LOCUS       BGC0000263             32801 bp    DNA     linear   BCT 10-NOV-2011
DEFINITION  Streptomyces ravidus ravidomycin biosynthetic gene cluster, strain
            C23201NS3.
ACCESSION   BGC0000263
VERSION     BGC0000263
KEYWORDS    .
SOURCE      Streptomyces ravidus
  ORGANISM  Streptomyces ravidus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: 7.1.0
            Run date     :: 2024-10-17 13:17:06
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 32801
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     gene            complement(1..1695)
                     /gene="ravX8"
     CDS             complement(1..1695)
                     /codon_start=1
                     /db_xref="InterPro:IPR007391"
                     /db_xref="UniProtKB/TrEMBL:D1H0H9"
                     /gene="ravX8"
                     /product="hypothetical protein"
                     /protein_id="CBH32788.1"
                     /transl_table=11
                     /translation="MRRRIHPAAVASGAVVLGAGALYVTGLLVTGDEVPKGTTVRGVDI
                     GGLSESAAKQKLDQQLQGIASAPLPVKIGDKSDNVDPAKAGLSFDTAETAALAARSDKD
                     PLTVVGNLFTSGGGKVEPVVNADEDRTRAALEELAKKHDRKVREGSITFAKGEAKQVEP
                     LSGQSLDVADSVDAVRTAFTGSKPGPTALPVKETAAKIGAAEIDRAMNEFARPAMSGSV
                     TLTTASGRITISPSTLGKHLTMAPGKDDRLAPKLNGAALLKDPRIAPQLAAATNEATDA
                     TLRLNGGKVEVVADGKPGQEVNAKSLGDAVMPLLTKTGSAARTGAVATVETQPKVTAES
                     VAKLGITEQVSSYTSTFERAEYRTKNIGRAAELINGSTIMPGETWSFNGTVGERTPENG
                     FVDGIIILNDKYTKAAGGGVSTVATTMFNAFFFAGLKPVEYGAHSFYIERYPEGREATV
                     AWGSLDLRFKNDSDSAIHILTSASDTEVTVTFLGTKKYDEVKAVKGPRTNVKEPGTRPG
                     ATKDCQPQTPLEGFDVTVERIFMDGGQEVKREPFKTRYTPRDEVTCD"
     source          1..32801
                     /db_xref="taxon:691266"
                     /identified_by="Wyeth Pharmaceuticals"
                     /isolation_source="soil"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces ravidus"
                     /strain="C23201NS3"
     protocluster    1..32801
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[20026:22500]"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="8|9 (Score: 703.9; E-value:
                     1.2e-214)"
                     /t2pks_molecular_weights="propionyl-CoA_8 (Da): 574.572"
                     /t2pks_molecular_weights="propionyl-CoA_9 (Da): 616.608"
                     /t2pks_product_classes="angucycline"
                     /t2pks_starter_units="propionyl-CoA (Score: 633.0; E-value:
                     0)"
                     /tool="antismash"
     proto_core      20027..22500
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /t2pks_malonyl_elongations="8|9 (Score: 703.9; E-value:
                     1.2e-214)"
                     /t2pks_molecular_weights="propionyl-CoA_8 (Da): 574.572"
                     /t2pks_molecular_weights="propionyl-CoA_9 (Da): 616.608"
                     /t2pks_product_classes="angucycline"
                     /t2pks_starter_units="propionyl-CoA (Score: 633.0; E-value:
                     0)"
     cand_cluster    1..32801
                     /SMILES=""
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(t2ks and t2clf)"
                     /kind="single"
                     /product="T2PKS"
                     /protoclusters="1"
                     /tool="antismash"
     subregion       1..32801
                     /aStool="externally annotated by: MIBiG"
                     /contig_edge="True"
                     /label="BGC0000263"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..32801
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T2PKS"
                     /region_number="1"
                     /rules="(t2ks and t2clf)"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            complement(1807..2550)
                     /gene="ravW"
     CDS             complement(1807..2550)
                     /codon_start=1
                     /db_xref="GOA:D1H0I0"
                     /db_xref="InterPro:IPR000182"
                     /db_xref="InterPro:IPR016181"
                     /db_xref="UniProtKB/TrEMBL:D1H0I0"
                     /function="putative role in N-acetylation"
                     /gene="ravW"
                     /product="putative N-acetyltransferase"
                     /protein_id="CBH32789.1"
                     /transl_table=11
                     /translation="MTADDLPHVVAEHLTHFPDGFFARLGPAFLTAYCGTYLNNPYARG
                     YLAETDLGPAGYLLGALDPPGHRAHVLRSHRLSLAARGALSLAVRPRVAGHFLRTRAGR
                     YARTLAPGRRAAPSTEPPAPPVPDAGAEPAPEPAGPTAVLAYVAVAARARSLGLGAALI
                     ARFVADAAEAGCARVCLVTLTGEGGAGPYYERHGWLARGGSTTPDGRSFTTYELPLTIA
                     PKTPPDLPPDAPEPDPGVHPLKYER"
     gene            complement(2838..3218)
                     /gene="ravX7"
     CDS             complement(2838..3218)
                     /codon_start=1
                     /db_xref="GOA:D1H0I1"
                     /db_xref="InterPro:IPR001387"
                     /db_xref="InterPro:IPR010982"
