BGC0000254 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000254 (Streptomyces rimosus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	25,222	oxytetracycline	PKS	100%

BGC0000254 - Region 1 - T2PKS

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Location: 1 - 25,222 nt. (total: 25,222 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 25,223
Label		BGC0000254

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000254	1.00	Polyketide	oxytetracycline	Streptomyces rimosus
BGC0000231	0.39	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000234	0.34	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000272	0.28	Polyketide	spore pigment	Streptomyces collinus
BGC0000885	0.27	Other	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000937	0.25	Other	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0000866	0.25	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000867	0.25	Other	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000056	0.24	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000846	0.23	Other	tabtoxin	Pseudomonas syringae

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000254	1.00	Polyketide	oxytetracycline	Streptomyces rimosus
BGC0000231	0.71	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000234	0.67	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000272	0.61	Polyketide	spore pigment	Streptomyces collinus
BGC0000885	0.61	Other	4-hydroxy-3-nitrosobenzamide	Streptomyces murayamaensis
BGC0000937	0.59	Other	fosfazinomycin A, fosfazinomycin B	Streptomyces sp. WM6372
BGC0000866	0.59	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0000867	0.59	Other	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000056	0.57	Polyketide	esperamicin	Actinomadura verrucosospora
BGC0000846	0.57	Other	tabtoxin	Pseudomonas syringae

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

oxyP

PKS_AT (22..298): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; inactive: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 47.1
Methylmalonyl-CoA: 39.2
Methoxymalonyl-CoA: 29.2
Propionyl-CoA: 25.8
Ethylmalonyl-CoA: 16.0
inactive: 14.2
2-Methylbutyryl-CoA: 12.2
CHC-CoA: 11.2
trans-1,2-CPDA: 9.0
Isobutyryl-CoA: 6.7
fatty_acid: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 0 to 25222
Starter unit(s):: malonamyl-CoA (Score: 1234.0; E-value: 0)
propionyl-CoA (Score: 363.0; E-value: 1.71e-128)
Malonyl elongations:: 8|9 (Score: 685.7; E-value: 3.9e-209)
Product class(es):: anthracycline
aureolic acid
tetracycline
Product molecular weight(s):: malonamyl-CoA_8: 440 Da
malonamyl-CoA_9: 482 Da
propionyl-CoA_8: 411 Da
propionyl-CoA_9: 453 Da

oxyA: KS (Score: 732.6; E-value: 2.9e-223)
oxyB: CLF 8|9 (Score: 685.7; E-value: 3.9e-209)
oxyC: ACP (Score: 120.4; E-value: 5.5e-38)
oxyD: AMID (Score: 1221.6; E-value: 0.0); AMID ELQ83270.1_Oxytetracycline_malonamyl-CoA (Score: 1234.0; E-value: 0.0)
oxyE: OXY (Score: 229.0; E-value: 2.8e-70)
oxyF: MET C6|C8 (Score: 569.9; E-value: 3.3e-174)
oxyI: CYC C1-C18|C2-C19 (Score: 236.1; E-value: 2.4e-73)
oxyJ: KR C9 (Score: 444.8; E-value: 2.1e-136)
oxyK: CYC C7-C12 (Score: 451.3; E-value: 3.1e-138)
oxyL: OXY (Score: 449.7; E-value: 3.2e-137)
oxyM: KR (Score: 136.8; E-value: 2.4e-42)
oxyN: CYC C5-C14/C3-C16 (Score: 452.8; E-value: 7.5e-139)
oxyP: AT (Score: 408.0; E-value: 6.9e-125); AT BAB72049.1_Aklavinone_propionyl-CoA (Score: 363.0; E-value: 1.71e-128)
oxyQ: AMIN (Score: 626.1; E-value: 4e-191)
oxyS: OXY (Score: 502.8; E-value: 2.4e-153)
oxyT: MET C2O|C2N (Score: 591.0; E-value: 1.5e-180)