LOCUS       BGC0000259             24834 bp    DNA     linear   BCT 08-NOV-2004
DEFINITION  Serratia marcescens prodigiosin biosynthesis gene cluster.
ACCESSION   BGC0000259
VERSION     BGC0000259
KEYWORDS    .
SOURCE      Serratia marcescens
  ORGANISM  Serratia marcescens
            Bacteria; Proteobacteria; Gammaproteobacteria; Enterobacterales;
            Yersiniaceae; Serratia.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2022-11-07 17:57:44
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 24834
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..24834
                     /db_xref="taxon:615"
                     /mol_type="genomic DNA"
                     /organism="Serratia marcescens"
                     /strain="ATCC 274"
     subregion       1..24834
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="Polyketide"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..24834
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(168..575)
                     /gene="cueR"
     CDS             complement(168..575)
                     /codon_start=1
                     /db_xref="GOA:Q5W255"
                     /db_xref="HSSP:P0A9G4"
                     /db_xref="InterPro:IPR000551"
                     /db_xref="InterPro:IPR009061"
                     /db_xref="InterPro:IPR011789"
                     /db_xref="UniProtKB/TrEMBL:Q5W255"
                     /gene="cueR"
                     /gene_functions="regulatory (smcogs)
                     SMCOG1171:transcriptional regulator, MerR family (Score:
                     84.2; E-value: 2.4e-25)"
                     /gene_kind="regulatory"
                     /product="putative transcriptional regulator of CopA"
                     /protein_id="CAH55645.1"
                     /transl_table=11
                     /translation="MNISDVAKKTGLTSKTIRFYEEKSADYPAPIRSDNGYCPLFPPGT
                     LKSCTLLRQARQVGFNLDKCRELVALFNDPARHSADVKARTLQKVAEIERHISELGEMR
                     QRLLTLAEQCPGDEGAECPIINNLAGCCRSN"
     gene            982..2139
                     /gene="pigA"
     CDS             982..2139
                     /codon_start=1
                     /db_xref="GOA:Q5W254"
                     /db_xref="HSSP:Q06319"
                     /db_xref="InterPro:IPR006089"
                     /db_xref="InterPro:IPR006090"
                     /db_xref="InterPro:IPR006091"
                     /db_xref="InterPro:IPR009075"
                     /db_xref="InterPro:IPR009100"
                     /db_xref="InterPro:IPR013764"
                     /db_xref="UniProtKB/TrEMBL:Q5W254"
                     /gene="pigA"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_N"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_M"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Acyl-CoA_dh_1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1006:acyl-CoA dehydrogenase (Score: 339.5; E-value:
                     4.2e-103)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative acyl-CoA dehydrogenase"
                     /protein_id="CAH55646.1"
                     /sec_met_domain="Acyl-CoA_dh_N (E-value: 2.8e-22, bitscore:
                     69.7, seeds: 790, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_M (E-value: 2.1e-25, bitscore:
                     78.9, seeds: 43, tool: rule-based-clusters)"
                     /sec_met_domain="Acyl-CoA_dh_1 (E-value: 9.3e-39, bitscore:
                     123.1, seeds: 49, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDFNLSSEQQALSESAQRFAREVLDQDAHARLSRQVLSLDLWQQA
                     AAYGFTRAPVTTAFGGLGMNALDTALMIEALGKGSRDIGMSFSLCAHLCACVIPLSRFG
                     SEALKARYLEALAAGKLIAANAATEPDAGSDIYAMKSTAQPCEGGYRLNGNKIFITNAP
                     IADIFIVYAKTHPEHGFMGVSAFVLEKGMPGLNVGAVSPKDCLSNCPWSELTFNDVFIP
                     ETQRIGMPGAGGAIFHDSMIWEKGCLSALFIGAMERVFDSALDYAKQRRQFGKAIGQFQ
                     SVSNRIIDMKLRLEQCRLMLYRACWKHDRGQDAEIDIAMSKLLISEYAVQSALDAIQIF
                     GGAGMDQELGLVRHLLNVIPSRIFSGTNEIQKEIVARKLGLRGGA"
     gene            2136..4151
                     /gene="pigB"
     CDS             2136..4151
                     /codon_start=1
                     /db_xref="GOA:Q5W253"
                     /db_xref="InterPro:IPR003953"
                     /db_xref="UniProtKB/TrEMBL:Q5W253"
                     /gene="pigB"
                     /product="hypothetical protein"
                     /protein_id="CAH55647.1"
                     /transl_table=11
                     /translation="MMIVQRVFAVLYMLAGLAKAFPQLENVADILQQAAVANQGTWYAG
                     ATAWLAAQGTVVNALIGVALFASGAVLMFNPRWTPLIIYCQLLMMAGFVTILHRAQPQV
                     MLLDAIFALAALYMLRQQHHRKPKPRTFPTRDFSTPTPAAGGPVTPALDGEYDVVIIGG
                     GVSGLAAASELTDRRVLVLEKSASFGGNARYSTVNRLKFPIAGVCFQEPLPNSFMAQLL
                     KKIGLSGVYKSNEKDTLVFFDTFLLLRCLGEVVVGFIKQPVYLLKPAVWRLTGQLFLHA
                     LIGKPYVIAAKQLGDPIFADLYAFLDTFSPRGERYPSLPWTPQSAWSKTNMALLDTIPL
                     YTYLFEPHKLDQIPTDLRPPRKFGKLVENAVSTTLRVECLDIREVSAYVGLHFLVGYLR
                     GNLVTLPGGNGSISAGLLDYLEEQNNVRLQSRVQLQSITPGGDETVIRFSVNGAASEIR
                     AKQVIWAAPKTHVPTWLPTLPKEQLAAIRQIRHEDYYLANVLLKKPILERSFGGYLIEP
                     ENTRTPYYWSKAGTCLVANWMDNHLSAEAGVLTLLKPTTRPERQGRTAQNEFPALQQQT
                     YVEIAKVLGNMGIDADVIEDIQIWFWPAGLVTSVAGQQAQGVFHQASRPFENIHFANQD
                     SVGIGNIESAVLAGLNAAKAVRERLAMPVTSAEVMS"
     gene            4148..6814
                     /gene="pigC"
     CDS             4148..6814
                     /codon_start=1
                     /db_xref="GOA:Q5W252"
                     /db_xref="InterPro:IPR002192"
                     /db_xref="InterPro:IPR008279"
                     /db_xref="UniProtKB/TrEMBL:Q5W252"
                     /gene="pigC"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     prodigiosin: PPDK_N"
                     /gene_kind="biosynthetic"
                     /product="putative phosphoenolpyruvate-utilizing enzyme"
                     /protein_id="CAH55648.1"
                     /sec_met_domain="PPDK_N (E-value: 1.3e-79, bitscore: 257.8,
                     seeds: 105, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNPTLVVELSGDKTLEPHRLGGKAHSLNHLIHAGLPVPPAFCITA
                     QAYRQFIEFAVPGALLDTGAPGNVRDMILSAAIPAPLDLAIRHACKQLGDGASLAVRSS
                     ALEEDGLTHSFAGQYDTYLHVRGDDEVVRKVQSCWASLWAERAAQYSRTSAAQSDIAVV
                     LQIMVDADAAGVMFTQDPLTGDANHIVIDSCWGLGEGVVSGQVTTDSFILDKASGEIRE
                     RQIRHKPHYCQRDPQGRVTLLQTPEARRDAPSLTPEQLQQLARLARQTRMIYGAELDIE
                     WAVKDDRVWLLQARPITTQAKPVQMLYANPWESDPTIKERAFFSRMDTGEIVTGLMTPL
                     GLSFCQFYQKHIHGPAIKTMGLADIGDWQIYMGYLQGYVYLNISGSAYMLRQCPPTRDE
                     MKFTTRYATADIDFSGYKNPYGPGVQGWAYLKSAWHWLKQQRHNLRSAGATVDAMIALR
                     QRETRRFLALDLTTMTHQELERELSRIDGYFLDSCAAYMPFFLQSFALYDALALTCERY
                     LKGRGNGLQNRIKASMNNLRTIEVTLGILSLVETVNRQPALKALFERHSAQELVTVLPT
                     DPESRAFWQSDFSAFLFEFGARGRQEFELSLPRWNDDPSYLLQVMKMYLQHPVDLHTKL
                     RETERLRHEDSAALLKAMPWFGRMKLKFITKLYGVMAERREATRPTFVTETWFYRRIML
                     EVLRRLEAQGLVKSADLPYVDFERFRAFMAGEQSAQEAFAADLIERNRHQHLLNLHAEE
                     PPMAIVGGYQPRMKAPTAENAAGMLSGLAASPGKVVAKARVITDLLAQAGELQPNEILV
                     ARFTDASWTPLFALAAGIVTDIGSALSHSCIVAREFGIPAAVNLKNATQLINSGDTLIL
                     DGDSGTVIIQRGERADG"
     gene            6877..9591
                     /gene="pigD"
     CDS             6877..9591
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:Q5W251"
                     /gene="pigD"
                     /product="hypothetical protein"
                     /protein_id="CAH55649.1"
                     /transl_table=11
                     /translation="MRAATAACRDRRGLCRAEFARLAEAVTPFWLHKELIMTTLTGQAR
                     LTNSAAYEQVWQAERQACRTDADPDTLTVGVVVVTRNPAFFQTGLSVLNDIRDYVFNRV
                     HIQSEMPLKLLDLAADSLYLAAREKALHFLKGQNKAINVRIIQCASLAEATGKIIYTHA
                     LEQRPEFHLGMLFYDQTTPAGVDDSIEQIDRDLDAFYSALQRSGIPAFYTTFSTVAFIR
                     QLRSPFRYLPQQYREIVRSEDPAIFQTELLCLWMDFFEMNYTNRRVKPIGALALHNTLG
                     EQLIQFFERTAAERWLVSYYTGSIISNLIGYLDRHAEARGALILRGPNEHAIACGAMAN
                     WQLYRMPFLGVVTSGMMDEFKGTLANLKETAAQGIIVAAENRGNQWYSFQGTLTPTEDM
                     REVLIARRIPFVYIDDVEMIGAGLTEAFRLYHQGQGPVVILATQNVLESTLSLEGAVCD
                     PSPIPVLSADDPLPMSESLAQAIALINRGPERLVWQLGPVSDDEYALIHDIADAAGIAL
                     VDSLAHPGSAPKYYQGRRNPHYLGTLAIYGYSPRVYNFLHTNDKLNAMSEQSLFMIKSR
                     VAQITTPFSDGRLERKVHLVQLTHDDRHLSAYADLHLHMNCLAFLRTVKAHLDVDPALR
                     ERRRALIAAYLDSPSDVVSQLPSLPMSANYFFCQLNRVIEELIETEGFDFTGVYDVGRC
                     GISAARNVAKTRRGFSGWYGRALMGDALLATGYLAYTSPSHVMAFIGDGAKGIVPDILP
                     AFIDNILTHPQLLNKSITVFYLCNGGLSVINTYQERILFNRTSRQMRLVNVEQPDVEQT
                     VNNFHIQSKTLTHFDEDVIRQALTTSHRLNLFSVVLGHNNEGDGISPGHRQRLAALIRA
                     DHDALQERKAWAAQQPESTSTAFDQDPTQEATS"
     gene            9588..12149
                     /gene="pigE"
     CDS             9588..12149
                     /NRPS_PKS="Domain: Aminotran_3 (420-743). E-value: 9.2e-95.