                     /db_xref="UniProtKB/TrEMBL:D1H0I1"
                     /gene="ravX7"
                     /product="hypothetical protein"
                     /protein_id="CBH32790.1"
                     /transl_table=11
                     /translation="MRNPVDAPPASYTESGTWPDGPLTADAPPTAHAGQALARSLRALM
                     RARSLSARALAARTGTTHPTVRRILTGAGLVDVRTVFLLEVALQAPLWPADLYADFHRR
                     KGTSGASSAAATPAVDEGQRRD"
     gene            complement(3319..5649)
                     /gene="ravRM"
     CDS             complement(3319..5649)
                     /codon_start=1
                     /db_xref="GOA:D1H0I2"
                     /db_xref="InterPro:IPR006094"
                     /db_xref="InterPro:IPR012951"
                     /db_xref="InterPro:IPR016166"
                     /db_xref="InterPro:IPR016167"
                     /db_xref="InterPro:IPR016168"
                     /db_xref="UniProtKB/TrEMBL:D1H0I2"
                     /function="putative role in oxidation of hemiacetal"
                     /gene="ravRM"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138:FAD linked oxidase domain protein (Score: 503.9;
                     E-value: 1e-152)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative dehydrogenase"
                     /protein_id="CBH32791.1"
                     /transl_table=11
                     /translation="MTVESSVPDPVVVLPTDRRYAEFVRGDNYRFTGEPDRVVLVRTAE
                     QVADALGAALAEGKRVAVRSGGHCGEAFVADPAVEVVIDMSLMSEVSYDAERGAFAVAA
                     GANVGQVYKELYRNWGVTVPAGVCTAVGMGGHVTGGGYGPLGRLHGLVADHLYAVEVVH
                     VDADGRVCTVVATREEDDPHRELWWAHTGGGGGNFGIVTRFWLRSPGDGGPAPEQLLPK
                     APSSLLTAMVAWSWESCDQAAFTRLVRNFMAWHVANSAPDSRFARLFASLWVRHRSGGD
                     LTMYVQIANAADATEGPNGCDDPESGADALLDEFLAAVEEGTGVSPFVFRHRLPWLTGV
                     RYMGQGDSGPVLGARNKAKAAYLRGVHSDEQIAALYRWFHQEDYFGRESLMMLNSYGGA
                     INAVAPGDTASAQRDSVIKAAYSAAWHDPAEDEGHIAWVRGLYRELFASTGGAPVSGEV
                     ADGSYINYPDVDLTDPAENTSGVPWHELYYKDNYPALQRVKAAYDPRDVFHHAMSVRPP
                     ADDAGSADRPHPQIPEQNVSFAADHIPDRYDFVSMYQGDQDAPPVQPWDIGRPQPALVD
                     AHKAGLITGDVLDVGCGLGDNAAFLASQGHRVTAVDVSQIAVDEASARASAKGVEVEFA
                     VTDATRLTGFDGRFDTVVDSACYHSLAEDDRVRYLEALHRAARPGARLHIFSFAEELPA
                     PFPGPHRHSARSLREVVGGVWDVVSVEEATYASSLGAADVVEMTRAEYPDRDVDADSLP
                     GLELDEFGKATMPVWHVVAVRRD"
     gene            complement(5646..6341)
                     /gene="ravOII"
     CDS             complement(5646..6341)
                     /codon_start=1
                     /db_xref="GOA:D1H0I3"
                     /db_xref="InterPro:IPR007138"
                     /db_xref="InterPro:IPR011008"
                     /db_xref="UniProtKB/TrEMBL:D1H0I3"
                     /function="putative role in oxygenation"
                     /gene="ravOII"
                     /product="putative anthrone oxygenase"
                     /protein_id="CBH32792.1"
                     /transl_table=11
                     /translation="MPFITPDNGSLTVFNLFDTRTREDQTTLLDTMQGIIQGANYPGWR
                     SSTLHGGIDQPCAANYIQWRSVEDLRDRYEGESFKHNTVPYFTDLTTSVHLLKTEVVAT
                     HLHPELERIEISPDRDDFTVIVIMGVEEANQARLVDLFAKPDPWMEGVAGYRSHSILRG
                     LEGDFVVNYAQWESRAAYEAFHNLPEEERPADSRSMRAAARPLLTSRSSNTYEVVFSRS
                     AADDAAGAQ"
     gene            complement(6469..7488)
                     /gene="ravMT"
     CDS             complement(6469..7488)
                     /codon_start=1
                     /db_xref="GOA:D1H0I4"
                     /db_xref="InterPro:IPR001077"
                     /db_xref="InterPro:IPR011991"
                     /db_xref="InterPro:IPR016461"
                     /db_xref="UniProtKB/TrEMBL:D1H0I4"
                     /function="putative role in methylation of phenolic
                     hydroxyl groups"
                     /gene="ravMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1042:O-methyltransferase (Score: 344.2; E-value:
                     1.4e-104)"
                     /gene_functions="biosynthetic-additional (t2pks) MET
                     (Score: 314.3; E-value: 2.3e-96)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative O-methyltransferase"
                     /protein_id="CBH32793.1"
                     /transl_table=11
                     /translation="MTPPPQLPPSVRVLQLATASWMAAAVSAAAELGIADALAGGPRTS
                     DEIADAVDAHPPTLYRLLRAGTDVGLFEERAGRVFALTEVGEALRSDSPTSMRNFARWV
                     GLTADRATWAGLADSVRTGAPAFERMHGQDVWDFMRDHTDVSGVFNDAMTEASRQLIAP
                     VVDAFDFGDIGTLVDVAGGRGALLSAVLKANPKTRGVLYDQPEVVSEARQNFARSGVAD
                     RVEIIGGDFFSSVPPAGDAYLLSNVLHDWDDESSLKILANCRAALGDGGRVLLVEAVMT
                     DGARPNPTVSLMDLNMLVLCGGQQRTEAEFADLFDRAGLRLTRIVGAGLHSVVEAVRA"
     gene            complement(7615..8724)
                     /gene="ravAMT"
     CDS             complement(7615..8724)
                     /NRPS_PKS="Domain: Aminotran_5 (34-164). E-value: 6.8e-10.
