BGC0000261 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000261 (Streptomyces sp. R1128)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	17,200	R1128	PKS	100%

BGC0000261 - Region 1 - T2PKS

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Location: 1 - 17,200 nt. (total: 17,200 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

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TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 17,201
Label		BGC0000261

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000261	1.00	Polyketide	R1128	Streptomyces sp. R1128
BGC0000272	0.28	Polyketide	spore pigment	Streptomyces collinus
BGC0001903	0.25	Other	neocarazostatin A	Streptomyces sp. MA37
BGC0002554	0.25	Alkaloid	carquinostatin A, carquinostatin B	Streptomyces exfoliatus
BGC0001197	0.22	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0000286	0.22	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0001366	0.21	Polyketide	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0000271	0.21	Polyketide	spore pigment	Streptomyces avermitilis
BGC0001513	0.21	Polyketide	anthrabenzoxocinone	Actinobacteria bacterium
BGC0000231	0.21	Polyketide	griseusin A, griseusin B	Streptomyces griseus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000261	1.00	Polyketide	R1128	Streptomyces sp. R1128
BGC0000272	0.61	Polyketide	spore pigment	Streptomyces collinus
BGC0001903	0.58	Other	neocarazostatin A	Streptomyces sp. MA37
BGC0002554	0.58	Alkaloid	carquinostatin A, carquinostatin B	Streptomyces exfoliatus
BGC0001197	0.55	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0000286	0.55	Polyketide	viguiepinol	Streptomyces sp. KO-3988
BGC0001366	0.54	Polyketide	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0000271	0.54	Polyketide	spore pigment	Streptomyces avermitilis
BGC0001513	0.54	Polyketide	anthrabenzoxocinone	Actinobacteria bacterium
BGC0000231	0.54	Polyketide	griseusin A, griseusin B	Streptomyces griseus

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

zhuC

PKS_AT (15..303): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 70.8%; inactive: 58.3%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 68.7
Methoxymalonyl-CoA: 34.7
Methylmalonyl-CoA: 29.6
inactive: 19.5
Isobutyryl-CoA: 12.3
Propionyl-CoA: 12.1
2-Methylbutyryl-CoA: 11.1
CHC-CoA: 9.3
trans-1,2-CPDA: 9.1
fatty_acid: 0.0
Ethylmalonyl-CoA: 0.0
Benzoyl-CoA: 0.0
Acetyl-CoA: 0.0
3-Methylbutyryl-CoA: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 0 to 17200
Starter unit(s):: acetyl-CoA (Score: 335.5; E-value: 0)
propionyl-CoA (Score: 335.5; E-value: 0)
isobutyryl-CoA (Score: 335.5; E-value: 0)
butyryl-CoA (Score: 335.5; E-value: 0)
Malonyl elongations:: 7 (Score: 747.1; E-value: 9.5e-228)
Product molecular weight(s):: acetyl-CoA_7: 321 Da
butyryl-CoA_7: 349 Da
isobutyryl-CoA_7: 349 Da
propionyl-CoA_7: 335 Da

zhuA: CLF 7 (Score: 747.1; E-value: 9.5e-228)
zhuB: KS (Score: 759.4; E-value: 2.1e-231)
zhuC: AT (Score: 415.9; E-value: 2.7e-127); AT AAG30190.1_R1128_acetyl-CoA/propionyl-CoA/isobutyryl-CoA/butyryl-CoA (Score: 674.0; E-value: 0.0)
zhuG: ACP (Score: 88.5; E-value: 5.1e-28)
zhuH: KSIII (Score: 413.3; E-value: 1.8e-126); KSIII AAG30195.1_R1128_acetyl-CoA/propionyl-CoA/isobutyryl-CoA/butyryl-CoA (Score: 668.0; E-value: 0.0)
zhuI: CYC C7-C12 (Score: 129.7; E-value: 2.4e-40)
zhuJ: CYC C5-C14/C3-C16 (Score: 340.2; E-value: 1.7e-104)
zhuK: OXY (Score: 508.4; E-value: 4.9e-155)
zhuM: OXY (Score: 488.4; E-value: 5.6e-149)
zhuN: ACP (Score: 123.2; E-value: 7.8e-39)