BGC0000258 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000258 (Serratia sp. (in: enterobacteria))

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	prodigiosin	1	25,055	High	prodigiosin	PKS

BGC0000258 - Region 1 - prodigiosin

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Location: 1 - 25,055 nt. (total: 25,055 nt) Show pHMM detection rules used

Region on contig edge.

prodigiosin: (PPDK_N and AMP-binding and PP-binding and PKS_KS)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 25,056
Label		BGC0000258

Tailoring functions

Oxidoreductases: dehydrogenase

pigA: acyl-CoA dehydrogenase

smcogs: SMCOG1006: acyl-CoA dehydrogenase

Transferases: PPTase aminotransferase methyltransferase

pigE: aminotransferase class-III

smcogs: SMCOG1013: aminotransferase class-III

pigF: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

pigL: 4'-phosphopantetheinyl transferase

smcogs: SMCOG1012: 4'-phosphopantetheinyl transferase

Ligases: ligase synthase

pigH: 8-amino-7-oxononanoate synthase

smcogs: SMCOG1109: 8-amino-7-oxononanoate synthase

pigI: AMP-dependent synthetase and ligase

smcogs: SMCOG1002: AMP-dependent synthetase and ligase

pigJ: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000258.3	0.98	PKS	prodigiosin	Serratia sp.
BGC0002675.2	0.78	PKS	prodigiosin	Pseudoalteromonas rubra
BGC0000259.3	0.75	PKS	prodigiosin	Serratia marcescens
BGC0000260.3	0.61	PKS	prodigiosin	Hahella chejuensis KCTC 2396
BGC0001244.3	0.60	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.60	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.60	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002154.2	0.60	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001273.3	0.60	PKS	asperlactone	Aspergillus ochraceus
BGC0001135.5	0.60	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000258.3	0.98	PKS	prodigiosin	Serratia sp.
BGC0002675.2	0.78	PKS	prodigiosin	Pseudoalteromonas rubra
BGC0000259.3	0.75	PKS	prodigiosin	Serratia marcescens
BGC0000260.3	0.61	PKS	prodigiosin	Hahella chejuensis KCTC 2396
BGC0001244.3	0.60	PKS	(-)-Mellein	Parastagonospora nodorum
BGC0001276.3	0.60	PKS	6-methylsalicyclic acid	Aspergillus terreus
BGC0001275.3	0.60	PKS	6-methylsalicyclic acid	Glarea lozoyensis
BGC0002154.2	0.60	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0001273.3	0.60	PKS	asperlactone	Aspergillus ochraceus
BGC0001135.5	0.60	NRPS	bicornutin A1, bicornutin A2	Xenorhabdus budapestensis

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

NRPS/PKS substrate predictions

pigI: X

AMP-binding (13..396): X

nrpys: (unknown)

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: Apolar, aliphatic (Gly, Ala, Val, Leu, Ile, Abu, Ival)
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: DLFYIAWVCK
Nearest Stachelhaus code(s):: Pro DLFYLAWVCK (85% 8Å match)
Stachelhaus code match:: 90% (moderate)

Link to PARAS substrate predictor