LOCUS       BGC0000255             10000 bp    DNA     linear   BCT 10-JAN-2005
DEFINITION  Symbiont bacterium of Paederus fuscipes tRNA-Arg gene, complete
            sequence; MutM gene, complete cds; and pederin biosynthesis gene
            cluster, complete sequence.
ACCESSION   BGC0000255
VERSION     BGC0000255
KEYWORDS    .
SOURCE      symbiont bacterium of Paederus fuscipes
  ORGANISM  symbiont bacterium of Paederus fuscipes Bacteria.
            .
COMMENT     ##antiSMASH-Data-START##
            Version      :: 6.2.0-924c3663(changed)
            Run date     :: 2022-11-07 17:56:40
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..10000
                     /db_xref="taxon:176282"
                     /mol_type="genomic DNA"
                     /organism="symbiont bacterium of Paederus fuscipes"
     protocluster    1..10000
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[6282:7575]"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      6283..7575
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /neighbourhood="20000"
                     /product="T3PKS"
                     /protocluster_number="1"
     protocluster    1..10000
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[3257:4589]"
                     /cutoff="10000"
                     /detection_rule="(t2pks2 or ksIII)"
                     /neighbourhood="20000"
                     /product="PKS-like"
                     /protocluster_number="2"
                     /tool="antismash"
     proto_core      3258..4589
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="10000"
                     /detection_rule="(t2pks2 or ksIII)"
                     /neighbourhood="20000"
                     /product="PKS-like"
                     /protocluster_number="2"
     cand_cluster    1..10000
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /detection_rules="(t2pks2 or ksIII)"
                     /kind="neighbouring"
                     /product="T3PKS"
                     /product="PKS-like"
                     /protoclusters="1"
                     /protoclusters="2"
                     /tool="antismash"
     subregion       1..10000
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000255"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..10000
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T3PKS"
                     /product="PKS-like"
                     /region_number="1"
                     /rules="(Chal_sti_synt_C or Chal_sti_synt_N)"
                     /rules="(t2pks2 or ksIII)"
                     /subregion_numbers="1"
                     /tool="antismash"
     tRNA            627..702
                     /product="tRNA-Arg"
     CDS             complement(797..1609)
                     /codon_start=1
                     /note="putative formamidopyrimidine-DNA glycosylase;
                     similar to PA0357 from Pseudomonas aeruginosa"
                     /product="MutM"
                     /protein_id="AAW33970.1"
                     /transl_table=11
                     /translation="MPELPEVETIRRGIAPYLEGQRVNRVIIRERRLRWPISDNLDVRL
                     SGQRILSVERRAKYLLLRAEVGTLINHLGMSGSLRLIESGLPAKRHDHVDIELESGLAL
                     RYTDPRRFGALLWSQAPLEHELLRNLGPEPLTDAFAGQRLFELSRGRSVAVKPFIMDNT
                     VVVGVGNIYASEVLFTAGIDPRRSAGNISKTRYSRLAGEIKRILANAIECGGTTLCDFI
                     GGDGQPGYFQQELFVYGRGGEFCKACGGTLREIRLGQRTSVYCPHCQR"
     CDS             complement(2401..3156)
                     /NRPS_PKS="Domain: ECH (8-243). E-value: 1.8e-47. Score:
                     153.5. Matches aSDomain: nrpspksdomains_AAW33971.1_ECH.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1023:enoyl-CoA hydratase (Score: 204.3; E-value:
                     2.8e-62)"
                     /gene_kind="biosynthetic-additional"