                     Score: 30.2. Matches aSDomain:
                     nrpspksdomains_ravAMT_Aminotran_5.1"
                     /codon_start=1
                     /db_xref="GOA:D1H0I5"
                     /db_xref="InterPro:IPR000653"
                     /db_xref="InterPro:IPR015421"
                     /db_xref="InterPro:IPR015422"
                     /db_xref="InterPro:IPR015424"
                     /db_xref="UniProtKB/TrEMBL:D1H0I5"
                     /function="putative role in transamination of sugar keto
                     group"
                     /gene="ravAMT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_1_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Aminotran_5"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     400.6; E-value: 1.2e-121)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative aminotransferase"
                     /protein_id="CBH32794.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 1.2e-132,
                     bitscore: 433.7, seeds: 38, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_1_2 (E-value: 4.1e-09, bitscore:
                     27.2, seeds: 48, tool: rule-based-clusters)"
                     /sec_met_domain="Aminotran_5 (E-value: 5e-08, bitscore:
                     23.4, seeds: 34, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVPYLDLKGPHTEIRAELDAAYHRVVDSGWFVLGEEVRAFEEEY
                     AAYCGAAHCVSVATGCDALELALRALDIGPGDEVVVPSATYIATWLAVSETGADVVPVE
                     VDPDTHLLDPAAVEAAVTPATRAVMPVHLYGQPADLPALRRVADRHGLALIDDAAQAHG
                     ARLNGTRVGGGGLATATAFSFYPGKNLGALGDGGGILTDDAELAERLRLLRNYGSRRKY
                     HHELKSTNSRLDELHAAVLRAKLPHLDRWNARRAEIAERYRAAFADLPGLRPTAVPEGA
                     EPSWHLYVVCCDDRDAVQRSLTDAGVGTLIHYPVPVHLSPAYADEKRWPAGAFPRAEAI
                     AAQVLSLPMGPHLSDADVSYVIEAVRAAV"
     aSDomain        complement(8233..8622)
                     /aSDomain="Aminotran_5"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ravAMT_Aminotran_5.1"
                     /evalue="6.80E-10"
                     /label="ravAMT_Aminotran_5.1"
                     /locus_tag="ravAMT"
                     /protein_end="164"
                     /protein_start="34"
                     /score="30.2"
                     /tool="antismash"
                     /translation="GEEVRAFEEEYAAYCGAAHCVSVATGCDALELALRALDIGPGDEV
                     VVPSATYIATWLAVSETGADVVPVEVDPDTHLLDPAAVEAAVTPATRAVMPVHLYGQPA
                     DLPALRRVADRHGLALIDDAAQAHGA"
     gene            complement(8721..9191)
                     /gene="ravIM"
     CDS             complement(8721..9191)
                     /codon_start=1
                     /db_xref="GOA:D1H0I6"
                     /db_xref="InterPro:IPR008894"
                     /db_xref="InterPro:IPR011051"
                     /db_xref="InterPro:IPR014710"
                     /db_xref="UniProtKB/TrEMBL:D1H0I6"
                     /function="putative role in TDP-D-ravidosamine
                     biosynthesis"
                     /gene="ravIM"
                     /product="putative keto-isomerase"
                     /protein_id="CBH32795.1"
                     /transl_table=11
                     /translation="MTDTTAATGTTAGTDVSRVGKVRPCALMKLQTIGDPRGQLAVVEG
                     AKDIGFPVKRLFYLYDLPTSSVRGDHAHRNLEQFVIPINGSFDVAVDDTVDTAVCRLDD
                     PGQGLYIGPMVWNSLVNFSEGAIALVLASEHYDEADYYRRYDEFLADAGARP"
     gene            complement(9188..9985)
                     /gene="ravNMT"
     CDS             complement(9188..9985)
                     /codon_start=1
                     /db_xref="GOA:D1H0I7"
                     /db_xref="UniProtKB/TrEMBL:D1H0I7"
                     /function="putative role in TDP-D-ravidosamine
                     biosynthesis"
                     /gene="ravNMT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1248:methyltransferase (Score: 216.7; E-value: 6e-66)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative N,N-dimethyltransferase"
                     /protein_id="CBH32796.1"
                     /transl_table=11
                     /translation="MSTLSVSQPGTPPTPADVEQAYGAEHADVYDAIYRGRGRDYAAEA
                     DAFLAVLRTRRPEITSLLDVACGTGAHLAALRGSVDHVEGVELSPWMHTLATRQLPGVA
                     VHQDDMRSFNLSRRFSAVTCLFSSVGYLKSVEDLRRTLRTFRAHVAPGGVALVEPWWFP
                     ETFLDGYVGSSLVEVDGRTIARVSHTVRAGSTSRMTVEYTVAEPVNGVRRFSDLHVLSL
                     FTREQYEDAFERAGFAVEFLKDGPSGRGLFLGVAPETTDGGPR"
     gene            complement(9982..11121)
                     /gene="ravGT"
     CDS             complement(9982..11121)
                     /codon_start=1
                     /db_xref="GOA:D1H0I8"
                     /db_xref="InterPro:IPR004276"
                     /db_xref="InterPro:IPR010610"
                     /db_xref="UniProtKB/TrEMBL:D1H0I8"
                     /function="putative role in ravidomycin biosynthesis"
                     /gene="ravGT"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) MGT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1062:glycosyltransferase, MGT family (Score: 252.9;
                     E-value: 1e-76)"
                     /gene_functions="biosynthetic-additional (t2pks) GT (Score:
                     381.4; E-value: 1.5e-116)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative C-glycosyltransferase"
                     /protein_id="CBH32797.1"
                     /sec_met_domain="MGT (E-value: 8.4e-94, bitscore: 306.1,
                     seeds: 193, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKVLFIAAGTSPAGVFALAPLATAVRNAGHEILVASFDELTSSIE
                     AIGLPPVAVVTEHTTESIKQLDRPGGPIEFPWSPDQELPYVGRWFGRQAAVSLDGLLEL
                     TRHWRPDLVIGGTDAHAAGLVAAHLGVPHVRQAWDWLHFGGAEQYAAEELAPELERLGL
                     AELPAPDMFLDICPPSLLPSFATPGRPMRWVPGNRQRSLEPWMYTKGERPRICVTYGSF
                     RTAMPQIFEHLCALLSRLVDLDAEIVVAANEAATEKLRERFPQVRAGWVPLEFLLRTCD
                     GIVHSGGLTALNAMSAGIPQVVLNQFVAFEPSLALLQQQGSAVVLHREEGSPDGTFEAC
                     RKVLSDGSYGQQARVLADELNSLPTPNDVVKDLEGLVRG"
     gene            11699..11866
                     /gene="ravX6"
     CDS             11699..11866
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:D1H0I9"
                     /gene="ravX6"
                     /product="hypothetical protein"
                     /protein_id="CBH32798.1"
                     /transl_table=11
                     /translation="MPLVNQHSTPAAIPGAVIRKPGQSRRRVPRLYRRCITHDQACCSV
                     PGMKFGRYTA"
     gene            11967..13034
                     /gene="ravD"
     CDS             11967..13034
                     /codon_start=1
                     /db_xref="GOA:D1H0J0"
                     /db_xref="InterPro:IPR005835"
                     /db_xref="InterPro:IPR005908"
                     /db_xref="UniProtKB/TrEMBL:D1H0J0"
                     /function="putative role in TDP-D-ravidosamine
                     biosynthesis"
                     /gene="ravD"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NTP_transf_3"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1064:glucose-1-phosphate
                     adenylyl/thymidylyltransferase (Score: 335.2; E-value:
                     5.4e-102)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative NDP-glucose synthase"
                     /protein_id="CBH32799.1"
                     /sec_met_domain="NTP_transf_3 (E-value: 5.7e-12, bitscore:
                     37.4, seeds: 297, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MKALVLSGGAGTRLRPLTHTSAKQLVPVANKPVLFYGLEAIAEAG
                     IREVGIIVGDTADEIRDAVGDGSKFGIDVTYIPQELPLGLAHAVLIARDFLGDDDFVMY
                     LGDNFIVGGIADLVQGFRDDRPDAQILLTRVSDPSVFGVAELDAAGEVVRLEEKPQCPR
                     SDLALVGVYLFTSAVHEAVRAIQPSLRGELEITHAIQWLIDRGYRVRSTTISGYWKDTG
                     NVIDMLEVNRSVLETMEPWIEGSVDEESQLIGRVTVEAGAQVLRSRIVGPAIIGRSTVI
                     SDSYVGAYTSVSEGCRIENSEIEFSIVLRDSSIKGVRRVEASLIGRSVTVAPAPAVPHA
                     HRLILGDHSKVQISS"
     gene            13031..14017
                     /gene="ravE"
     CDS             13031..14017
                     /NRPS_PKS="Domain: NAD_binding_4 (7-184). E-value: 3.7e-17.