                     Score: 309.3. Matches aSDomain:
                     nrpspksdomains_pigE_Aminotran_3.1"
                     /codon_start=1
                     /db_xref="GOA:Q5W250"
                     /db_xref="HSSP:P12995"
                     /db_xref="InterPro:IPR005814"
                     /db_xref="UniProtKB/TrEMBL:Q5W250"
                     /gene="pigE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1013:aminotransferase class-III (Score: 417.6;
                     E-value: 8.7e-127)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative aminotransferase"
                     /protein_id="CAH55650.1"
                     /sec_met_domain="Aminotran_3 (E-value: 2.3e-91, bitscore:
                     296.5, seeds: 13, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKFGFIAHPTSLGLKRYVKMLDLLQRNSTEQHSGYTRELWERQNL
                     VPFMNFARITSATGATCEGVIKYMPLVADEMLADARGIAARVVQGIEELAGDGAELVGL
                     GGLTSIVGRRGEATAEKSPVPVTSGNSLTTYAGYKALMQIQSWLEISPEEEPVAIVGYP
                     GSICLALSRLLLAHGFSLHLLHRAGNHDRSELLSHLPEEYHSRVTLTSDPEDLYPRCKL
                     FAAATSAGGVIDPARLQPGSIFIDVALPRDIASETRPARDDILIIDGGCVTATDAVKLG
                     GESLNVTIKQQLNGCMAETIVLALENRRENFSLGRYLAPEKVLEIGEIAERHGFFAYPL
                     ASYGERIDRQSVTNLKRYYHHDIYAGEPADAALPASRLAFIDAVIAQTPAREDTLDRYH
                     QYINPMMVDFLKLQRCDNVFRSAAGTQLYDDAGEAFLDMVAGYGCLNLGHNPQPVVNAL
                     KNYLDAQGPNFIQYISIPEQTAKLAEVLCRLAPGNMGRVFFSNSGTEAVEAAMKIAKAS
                     TGKPGIAYLRNSYHGKTLGALSITGRDKHRRYFTPLLDAMVEVPFGDLAALREALNRED
                     VGALMIEPIQGEGGVHIPPAGYLQAVQQLCRETGVLLMVDEVQTGLGRTGKLFACEWDG
                     IEPDVLMLSKSLSGGLIPIGATLCRTELWQKAYGTADRFLVHSSTYGGGNLASVVALSA
                     LREILAQDLVGHAERMGAYFKQALSEIAARYPFVSEVRGRGLMLGIQFDQAFTGAVNAS
                     AREFATRLPGDWHTTWKFLPDPVQAHLRAAMDRMEQALGEMFCMKFVTKLCQDHKILTF
                     ITANSSTVIRIQPPLIISKAEIDRFVGAFATVCEELSTFLD"
     aSDomain        10848..11816
                     /aSDomain="Aminotran_3"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pigE_Aminotran_3.1"
                     /evalue="9.20E-95"
                     /label="pigE_Aminotran_3.1"
                     /locus_tag="pigE"
                     /protein_end="743"
                     /protein_start="420"
                     /score="309.3"
                     /tool="antismash"
                     /translation="SAAGTQLYDDAGEAFLDMVAGYGCLNLGHNPQPVVNALKNYLDAQ
                     GPNFIQYISIPEQTAKLAEVLCRLAPGNMGRVFFSNSGTEAVEAAMKIAKASTGKPGIA
                     YLRNSYHGKTLGALSITGRDKHRRYFTPLLDAMVEVPFGDLAALREALNREDVGALMIE
                     PIQGEGGVHIPPAGYLQAVQQLCRETGVLLMVDEVQTGLGRTGKLFACEWDGIEPDVLM
                     LSKSLSGGLIPIGATLCRTELWQKAYGTADRFLVHSSTYGGGNLASVVALSALREILAQ
                     DLVGHAERMGAYFKQALSEIAARYPFVSEVRGRGLMLGIQFD"
     gene            12160..13176
                     /gene="pigF"
     CDS             12160..13176
                     /codon_start=1
                     /db_xref="GOA:Q5W249"
                     /db_xref="InterPro:IPR000051"
                     /db_xref="InterPro:IPR001077"
                     /db_xref="UniProtKB/TrEMBL:Q5W249"
                     /gene="pigF"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 238.4; E-value:
                     2.1e-72)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative O-methyl transferase"
                     /protein_id="CAH55651.1"
                     /transl_table=11
                     /translation="MPLTKQDAVNQMMGFFQAKALTAALALKLFDQLRDRDADAAHIAA
                     RLDCPARSTEQLLIALRAMGYLDQRDGLYHLPAAHRAFLLSDEPQWLGWLGRHIDTFLY
                     PLWGELKTAVRNDAHQRRTVFGDDRSWFDILYQNPDDVADFQEFLGKFAAPFIAGFVRD
                     YDFSQHRAFLDIGSGIGSLPMAIADAYPGIALAICELPQASAFLRDKLTLQGYGERIDV
                     VEGDVISGDLPIGGYDLIHLGWMLHDYAPETQLTILRNIYRAMPAGGRFIASETPLNED
                     KSGPEFTALLSLNMLVSTDGGIESSAQEYLDRFRLAGFSNARIMKIAGPRTLIVGEK"
     gene            13200..13463
                     /gene="pigG"
     CDS             13200..13463
                     /codon_start=1
                     /db_xref="InterPro:IPR009081"
                     /db_xref="UniProtKB/TrEMBL:Q5W248"
                     /gene="pigG"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1147:putative acyl carrier protein (Score: 59.5;
                     E-value: 3.9e-18)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative peptidyl carrier protein"
                     /protein_id="CAH55652.1"
                     /transl_table=11
                     /translation="MLESKLIQHIATQYLDGDHDGLNAQTPLFELNVVDSASIFDLVDF
                     LRQESHVAIGMHEIHPANFASVQAMVALVQRLQAQVAAGGVA"
     gene            13460..15406
                     /gene="pigH"
     CDS             13460..15406
                     /NRPS_PKS="Domain: PP-binding (19-79). E-value: 1e-08.
                     Score: 27.5. Matches aSDomain:
                     nrpspksdomains_pigH_PP-binding.1"
                     /NRPS_PKS="Domain: PKS_PP (96-181). E-value: 7.3e-09.
                     Score: 27.7. Matches aSDomain:
                     nrpspksdomains_pigH_PKS_PP.1"
                     /NRPS_PKS="Domain: Aminotran_1_2 (281-618). E-value:
                     3.5e-52. Score: 169.5. Matches aSDomain:
                     nrpspksdomains_pigH_Aminotran_1_2.1"
                     /codon_start=1
                     /db_xref="GOA:Q5W247"
                     /db_xref="HSSP:P0AB77"
                     /db_xref="InterPro:IPR001917"
                     /db_xref="InterPro:IPR004839"
                     /db_xref="InterPro:IPR006162"
                     /db_xref="InterPro:IPR006163"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="UniProtKB/TrEMBL:Q5W247"
                     /gene="pigH"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     prodigiosin: PP-binding"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1109:8-amino-7-oxononanoate synthase (Score: 537.2;
                     E-value: 4.1e-163)"
                     /gene_kind="biosynthetic"
                     /product="putative aminotransferase"
                     /protein_id="CAH55653.1"
                     /sec_met_domain="PP-binding (E-value: 3e-09, bitscore:
                     27.5, seeds: 164, tool: rule-based-clusters)"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 5.2e-07,
                     bitscore: 19.2, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSVHAVDSAANAHEAVRQSVLHTFARLTEYEPSALALTSHLENDL
                     GVDSIALAEIAMVLNRQFQLNTPLAIQEIKTIQDALDGILQRGFTLPTPNAAAQPAPQT
                     PQAWLSALVRQVFATHSGYEVRDLSPDAAIEGDLGIDSVAVVMARNELLKTLGLDDNAA
                     LAECRTLAELEHNLAARLVQEQGEAWFSRFGQHTTASAAPQPTKAPASPDARDELGDPR
                     TMRDFVGIEHPDLFHKTREFGAFYRDKKQRQLYWYGMPLETPCKNRAVMFDEVTGKSRE
                     FLMFGSNSYLGLSNHPEVIHAIQDAAGLYGATNTGCRIIAGSNVLHLELERKLAKLKGR
                     EDCIVYPSGYSANLGCISALTSRHDLVFTDAINHMSIQDGCKLAGAQRKIYDHSLTSLE
                     KSLAKYADHPGGKLIVTDGVFSMHGDIVDLPRLMKLAERYGARVLVDDAHATGVLGKTG
                     SGTAEHFNMKGQVDLELGTMSKALSGLGGFVCADGEVVEYLRFYSNSYVFAATIPAAVA
                     AGVIASIDVMLREPERLTKLWDNIYYFRTLLLNAGFDLEHSDSAIIPVVVGDDAKTLLF
                     GRAVRARGLFCQTVVFPGVSVGDARLRISVTSEHTREDLDEANAILVAAALETGVPVNG
                     DVRREERARATEV"
     aSDomain        13517..13696
                     /aSDomain="PP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pigH_PP-binding.1"
                     /evalue="1.00E-08"
                     /label="pigH_PP-binding.1"
                     /locus_tag="pigH"
                     /protein_end="79"
                     /protein_start="19"
                     /score="27.5"
                     /tool="antismash"
                     /translation="VLHTFARLTEYEPSALALTSHLENDLGVDSIALAEIAMVLNRQFQ
                     LNTPLAIQEIKTIQD"
     aSDomain        13748..14002
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pigH_PKS_PP.1"
                     /evalue="7.30E-09"
                     /label="pigH_PKS_PP.1"
                     /locus_tag="pigH"
                     /protein_end="181"
                     /protein_start="96"
                     /score="27.7"
                     /tool="antismash"
                     /translation="AAQPAPQTPQAWLSALVRQVFATHSGYEVRDLSPDAAIEGDLGID
                     SVAVVMARNELLKTLGLDDNAALAECRTLAELEHNLAARL"
     aSModule        13748..15313
                     /domains="nrpspksdomains_pigH_PKS_PP.1"
                     /domains="nrpspksdomains_pigH_Aminotran_1_2.1"
                     /incomplete
                     /locus_tags="pigH"
                     /tool="antismash"
                     /type="pks"
     aSDomain        14303..15313
                     /aSDomain="Aminotran_1_2"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pigH_Aminotran_1_2.1"
                     /evalue="3.50E-52"
                     /label="pigH_Aminotran_1_2.1"
                     /locus_tag="pigH"
                     /protein_end="618"
                     /protein_start="281"
                     /score="169.5"
                     /tool="antismash"
                     /translation="FLMFGSNSYLGLSNHPEVIHAIQDAAGLYGATNTGCRIIAGSNVL
                     HLELERKLAKLKGREDCIVYPSGYSANLGCISALTSRHDLVFTDAINHMSIQDGCKLAG
                     AQRKIYDHSLTSLEKSLAKYADHPGGKLIVTDGVFSMHGDIVDLPRLMKLAERYGARVL
                     VDDAHATGVLGKTGSGTAEHFNMKGQVDLELGTMSKALSGLGGFVCADGEVVEYLRFYS
                     NSYVFAATIPAAVAAGVIASIDVMLREPERLTKLWDNIYYFRTLLLNAGFDLEHSDSAI
                     IPVVVGDDAKTLLFGRAVRARGLFCQTVVFPGVSVGDARLRISVTSEHTREDLDEA"
     gene            15411..16883
                     /gene="pigI"
     CDS             15411..16883
                     /NRPS_PKS="Domain: AMP-binding (12-395). E-value: 1.2e-80.