                     /note="crotonase superfamily"
                     /product="PedL"
                     /protein_id="AAW33971.1"
                     /transl_table=11
                     /translation="MVYQTIQVRFTSPIYRIELHRPQSDNTLNQLMIDECLHALSVCTT
                     QTHIVVLEGSTEVFCLGADFNALATDQPDIPINPERLYELWEQLAYGPFISIAHVRGKA
                     NAGGVGFTAACDIVLADKRVEFSLSELLFGLFPACVLPFLIRRIGWQKAHYMTLTTKAI
                     TLQNALDWGLVDAAQGDSQALLRKYLLRLRHLSKSAISDYKHYMNGLHPLISSARKQAV
                     AANRELFDNPNNLENIYRYARTGQFPWEA"
     aSDomain        complement(2428..3132)
                     /aSDomain="ECH"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AAW33971.1_ECH.1"
                     /evalue="1.80E-47"
                     /label="AAW33971.1_ECH.1"
                     /locus_tag="AAW33971.1"
                     /protein_end="243"
                     /protein_start="8"
                     /score="153.5"
                     /tool="antismash"
                     /translation="RFTSPIYRIELHRPQSDNTLNQLMIDECLHALSVCTTQTHIVVLE
                     GSTEVFCLGADFNALATDQPDIPINPERLYELWEQLAYGPFISIAHVRGKANAGGVGFT
                     AACDIVLADKRVEFSLSELLFGLFPACVLPFLIRRIGWQKAHYMTLTTKAITLQNALDW
                     GLVDAAQGDSQALLRKYLLRLRHLSKSAISDYKHYMNGLHPLISSARKQAVAANRELFD
                     NPNNLENIYRYAR"
     CDS             complement(3258..4589)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (105-431). E-value:
                     1.3e-39. Score: 128.2. Matches aSDomain:
                     nrpspksdomains_AAW33972.1_PKS_KS.1"
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters)
                     PKS-like: t2pks2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 337.1; E-value:
                     2.7e-102)"
                     /gene_kind="biosynthetic"
                     /note="putative ketoacyl synthase"
                     /product="PedM"
                     /protein_id="AAW33972.1"
                     /sec_met_domain="t2pks2 (E-value: 1.1e-168, bitscore:
                     550.4, seeds: 54, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MYSDRNTTGFPVDVQISGMGVVSSIGHDLTTFTVSLAEGRSGIRQ
                     LDNRCSTGMGATNIIAGIADFNFSYALEVCTSIPPTLKRAALRIARRAPFAIQTCVLSA
                     LEAWTTALLHDAHLLPESIGLVMAGHNTTQNYQYQLHEAFQQAPYHLSPRYALQFMDSY
                     LLGVLSEIFKIRGEGFVCGGASASGNVGIIHGLRMIQAGIVDACLVCGVTADLSPMELQ
                     GFNAIGALGGKHFHDRADLACRPFDTQHEGFIYGQASACLLLESTTSAKCRGTVGMARL
                     LSGAIRLHASSSSEPNLEGEVQTMRTALQRSSLEPGNIDYVNTHGSSSPLGDKIEMQAI
                     EQVFGEHFPNIWLNSSKGLIGHCLYSAGVVEVIASVVQMRQGFIHPSLNLDTPINNRAK
                     FSGPIAVRHPIHTAMSNSFGFGGINTSVVLGSIPQPKNSPKQDR"
     aSDomain        complement(3297..4274)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AAW33972.1_PKS_KS.1"
                     /domain_subtype="Iterative-KS"
                     /evalue="1.30E-39"
                     /label="AAW33972.1_PKS_KS.1"
                     /locus_tag="AAW33972.1"
                     /protein_end="431"
                     /protein_start="105"
                     /score="128.2"
                     /tool="antismash"
                     /translation="EAWTTALLHDAHLLPESIGLVMAGHNTTQNYQYQLHEAFQQAPYH
                     LSPRYALQFMDSYLLGVLSEIFKIRGEGFVCGGASASGNVGIIHGLRMIQAGIVDACLV
                     CGVTADLSPMELQGFNAIGALGGKHFHDRADLACRPFDTQHEGFIYGQASACLLLESTT
                     SAKCRGTVGMARLLSGAIRLHASSSSEPNLEGEVQTMRTALQRSSLEPGNIDYVNTHGS
                     SSPLGDKIEMQAIEQVFGEHFPNIWLNSSKGLIGHCLYSAGVVEVIASVVQMRQGFIHP
                     SLNLDTPINNRAKFSGPIAVRHPIHTAMSNSFGFGGINTSVVLGS"
     CDS             complement(4579..4821)
                     /NRPS_PKS="Domain: PP-binding (15-74). E-value: 5.1e-09.
