BGC0000257: Roseophilin biosynthetic gene cluster from Streptomyces griseoviridis
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Location: 1 - 49,025 nt. (total: 49,025 nt).
This entry is originally from NCBI GenBank AB469822.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000257
Short description Roseophilin biosynthetic gene cluster from Streptomyces griseoviridis
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: unknown
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type I)
Loci
AB469822.1
via
Compounds
  • Roseophilin
  • Prodigiosin R1
  • Prodigiosin R2
  • Prodigiosin R3
Species Streptomyces griseoviridis [taxonomy]
References
Chemical products information
Roseophilin Evidence: NMR [1]
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C27H33Cl1N2O2
Chemical database entries
NPAtlas
Prodigiosin R1 Evidence: NMR [2]
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C27H37N3O1
Chemical database entries
NPAtlas
Prodigiosin R2 Evidence: NMR [3]
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C27H35N3O1
Chemical database entries
NPAtlas
Prodigiosin R3 Evidence: NMR [4]
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C27H33N3O1
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • BAG84240.1
  • rphY
 2580 - 2906 (-) hypothetical protein
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    • BAG84241.1
    • rphW
    		 2982 - 4187 (-) putative L-prolyl-PCP dehydrogenase
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      • BAG84242.1
      • rphX
      		 4184 - 6967 (-) putative beta-ketomyristoyl-ACP synthase
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        • BAG84243.1
        • rphD
        		 7132 - 7893 (-) putative transcriptional regulator
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          • BAG84244.1
          • rphA1
          		 8450 - 10783 (-) putative ABC-transporter
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            • BAG84245.1
            • rphA2
            		 10800 - 11525 (-) putative ABC-transporter
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              • BAG84246.1
              • rphA3
              		 11617 - 12294 (-) putative transcriptional regulator
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                • BAG84247.1
                • rphM
                		 13296 - 15173 (+) putative L-prolyl-AMP ligase
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                  • BAG84248.1
                  • rphL
                  		 15281 - 22489 (+) putative polyketide synthase
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                    • BAG84249.1
                    • rphK
                    		 22498 - 23610 (+) putative oxidoreductase
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                      • BAG84250.1
                      • rphJ
                      		 23659 - 24921 (+) putative thioesterase
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                        • BAG84251.1
                        • rphG2
                        		 24976 - 26304 (+) putative oxygenase
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                          • BAG84252.1
                          • rphG3
                          		 26436 - 27416 (+) putative oxygenase
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                            • BAG84253.1
                            • rphG4
                            		 27450 - 28550 (+) putative oxygenase
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                              • BAG84254.1
                              • rphI
                              		 28562 - 29650 (+) putative O-methyltransferase
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                                • BAG84255.1
                                • rphH
                                		 30049 - 33294 (+) putative pyrrole-condensing enzyme
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                                  • BAG84256.1
                                  • rphG
                                  		 33398 - 34543 (+) putative oxygenase
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                                    • BAG84257.1
                                    • rphZ
                                    		 35000 - 35680 (-) putative response regulator
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                                      • BAG84258.1
                                      • rphV
                                      		 35854 - 37206 (-) putative dehydrogenase
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                                        • BAG84259.1
                                        • rphU
                                        		 37214 - 38080 (-) putative 4'-phosphopantetheinyl transferase
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                                          • BAG84260.1
                                          • rphT
                                          		 38085 - 38978 (-) hypothetical protein
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                                            • BAG84261.1
                                            • rphP
                                            		 39949 - 40971 (+) putative 3-oxoacyl-ACP synthase
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                                              • BAG84262.1
                                              • rphO
                                              		 41045 - 41323 (+) putative peptidyl carrier protein
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                                                • BAG84263.1
                                                • rphN
                                                		 41335 - 43239 (+) putative 4-hydroxy-2,2'-bipyrrole-4-methanol synthase
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                                                  Biosynthesis information
                                                  Annotation changelog

                                                  Entry version: next

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2024-05-14
                                                  MIBiG v4 annotathon
                                                  • (ID: VN4WQJSSFIJHEVCKX4HDODAG)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 4

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-10-07
                                                  Update chemical activity to schema version 2.11
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 3

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2022-09-15
                                                  Updated bioactivity data
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 2

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2019-10-16
                                                  Migrated from v1.4
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                                                  Entry version: 1

                                                  Date
                                                  Changes
                                                  Submitters
                                                  Reviewers
                                                  2015-06-12
                                                  Submitted
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                                                  Detailed domain annotation
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