                     Score: 54.1. Matches aSDomain:
                     nrpspksdomains_ravE_NAD_binding_4.1"
                     /codon_start=1
                     /db_xref="GOA:D1H0J1"
                     /db_xref="InterPro:IPR001509"
                     /db_xref="InterPro:IPR005888"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR020904"
                     /db_xref="UniProtKB/TrEMBL:D1H0J1"
                     /function="putative role in TDP-D-ravidosamine
                     biosynthesis"
                     /gene="ravE"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Polysacc_synt_2"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) NAD_binding_4"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     332.6; E-value: 4.2e-101)"
                     /gene_kind="biosynthetic-additional"
                     /product="NDP-glucose-4,6-dehydratase"
                     /protein_id="CBH32800.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 6.6e-19, bitscore:
                     59.2, seeds: 37, tool: rule-based-clusters)"
                     /sec_met_domain="Polysacc_synt_2 (E-value: 9.5e-22,
                     bitscore: 68.6, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="NAD_binding_4 (E-value: 2.3e-17, bitscore:
                     54.1, seeds: 102, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTSTHILVTGGAGFIGSTYVRTLLGPDGPGDVKVTVLDRLTYAGN
                     PANLDPVREHPAFGFVRGDITDSALVGMLMARVDQVVNFAAESHVDRSLASSAPFVRTN
                     VVGTQVLLDAALQAGVRTFVQISTDEVYGSIAEGSWSEERPLAPNSPYSASKAAADLLA
                     LSYHRSHGLDVRVTRCSNNYGSHQYPEKIIPLFVTNLLDGKKVPLYGDGRNVRDWLHVD
                     DHVQGVELVRTAGRPGEVYNIGGGTELTNRELADLLVTACDADGDSVEYVADRKGHDRR
                     YSVDCTKIRTELGYRPVRNLTAGLAETVAWYRGNRKWWEPLKERAMV"
     aSDomain        13052..13582
                     /aSDomain="NAD_binding_4"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ravE_NAD_binding_4.1"
                     /evalue="3.70E-17"
                     /label="ravE_NAD_binding_4.1"
                     /locus_tag="ravE"
                     /protein_end="184"
                     /protein_start="7"
                     /score="54.1"
                     /tool="antismash"
                     /translation="VTGGAGFIGSTYVRTLLGPDGPGDVKVTVLDRLTYAGNPANLDPV
                     REHPAFGFVRGDITDSALVGMLMARVDQVVNFAAESHVDRSLASSAPFVRTNVVGTQVL
                     LDAALQAGVRTFVQISTDEVYGSIAEGSWSEERPLAPNSPYSASKAAADLLALSYHRSH
                     GLDVRVTRCSNNYG"
     gene            14215..14820
                     /gene="ravX5"
     CDS             14215..14820
                     /codon_start=1
                     /db_xref="GOA:D1H0J2"
                     /db_xref="InterPro:IPR000792"
                     /db_xref="InterPro:IPR001789"
                     /db_xref="InterPro:IPR011006"
                     /db_xref="InterPro:IPR011991"
                     /db_xref="InterPro:IPR016032"
                     /db_xref="UniProtKB/TrEMBL:D1H0J2"
                     /function="a putative regulator of ravidomycin biosynthetic
                     pathway"
                     /gene="ravX5"
                     /gene_functions="regulatory (smcogs) SMCOG1016:LuxR family
                     DNA-binding response regulator (Score: 140.4; E-value:
                     7.6e-43)"
                     /gene_kind="regulatory"
                     /product="putative regulatory gene"
                     /protein_id="CBH32801.1"
                     /transl_table=11
                     /translation="MIKVLLAQDGRMVRGAFLALLAQENDIVVVAELAAGRELVPAARR
                     FEPDVAVVDIDTPGHDDLSSIQQIHEELPQTRTLILTSTWRPTIVRRALDIQVGGFLVK
                     ESPPEKLVSTIRELAAGLRVIDFDLAVSAWQSPPPPLTERQLEILRLAAAGDGVPEIAA
                     RLHLSPGTVRNYLSSVTTKLNARTRMDAVRIAADAGWL"
     misc_feature    14311..14313
                     /note="tta leucine codon, possible target for bldA
                     regulation"
                     /tool="antismash"
     gene            15199..16068
                     /gene="ravJ"
     CDS             15199..16068
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:D1H0J3"
                     /gene="ravJ"
                     /product="hypothetical protein"
                     /protein_id="CBH32802.1"
                     /transl_table=11
                     /translation="MESCCPTVVGNQSSCLAEQGGSGATMRSPSWNHCRAPKVTVGCTA
                     EGGTTLCDCCKDELFNTLGELPALYLACEVALGGSRTVQERVSGGAGRRDLPFNENVAE
                     VRSRVRAVLASWSALVVEEREVEAPERRVAPMARFCQENVDWLAEHWAAGDVLEELRAL
                     TRLARKATETDRVRVVPLGACVREGCSGKLRAVVKAPGPDAKPSEIRCSADATHAWGPD
                     EWAALRSDAQGRTANPRAWYTVVDIKALWNLPNGSIYRLANQNEWRRRKVAGRVYYHAG
                     DVTAALRG"
     gene            complement(16226..17218)
                     /gene="ravQ"
     CDS             complement(16226..17218)
                     /NRPS_PKS="Domain: PKS_AT (9-302). E-value: 1.1e-66. Score:
                     217.1. Matches aSDomain: nrpspksdomains_ravQ_PKS_AT.1"
                     /codon_start=1
                     /db_xref="GOA:D1H0J4"
                     /db_xref="InterPro:IPR000794"
                     /db_xref="InterPro:IPR001227"
                     /db_xref="InterPro:IPR014043"
                     /db_xref="InterPro:IPR016035"
                     /db_xref="InterPro:IPR016036"
                     /db_xref="UniProtKB/TrEMBL:D1H0J4"
                     /function="putative role in ravidomycin biosynthesis"
                     /gene="ravQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021:malonyl CoA-acyl carrier protein transacylase