                     Score: 28.4. Matches aSDomain:
                     nrpspksdomains_AAW33973.1_PP-binding.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_kind="biosynthetic-additional"
                     /note="putative acyl carrier protein"
                     /product="PedN"
                     /protein_id="AAW33973.1"
                     /sec_met_domain="PP-binding (E-value: 7.4e-10, bitscore:
                     28.4, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MIRERIFNVIARNTLEVLPDIQPEAISTLKSLAELGANSVDRMEI
                     ITLSMAELGVTIPLVSFATVSNIEGLVDTLSQYVQ"
     aSDomain        complement(4600..4776)
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AAW33973.1_PP-binding.1"
                     /evalue="5.10E-09"
                     /label="AAW33973.1_PP-binding.1"
                     /locus_tag="AAW33973.1"
                     /protein_end="74"
                     /protein_start="15"
                     /score="28.4"
                     /tool="antismash"
                     /translation="EVLPDIQPEAISTLKSLAELGANSVDRMEIITLSMAELGVTIPLV
                     SFATVSNIEGLVDT"
     CDS             5045..6052
                     /NRPS_PKS="Domain: oMT (84-289). E-value: 2.9e-79. Score:
                     258.2. Matches aSDomain: nrpspksdomains_AAW33974.1_oMT.1"
                     /codon_start=1
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1089:methyltransferase (Score: 214; E-value: 4.2e-65)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative methyltransferase"
                     /product="PedO"
                     /protein_id="AAW33974.1"
                     /transl_table=11
                     /translation="MSISAPDFVGLLKQRLLDNISTQIDHVFNVPADIQKMLGGSEKNL
                     SLEESAKIFDAGIVELMRKPEEDSSKEGGSSFISHVNNHYDHVFYDDNGMTGVLFGDTD
                     YRNHGYWDRNTVSQDQACRQLQEILLDFIPVKTGKILDVACGMGASTRHLLKYYPAENI
                     WAINISDKQIDTARRNAPGCHVQVMDATNMSFADEAFENILCIEAAFHFNTRRKFLEEA
                     LRILKPGGRVVLSDFIFSSPERLEQNNILPGPVNHLASIEEYAQLLNDVGFSDFTIQDV
                     SDEVWGGQFLNGTSKLHKAFYDGKLDIVRMTEALWCYYYINASTEKSLFVSAQK"
     aSDomain        5297..5911
                     /aSDomain="MT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_AAW33974.1_oMT.1"
                     /domain_subtype="oMT"
                     /evalue="2.90E-79"
                     /label="AAW33974.1_oMT.1"
                     /locus_tag="AAW33974.1"
                     /protein_end="289"
                     /protein_start="84"
                     /score="258.2"
                     /tool="antismash"
                     /translation="YDHVFYDDNGMTGVLFGDTDYRNHGYWDRNTVSQDQACRQLQEIL
                     LDFIPVKTGKILDVACGMGASTRHLLKYYPAENIWAINISDKQIDTARRNAPGCHVQVM
                     DATNMSFADEAFENILCIEAAFHFNTRRKFLEEALRILKPGGRVVLSDFIFSSPERLEQ
                     NNILPGPVNHLASIEEYAQLLNDVGFSDFTIQDVSDEVWGGQ"
     CDS             6283..7575
                     /codon_start=1
                     /gene_functions="biosynthetic (rule-based-clusters) T3PKS:
                     Chal_sti_synt_N"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1043:hydroxymethylglutaryl-CoA synthase (Score: 491.5;
