Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000262.1:
Cluster 1Polyketide / Saccharide154042

BGC0000262, rabelomycin biosynthetic gene cluster from Streptomyces sp. PGA64. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: prejadomycin
SMILES string: Copy to clipboard
Molecular activity: Unknown

Class-specific details

Biosynthetic class(es):
Polyketide / Saccharide
Polyketide subclass:
Angucycline (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
AAK57525.1
Genes involved in folding/cyclization:
AAK57524.1,AAK57528.1,AAK57529.1,

Saccharide subclass:
hybrid/tailoring
Glycosyltransferases:
AHW57778.1:
Specificity: Unknown
Evidence for specificity: Unknown
AHW57780.1:
Specificity: Unknown
Evidence for specificity: Unknown
AHW57782.1:
Specificity: Unknown
Evidence for specificity: Unknown
AHW57794.1:
Specificity: Unknown
Evidence for specificity: Unknown
AHW57783.1:
Specificity: Unknown
Evidence for specificity: Unknown
AHW57791.1:
Specificity: Unknown
Evidence for specificity: Unknown

Gene cluster description

rabelomycin (BGC0000262). Gene Cluster 1. Biosynthetic class = Polyketide/Saccharide. GenBank AY034378. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Enzymatic assays, Heterologous expression, Proven expression in natural host
MIxS-compliance:Unknown
Contact for this cluster:Mikko Metsae-Ketelae (University of Turku)

Literature references

1. Metsa-Ketela M et al. (2003) Engineering anthracycline biosynthesis toward angucyclines. Antimicrob Agents Chemother 47(4):1291-6.
2. Metsa-Ketela M et al. (2004) Partial activation of a silent angucycline-type gene cluster from a rubromycin beta producing Streptomyces sp. PGA64. J Antibiot (Tokyo) 57(8):502-10.
3. Palmu K et al. (2007) Artificial reconstruction of two cryptic angucycline antibiotic biosynthetic pathways. Chembiochem 8(13):1577-84. doi: 10.1002/cbic.200700140.
4. Kallio P et al. (2008) Sequential action of two flavoenzymes, PgaE and PgaM, in angucycline biosynthesis: chemoenzymatic synthesis of gaudimycin C. Chem Biol 15(2):157-66. doi: 10.1016/j.chembiol.2007.12.011.