                     (Score: 257.2; E-value: 6.1e-78)"
                     /gene_functions="biosynthetic-additional (t2pks) AT (Score:
                     384.2; E-value: 1.2e-117)"
                     /gene_functions="biosynthetic-additional (t2pks) AT
                     CBH32803.1_Ravidomycin_propionyl-CoA (Score: 633.0;
                     E-value: 0)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative acyltransferase"
                     /protein_id="CBH32803.1"
                     /sec_met_domain="PKS_AT (E-value: 7e-67, bitscore: 217.1,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRASPIALLLPGQGFQHVGMAVELYRREPRFTAVADEFLHALGAW
                     GAEVRRTWLGRVDGAPADRGVTAQPLLFLIGYGIGEALAARGVRPAVLVGHSVGELAAA
                     TLAGVFSPAAAARILAARCAALSQAPAGGMLAVAGAPEPVLERVRAGDGCAGVALGAHN
                     GPAQTVLAGPEPALTAAERHLRDEGLTARRVRALEPWHAPAMRRAADRFCAAVADEVLS
                     PPRIPIVSTRTGRPVSEREAVRPDFWAEQMALPVQFWPALCTVLDGAAHTVVDAAPAGA
                     LATLARRHPSVRAGHSPVVPLLAPASREPWPVWTAAVDQLGGSVAQPAS"
     aSDomain        complement(16313..17191)
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ravQ_PKS_AT.1"
                     /evalue="1.10E-66"
                     /label="ravQ_PKS_AT.1"
                     /locus_tag="ravQ"
                     /protein_end="302"
                     /protein_start="9"
                     /score="217.1"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="LPGQGFQHVGMAVELYRREPRFTAVADEFLHALGAWGAEVRRTWL
                     GRVDGAPADRGVTAQPLLFLIGYGIGEALAARGVRPAVLVGHSVGELAAATLAGVFSPA
                     AAARILAARCAALSQAPAGGMLAVAGAPEPVLERVRAGDGCAGVALGAHNGPAQTVLAG
                     PEPALTAAERHLRDEGLTARRVRALEPWHAPAMRRAADRFCAAVADEVLSPPRIPIVST
                     RTGRPVSEREAVRPDFWAEQMALPVQFWPALCTVLDGAAHTVVDAAPAGALATLARRHP
                     SVRAGHSPVVPL"
     CDS_motif       complement(16397..16417)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ravQ_0004"
                     /evalue="9.10E+01"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="ravQ"
                     /protein_end="274"
                     /protein_start="267"
                     /score="-2.7"
                     /tool="antismash"
                     /translation="GAAHTVV"
     CDS_motif       complement(16703..16738)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ravQ_0003"
                     /evalue="8.10E-04"
                     /label="PKSI-AT-M_m5"
                     /locus_tag="ravQ"
                     /protein_end="172"
                     /protein_start="160"
                     /score="12.7"
                     /tool="antismash"
                     /translation="AHNGPAQTVLAG"
     CDS_motif       complement(16850..16960)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ravQ_0002"
                     /evalue="2.90E-15"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="ravQ"
                     /protein_end="123"
                     /protein_start="86"
                     /score="48.3"
                     /tool="antismash"
                     /translation="GVRPAVLVGHSVGELAAATLAGVFSPAAAARILAARC"
     CDS_motif       complement(17144..17194)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ravQ_0001"
                     /evalue="3.50E-05"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="ravQ"
                     /protein_end="25"
                     /protein_start="8"
                     /score="16.3"
                     /tool="antismash"
                     /translation="LLPGQGFQHVGMAVELY"
     gene            complement(17215..18186)
                     /gene="ravP"
     CDS             complement(17215..18186)
                     /NRPS_PKS="Domain: PKS_AT (6-297). E-value: 2.5e-59. Score:
                     192.9. Matches aSDomain: nrpspksdomains_ravP_PKS_AT.1"
                     /codon_start=1
                     /db_xref="GOA:D1H0J5"
                     /db_xref="InterPro:IPR001227"
                     /db_xref="InterPro:IPR014043"
                     /db_xref="InterPro:IPR016035"
                     /db_xref="InterPro:IPR016036"
                     /db_xref="UniProtKB/TrEMBL:D1H0J5"
                     /function="putative role in ravidomycin biosynthesis"
                     /gene="ravP"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PKS_AT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1021:malonyl CoA-acyl carrier protein transacylase
                     (Score: 256.5; E-value: 9.8e-78)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative acyltransferase"
                     /protein_id="CBH32804.1"
                     /sec_met_domain="PKS_AT (E-value: 1.6e-59, bitscore: 192.9,
                     seeds: 1682, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSTAFVFPGQGSQRVGMGRDLVADRPDLIESHYRVADEILGIPL
                     TRLCWEGPAQELRAMPVTQPAVFLTSVVAHEVLRGHGVVPDVVTGHSLGEFAAMVAAGV
                     LDLRDGLRLVRLRGELMDSVNRTVPGCLGVVIGVPVAGVEELCVRAAADTGEVVEIANL
                     NEDRQIVVSGGLAGVAALLKYADEAGAERVLTLDVGGPAHCSLLSGIEEEFGRAIDGLD
                     LRDPVVPVYSALTAAPVLDARQAAECLRRQFTSRVLWADTVRALTDFGVDRFVEVGPGK
                     ALSKLCQRISPDSTTYRTNDAPRLAQAVAALGAVRSPGALVR"
     aSDomain        complement(17296..18168)
                     /aSDomain="PKS_AT"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ravP_PKS_AT.1"
                     /evalue="2.50E-59"
                     /label="ravP_PKS_AT.1"
                     /locus_tag="ravP"
                     /protein_end="297"
                     /protein_start="6"
                     /score="192.9"
                     /specificity="substrate consensus: mal"