                     E-value: 2.8e-149)"
                     /gene_kind="biosynthetic"
                     /note="putative 3-hydroxy-3-methylglutaryl coenzyme A-like
                     protein"
                     /product="PedP"
                     /protein_id="AAW33975.1"
                     /sec_met_domain="Chal_sti_synt_N (E-value: 6.4e-09,
                     bitscore: 24.6, seeds: 21, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MPVGIEAMNLYGGSAFVDVMELAVYRKHDLSRFDNLLMKQKTVAL
                     PYEDSVSFAINAAQPLIDTLSETEKERIELLITCSESGIDFGKSISTYIHHYLGLNRNC
                     RLFELKQACYSGTAGLQMAVNFIVSKVSPGAKALVIASDLSRFLVTRDEEGELTMDWDF
                     FEPSGGAGAIAMLVSEKPDIFELDIGANGYYTYEVMDTCRPIADSEAGNADLSLLSYLD
                     CCDQSFKEYKKRVFKVDYCDTFQYLCFHTPFGGMVKGAHRNMMRKYSDLSREAIEADFQ
                     QRVQPGLTYCQRVGNIMGGTIMLSLASTIDNAIMRNTCRVGCFSYGSGCCSEFYSGVVS
                     PSGQAKLRDWALGKHLDSRHRLTMEQYEIVLQRSELVKFGTRNVVLSNDLIPGAWKTIT
                     RNVRENKDIDIGKRIFLSEIKEFHRHYEWIE"
     CDS             7576..8520
                     /codon_start=1
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Abhydrolase_6"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF00561"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1262:haloalkane dehalogenase (Score: 105.1; E-value:
                     6.7e-32)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative hydrolase"
                     /product="PedQ"
                     /protein_id="AAW33976.1"
                     /sec_met_domain="Abhydrolase_6 (E-value: 1.5e-20, bitscore:
                     63.8, seeds: 455, tool: rule-based-clusters)"
                     /sec_met_domain="PF00561 (E-value: 1.6e-19, bitscore: 59.6,
                     seeds: 48, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELLVGSIGLVFLTILIVLLCIAVAFYLIAPGLLLDSFLALGRWH
                     AGLKRRESTLDMVNWVWLDSGGEGDVIVLIHGFAAHKYGWLQVASRLRGRGYRLIIPDL
                     PGFGENQVSADISYSVLEQAQRLQTFLASLGINRFHAVGHSMGGYVAGACAFIDSDMLL
                     SLYLVAPAGITVEGEPIDLSEKGKKNNLFIIETVEQFQEVMAIAMANPPKLPRRIVESM
                     VARELTMRKLREKQNEVWDSPSLQRLLSNCSIPLRMLWGERDRMLSVDRAALIVEAVPM
                     ASIRYLPDIAHVIPQEAPSVMVRDYLISLLLSH"
     CDS             complement(8547..9440)
                     /codon_start=1
                     /gene_functions="regulatory (smcogs) SMCOG1031:LysR family
                     transcriptional regulator (Score: 227.5; E-value: 3.8e-69)"
                     /gene_kind="regulatory"
                     /note="putative LysR-type regulatory protein"
                     /product="PedR"
                     /protein_id="AAW33977.1"
                     /transl_table=11
                     /translation="MFANVPLTSLRSFESAARLGSFKAAAAELSVTASAVSHQIKSLES
                     KLGVLLFHRQAKGVELTPPGFNLYNETHQYFSNLSSSLDQLRPRVDSKVLTVTTTHAFT
                     ALWLIPRIGDFYRHYPDIKVNIITSNVLIDLHRNSTIDLGIRGLFQQEASTYQLHLMDE
                     YFKVYMPYHRNPSEDTHRQLINVRWEPRAQGPFDWPTWCKAAGHEDWLEHAILREYDDE
                     HYAVQAAISGYGMVLASNVLTAEYVAKGTLSPYKPEIKLPGARYVAACIPGRERHLPVK