                     Score: 262.9. Matches aSDomain:
                     nrpspksdomains_pigI_AMP-binding.1"
                     /codon_start=1
                     /db_xref="GOA:Q5W246"
                     /db_xref="HSSP:P0C061"
                     /db_xref="InterPro:IPR000873"
                     /db_xref="UniProtKB/TrEMBL:Q5W246"
                     /gene="pigI"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     prodigiosin: AMP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1002:AMP-dependent synthetase and ligase (Score: 286;
                     E-value: 7.8e-87)"
                     /gene_kind="biosynthetic"
                     /product="putative L-prolyl-AMP ligase"
                     /protein_id="CAH55654.1"
                     /sec_met_domain="AMP-binding (E-value: 1.1e-83, bitscore:
                     271.1, seeds: 400, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATFISPILEALFRHARQAPESTALLCGDRRWSYRRLADRACMMA
                     AALRHAGLKQQAVLLNLQKGPDAVAAMYACWLSGNHYVPIDFSQPTARIERIIAAASPA
                     LIVDEGWLSALDDRTDLDGAWPEAIAAFGSPLAAILYTSGSTGTPKGVQITHDMLTFFI
                     GWAVSDTQLTARDVLANHASFAFDLSTFDLFAGVCAGAATWIVREDEQKDCQALVRGLQ
                     THGVTLWYSVPSILAMLEKSALLAPSTVKTLRQVTFAGEPYPAAALRRLVAHLPARCRV
                     SNWYGPTETNVCTAYALDRTQLATLEQIPIGHPLPGLTAQLVDEQGRCRRLTSPGRRGE
                     LLIGGPCVTPGYSNVASSRQAQWHPRQCHATGDWVETTANGLVYRGRLDDMVKINGYRV
                     ELGEIESILHHHPSVCQAALYVELGELKQKLIAVITLHPGALRPNLLELKQFLQPRLPA
                     YMLPSQLVVADSLPTNANGKVDRGRLSEVNAR"
     aSDomain        15447..16595
                     /aSDomain="AMP-binding"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pigI_AMP-binding.1"
                     /evalue="1.20E-80"
                     /label="pigI_AMP-binding.1"
                     /locus_tag="pigI"
                     /protein_end="395"
                     /protein_start="12"
                     /score="262.9"
                     /tool="antismash"
                     /translation="FRHARQAPESTALLCGDRRWSYRRLADRACMMAAALRHAGLKQQA
                     VLLNLQKGPDAVAAMYACWLSGNHYVPIDFSQPTARIERIIAAASPALIVDEGWLSALD
                     DRTDLDGAWPEAIAAFGSPLAAILYTSGSTGTPKGVQITHDMLTFFIGWAVSDTQLTAR
                     DVLANHASFAFDLSTFDLFAGVCAGAATWIVREDEQKDCQALVRGLQTHGVTLWYSVPS
                     ILAMLEKSALLAPSTVKTLRQVTFAGEPYPAAALRRLVAHLPARCRVSNWYGPTETNVC
                     TAYALDRTQLATLEQIPIGHPLPGLTAQLVDEQGRCRRLTSPGRRGELLIGGPCVTPGY
                     SNVASSRQAQWHPRQCHATGDWVETTANGLVYRGRLDDMVKIN"
     CDS_motif       15819..15878
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pigI_0001"
                     /evalue="2.70E-09"
                     /label="NRPS-A_a3"
                     /locus_tag="pigI"
                     /protein_end="156"
                     /protein_start="136"
                     /score="29.0"
                     /tool="antismash"
                     /translation="AAILYTSGSTGTPKGVQITH"
     CDS_motif       16356..16472
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pigI_0002"
                     /evalue="9.30E-06"
                     /label="NRPS-A_a6"
                     /locus_tag="pigI"
                     /protein_end="354"
                     /protein_start="315"
                     /score="18.1"
                     /tool="antismash"
                     /translation="PGLTAQLVDEQGRCRRLTSPGRRGELLIGGPCVTPGYSN"
     CDS_motif       16560..16625
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pigI_0003"
                     /evalue="7.10E-11"
                     /label="NRPS-A_a8"
                     /locus_tag="pigI"
                     /protein_end="405"
                     /protein_start="383"
                     /score="34.1"
                     /tool="antismash"
                     /translation="YRGRLDDMVKINGYRVELGEIE"
     gene            16880..19168
                     /gene="pigJ"
     CDS             16880..19168
                     /NRPS_PKS="Domain: PKS_KS(Hybrid-KS) (502-760). E-value:
                     1.9e-61. Score: 200.1. Matches aSDomain:
                     nrpspksdomains_pigJ_PKS_KS.1"
                     /codon_start=1
                     /db_xref="GOA:Q5W245"
                     /db_xref="InterPro:IPR000794"
                     /db_xref="UniProtKB/TrEMBL:Q5W245"
                     /gene="pigJ"
                     /gene_functions="biosynthetic (rule-based-clusters)
                     prodigiosin: PKS_KS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 151.9; E-value:
                     4.5e-46)"
                     /gene_kind="biosynthetic"
                     /product="putative Beta-ketomyristol-ACP synthase"
                     /protein_id="CAH55655.1"
                     /sec_met_domain="PKS_KS (E-value: 5.4e-62, bitscore: 200.1,
                     seeds: 2284, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MNQEIHAAPLALVGIGCALPGIDRIDLSNGAAWSALFDAPPPMPW
                     SDAAAPIRGRQIDDAAFDFKKFAIPPLFRLAVSRETRLALQAASAAMQHLTLSDALRDR
                     CDQFCATHLGSDAAYRNATKIGALRRLAERLDAQGLSPAAVMRRIDDYKQPLAQAFGSS
                     SHDRVGEMASSIPARIAHFARTRGKCQTLDGADLGGLRLLQLAQDCFRHADSRMAVLTA
                     VQCFHHQPQADMLLAQGVSSSACWLEGAISLVVCPLDVAQEQGWPAIAQLSTLIAERQD
                     AAPSAGYFAGANQVFCHLLDMLLQRQQACAGHSFTGYRWRIDAASPPSLKPTASPRISI
                     IDYQPITAQGLDKARFWQALRNGEDALRDHSPEQLHPGAFVRPTPQKLSAYTAHAMCFP
                     THDPVQLELTRPMMPAKKQRLDVTQLHALNGCAAWPDSLRRFERIAIIVASNLSLSADR
                     QQAMRALWPALPPAGVSLSPPPQPAINRWSWHGACGLGTAQLLAQQLGVEADCYAVEAA
                     CASSLAALHNAVRALQAGRYDAVLVGGIETATLERDMVLCSAQMMLSASRMRPFARQAD
                     GFTPGDGGGFFILTGQATSRAIATIEAISGSCDSYSMTAPDPEGQALAIEKTQSLSAVE
                     ARQIQYLEAHGTGTELGDRAEVASLHQGYRRAARAPLYIGSVKYNFGHCFAGAGALSLC
                     KVLSAFEHGQIPPTPVATLNAELPLAAIPAEIPQVALDWPHGEGGRRAAINGFGTGGIN
                     YHLLIHQPV"
     aSDomain        18386..19159
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_pigJ_PKS_KS.1"
                     /domain_subtype="Hybrid-KS"
                     /evalue="1.90E-61"
                     /label="pigJ_PKS_KS.1"
                     /locus_tag="pigJ"
                     /protein_end="760"
                     /protein_start="502"
                     /score="200.1"
                     /tool="antismash"
                     /translation="QQLGVEADCYAVEAACASSLAALHNAVRALQAGRYDAVLVGGIET
                     ATLERDMVLCSAQMMLSASRMRPFARQADGFTPGDGGGFFILTGQATSRAIATIEAISG
                     SCDSYSMTAPDPEGQALAIEKTQSLSAVEARQIQYLEAHGTGTELGDRAEVASLHQGYR
                     RAARAPLYIGSVKYNFGHCFAGAGALSLCKVLSAFEHGQIPPTPVATLNAELPLAAIPA
                     EIPQVALDWPHGEGGRRAAINGFGTGGINYHLLIHQ"
     CDS_motif       18410..18451
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pigJ_0001"
                     /evalue="1.50E-02"
                     /label="PKSI-KS_m3"
                     /locus_tag="pigJ"
                     /protein_end="524"
                     /protein_start="510"
                     /score="8.3"
                     /tool="antismash"
                     /translation="CYAVEAACASSLAA"
     CDS_motif       18800..18847
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_pigJ_0002"
                     /evalue="5.00E-04"
                     /label="PKSI-KS_m5"
                     /locus_tag="pigJ"
                     /protein_end="656"