                     /specificity="PKS signature: Malonyl-CoA"
                     /specificity="Minowa: mal"
                     /tool="antismash"
                     /translation="VFPGQGSQRVGMGRDLVADRPDLIESHYRVADEILGIPLTRLCWE
                     GPAQELRAMPVTQPAVFLTSVVAHEVLRGHGVVPDVVTGHSLGEFAAMVAAGVLDLRDG
                     LRLVRLRGELMDSVNRTVPGCLGVVIGVPVAGVEELCVRAAADTGEVVEIANLNEDRQI
                     VVSGGLAGVAALLKYADEAGAERVLTLDVGGPAHCSLLSGIEEEFGRAIDGLDLRDPVV
                     PVYSALTAAPVLDARQAAECLRRQFTSRVLWADTVRALTDFGVDRFVEVGPGKALSKLC
                     QRISPDSTTY"
     CDS_motif       complement(17824..17943)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ravP_0002"
                     /evalue="1.40E-19"
                     /label="PKSI-AT-M_m3"
                     /locus_tag="ravP"
                     /protein_end="121"
                     /protein_start="81"
                     /score="62.3"
                     /tool="antismash"
                     /translation="GVVPDVVTGHSLGEFAAMVAAGVLDLRDGLRLVRLRGELM"
     CDS_motif       complement(18121..18171)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ravP_0001"
                     /evalue="7.70E-09"
                     /label="PKSI-AT-mM_m1"
                     /locus_tag="ravP"
                     /protein_end="22"
                     /protein_start="5"
                     /score="27.3"
                     /tool="antismash"
                     /translation="FVFPGQGSQRVGMGRDL"
     gene            complement(18271..18489)
                     /gene="ravY"
     CDS             complement(18271..18489)
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:D1H0J6"
                     /function="putative role in ravidomycin biosynthesis"
                     /gene="ravY"
                     /gene_functions="other (smcogs) SMCOG1265:ferredoxin
                     (Score: 57.1; E-value: 2.5e-17)"
                     /gene_kind="other"
                     /product="putative ferrodoxin protein"
                     /protein_id="CBH32805.1"
                     /transl_table=11
                     /translation="MTTADEQTGRLRISVDLDRCEGYGLCEAEAPELLLLDDGHANVLV
                     AGDVPEDQRAAALSAVHTCPIAALRFA"
     gene            complement(18486..19670)
                     /gene="ravOIII"
     CDS             complement(18486..19670)
                     /codon_start=1
                     /db_xref="GOA:D1H0J7"
                     /db_xref="InterPro:IPR001128"
                     /db_xref="InterPro:IPR002397"
                     /db_xref="InterPro:IPR017972"
                     /db_xref="UniProtKB/TrEMBL:D1H0J7"
                     /function="putative role in ravidomycin biosynthesis"
                     /gene="ravOIII"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007:cytochrome P450 (Score: 269; E-value: 1.1e-81)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative cytochrome p450 monooxygenase"
                     /protein_id="CBH32806.1"
                     /sec_met_domain="p450 (E-value: 1.6e-15, bitscore: 47.9,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MATGTIPRSDIDPYTDASILSPYEDYRRLRDLGPVVWLEAHEVYA
                     VARYREVYDALHDHTTFSSASGVGLTETLNKAQKGSSFTSDPPYHDYVRGLVARHLKPK
                     ALEEFHDYIEGWANTLVDQLIEKGTFDAVTDFAQAFPLAVVPDLLGWPVDEGKERLLEW
                     ATAGFNAFGPLNQRTMSGFPLLKEMSEFLARMSVPGNLRPGSWGEQLVTDAKDGKIEEY
                     LLPGLLGDFLAPSMDTSVSALSSMLWLLGTHQEQWEEIRADESHIPRAFNEIIRIESPL
                     RGFTRLVTRERELGGVSLEPGMRVLLLYGSANRDERHWTEPDAFDIHRRAVAQHVGFGH
                     GIHGCVGQALSRLEGHSLLKALSTKVRSIEVGEPTWRLHNTIRGIASLPVTLHT"
     gene            complement(19699..19959)
                     /gene="ravC"
     CDS             complement(19699..19959)
                     /NRPS_PKS="Domain: ACP (10-79). E-value: 4.2e-16. Score:
                     50.9. Matches aSDomain: nrpspksdomains_ravC_ACP.1"
                     /codon_start=1
                     /db_xref="GOA:D1H0J8"
                     /db_xref="InterPro:IPR006162"
                     /db_xref="InterPro:IPR006163"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="UniProtKB/TrEMBL:D1H0J8"
                     /function="putative role in ravidomycin biosynthesis"
                     /gene="ravC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1129:acyl carrier protein (Score: 100.7; E-value:
                     5.8e-31)"
                     /gene_functions="biosynthetic-additional (t2pks) ACP
                     (Score: 114.4; E-value: 4.2e-36)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative acyl carrier protein"
                     /protein_id="CBH32807.1"
                     /sec_met_domain="PP-binding (E-value: 3.4e-11, bitscore:
                     34.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSSFSIDDLKRILREGAGATAELDGDILDASFDDLGYDSLALLET
                     GSRIGREYGLEFEDTAFADVETPRDLVGVVNAQLSAPAPRG"
     aSDomain        complement(19723..19929)
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ravC_ACP.1"
                     /evalue="4.20E-16"
                     /label="ravC_ACP.1"
                     /locus_tag="ravC"
                     /protein_end="79"
                     /protein_start="10"
                     /score="50.9"
                     /tool="antismash"
                     /translation="RILREGAGATAELDGDILDASFDDLGYDSLALLETGSRIGREYGL
                     EFEDTAFADVETPRDLVGVVNAQL"
     gene            complement(20027..21232)
                     /gene="ravB"
     CDS             complement(20027..21232)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (3-400). E-value:
                     2.8e-35. Score: 113.9. Matches aSDomain:
                     nrpspksdomains_ravB_PKS_KS.1"
                     /codon_start=1
                     /db_xref="GOA:D1H0J9"
                     /db_xref="InterPro:IPR000794"
                     /db_xref="InterPro:IPR014030"
                     /db_xref="InterPro:IPR014031"
                     /db_xref="InterPro:IPR016038"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="UniProtKB/TrEMBL:D1H0J9"
                     /function="putative role in ravidomycin biosynthesis"
                     /gene="ravB"
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2clf"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093:Beta-ketoacyl synthase (Score: 660.1; E-value:
                     1.7e-200)"
                     /gene_functions="biosynthetic-additional (t2pks) CLF 8|9
                     (Score: 703.9; E-value: 1.2e-214)"
                     /gene_kind="biosynthetic"
                     /product="putative chain length factor"
                     /protein_id="CBH32808.1"
                     /sec_met_domain="t2clf (E-value: 3.8e-206, bitscore: 675.6,
                     seeds: 26, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAVAVTGVGAIAPNGQGTEEYWRATLEGRSGIGPLRRFDASGYP
                     AKLAGEIDFDPAEHLPSRLVPQTDHMTRLSLAAAQWALDDAGVEPQDLPDFAAGVITAS
                     SAGGFEFGQRELENLWREGPKYVSAYQSYAWFYAVNSGQISIRHGMRGPSGVVVSDQAG
                     GLDALAQSRRQIRKGTRLVVSGGVDGSLCPWGWVAQMAGDRMSTSQDPECAYLPFDARA
                     RGHVPGEGGAHLVVEDVASARERGARIHGLISGYGSTMDPRPGSGREPGLRRALTLALE
                     DAGVRPDEVDVVFADGAAVPELDRIEADALGEVFGRGGVPVTAPKTMTGRLTAGAAALD
                     VATALLAIRDGVIPPTLHVTGAAEYGIDLVTGEPRKADVRTAVVLARGHGGFNSAVVVQ
                     AA"
     aSDomain        complement(20033..21223)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ravB_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.80E-35"
                     /label="ravB_PKS_KS.1"
                     /locus_tag="ravB"
                     /protein_end="400"
                     /protein_start="3"
                     /score="113.9"
                     /tool="antismash"
                     /translation="VAVTGVGAIAPNGQGTEEYWRATLEGRSGIGPLRRFDASGYPAKL
                     AGEIDFDPAEHLPSRLVPQTDHMTRLSLAAAQWALDDAGVEPQDLPDFAAGVITASSAG
                     GFEFGQRELENLWREGPKYVSAYQSYAWFYAVNSGQISIRHGMRGPSGVVVSDQAGGLD
                     ALAQSRRQIRKGTRLVVSGGVDGSLCPWGWVAQMAGDRMSTSQDPECAYLPFDARARGH
                     VPGEGGAHLVVEDVASARERGARIHGLISGYGSTMDPRPGSGREPGLRRALTLALEDAG
                     VRPDEVDVVFADGAAVPELDRIEADALGEVFGRGGVPVTAPKTMTGRLTAGAAALDVAT
                     ALLAIRDGVIPPTLHVTGAAEYGIDLVTGEPRKADVRTAVVLARGHGGFNSAVVVQA"
     CDS_motif       complement(20543..20581)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ravB_0001"
                     /evalue="5.90E-03"
                     /label="PKSI-KS_m4"
                     /locus_tag="ravB"
                     /protein_end="230"
                     /protein_start="217"
                     /score="10.0"
                     /tool="antismash"
                     /translation="FDARARGHVPGEG"
     gene            complement(21229..22500)
                     /gene="ravA"
     CDS             complement(21229..22500)
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (5-416). E-value:
                     2.9e-51. Score: 166.5. Matches aSDomain:
                     nrpspksdomains_ravA_PKS_KS.1"
                     /codon_start=1
                     /db_xref="GOA:D1H0K0"
                     /db_xref="InterPro:IPR000794"
                     /db_xref="InterPro:IPR014030"
                     /db_xref="InterPro:IPR014031"
                     /db_xref="InterPro:IPR016038"
                     /db_xref="InterPro:IPR016039"
                     /db_xref="InterPro:IPR018201"
                     /db_xref="UniProtKB/TrEMBL:D1H0K0"
                     /function="putative role in ravidomycin biosynthesis"
                     /gene="ravA"
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2ks"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022:Beta-ketoacyl synthase (Score: 500.8; E-value:
                     5.5e-152)"
                     /gene_functions="biosynthetic-additional (t2pks) KS (Score:
                     782.8; E-value: 1.6e-238)"
                     /gene_kind="biosynthetic"
                     /product="putative ketoacyl synthase"
                     /protein_id="CBH32809.1"
                     /sec_met_domain="t2ks (E-value: 5.6e-244, bitscore: 800.7,
                     seeds: 25, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTRRRVVITGIGVLAPGGVGTKNFWSLISEGRTATRTLTHFDPTP
                     YRSRVAAEVDFHPEEHGLRAQEIRRMDRAAQFAVVAAAEAVTDSGLELPEVDPYRIGVT
                     IGSAVGATTSLEDEYRVVSDDGTKHLVDHAYATPHLYDYLVPSSFATEVAWAVGAEGPA
                     TVVSTGCTSGIDAVGHAVELIREGSADVMVTGATDAPISPITVACFDAIKATTVHNDDP
                     EHASRPYDSTRNGFVLGEGSAVFVLEEYESARRRGATVYAEVTGYATRSNAYHMTGLRA
                     DGAEMAAAITAALDESRFAPQDVDYVNAHGSGTKQNDRHETAAFKASLGAHAYRVPVSS
                     IKSMVGHSLGAIGSIEIAASALAIRHNVVPPTANLHQQDPELDLDYVPLTARDWPTDRV
                     LTVGSGFGGFQSAMVLSRPERSAA"
     aSDomain        complement(21253..22485)
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ravA_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="2.90E-51"
                     /label="ravA_PKS_KS.1"
                     /locus_tag="ravA"
                     /protein_end="416"
                     /protein_start="5"
                     /score="166.5"
                     /tool="antismash"