                     RFLDWLVHEASRHVNE"
ORIGIN
        1 ctacatccac ggcttccaca atccctctcg cgtgcactcc gtgctcggct atctgtcgtc
       61 caacgaatag gcaagggggc tgaagcaaac cgcttgactc caggcctctt ggcctccgtt
      121 ctcgggggaa ggttcatatc aacctaatga agctgcgcgg ctcggcttta ttagggggga
      181 agtccagcct ggagagcgct cagccaataa ttcgaccaga cggactaatc aaggatcttc
      241 gacctcaagg caacgctagc ttttttaggc ctttcacgga atcaggtgga agaaccaata
      301 ggacagtcag agaagtgggt aaataggaag tcaccaaaca tccccacccc ccgctgctgc
      361 cgtgcattct attgatgtct tgcccgtagt ctggccaaga gacgaggttg ctgcctgtcg
      421 accagccgtt gataacatcc tactgattga gctggcgctc caggcaggtt gtttgcccgt
      481 ttgcgggcgt tgtctgcttt ctgaaaagta aaaccgactt cccgggaaag cgcgataaac
      541 caaatttgag attcttatct tgagcatgtt ccctatgcgc attaggattg caacgtttag
      601 ctgagcggac aaccatgact cggccacgtc cccatagttc aatggataga ataagcccct
      661 cctaagggct agatactggt tcgaatccag ttggggacgc cacctttctg gccaaagcta
      721 ctcttgagct tcagctaaaa ctaacccatg aatggtaaat ggggaagtca gactacgaga
      781 ttcgtccgtc tttatattaa cgttggcaat gcgggcaata cacgctggta cgttgaccta
      841 ggcggatctc gcgtagggtg ccaccgcaag ccttacagaa ttctccacca cggccataga
      901 caaacaattc ctgctggaag tacccaggct gaccatcgcc gccgatgaaa tcgcacaggg
      961 tggtgccacc acactcaatg gcgttcgcca ggatccgctt gatctcaccg gccaagcgcg
     1021 agtagcgcgt cttggaaata ttcccggcgg atctacgtgg atcgatgccg gcggtaaaca
     1081 gcacctcgct tgcgtagata ttgccgactc cgaccactac agtgttgtcc atgatgaacg
     1141 gctttaccgc tacactccga cccctcgaca actcgaatag cctctgaccg gcgaaagcgt
     1201 cggtcaaagg ctcggggcct aggttgcgca acaactcgtg ctctagtggc gcctggctcc
     1261 agagtagtgc gccgaaacgt cgcggatcgg tgtagcgcaa cgccagtccg gactctaact
     1321 cgatatccac atgatcatgg cgtttcgctg gtagaccgct ctcgatcagg cgcaggctac
     1381 cggacatgcc taagtggttg atcaacgtac cgacctcagc acgcagcagt aggtacttag
     1441 cgcggcgctc gacgctcaga atacgttgtc cagacagacg tacatctaag ttatcagaga
     1501 tcggccagcg caggcggcgc tcgcggatga tcacgcggtt gacgcgttga ccttccaggt
     1561 aaggggcgat gcctcgacga atagtttcga cttcgggtag ttcaggcatg acaggagacg
     1621 aagggtaaag gcgttgagga aatgcgtagt ttacccataa gtctcattgt tgattcatgc
     1681 taaagcgggc ttttcccagg gaaacggtat ctggagaaat gcaccgggaa tcttcaccca
     1741 gtgtggcagg gctggaatga gtagagtaaa tgcatcgcct tgcccacagt actggggagg
     1801 agcatgagat agtagccaat agtaggctaa tcgatgacta caagccaaag tttgatagcc
     1861 attggccacg gaactgctca aggggaactc tggcatgccc ctagagtagt gaaggctggt
     1921 tatgtctgtg ggagcagtag tttggctgcg tttgcaaggc tttgcctaca acgcccacaa
     1981 cctacgccaa taaggctgag gcattctcgc caaagcctgc ttcccgaata gcagtgcgca
     2041 ggaaagggtg aacaagtgcc tagcctcacg aggtacttct ttttttgaaa atcaaggccc
     2101 gacttccatg agaaagcacg atgaaccgaa aatcaaggcg agagtggttg atagcgaggg
     2161 atagagtcca ggcgtgctga aagagcatat ttgaatgtcg ctgccaacgc actgatgcgt
     2221 gccagttcgt aagtaggttc ttattgaaaa atatcccaac tcagtcacgc ggtattgaag
     2281 acactatagt gcgatttggg aggatcggag ctaatcatga tcattgcctt ttgataaact
     2341 caacttcttc aacggacttc gtcttacttg acttttgctt ggaagctttt tgtacggcgc
     2401 ctaagcttcc caaggaaact gtccggtacg agcgtagcga tagatgtttt caagattatt
