux MFS transporter permease subunit
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  • MB828_08140
  • MCG7203812.1
 111490 - 112284 (+) TetR family transcriptional regulator
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  • MB828_08145
  • MCG7203813.1
 112281 - 112712 (+) PPOX class F420-dependent oxidoreductase
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  • MB828_08150
  • MCG7203814.1
 112758 - 113702 (-) TIGR03619 family F420-dependent LLM class oxidoreductase
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  • MB828_08155
  • MCG7203815.1
 113954 - 114817 (+) SAM-dependent methyltransferase
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  • MB828_08160
  • MCG7203816.1
 114821 - 115381 (+) hypothetical protein
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  • MB828_08165
  • MCG7203817.1
 115539 - 116486 (-) aromatase/cyclase
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  • MB828_08170
  • MCG7203818.1
 116483 - 116743 (-) acyl carrier protein
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  • MB828_08175
  • MCG7203819.1
 116788 - 118077 (-) ketosynthase chain-length factor
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  • MB828_08180
  • MCG7203820.1
 118074 - 119339 (-) beta-ketoacyl-[acyl-carrier-protein] synthase family protein
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  • MB828_08185
  • MCG7203821.1
 119451 - 120395 (-) M56 family metallopeptidase
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  • MB828_08190
  • MCG7203822.1
 120404 - 120787 (-) BlaI/MecI/CopY family transcriptional regulator
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Polyketide-specific information
Subclass Type II/Benzoisochromanequinone
Starter unit Malonyl-CoA
Ketide length 8
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
MB828_08175
+
MB828_08180 		Synthase subclass:
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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