                     /protein_start="640"
                     /score="12.3"
                     /tool="antismash"
                     /translation="YLEAHGTGTELGDRAE"
     gene            19182..19496
                     /gene="pigK"
     CDS             19182..19496
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:Q5W244"
                     /gene="pigK"
                     /product="hypothetical protein"
                     /protein_id="CAH55656.1"
                     /transl_table=11
                     /translation="MHIIVHKIRLKDIAHRAAFRDWVETTDYQACRHLDAVRAFDVIEV
                     SPSAEAPFHFIEIIQLNSLKMFEREMQTPLFQSLVERFNQLAEVVDEISGERIADGYRA
                     "
     gene            19480..20127
                     /gene="pigL"
     CDS             19480..20127
                     /codon_start=1
                     /db_xref="GOA:Q5W243"
                     /db_xref="InterPro:IPR008278"
                     /db_xref="UniProtKB/TrEMBL:Q5W243"
                     /gene="pigL"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1012:4'-phosphopantetheinyl transferase (Score: 73.9;
                     E-value: 1.8e-22)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative 4'-phosphopantetheinyl transferase"
                     /protein_id="CAH55657.1"
                     /transl_table=11
                     /translation="MVIELSVTPRIVIALGGAHRCAAVRGLRPLSAVKNLARAQAVALL
                     NRTWCQGHATGFTLRHEASGQPFGEHLLLGRRHVSLSHSLAWYASATGDIPLGIDLQHY
                     RPFSGAALRWAFSEAEQRLGHIQACAVWAIREAFLKSHGRGLPYELRTIGIDWRTGLVS
                     SADGSLASRRFWLWRSLDWTCALCFPAEESMSFRANVTVFSLPAPSAFGALS"
     gene            20124..21182
                     /gene="pigM"
     CDS             20124..21182
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:Q5W242"
                     /gene="pigM"
                     /product="hypothetical protein"
                     /protein_id="CAH55658.1"
                     /transl_table=11
                     /translation="MTQDLFAAALQQAVDIARQAPSSHNCQPWSLHYDADARCGRLAID
                     RRRALQSLPSLEREMLMSCGIFFEYLSALLNCAGSPLAWRWENGPTHLLSFAPAAPAAP
                     DRAAHRQLAQLIGERHTARAAYQPTPINEAQRMQLQTLFDGTASSLSIAGDERARRRVA
                     QLTARHAALDFSDRQAWRETYQYIRFNERQPTDDGFHLHHLFGPVSPAFKRFFQVAFHP
                     RLSRLATGLRLPAYMAQGLAQRVAEGPQYLALCLNDESAEHLFATGMRLGRLWLTLQHW
                     GWGLHPISVLVQHAEARRELAATLALSAPPVFFARFGHLQQWGSAAPRRSWQSILTAPP
                     SGECAHSGNDSP"
     gene            21201..21929
                     /gene="pigN"
     CDS             21201..21929
                     /codon_start=1
                     /db_xref="GOA:Q5W241"
                     /db_xref="InterPro:IPR001104"
                     /db_xref="InterPro:IPR010721"
                     /db_xref="InterPro:IPR011024"
                     /db_xref="UniProtKB/TrEMBL:Q5W241"
                     /gene="pigN"
                     /product="putative oxidoreductase"
                     /protein_id="CAH55659.1"
                     /transl_table=11
                     /translation="MNVWIALAVVLLILALLAFITSRGAQDTRPMFLWGFNAMGPVTLV
                     YCYFGEGDLSHKALILLMVGLYLLRMNIVLTRWYGNTAAAKLKDVMPTQQVPWLAVMMV
                     MIFGGLYCLPFYWASQLQGTWGALQWLAIGVYLIGTLFHFGSDYQKRRFKQDPNNKGRL
                     LNSGFWGLARHPNYFGDFLIFVSFGLLAGNLFGLIAPLTNLVQYFADAIPKSEKMAEKR
                     YGEVWRNYKRQVKCFIPFVL"
     gene            22123..24834
                     /gene="copA"
     CDS             22123..24834
                     /codon_start=1
                     /db_xref="GOA:Q5W240"
                     /db_xref="HSSP:P04129"
                     /db_xref="InterPro:IPR000150"
                     /db_xref="InterPro:IPR001412"
                     /db_xref="InterPro:IPR001756"
                     /db_xref="InterPro:IPR001757"
                     /db_xref="InterPro:IPR005834"
                     /db_xref="InterPro:IPR006121"
                     /db_xref="InterPro:IPR006403"
                     /db_xref="InterPro:IPR006416"
                     /db_xref="InterPro:IPR008250"
                     /db_xref="UniProtKB/TrEMBL:Q5W240"
                     /gene="copA"
                     /gene_functions="other (smcogs) SMCOG1037:heavy metal
                     translocating P-type ATPase (Score: 693.9; E-value:
                     4.1e-210)"
                     /gene_kind="other"
                     /product="putative copper transporting P-type ATPase efflux
                     pump"
                     /protein_id="CAH55660.1"
                     /transl_table=11
                     /translation="MSHTTMLALQGLSCMNCAQRVKKALESRSDVEQAEVNVHYAKVTG
                     DAPDSALIDSVIAAGYQAEVAPHADTELQLSGLSCMHCVGTTRKALEAVPGVFAADVAI
                     DSAKVYGDADPQTLIAAVEDAGYHASVAGAAAPKTEPLTDATPSLPDVQPAAQPSLPAT
                     DSADDSVQLLLSGMTCASCVNKVQLALQSVPGVEHARVNLAERSALVTGAADAQALVAA
                     VEKAGYGAEMIQDETERRERQQQTARANMKRFSWQAALGLALGIPLMAWGLFGGSMTLT
                     PETQRPWLLVGVITLAVMVFAGGHFYRNAWRALMNGSATMDTLVALGTGAAWLYSIAVN
                     IWPDFFPMAARHLYYEASAMIIGLINLGHALEQRARQRSSQALERLLDLTPPTARLVTD
                     DGERDIPLAEVQLGMTLRLTTGDRVPVDGEIEQGEVWLDEAMLTGEAVPQQKGPGDTVH
                     AGTVVDDGSVLFRAAAIGSQTTLARIIKLVRQAQSSKPAIGQLADRVSAVFVPAVVAIA
                     LFSAAMWYFFGPQPQLVYTLVIATTVLIIACPCALGLATPMSIISGVGRAAEFGVLVRD
                     ADALQQASQLDTLVFDKTGTLTEGKPQVVEILTFNQVSEQQAIGWAAALEQGSNHPLAR
                     AIMERAAGQTLPQVAQFRTLRGAGVSGEIDGVQVLLGNAALLEQHQVATAELEAPMRAQ
                     AERGVTPVLLAVDGKPAALFAIRDPLHEDSVAALQRLHQQGYQLVMLTGDNPVTANAIA
                     KEAGIDRVIAGVLPDGKAAAIKQLQAQGQRVAMVGDGINDAPALAQADVGIAMGGGSDI
                     AIETAAITLMRHSLHGVADAVELSKATLRNMKQNLFGAFIYNTLGIPIAAGVLYPLTGT
                     LLSPVVAGAAMALSSITVVSNANRLLRFKPRK"
ORIGIN
        1 atcggcaccc gcgccacgct gacggaaccg atgcacaacg gcatgggccg catcaatatc
       61 ggcgacagca gctggcgcgc gcaggcggcg gaagatctgc ctgccggcac tgaagtggaa
      121 gtggtggcgg tggaaggggt cacgctggtg atccgcgcca tcagccgtta attcgaacga
      181 cagcatcccg ccagattatt gatgatgggg cactccgccc cctcgtcgcc cggacattgt
      241 tccgccagcg tcaacaggcg ttggcgcatt tctcccagtt cgctgatgtg cctttcgatc
      301 tccgccacct tctgcagcgt gcgcgccttc acgtcggcgc tgtggcgggc cggatcgttg
      361 aataacgcca ccagctcacg gcacttgtcc aggttgaagc ccacctgccg cgcctggcgc
      421 agcagcgtgc aactcttcaa cgtgcctggc gggaataatg ggcaataacc gttatcgctg
      481 cggatcgggg ccgggtaatc agcgcttttc tcctcgtaaa aacgaatcgt cttgctggtt
      541 aacccggtct ttttcgcgac gtcgctaata ttcatttttt cctccggaat gctcctgctc
      601 atctcctatc ttaagccgct ttccgccact caccaagcct caacgcccta ccgtcgatat
      661 cgatgagaaa ccgatagcca catccaaaag atagatactt cacctgcaaa gtattcatca
      721 aaaaacaata gccaatctaa cctattaaaa tttgatcaaa ttaagatttt tattatatgt
      781 aaatttttgt gtataaataa cacaaaataa aacacaacaa aaacaacaaa ataaaaacat
      841 caattaacaa aattgtaata atagaccaca taaataaaca tttacttaca tttaccatta
      901 ctttgcctgt ttgagttttg gccacctcca aactagaaat attagctaat ttaatctctc
      961 aacccaatgg cggagttcgt catggatttt aacttatcaa gtgagcagca ggctctaagc
     1021 gaatccgctc agcgttttgc ccgcgaggtg ctggatcagg atgcgcatgc tcggctttca
     1081 cggcaggtat taagcctgga tttgtggcaa caagccgccg cctatggttt tacccgagcc
     1141 cccgtgacga ccgcgttcgg cggattgggc atgaatgcgc tcgatactgc actgatgatt
     1201 gaggcgctgg gtaaaggcag ccgcgacatc ggcatgtcct tctcgctctg cgcccatctg