     2461 aggattgtcg aacagttcgc ggttggcagc aactgcttgc tttctagcgg aactgatcaa
     2521 gggatgaagt ccgttcatat aatgcttata gtcgctgatt gcgctcttgg atagatgccg
     2581 taaacgtaat aagtacttgc gcagcagcgc ttgactgtcg ccttgcgccg cgtctaccaa
     2641 gccccagtcc agggcatttt gtagggtaat cgccttggtc gttaacgtca tatagtgcgc
     2701 tttctgccaa ccgatacgcc tgatcagaaa aggtaggaca caagctggaa acaatccgaa
     2761 cagcagttcc gacaaactga attctacgcg tttatcggcg agtacgatgt cgcaagctgc
     2821 agtgaaacct actcctccgg cattggcttt accgcgaaca tgggcaatgc tgatgaacgg
     2881 tccataagct agttgctccc ataactcata aagccgttct ggattgatag gaatgtctgg
     2941 ctgatccgtc gcaagagcgt tgaaatcggc acccagacag aaaacttcgg ttgacccttc
     3001 gagcaccacg atgtgagtct gagttgtgca gactgagaga gcatgtaagc attcgtcaat
     3061 catcagttga ttcagagtgt tatctgattg cgggcggtgc aactcgatac ggtaaatggg
     3121 ggatgtaaac cgaacctgga tcgtttgata gaccattagg agtaacctca gctttcgcaa
     3181 gattgatgaa cagtctcgga gtttccgaaa gattgttcca tttttgttgc ctcagccgat
     3241 gctgacggct gtctgagtca tcgatcttgc tttgggctgt ttttgggctg tgggatactg
     3301 cccagcacaa cgctggtatt gataccgccg aacccaaagc tattactcat agctgtgtgg
     3361 attgggtgcc gaactgcaat cgggccgctg aactttgcgc gattgttgat cggagtgtcg
     3421 aggttcaagg agggatggat gaacccttgc cgcatttgca ctaccgaagc gatgacctca
     3481 actactccgg ccgagtaaag acaatgacca attagccctt tgctcgagtt gagccagata
     3541 tttgggaaat gctcgccaaa gacctgctcg atcgcttgca tctcgatctt atcacccagt
     3601 ggcgatgagc tgccatgggt gtttacgtag tcaatattac ccggctccaa gctactacgt
     3661 tgcagagcag tccgcatcgt ttgcacctca ccttccagat tcggctcaga tgatgagctg
     3721 gcatgaagcc tgatcgctcc acttagcagc ctggccatac ccacagttcc tctgcacttt
     3781 gcgctggtag tagattccag taggagacat gcggaagcct gaccgtaaat gaacccttca
     3841 tgctgtgtat cgaatggtcg acaggccaga tcggctcggt catgaaaatg cttgcccccc
     3901 aaggcaccga tggcattaaa gccttgtagc tccatgggag aaagatccgc agtcaccccg
     3961 cagacgaggc aagcgtccac aatcccggcc tgaatcatgc gtaacccatg gattatcccg
     4021 acgttccctg aagcagaagc accaccacaa acgaaaccct caccccgaat tttgaatatc
     4081 tcactcaaaa cacccagtaa ataactatcc atgaactgta gtgcgtacct gggagacaag
     4141 tgatatggag cctgctgaaa agcttcgtgc aattggtact gatagttctg agtagtgtta
     4201 tgcccagcca tgactaggcc gatactctct ggtaatagat gggcatcatg tagcagtgct
     4261 gtagtccagg cttccagcgc tgacaacacg caggtctgaa tagcaaaagg agctctcctt
     4321 gcaatacgca aggcagctcg tttcagtgtt ggaggaatgg atgtgcatac ttcgagagca
     4381 tacgagaaat taaaatcagc aattcctgcg attatattcg tagcgcccat gccagtagaa
     4441 catctattat caagctgtct gatgcctgat cggccttctg ccaacgaaac tgtgaaagtc
     4501 gtaagatcat ggccgatcga tgaaacgacc cccatccccg aaatttgcac atccaccgga
     4561 aagccggtgg tatttctatc actgtacata ctggctgagt gtatcgacca aaccttcgat
     4621 attgcttact gttgcaaagc taaccaaagg aatcgtgacc cccagttctg ccatggacag
     4681 ggtaattatt tccattctat cgactgagtt ggcccctagc tcagctagac tcttgagggt
     4741 ggatatcgct tccggctgaa tatcaggaag gacttcaagc gtatttctcg ctatcacatt
     4801 gaatattctt tctctgatca tcttagttat aaaatcctaa tacaagaagg agttgaaagt
     4861 gttgcacgct cagatttcaa gtaaaccacg gattttaaaa ataatataga gaagcagcgc
     4921 attcagtaaa agactttagc taagtatgga taaatttatc tcgcttgttc gtatatttta
