Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000253.1:
Cluster 1Polyketide124720

BGC0000253, oviedomycin biosynthetic gene cluster from Streptomyces antibioticus. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: oviedomycin
PubChem ID: 5323531
SMILES string: Copy to clipboard
Molecular formula: C19H10O7
Average molecular mass: 350.282 Da
Molecular activity: Cytotoxic
Molecular target: unknown

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Angucycline (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
Malonyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
CAG14965.1,CAG14967.1
Genes involved in folding/cyclization:
CAG14964.1, CAG14969.1

Gene cluster description

oviedomycin (BGC0000253). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank AJ632203. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Carmen Mendez (University of Oviedo)

Literature references

1. Lombo F et al. (2004) Genetic organization of the biosynthetic gene cluster for the antitumor angucycline oviedomycin in Streptomyces antibioticus ATCC 11891. Chembiochem 5(9):1181-7. doi: 10.1002/cbic.200400073.
2. Lombo F et al. (2009) Elucidation of oxygenation steps during oviedomycin biosynthesis and generation of derivatives with increased antitumor activity. Chembiochem 10(2):296-303. doi: 10.1002/cbic.200800425.