     1261 tgcgcctgcg tgatcccgct ttcccgcttc ggttccgagg cattaaaagc gcgctatctc
     1321 gaagcgttgg cggccggaaa actgatcgcg gcgaatgcgg cgacggagcc ggacgccggt
     1381 tccgatattt atgccatgaa atcaaccgct caaccctgtg aaggcggcta ccggctcaac
     1441 ggaaacaaaa ttttcatcac caacgcgccg attgccgaca tcttcatcgt ctatgcgaaa
     1501 acccatcccg aacatggctt tatgggcgtg tccgcatttg tgctcgagaa agggatgcca
     1561 ggcttaaacg taggcgccgt cagcccgaaa gattgcctct ccaactgccc gtggagcgaa
     1621 ctgaccttca acgacgtctt cattccagag acccaacgga tcggtatgcc gggcgccggc
     1681 ggcgccatct tccacgattc aatgatctgg gaaaagggct gcctgtcggc tctgtttatc
     1741 ggcgcaatgg agcgcgtgtt cgacagcgcg ctggactatg ccaaacaacg ccgacaattc
     1801 ggcaaagcga tcggccaatt tcagtccgtc tccaaccgca tcatcgatat gaaactgcgt
     1861 ctggaacagt gtcggctaat gctctaccgc gcctgttgga aacacgatcg gggccaggat
     1921 gccgagatcg acatcgccat gagcaaactg ttgatttccg aatatgccgt gcagtccgcg
     1981 ctggacgcga ttcaaatctt cggcggagcc ggcatggatc aagaactcgg tctggtgcgc
     2041 cacttgctga acgtgatccc cagccggatc ttctccggca ccaacgagat acaaaaagaa
     2101 attgtcgccc gcaagctggg tctgcgggga ggcgcatgat gatcgttcaa cgcgtttttg
     2161 ccgtgctcta tatgttggcc ggcctggcga aagccttccc tcagttggaa aacgtcgccg
     2221 atattctgca gcaggcggcc gtggcgaacc agggcacctg gtacgccggg gcgacggctt
     2281 ggttggcggc gcaaggtaca gtggttaacg cgctgatcgg cgtggcgctg tttgcctccg
     2341 gtgcggtctt gatgttcaac ccgcgttgga cgccattgat catctactgc cagctgctga
     2401 tgatggcggg atttgtcacg atcctgcacc gcgcccagcc gcaggtcatg ttgctcgatg
     2461 cgattttcgc gctggcggcg ctgtacatgc tgcgtcagca gcaccaccgc aaacccaagc
     2521 cgcgcacgtt ccccacgcgc gacttttcca cgcccacgcc ggcggcaggc ggcccggtaa
     2581 cccccgcgct ggacggcgag tatgacgtgg tgatcatcgg cggcggcgtc tccggtttgg
     2641 ccgcggccag cgaactgacc gatcgccggg ttttggtgct ggaaaaaagc gcctccttcg
     2701 gcggcaacgc ccgctacagt acggtgaacc gcctgaaatt tcctatcgcc ggcgtctgct
     2761 tccaggaacc gctgccgaat tctttcatgg cgcaactgct gaagaaaatc ggtctgagcg
     2821 gcgtatataa atccaatgaa aaggacacgc tggtattttt cgacaccttc ttgctgctcc
     2881 gctgcctggg tgaagtcgtc gtcggtttta tcaaacaacc ggtctacctg cttaaacccg
     2941 ccgtctggcg cctgacggga caactattcc tgcatgcctt gatcggtaaa ccttatgtta
     3001 tcgcggcaaa acagctgggc gatccgatct ttgccgatct gtacgccttc ctggatacct
     3061 tctcgccgcg cggcgagcgc taccccagcc tgccctggac gccgcagagc gcctggagca
     3121 aaacgaatat ggcgctgctc gacactatcc cgctgtacac gtatctgttc gaaccgcaca
     3181 aactggatca gatcccgacg gatctgcggc caccgagaaa attcggcaag ctggtagaga
     3241 atgccgtcag caccacgctg cgcgtggaat gtctcgatat tcgcgaagtc tccgcctatg
     3301 tcggattgca cttcctggtg gggtatttac gcggcaatct ggtcacgctg ccgggcggta
     3361 acggcagcat cagcgccggg ctgctcgact atcttgagga gcaaaacaac gtcaggctgc
     3421 aaagccgcgt acagcttcaa agcatcacgc ccggcggcga cgaaacggtg atccggttca
     3481 gcgtcaatgg cgcggccagc gaaatcagag ccaaacaagt gatctgggcc gcccccaaaa
     3541 cgcatgtgcc cacctggttg cccaccctgc ccaaagagca attggcggcg atccgccaga
     3601 tccgccatga agattactac ctggcgaacg tgctgttgaa aaaaccgatc ctcgaacgct
     3661 cgttcggcgg ctatctgatc gagccggaaa acacccgcac accttactat tggagcaaag
     3721 ccggcacctg cctggtcgcc aattggatgg acaatcacct cagcgcggaa gccggggtat
     3781 taaccctgct caaaccaacc actcgtccag aacggcaagg tcgcaccgcg caaaacgagt
     3841 tcccggcgct gcagcaacag acctatgtcg aaatcgccaa agtgctgggc aacatgggca
     3901 ttgacgccga cgtcattgaa gacattcaaa tctggttctg gcccgcgggt ctggtgacct
     3961 cggtcgccgg gcaacaggcc cagggcgtgt ttcaccaggc cagcaggccg tttgagaata
     4021 ttcacttcgc caatcaggac agcgtgggca tcggtaatat cgaaagcgcg gtgttagccg
     4081 gactgaacgc cgccaaagcg gtgagagaac gcctcgcaat gcccgttacg tctgcggagg
     4141 tgatgtcatg aatcctaccc tggtggttga actttccggc gataaaacgc tggaacccca
     4201 tcgtctgggc ggcaaagccc attcgttgaa tcatttgatt cacgcgggct tgccggtgcc
     4261 gccggcgttt tgcatcaccg cgcaggctta ccggcagttt atcgaattcg ccgtgccggg
     4321 agcgctgctc gacacgggcg caccgggcaa cgtgcgcgat atgattttga gcgccgccat
     4381 ccccgccccg ctcgatctgg cgatccgtca cgcctgcaaa cagttgggcg acggcgcctc
     4441 gctcgccgtg cgctcttcgg cgctggaaga agacggcctg acccactctt tcgccgggca
     4501 atacgacact tacctgcacg tgcgcgggga tgacgaggtg gtgcgcaagg tgcaatcctg
     4561 ctgggcgtcg ctctgggcgg aacgcgccgc ccagtatagc cggacatcgg cggcgcagag
     4621 cgatatcgcc gtcgtcttgc aaatcatggt ggatgcagac gccgccggcg tcatgtttac
     4681 ccaagatccg ctgacaggcg atgccaacca catcgtcatc gacagctgct gggggctggg
     4741 ggaaggcgtg gtctccggac aagtcaccac cgacagcttc attttggata aggcgagcgg
     4801 cgagatccgc gagcggcaaa ttcgtcacaa accgcactat tgccaacgcg atccgcaggg
     4861 acgggtcacg ctgctgcaaa cgcccgaagc caggcgagac gcccccagct taaccccgga
     4921 acagctgcaa cagcttgcca ggctggcccg gcaaacgcgg atgatttacg gcgcggaact
     4981 ggatatcgaa tgggcggtga aagacgatcg cgtgtggctc ctgcaggcgc ggccgatcac
     5041 cacgcaggcc aaaccggttc agatgcttta cgccaacccg tgggaaagcg atccgacgat
     5101 caaggaacgg gcctttttct cccgaatgga caccggcgag atcgtcaccg gcttgatgac
     5161 gccgctgggg ctgtcgtttt gccagttcta ccaaaagcat attcatggcc cggcgatcaa
     5221 aaccatgggg ctggcggata tcggcgattg gcagatttat atggggtatt tgcaaggcta
     5281 cgtctatctg aatatctccg gatcggccta catgctccga caatgcccgc ccacccgcga
     5341 cgaaatgaag ttcacgaccc ggtacgccac cgccgatatc gatttcagcg ggtacaaaaa
     5401 cccctatggc cccggcgtac agggatgggc ttatctcaag agcgcctggc attggctgaa
     5461 acagcagagg cataacctgc gcagcgccgg cgcgaccgtc gatgccatga tcgccctgcg
     5521 ccagcgcgag acgcgccgct ttctggcgct ggatctgacg accatgacac atcaggaact
     5581 ggagcgagaa ctcagccgca tcgacggtta cttcctcgac agctgcgccg cctatatgcc
     5641 cttcttcctt cagtcgttcg cgctctacga tgcgctggcg ctgacctgcg aacgttatct
     5701 caaaggccgc ggcaacggat tgcaaaatcg catcaaggcg tcgatgaaca acctgcgcac
     5761 catcgaagtc acgctgggca ttctcagcct ggtggagacg gtcaatcgtc aaccggcgtt
     5821 gaaggccctg ttcgagcgac acagcgcaca ggaactggtc accgtcctgc ccaccgatcc
     5881 cgaatcgcgc gccttctggc aaagcgactt cagcgccttc ctgttcgagt tcggcgcccg
     5941 tggccgccag gagttcgaat tgagtcttcc gcgctggaac gacgatccca gctacctgct
     6001 gcaagtgatg aaaatgtatc tgcaacatcc ggtggatctg cacacgaaac tgcgggaaac
     6061 agagcggctg cgccatgaag acagcgcggc gctgcttaaa gcgatgccct ggtttggccg
     6121 gatgaagctg aagttcatca ccaaactgta tggcgtgatg gccgaacgcc gcgaagcgac
     6181 ccggccaacc ttcgtcaccg aaacctggtt ctaccgccgc atcatgttgg aagtgctgcg
     6241 gcgcctggag gcgcaaggcc tggtcaaatc ggccgatctg ccctatgtgg acttcgagcg
     6301 cttccgcgcg tttatggcgg gggaacagtc ggcgcaggaa gcgttcgccg ccgatctgat
     6361 cgagcgcaat cgccaccagc atctgctgaa cctgcatgcg gaagagccgc cgatggcgat
     6421 cgtcgggggg tatcagccca ggatgaaagc ccccacggcg gaaaacgccg ccggcatgct
     6481 gtccggcctg gcggccagcc ccggcaaagt ggtggcgaaa gcgcgcgtca tcaccgatct
     6541 gctggcgcag gccggcgagc tgcagcccaa cgaaatcctg gtggcgcgct ttaccgacgc
     6601 cagctggacc ccgctcttcg cgctggcggc gggcatcgtc accgatatcg gctctgcgct
     6661 gtcccacagc tgcatcgtcg cacgcgaatt cggcattccc gcggcggtca atctcaagaa
     6721 cgccacccag ttgatcaaca gcggcgacac cttgattctc gacggcgaca gcgggacggt
     6781 cattattcaa cgcggagaac gtgccgatgg ctagtcagca ccacatccgg cgaaggtaaa
     6841 ccatccgcct gaacacagca caattcaacg aaggtgatgc gcgcggcaac cgccgcctgc
     6901 agagaccgtc gcgggctttg tcgtgccgaa tttgcccgcc tggctgaagc cgtcactcca
     6961 ttttggctgc acaaggaact catcatgacg accctgacag gacaagcaag actcaccaac
     7021 tccgccgcct acgagcaagt gtggcaagcg gagcgccagg cctgccgcac cgacgcggat
     7081 cccgacaccc tgacggtcgg cgtggtggtg gtgacgcgca acccggcgtt tttccaaacc