     4981 aagcacgcta aagttaacct tactactata actgtactta tttaacgcac caagaggtaa
     5041 tatcatgtct atatccgcac ctgattttgt aggcttgcta aaacagcgtc tgctggataa
     5101 tatttcgaca cagatagacc atgtttttaa tgtgcctgcc gatatacaaa agatgctggg
     5161 cggcagtgag aaaaatctgt cattggaaga gagcgcgaag atattcgatg ccggcattgt
     5221 ggaactgatg cggaaaccag aagaggattc ttctaaagaa ggaggctcat ctttcattag
     5281 tcatgtaaat aaccattacg atcatgtatt ttatgacgat aatggaatga cgggagtgtt
     5341 attcggtgat acagactatc ggaatcacgg ctactgggat agaaataccg tttctcaaga
     5401 tcaagcatgc cggcaattgc aagaaatact gcttgacttc atcccagtga aaacaggaaa
     5461 aattttagac gtcgcgtgtg gaatgggggc ttctactcgt catctgctta aatactatcc
     5521 agccgagaat atatgggcta tcaatatttc ggataaacag atcgatacag cgcgccgaaa
     5581 tgcaccaggt tgccatgtgc aggtcatgga tgccacgaac atgagcttcg ctgatgaagc
     5641 atttgaaaat attctgtgca tagaagctgc cttccatttt aacacgcggc gcaagttctt
     5701 agaggaggct ttacgtatcc tcaaacctgg tggaagggtg gtgttgtcgg attttatctt
     5761 cagctcacct gaacgactgg agcaaaataa tatacttcct ggcccagtca atcatctagc
     5821 gtcaattgag gaatacgctc aacttttgaa tgacgtgggt ttcagcgatt tcactattca
     5881 agacgtaagt gatgaggttt ggggcggaca gttcctgaat ggtacgagca agctgcataa
     5941 agcattttac gatggtaagc ttgatatcgt tcgcatgact gaagcactat ggtgttatta
     6001 ctatataaat gcttctaccg aaaagagcct tttcgtatct gcacaaaaat gattttttac
     6061 agacatcttc agtcgttgca atcacgagaa aggggctcgt gattgttcag atgaactatc
     6121 tgagctatcg tattttatta ccttaattta tgtcgtatgg tggcctccat ctattataaa
     6181 ttccatcgcc tctatgatcc acttgcggaa gttctacagg cttttatatg tcgagtcaga
     6241 aactggaatg aagtaattaa ttttaacgtg aggaagacta ttatgccagt tgggattgaa
     6301 gcgatgaacc tatatggtgg cagtgctttc gtagatgtca tggaattagc agtatatcgt
     6361 aaacatgatc tttcacgttt cgacaatctg ttaatgaagc agaaaaccgt tgcacttccc
     6421 tatgaagatt cagtgagttt cgctattaat gctgcgcaac cgttgataga cactttgtcg
     6481 gagactgaaa aggagcgtat cgagttattg atcacgtgtt cggaatcagg gatagatttc
     6541 gggaaatcca taagtactta tattcatcat tatttaggac tcaatcgtaa ctgtcggctt
     6601 tttgaattga aacaagcgtg ctactctggt actgcgggat tgcaaatggc agtcaatttc
     6661 atcgtgtcaa aggtatctcc aggtgccaag gcgctggtga tcgctagtga tctatcgagg
     6721 tttctggtca cgcgagacga ggagggagag ttgactatgg attgggattt ttttgagcct
     6781 agcggtgggg ctggtgcaat agccatgctt gtcagcgaga agcccgatat atttgagcta
     6841 gatattgggg caaacgggta ctacacctat gaggtaatgg atacttgccg accaattgcg
     6901 gatagcgaag cgggtaacgc tgatctatca cttctttcct atttggattg ctgtgatcag
     6961 agctttaaag agtataagaa acgagttttt aaagtggatt actgtgacac atttcaatat
     7021 ctatgcttcc atacaccttt tggcggaatg gtgaaagggg cgcatcgcaa catgatgcgc
     7081 aagtatagcg atttatcgcg tgaggctatt gaggcagatt ttcaacagag ggtgcaacct
     7141 ggccttacct attgccaacg tgtcggtaat atcatgggtg gcacaataat gctttctttg
     7201 gccagcacta ttgataacgc tattatgagg aatacctgta gagttggttg cttttcatat
     7261 ggatcaggct gttgttcgga attctacagt ggtgttgtgt caccctcagg gcaagccaaa
     7321 cttagagatt gggcacttgg taaacaccta gatagtcggc ataggttaac tatggagcag
     7381 tatgaaatag tgcttcagcg tagcgagctg gtgaaatttg gaactcgtaa tgttgtgctg
     7441 tcgaatgatc taatccctgg cgcctggaaa accataactc gtaatgtgcg agagaataaa
