BGC0000253 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000253 (Streptomyces antibioticus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	24,720	High	oviedomycin	PKS:Type II

BGC0000253 - Region 1 - T2PKS

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Location: 1 - 24,720 nt. (total: 24,720 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 24,721
Label		BGC0000253

Tailoring functions

Oxidoreductases: dehydrogenase oxygenase

CAG14976.1: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

ovmOI: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

ovmOII: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

ovmOIII: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

ovmT: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: PPTase carboxylase transferase

ovmF: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

ovmG: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

ovmH: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

Lyases: cyclase

ovmA: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

ovmC: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

Ligases: synthase

ovmK: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

ovmP: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000253.4	1.00	PKS	oviedomycin	Streptomyces antibioticus
BGC0001723.5	0.96	PKS	oviedomycin	Streptomyces antibioticus
BGC0000231.5	0.84	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.83	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002047.2	0.63	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0002477.3	0.63	PKS	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072
BGC0000235.5	0.63	PKS	kiamycin	Streptomyces sp. W007
BGC0002000.4	0.61	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0002276.2	0.61	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001596.3	0.58	PKS	fluostatin M, fluostatin N, fluostatin O, fluostatin P, fluostatin Q	Streptomyces albus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000253.4	1.00	PKS	oviedomycin	Streptomyces antibioticus
BGC0001723.5	0.96	PKS	oviedomycin	Streptomyces antibioticus
BGC0000231.5	0.84	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.83	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0002047.2	0.63	PKS	brasiliquinone A, brasiliquinone B	Nocardia brasiliensis
BGC0002477.3	0.63	PKS	thioangucycline A, thioangucycline B	Streptomyces sp. CB00072
BGC0000235.5	0.63	PKS	kiamycin	Streptomyces sp. W007
BGC0002000.4	0.61	PKS	setomimycin	Streptomyces aurantiacus JA 4570
BGC0002276.2	0.61	NRPS	choline	Aspergillus nidulans FGSC A4
BGC0001596.3	0.58	PKS	fluostatin M, fluostatin N, fluostatin O, fluostatin P, fluostatin Q	Streptomyces albus

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 24720
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 736.2; E-value: 1.8e-224)
Product class(es):: angucycline
Product molecular weight(s):: acetyl-CoA_8: 383 Da
acetyl-CoA_9: 425 Da

CAG14976.1: KR (Score: 134.7; E-value: 1.1e-41)
ovmA: CYC C7-C12 (Score: 500.0; E-value: 4.6e-153)
ovmC: CYC C4-C17/C2-C19 (Score: 204.0; E-value: 5e-63)
ovmK: CLF 8|9 (Score: 736.2; E-value: 1.8e-224)
ovmOI: OXY (Score: 593.9; E-value: 5.6e-181)
ovmOII: OXY (Score: 608.4; E-value: 2.2e-185)
ovmOIII: OXY (Score: 428.4; E-value: 9.3e-131)
ovmP: KS (Score: 677.7; E-value: 1.3e-206)
ovmS: ACP (Score: 127.7; E-value: 3.1e-40)
ovmT: KR C9 (Score: 490.5; E-value: 2.4e-150)