     7141 gggcttagcg tactgaacga tatccgcgat tatgttttca accgcgtgca tatccagtcc
     7201 gagatgccgc tgaaactgtt ggatctggcg gcggactcgc tttatctggc cgcgcgcgaa
     7261 aaggcgctgc actttctcaa aggccaaaac aaggctatca acgttcgcat catccaatgc
     7321 gccagcctgg ccgaggccac cggcaagatc atctatacgc atgcgctgga acagcgtccc
     7381 gaatttcatt tgggcatgct gttctacgat cagaccacgc cggccggcgt cgatgacagc
     7441 atcgaacaga tcgatcgcga tctggacgcc ttttacagcg ccttgcagcg cagcggcatt
     7501 cccgcgtttt acaccacctt ctccaccgtt gcgttcattc gccagctgcg atcgcccttc
     7561 cgctacctgc cgcagcaata ccgcgaaatc gtgcgcagcg aagatccggc gatcttccaa
     7621 accgagctgt tgtgcctgtg gatggacttc ttcgagatga actacaccaa ccgccgggtc
     7681 aagccgatcg gcgcgctggc gctgcacaac acgctgggtg agcagctgat tcaatttttc
     7741 gagcgtaccg ccgccgaacg ctggctggtg tcctattaca ccgggtcgat catctccaat
     7801 ctgatcggct atctggatcg gcatgcggag gcgcgcggcg cgctgatcct gcgcggccct
     7861 aacgaacacg ccatcgcctg cggcgccatg gccaactggc agctgtatcg catgccgttc
     7921 ctcggcgtag tgacctccgg gatgatggat gaattcaagg gcacgctggc caacctcaag
     7981 gaaaccgccg cccagggcat catcgtcgcg gcggaaaacc gcggcaatca atggtacagc
     8041 ttccagggaa cgctgacgcc gacggaggac atgcgcgaag tgcttatcgc ccgccgcatc
     8101 ccgttcgttt atatcgatga cgtcgaaatg atcggcgccg gtttgacgga agccttccgc
     8161 ctttatcatc aaggccaggg gccagtggtg attctggcga cgcaaaacgt gctggagtcg
     8221 accctgtcgc tggagggcgc cgtctgcgat ccctcgccga tcccggttct gtcggcggac
     8281 gatccgctgc cgatgagcga aagcctggca caggcgatag cgctgatcaa ccgcgggccg
     8341 gaacggttgg tgtggcagtt gggcccggtc agcgacgacg aatacgccct gatccatgac
     8401 atcgccgacg ccgccggcat cgccctggtg gactcgttgg cccatcccgg ctcggcgccg
     8461 aaatattatc agggccggcg caatccccac tacctgggca ccctggcgat ttacggctat
     8521 agcccgcgcg tctacaactt cctgcacacc aatgacaagc tcaacgccat gagcgagcag
     8581 agcctgttta tgatcaaaag ccgcgtcgct cagatcacca cccccttctc cgacggcagg
     8641 ctggagcgca aggttcatct ggtgcagctc acgcacgatg accgccatct gtcggcctat
     8701 gccgatctgc acctgcacat gaactgtctg gcgttcctgc gcacggtgaa agcgcatctc
     8761 gacgtcgatc cggcattgcg ggaaagacgc cgcgcgttga tcgccgccta tctcgattcg
     8821 ccttccgacg tggtcagcca gcttcccagt ctgcccatgt cggccaacta cttcttctgc
     8881 cagttgaacc gagtgattga agagttgatc gaaacggagg gcttcgattt taccggcgta
     8941 tatgacgtcg gccggtgcgg catctccgcc gcgcgcaacg tcgccaaaac gcgccgcggc
     9001 ttttccggct ggtatggccg cgccctgatg ggcgacgctc tgctggccac cggctacctg
     9061 gcttacacca gcccaagcca cgtgatggcg tttatcggcg acggcgctaa agggatcgta
     9121 ccggacatcc tgccggcttt tatcgacaac attctcaccc atccgcagtt gctgaataaa
     9181 agcatcaccg tcttctattt atgcaacggc ggtctgtccg tcatcaatac ctatcaggaa
     9241 cgcattctgt tcaatcgcac ctcgcggcaa atgcggttgg tgaacgtcga acagccggac
     9301 gtcgaacaaa cggtcaataa cttccatatc cagagcaaaa cgcttacgca tttcgacgaa
     9361 gacgtcattc gccaggcgct gaccacctcg caccgactca atctgttctc cgtggtgctg
     9421 gggcacaaca atgaaggcga cggtatctcg cctggccacc gccaaaggct ggcagcgctg
     9481 atccgagcag accacgacgc cctgcaggag cgcaaagcct gggcagccca acagcccgaa
     9541 tcgaccagca ccgccttcga ccaagatcct acacaggaag ccacctcatg aaattcggat
     9601 tcatcgctca tcccacctcg ctggggttga aacgttacgt taaaatgctc gatctgctgc
     9661 aacgcaactc gaccgagcag cacagcggct atacgcgtga actgtgggaa cgacaaaacc
     9721 tggttccctt tatgaacttc gccaggatca cctcggcgac cggcgccact tgcgaagggg
     9781 tgatcaaata catgccgctg gtggcggatg agatgctggc cgacgcacgc ggtatcgccg
     9841 ccagggtggt ccaaggtatc gaagagctgg ccggcgatgg cgccgaactg gtcggtctcg
     9901 gcggtttaac ctctatcgtt gggcgacgcg gcgaagccac cgcggaaaag tcgccggtgc
     9961 cggtcacctc cggcaactcg ctgaccacct acgccggcta caaggccttg atgcagatcc
    10021 agtcctggct ggaaattagc ccggaggagg aacccgtcgc catcgtcggc tatccggggt
    10081 cgatctgcct ggcgctaagc cgtctgctgc tggcgcacgg tttctctctc catttgctgc
    10141 accgcgccgg caaccatgat cgcagcgaac tgctcagcca tttgcccgag gagtatcact
    10201 cgcgcgtcac cctgaccagc gatcccgaag atctctaccc gcgctgcaaa ctgtttgccg
    10261 ccgcgacctc cgccggcggc gtgatcgacc ccgccagact gcaacccggt tcgatcttca
    10321 tcgacgtggc gctgccgcgc gatatcgctt cggaaacgcg cccggcgcgg gatgacattc
    10381 tgatcatcga cggcggctgc gtcaccgcca ccgatgcggt caagttgggt ggagaatcgc
    10441 tcaacgtcac catcaagcaa caattgaacg gctgcatggc ggaaaccatt gtgctggcgc
    10501 tggagaaccg gcgggaaaac ttttcgctgg gccgctatct ggcgccggaa aaagtgctgg
    10561 agatcggtga aatcgccgag cgccacgggt tcttcgccta tccgctggcc tcgtacggcg
    10621 agcgcatcga tcggcagagc gtgaccaatc tcaagcgcta ctaccaccat gacatctatg
    10681 ccggggaacc ggctgatgcg gcgctgcccg catcgcgcct ggcgtttatc gatgcggtca
    10741 tcgcccaaac gccggccagg gaagacaccc tcgaccgcta tcatcaatac atcaacccca
    10801 tgatggtgga cttcctcaag ttgcagcgct gcgacaacgt tttccgcagc gccgccggca
    10861 cccagttgta tgacgatgcg ggcgaggctt tcctggacat ggtggcgggc tacgggtgcc
    10921 taaacctggg ccacaacccg cagccagtgg tcaacgcgct gaaaaactac ctcgacgctc
    10981 aaggccccaa cttcattcaa tacatttcca ttcccgaaca gaccgccaag ctggccgaag
    11041 tgctctgtcg tctggcgcca ggcaacatgg gccgggtgtt cttcagcaac tccggcaccg
    11101 aagccgtcga ggccgcgatg aagatcgcca aggcctcgac gggcaagccg ggcatcgcct
    11161 atctgcgcaa cagttaccac ggtaaaacgc tgggcgcgtt gtccatcacc ggacgagaca
    11221 aacaccgccg ctatttcaca ccgctgctgg acgcgatggt ggaagtgccg ttcggcgatc
    11281 tcgccgcgct gcgggaagcg ctgaaccgtg aagacgtcgg cgcgctgatg atcgaaccga
    11341 tccagggcga aggcggcgtg catatcccgc ccgccggtta cctgcaggcg gtgcagcagc
    11401 tctgccgcga gaccggcgtg ctgctgatgg tggacgaagt gcaaaccggg cttgggcgca
    11461 ccggcaaact tttcgcctgc gaatgggacg gtatcgagcc ggacgtgctg atgctgtcga
    11521 aatccctgtc cggcggcctg atccccatcg gcgccacgct gtgccgaacc gagctttggc
    11581 aaaaagccta tggcacggcg gaccgcttcc tggtgcacag ctccacctac ggcggcggca
    11641 acctcgcctc ggtcgtcgcc ctcagcgcgc tgcgcgagat cctggcgcag gatttggtcg
    11701 gccatgccga acggatgggc gcctacttta agcaggcact gagcgagatc gccgcccgct
    11761 atccgttcgt cagcgaagtg cgcggccgcg gcctgatgct ggggatccag ttcgatcagg
    11821 cgttcaccgg cgcggtcaac gcctccgccc gcgaattcgc cacccggctg ccgggcgatt
    11881 ggcacaccac ctggaaattc ttgcccgatc cggtgcaagc ccatctgcgg gcggcgatgg
    11941 atcgcatgga acaggcgctc ggcgaaatgt tctgcatgaa attcgtcacc aagctgtgcc
    12001 aggaccacaa gatcctgacc ttcattaccg ccaacagctc gacggtgatc cgtattcaac
    12061 ccccgctcat catcagcaaa gccgagatcg accgtttcgt cggcgccttt gccacggtgt
    12121 gcgaggaact ctccaccttt ttagactagg gagccagcaa tgcctttaac caagcaagat
    12181 gccgtcaatc agatgatggg ctttttccag gccaaggcgc tgaccgccgc gcttgcgctg
    12241 aagctgttcg atcagctgcg cgatcgggac gccgacgcgg cgcacatcgc cgcgcggctt
    12301 gactgcccgg cgcgttccac cgagcagttg ctcatcgcgc tgcgggccat ggggtatctc
    12361 gaccaacgag acggccttta tcatttgccc gccgcccacc gggcttttct gttgagcgac
    12421 gaaccccagt ggctgggatg gctgggccgc cacatcgata ccttcctgta tccgctatgg
    12481 ggcgagctga aaacggcggt gcgaaacgat gcccaccagc gccgcacggt attcggcgat
    12541 gaccgcagtt ggttcgacat cctgtaccaa aatccggacg acgtggcgga cttccaggaa
    12601 tttctcggta aattcgccgc gccctttatc gccggctttg ttcgcgatta cgacttctcg
    12661 caacaccgtg cgtttttgga catcggcagc gggatcggca gcctgccgat ggcgatcgcc
    12721 gacgcttatc cggggatcgc actcgcgatc tgcgaactgc cgcaggcctc ggcgttcttg
    12781 cgcgacaagc tgacgctgca aggctatggc gaacgcattg acgtcgtgga gggcgatgtc
    12841 atcagcggcg atctgccgat cggcggctat gacctgatcc acctgggatg gatgctgcac
    12901 gactacgccc cggaaaccca actgaccatc ctgcgcaaca tctatcgggc gatgccggcc
    12961 ggcggccgct tcatcgcttc cgaaacgccg ctgaacgaag acaaatcagg gccggaattt