     7501 gatatagata taggcaaaag aatttttcta tcggaaatca aagaatttca tcgccattat
     7561 gaatggattg agtagatgga gttgcttgtt gggtctatag gtctagtctt cttgacgata
     7621 ctgatagttt tgttgtgtat agccgtcgcc ttttatttga ttgcgccagg tttattgctg
     7681 gactcctttc ttgctttggg gcgctggcat gcgggactaa agcgtcggga atcaaccttg
     7741 gatatggtca attgggtatg gctcgatagc ggtggagagg gagatgttat tgttctcata
     7801 catggtttcg ctgcacataa atatgggtgg ctacaggtag cgagccgatt gaggggacga
     7861 ggttaccgat tgattattcc cgatttgccg ggctttggtg aaaatcaggt gtctgccgac
     7921 ataagttaca gtgttttgga gcaggcacaa cgactccaga cgtttttggc atcgttgggt
     7981 ataaatagat ttcatgctgt cgggcattcg atgggtggat atgtggcggg ggcatgtgcg
     8041 tttattgact ctgatatgct gcttagtctt tatcttgtcg cacccgccgg tattacggtg
     8101 gaaggggagc caatagattt gtcagagaaa ggtaagaaga ataacttatt tatcatcgaa
     8161 acggtggagc aattccagga ggtcatggca atcgctatgg caaatcctcc gaagctccct
     8221 cgtcggatag tggagtcgat ggttgcgagg gagcttacaa tgcgtaagct gcgagaaaag
     8281 cagaatgagg tttgggactc tccctcttta cagcgactac tgtcgaattg ttcaattcct
     8341 ttacgcatgc tgtggggcga gcgagatcgc atgttatctg ttgatagagc agctttgatt
     8401 gtagaggccg ttcccatggc tagcatcagg tatcttcctg atatagcaca cgtcattccc
     8461 caagaagcac cgagtgtaat ggtccgggat tatctgattt cattgctgct ctcccattag
     8521 ggaaaaatga cattcttaat ccgaggttac tcgttaacgt gccttgaagc ttcatgaacg
     8581 agccagtcga ggaagcgttt gactggtaag tgtcgctctc tacctgggat gcaggctgcc
     8641 acataacggg cacccggtaa tttaatttca ggcttgtaag ggctcaaggt gcctttggct
     8701 acatattccg ctgtcagcac attgctggca agcaccatgc cgtagccaga gatggccgcc
     8761 tgtacggcat agtgctcatc gtcatactct cttaaaatcg catgttccaa ccaatcttca
     8821 tgcccagcag ccttgcacca tgtgggccag tcgaagggac cctgcgctct tggttcccag
     8881 cggacattga ttaattgccg atgcgtgtct tctgacggat tgcgatggta aggcatatag
     8941 actttgaaat attcgtccat taaatgaagt tgataggtac ttgcttcttg ctggaataga
     9001 cctcgaatgc cgagatcaat ggtagagttt cggtgcaggt ctatcaaaac gttgcttgtt
     9061 attatgttaa cttttatgtc ggggtagtgt cgatagaaat cgccgattct aggtattagc
     9121 cataacgccg taaatgcatg agtggtggtt actgttagca ccttgctatc cacacgagga
     9181 cgtaattggt ctagactgga gctgagattt gagaaatatt ggtgagtttc gttgtataaa
     9241 ttgaaacccg gtggggtaag ctctacacct tttgcctggc ggtggaataa taggacgccg
     9301 agtttacttt ctaaagattt gatttggtgt gaaacagcgg aggctgtgac tgaaagctct
     9361 gccgcagcag ccttgaaact gccaagcctg gctgctgact cgaaagacct caatgaggtc
     9421 aaaggtacgt tcgcgaacat acaagcacta accccttcta actaaagctc tgagtatctc
     9481 atctcactgg tataaatcga aatagtagct tatcaggcga ctaagagtta ttttaatacg
     9541 aaaaagtgac gctctcatgt cagcgccgtt tgagcataaa gttatgaaaa tcacctgata
     9601 tctgtcttac ggtagtatta cttagcatcc atgaggacca agtactgtac ctgatctttc
     9661 tcaatatgct gttacatgcc ttaactacga gcacggtgtc gcagagcact ccaactggtc
     9721 agtctcgtaa gagaataccg aggtgcttct tcatgacacc cgttaaccag gtgagtgtcc
     9781 tcccacgggg agactagaat ctatgaccgg cagcgacagg agcttgctag ctgtactctg
     9841 aaatttccgc tcggtgcaac ctttatcaac agagtacacc atacatgagt ggctcccaac
     9901 tcggtgaaaa acaaaaacca gaaagggcat cgagatattt tcgccattat ctccaataat
     9961 aactgaaacc tccggcgacc ggcggaactg ctaccctact
//