    13021 accgccctgc tgtcgctgaa catgctggtc tccaccgacg gcggcataga gagcagcgcg
    13081 caggaatacc tggacagatt ccgtctggcg ggattcagca acgcgcgcat catgaaaata
    13141 gccggcccac gcaccctgat cgtcggcgaa aaataaccag ttagcaacgg gagctcgcaa
    13201 tgttagaaag caaattgatc cagcatatcg ccacccagta tctggatggc gatcacgacg
    13261 gcctgaacgc tcaaaccccg ttgtttgaac tgaacgtcgt cgattccgcc tccattttcg
    13321 atctggtgga ttttctgcgt caggagtctc atgtcgccat cggcatgcat gagatccatc
    13381 cggcgaactt cgcctcggtg caggcgatgg ttgcgctggt gcaacggttg caagcgcaag
    13441 tcgccgcagg gggtgtcgca tgagcgttca cgccgtcgat agcgccgcaa acgcgcatga
    13501 agccgtccgg cagtcggtgc tgcacacctt cgcccggctg accgagtatg aaccgtcggc
    13561 actggccctg accagccatc tggaaaacga tttgggcgtc gactccatcg cgctggcgga
    13621 aattgccatg gtgctgaacc gtcagttcca attaaatacg ccgctggcga tccaggagat
    13681 caaaaccatt caggatgcgc tcgacggtat tttgcagcgc ggtttcacgc tgccgacgcc
    13741 gaacgccgcc gcgcaacctg ccccccagac gcctcaggcc tggttgagcg ctctcgttcg
    13801 ccaggtgttc gccacccaca gcggatatga agtgcgtgat ctgtcccccg acgccgccat
    13861 cgaaggcgac ctgggcatcg actccgtagc ggtggtgatg gcgcgcaacg agttgctcaa
    13921 aacgctgggc ctggacgata acgcagcgct ggcggagtgc cgcacgctgg ctgagctgga
    13981 gcacaacctg gcggcgcggc tggttcagga acagggcgaa gcgtggttca gccgctttgg
    14041 ccagcacacc accgcgtccg ccgcgccgca gcccaccaag gcgcccgcat cgccggacgc
    14101 gcgcgatgag ctcggcgatc cgcgcaccat gcgggacttc gtcggcatcg agcacccgga
    14161 tttgttccat aaaacgcgtg aattcggcgc tttttatcgc gataaaaaac agcgtcagct
    14221 ttactggtac ggcatgccgc ttgaaacgcc gtgcaaaaac cgcgcggtca tgttcgacga
    14281 ggtcaccggc aaaagccgcg aatttctgat gttcggctcc aacagctatc tgggattgtc
    14341 gaaccatccg gaagtgatcc acgccatcca ggacgccgct ggcctgtacg gcgccaccaa
    14401 caccgggtgc cgcatcatcg ccggcagcaa cgtgctgcat ctggaattgg agcgcaaact
    14461 ggccaagctc aaagggcgcg aagactgcat cgtctatccg tccggctact cggccaacct
    14521 gggatgcatc tcggctctga ccagccgaca cgacctggtg ttcaccgacg ccatcaacca
    14581 catgagcatc caggacggct gcaagttggc gggcgcgcag cggaaaattt atgaccactc
    14641 tttgaccagc cttgagaaat cgctggccaa atacgccgat caccccggcg gcaagctgat
    14701 cgtcaccgat ggcgttttca gcatgcacgg cgatatcgtc gatctgccgc gcctgatgaa
    14761 gctggccgaa cgctacggcg cacgcgtatt ggtcgacgac gcgcacgcga ccggcgtctt
    14821 gggcaaaacc ggctcgggca cggcggaaca cttcaatatg aaaggccagg tggatctcga
    14881 actgggcacc atgagcaagg cgctgtcggg gttaggcggc ttcgtttgcg ccgatggtga
    14941 agtggtcgaa tacctgcgtt tctactccaa ctcctatgtt ttcgccgcca ccatccccgc
    15001 cgcagtcgcc gccggcgtga tcgcctccat cgacgtgatg ctgcgtgaac ccgagcgact
    15061 gaccaagctg tgggacaaca tctactactt ccgcacgctg ctgcttaacg ccggttttga
    15121 ccttgagcat tccgactcgg ccatcattcc ggtggtggtg ggcgacgacg ccaaaacgct
    15181 gctgttcggc cgcgccgtcc gggcgcgcgg gctattctgc cagaccgtgg tcttcccggg
    15241 cgtcagcgtg ggtgacgccc gcttacgcat cagcgtgacc agtgaacaca cgcgtgaaga
    15301 tctggatgaa gccaacgcca ttttggtggc ggcggcgctg gagaccggcg tgccggtcaa
    15361 cggcgatgtt cgacgggaag agcgcgcacg cgccaccgag gtctgacatc atggcaacct
    15421 tcatttcacc gatactggag gccctgttcc ggcacgcccg ccaagcgccg gaaagcaccg
    15481 ctctgctgtg cggcgatcgg cgctggagct atcgtcgcct ggccgatcgc gcctgcatga
    15541 tggcggcggc gctgcgacat gccgggttga agcagcaggc cgtgctgctc aacctgcaga
    15601 aagggcccga cgccgtcgcc gccatgtacg cgtgttggct gagcggcaac cactatgtcc
    15661 ctatcgattt cagccaaccg acggcgcgca tcgaacgcat tatcgccgcc gcctcacccg
    15721 cgctgatcgt cgatgagggc tggttgagcg cgctcgatga ccgcaccgat ctcgatggcg
    15781 cctggccgga agcgatcgcc gcgttcggct ctcccctcgc cgccattctc tatacttcag
    15841 gctccacagg caccccgaaa ggggtgcaaa tcacccatga catgctgacg tttttcatcg
    15901 gctgggccgt cagcgataca caactgacgg cgcgcgacgt actggccaac catgccagtt
    15961 tcgcctttga tctgagcacc ttcgatctgt tcgccggcgt ttgtgccggc gccgcgacct
    16021 ggatcgtgcg cgaagatgaa cagaaagatt gccaggctct cgttcgcgga ttgcaaacgc
    16081 acggcgtcac cctgtggtat agcgtgcctt cgattttagc catgctggaa aagagcgcgt
    16141 tgctggcgcc gtcgacggtg aaaacgctgc gccaggtcac gttcgccgga gagccttatc
    16201 cggccgccgc gctgaggcgc ctggttgcgc atctgccggc ccgctgccgc gtcagcaact
    16261 ggtatggccc gacggaaacc aatgtctgca ccgcctacgc gctggatcga acgcagttgg
    16321 cgacgctgga gcagatcccc atcggccatc cgctgcccgg cttgacggcg cagttggtcg
    16381 atgagcaggg gcgttgcaga cgattgacgt cgccgggccg acgcggagaa ttgctgatcg
    16441 gcgggccgtg cgttaccccc ggctacagca acgtcgcctc atcgcggcaa gcgcaatggc
    16501 atccgcgcca atgccacgcg accggcgact gggtggagac gacggcgaat gggctggtct
    16561 atcgcggccg gctggacgac atggtgaaaa tcaacggcta ccgggtggaa ttgggggaga
    16621 tagaatcgat ccttcatcac catccctcgg tctgccaggc cgcactgtat gtcgagcttg
    16681 gcgagctgaa gcaaaaactg atcgccgtga tcacccttca tcccggcgcg ctccgcccca
    16741 acctgctgga gctcaagcag ttcctgcagc ccaggctgcc cgcctatatg ctccccagcc
    16801 aactggtggt cgccgacagc ctgcccacca acgcgaacgg caaggtggac agaggacgtt
    16861 tgtccgaggt gaatgcgcga tgaaccagga aattcatgcc gcgccgctgg cgctggtcgg
    16921 catcggctgc gcactgcccg gcatcgatcg tatcgatctg tccaacggcg ccgcctggtc
    16981 ggcgctgttc gacgccccgc cgccgatgcc gtggagcgat gcggccgcgc cgatccgcgg
    17041 ccgccagatc gacgacgccg cgtttgattt caaaaaattc gccatcccgc cgctgtttcg
    17101 actggcggtc agccgcgaga cccgcctggc gctgcaggcc gcctccgccg ccatgcagca
    17161 tctgacgtta tccgacgcgt tgcgcgaccg ctgcgatcaa ttttgcgcca cccatttggg
    17221 cagtgatgcc gcctatcgca acgccaccaa aatcggcgcg ctgcgcaggc tggccgaacg
    17281 gcttgacgct caggggctct caccggcggc ggtcatgcgc cggattgacg attacaaaca
    17341 gccgctggcc caggcgttcg gcagttcatc ccacgatcgc gtgggggaaa tggcctccag
    17401 cattcccgcg cgcatcgccc atttcgcccg cacgcgcggt aaatgccaaa ccctcgacgg
    17461 cgccgatctg ggcggcctgc gcttgctgca gctggcacaa gactgttttc gccatgccga
    17521 cagccgcatg gcggtgctga ccgccgtaca atgcttccac catcaacctc aggcggacat
    17581 gctgttggcg cagggcgttt cctcttcggc ctgttggctg gagggcgcga tcagcctggt
    17641 cgtttgcccg ctggacgtcg ctcaggaaca gggatggcca gcgatcgcgc aattgtcgac
    17701 cctgatcgcc gaacggcagg atgccgcgcc gagcgccggc tattttgccg gcgccaatca
    17761 ggttttctgc catctcctcg acatgctgtt gcaacggcaa caggcgtgcg ccggccactc
    17821 gttcaccggc taccgctggc ggatcgacgc ggcgtccccc ccctcattaa aaccgacggc
    17881 ttcgccacgc atcagcatca tcgactatca gcccatcacc gcgcaggggc tggataaagc
    17941 gcgtttctgg caggccttgc gcaacgggga ggacgccctg cgcgatcaca gccccgagca
    18001 gctgcacccc ggcgccttcg tgcgccccac gccgcaaaag ctcagcgcct acaccgctca
    18061 cgccatgtgc ttcccaacgc acgatccggt gcagcttgag ctgacgcggc ctatgatgcc
    18121 ggccaaaaaa cagcgcctcg acgtcacaca actgcacgcc ctcaacggct gcgcggcgtg
    18181 gcccgacagc ctgcgacgct ttgaacgcat cgccattatc gtcgccagca acctgtcttt
    18241 aagcgccgat cgacaacagg ccatgcgcgc cctgtggccg gcgttgcctc ccgccggcgt
    18301 ctccctttcg ccaccgcccc aacccgcgat caaccgctgg agctggcatg gcgcctgcgg
    18361 cctcggcacc gcgcagctgt tggcgcaaca gctcggcgtc gaggcggact gctacgcggt
    18421 cgaggcggcc tgcgccagtt cgctggccgc cttgcacaat gcggtcaggg cgttacaggc
    18481 cggccgctac gatgcggtgc tcgtcggcgg catagaaacg gcgacgctcg aacgcgatat
    18541 ggtgctgtgc agcgcgcaga tgatgctttc cgcttcgcgt atgcgacctt tcgcccgaca
    18601 agccgacggt tttactcccg gcgacggtgg cggcttcttc attctgaccg gccaggcgac
    18661 atcgcgggcc atcgccacca tcgaagcgat atcgggatct tgcgacagct attccatgac
    18721 cgcgcccgat cccgagggcc aggcgttggc aatcgaaaaa acccagagcc tgagcgccgt
    18781 cgaagcgcgc cagatacagt atctcgaagc gcacggcacc ggcaccgaac tgggcgatcg
    18841 ggcagaagtc gcgtcattgc atcaggggta tcgccgcgcc gcgcgcgccc ctttgtacat
    18901 cggttcggtg aagtacaact tcggccactg tttcgccggc gccggcgcgc tcagcctgtg
    18961 caaagtgctg agcgctttcg aacacggtca aatcccgccc acgccggtgg cgacattgaa
    19021 tgccgaactg ccgctggcgg cgatcccggc cgaaatcccg caagtcgcgc tcgactggcc
    19081 acacggtgaa ggcggacgtc gggcggcgat caacggcttt ggcaccggtg gcatcaatta
    19141 ccatttgctt atccatcaac ccgtttaaaa aggccgccca gatgcacatt atcgtccata
    19201 agattcggct aaaagacatc gcccaccgcg ccgcgtttcg cgactgggtg gagacgaccg
    19261 attaccaggc ttgccgccac ctcgacgcgg tacgcgcctt cgatgtcatc gaagtcagcc
    19321 cttcggcgga ggcgccgttt cactttatcg aaatcattca gctgaactcg ctgaaaatgt
    19381 tcgagcgcga gatgcaaacc ccgctgtttc aaagcctggt tgaacgcttt aatcagttgg
    19441 cggaagtcgt tgacgaaatc agcggagaac gcatcgccga tggttatcga gcttagcgtg
    19501 acgccgcgta tcgtcatcgc cctgggcggc gcccaccgct gcgccgccgt tcggggattg
    19561 cggcctctgt cggcggtgaa aaacctcgcg cgggcgcagg ccgtcgcgct gctgaaccgg
    19621 acatggtgcc aggggcacgc gaccggcttt acgctgcgcc atgaggcgag tggacaaccg
    19681 ttcggcgaac acctcctgct gggacgccgc cacgtttccc tcagccattc gcttgcctgg
    19741 tacgccagcg ccaccggcga tatcccgctc ggcatcgatc tgcagcatta tcgccccttc
    19801 tccggcgcgg cgctgcgctg ggcctttagc gaggcggaac agcgattggg acacatacag
    19861 gcctgcgccg tctgggccat tcgcgaagca tttttaaaaa gccacggccg cggtttgccc
    19921 tacgaattgc ggacgatcgg catcgactgg cgcaccgggt tggtctcaag cgccgacggc
    19981 agtttggcga gcagacgctt ctggctgtgg cgcagcctgg actggacatg cgcactctgc
    20041 tttccggcgg aggagagcat gtcgttcaga gcgaacgtta ccgtattttc cctgcccgcc
    20101 ccttccgctt tcggagcctt atcatgaccc aagacctttt cgccgcggcg ctgcaacagg
    20161 ccgtggacat cgcgcggcag gcgccctctt cacacaactg tcaaccctgg tctctccact
    20221 atgacgccga cgctcgatgt ggccggttgg ctatcgaccg ccgtcgcgcc ttgcagagcc
    20281 tgccttcgct ggaacgcgag atgctgatga gctgcgggat tttcttcgag tacctcagcg
    20341 cgctgctcaa ctgtgcaggc tcgcctctcg cctggcgttg ggagaatggc cccacgcatt
    20401 tactgagctt tgcccccgcc gcgcctgccg cgcccgatcg cgccgcccat cgccaattgg
    20461 cgcagctgat cggcgagcgg cataccgcac gggcggccta tcagcctacg ccaatcaatg
    20521 aagcgcagcg gatgcagctg cagaccttgt tcgacggaac ggcgagttca ctcagtatcg
    20581 caggtgacga acgcgctcgc cgtcgggtcg cgcagctcac cgctcgtcac gccgcgctcg
    20641 atttctcgga tcgccaagcc tggcgggaaa cctatcaata catccgcttc aacgaacggc
    20701 agcctaccga cgacggtttt cacctgcacc acctgtttgg cccggtatcc ccagcattca
    20761 agcgcttctt tcaagtggcg tttcatcctc gcttaagccg gctggcgacc gggctgcgcc
    20821 tgccggctta tatggcgcaa ggactggcgc aacgcgtcgc ggaaggcccg caatacctgg
    20881 cgctgtgtct gaacgacgaa agtgccgagc acctgttcgc caccggcatg cggcttgggc
    20941 gtctgtggct cacgctgcaa cactggggtt ggggattgca tccgatcagc gttctggtgc
    21001 aacacgccga ggcgcgtcgc gagctcgcag caaccctggc gctcagcgct cccccggtgt
    21061 tttttgcccg cttcggccac ctgcaacaat ggggcagcgc agcgcccaga cgcagttggc
    21121 aaagcatttt gaccgcgccg ccatccggcg aatgcgcgca ctcggggaac gattccccct
    21181 aatccgctga ggagaacaca atgaatgtat ggattgcttt ggccgttgtt ttgttgatcc
    21241 ttgccctgct ggcgtttatt accagccgcg gcgcccagga cactcgcccg atgttcctgt
    21301 gggggttcaa cgccatgggg ccggttaccc tggtctattg ctatttcggc gagggcgatc
    21361 tgagccacaa agccctgatc cttctcatgg tcggcctgta cctgctgcgc atgaacatcg
    21421 tgctgacacg ttggtacggc aacaccgccg cggccaaact caaggacgtg atgcccacgc
    21481 agcaggtgcc ctggctggcg gtgatgatgg tcatgatctt cggcggcctg tactgcctgc
    21541 ccttttactg ggccagccaa ctgcagggga cgtggggcgc gctgcaatgg ctggccattg
    21601 gggtctacct gataggcacg ctgttccact tcggcagcga ttatcaaaaa cggcgcttca
    21661 aacaggatcc gaacaataaa ggccggttgc tgaacagcgg cttttgggga ttggcgcgcc
    21721 atccgaatta tttcggcgac tttcttattt tcgtcagctt cgggctgctt gccggcaacc
    21781 tgtttggcct gatcgcaccg ctgactaacc tggtgcagta tttcgccgac gccattccca
    21841 aaagcgagaa aatggccgag aagcgctacg gcgaggtctg gcgcaactat aaacgtcagg
    21901 ttaagtgttt cattcctttc gtgctgtaac cccaatgcgg cagcggttcg ggtaagccga
    21961 ccctgaaaac gccttgtcat acaacacaaa acgaccgtca cgcccgcgca agtaaaaacc
    22021 gccttgacct tacccttgct ggaaggttta agctcccttc ttagtgaaaa caggtcaggc
    22081 ggtcaacctt taaacaccgc cttctaagca aggagtccaa tcatgtcaca caccactatg
    22141 ctggcattgc aggggctgtc ctgcatgaac tgcgcgcagc gggtgaaaaa agccctggaa
    22201 agccgcagcg atgtcgaaca ggcggaggtt aacgtccatt acgccaaagt gaccggcgac
    22261 gcaccggaca gcgcgctgat cgacagcgtg atcgccgccg gttatcaggc cgaagtcgcg
    22321 ccgcacgccg ataccgaact gcagctgagc ggcctgagct gcatgcactg cgtcggcacc
    22381 acccgcaagg cgctggaggc ggtgccgggc gtattcgccg ccgacgtcgc tatcgacagc
    22441 gcgaaagtgt atggcgatgc cgatccgcaa acgctgatcg ccgcggtgga agatgccggt
    22501 tatcacgcca gcgtagcggg cgccgccgcc ccaaaaactg agccgttgac tgacgcaaca
    22561 ccttcgttgc cggacgttca gccagcggcg caaccttccc ttccggcaac cgacagcgcg
    22621 gacgacagcg tacagctgct gctcagcggc atgacctgcg ccagctgcgt caataaagtg
    22681 cagttggcgc tgcaaagcgt acccggcgta gagcacgcgc gcgtcaacct ggcggaacgc
    22741 agcgcgctgg tgaccggcgc cgccgatgcg caagcgctgg tggcggcggt ggaaaaagcc
    22801 ggctacggcg ccgagatgat tcaggacgag accgaacgcc gcgagcgcca gcagcagacc
    22861 gcacgcgcca acatgaagcg ctttagctgg caggcggcgc tcggtctggc gttgggtatc
    22921 ccgctgatgg cctgggggct gttcggcggc agcatgacgc tgacgccgga aactcagcgc
    22981 ccctggctgc tggtcggcgt catcaccctg gcggtgatgg tgttcgccgg cgggcacttc
    23041 taccgcaacg cctggcgcgc gctgatgaac ggcagcgcta ccatggacac cctggtggcg
    23101 ctcggcaccg gcgccgcctg gctttattcg atcgccgtca acatttggcc cgatttcttc
    23161 ccgatggcgg cgcgccacct ctattacgag gccagcgcga tgatcatcgg tttgatcaac
    23221 ctcggccatg cgctggagca acgcgcccgt cagcgctctt cacaggcgct ggagcggctg
    23281 ctggatctga cgccgcccac cgcgcgcctg gtgaccgacg acggcgagcg cgatatcccg
    23341 ctggcggagg tgcagctcgg catgacgctg cggctgacca ccggcgatcg cgtgccggtc
    23401 gacggtgaaa tcgagcaggg cgaagtctgg ctcgatgaag cgatgctgac cggcgaagcg
    23461 gtgccgcagc agaaaggccc cggcgatacg gtgcatgccg ggacggtggt cgacgacggc
    23521 agcgtgctgt tccgcgccgc cgccatcggc agccaaacca cgctggcgcg catcatcaaa
    23581 ctggtgcgtc aggcgcagag cagtaaaccg gcgatcggcc aactggccga ccgcgtctcg
    23641 gcggtgttcg tgccggcggt ggtggcgatc gcgctgttca gcgcggcgat gtggtacttc
    23701 ttcggcccgc agccgcagct ggtctatacg ctggtgatcg ccaccacggt gctgatcatc
    23761 gcctgcccgt gcgcattggg cctggcaacg ccgatgtcga tcatctccgg cgtcggccgc
    23821 gcggcggagt tcggcgtgct ggtgcgcgac gccgacgccc tgcagcaggc cagccagctg
    23881 gacaccctgg tgttcgacaa aaccggcacc ctgaccgaag ggaaaccgca ggtggtggag
    23941 atcctcacct tcaatcaggt cagcgaacag caggcgatcg gctgggccgc cgcgctggaa
    24001 caaggctcca accacccgct ggcgcgcgcc atcatggaac gcgccgccgg gcaaacgctg
    24061 ccgcaggtag cgcagttccg caccctgcgc ggcgccggcg tcagcgggga gatcgacggc
    24121 gttcaggtgc tgctgggcaa cgccgcgctg ctggagcagc atcaggtcgc gaccgccgaa
    24181 ctggaagcgc cgatgcgcgc ccaggccgaa cgcggcgtga cgccggtgct tctggccgtg
    24241 gacggtaaac cggccgcgct gttcgccatt cgcgatccgc tgcacgagga cagcgtcgcg
    24301 gcgctgcagc gcctgcacca acaggggtat cagttggtga tgctgaccgg cgacaacccg
    24361 gtaaccgcca acgccatcgc caaagaggcc ggtatcgatc gggtgattgc cggcgtgctg
    24421 ccggacggca aagcggcggc gatcaagcag ctgcaggcgc agggccagcg cgtggcgatg
    24481 gtcggcgacg gcatcaacga cgccccggcg ctggcgcagg ccgacgtggg catcgcgatg
    24541 ggcggcggca gcgacatcgc catcgagacc gccgccatca ccctgatgcg ccacagcctg
    24601 cacggcgtgg cggatgcggt ggaactgtcg aaggccacgc tgcgcaacat gaagcagaac
    24661 ctgttcggcg cctttatcta caatacgctg ggcatcccga tcgccgccgg cgtgctctac
    24721 cctctgaccg gcacgctgct cagcccggtg gtggcgggcg cggcgatggc gctgtcgtcc
    24781 attaccgtgg tcagcaacgc caaccggctg ctgcgtttta aacccaggaa atga
//