                     /translation="VVITGIGVLAPGGVGTKNFWSLISEGRTATRTLTHFDPTPYRSRV
                     AAEVDFHPEEHGLRAQEIRRMDRAAQFAVVAAAEAVTDSGLELPEVDPYRIGVTIGSAV
                     GATTSLEDEYRVVSDDGTKHLVDHAYATPHLYDYLVPSSFATEVAWAVGAEGPATVVST
                     GCTSGIDAVGHAVELIREGSADVMVTGATDAPISPITVACFDAIKATTVHNDDPEHASR
                     PYDSTRNGFVLGEGSAVFVLEEYESARRRGATVYAEVTGYATRSNAYHMTGLRADGAEM
                     AAAITAALDESRFAPQDVDYVNAHGSGTKQNDRHETAAFKASLGAHAYRVPVSSIKSMV
                     GHSLGAIGSIEIAASALAIRHNVVPPTANLHQQDPELDLDYVPLTARDWPTDRVLTVGS
                     GFGGFQSAMVLS"
     gene            complement(22636..24198)
                     /gene="ravOIV"
     CDS             complement(22636..24198)
                     /codon_start=1
                     /db_xref="GOA:D1H0K1"
                     /db_xref="InterPro:IPR002938"
                     /db_xref="InterPro:IPR003042"
                     /db_xref="UniProtKB/TrEMBL:D1H0K1"
                     /function="putative role in ravidomycin biosynthesis"
                     /gene="ravOIV"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 522.2; E-value:
                     2.6e-158)"
                     /gene_functions="biosynthetic-additional (t2pks) OXY
                     (Score: 488.2; E-value: 6.3e-149)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative oxygenase"
                     /protein_id="CBH32810.1"
                     /transl_table=11
                     /translation="MLVVGAGPVGLLLAGDLAERGVDVVVADRLSAPMTESRASQLGAR
                     TMEVLAQRGLLADFGDELVPEPRGHFAGLSFDASAVRSPYPGHWKVPQFRTEAVLARRA
                     LAAGARLLRGYELYELCDVHTDGADDAAADAGVVARFRTEDGPLTVRAGYVVGCDGAHS
                     TVRSLAGFPVESGPARRELLRADLTGIEVPDRRFQLLERGFAASARRPDGVTRVMVRVD
                     GAPPVRRQGPPALREIAAAWRTVTGEDLTGATPIWRDAFDDSWVQAAAYRRGRVLLAGD
                     AAHAHMPVGGQSLNLGLQDAANLGWKLAAQVRGWAPPGLLDSYHDERHPVGRRVLDNVQ
                     AQGMLMFGGAQTAPVRQVLAEVLSDPGPRDRIAAWVTGLDVRYDVRYHGHDYIRDNIRD
                     DVRGADDIPALLLGSRVPDLALTCSNGEGTTVHALLRDGRGLLLDLAPGPASTDADADA
                     DGWADRVRTVRATAGPDDAPFASGTSVTSVLVRPDGHVVWTDRTTTPLRTALTDWFGTA
                     DRP"
     gene            complement(24258..25205)
                     /gene="ravK"
     CDS             complement(24258..25205)
                     /NRPS_PKS="Domain: Polyketide_cyc2 (7-149). E-value:
                     4.2e-17. Score: 54.7. Matches aSDomain:
                     nrpspksdomains_ravK_Polyketide_cyc2.1"
                     /NRPS_PKS="Domain: Polyketide_cyc (169-259). E-value:
                     9.3e-08. Score: 24.2. Matches aSDomain:
                     nrpspksdomains_ravK_Polyketide_cyc.1"
                     /codon_start=1
                     /db_xref="InterPro:IPR005031"
                     /db_xref="InterPro:IPR019587"
                     /db_xref="InterPro:IPR023393"
                     /db_xref="UniProtKB/TrEMBL:D1H0K2"
                     /function="putative role in ravidomycin biosynthesis"
                     /gene="ravK"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1128:cyclase/dehydrase (Score: 425; E-value:
                     2.9e-129)"
                     /gene_functions="biosynthetic-additional (t2pks) CYC C7-C12
                     (Score: 462.7; E-value: 1e-141)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative aromatase/cyclase"
                     /protein_id="CBH32811.1"
                     /transl_table=11
                     /translation="MPGPEVREVEHEITVAAPAKDVYQLLVEVEDWPAMFPPSVHVERV
                     EQDGEHERIRICATANGAAKRWTSIRRLLPDQGVIEFRQEKSSPPVAGMGGTWIVEPQG
                     DELCRVRLLHDYRAVDDDPAALQWIAEAVDRNSHAELAALKTTAELGPDAAQKPFTFED
                     GLQIAGTAADVFAFIDQAQLWSERLPHVARVILTEETEGLQLLEMDTRSPDGSIHTTKS
                     VRVCQRPAGTIHYKQIKLPALMTLHTGRWSFEENADGVLAVSRHTVAIDETKIAQVLGE
                     GAGLAEARAAVRRALGTNSLSTLNHAKAHVEGGS"
     aSDomain        complement(24429..24698)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ravK_Polyketide_cyc.1"
                     /domain_subtypes="Polyketide_cyc"
                     /evalue="9.30E-08"
                     /label="ravK_Polyketide_cyc.1"
                     /locus_tag="ravK"
                     /protein_end="259"
                     /protein_start="169"
                     /score="24.2"
                     /tool="antismash"
                     /translation="TAADVFAFIDQAQLWSERLPHVARVILTEETEGLQLLEMDTRSPD
                     GSIHTTKSVRVCQRPAGTIHYKQIKLPALMTLHTGRWSFEENADG"
     aSModule        complement(24429..25184)
                     /domains="nrpspksdomains_ravK_Polyketide_cyc2.1"
                     /domains="nrpspksdomains_ravK_Polyketide_cyc.1"
                     /incomplete
                     /locus_tags="ravK"
                     /tool="antismash"
                     /type="unknown"
     aSDomain        complement(24759..25184)
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ravK_Polyketide_cyc2.1"
                     /domain_subtypes="Polyketide_cyc2"
                     /evalue="4.20E-17"
                     /label="ravK_Polyketide_cyc2.1"
                     /locus_tag="ravK"
                     /protein_end="149"
                     /protein_start="7"
                     /score="54.7"
                     /tool="antismash"
                     /translation="EVEHEITVAAPAKDVYQLLVEVEDWPAMFPPSVHVERVEQDGEHE
                     RIRICATANGAAKRWTSIRRLLPDQGVIEFRQEKSSPPVAGMGGTWIVEPQGDELCRVR
                     LLHDYRAVDDDPAALQWIAEAVDRNSHAELAALKTTAE"
     gene            complement(25246..25494)
                     /gene="ravC1"
     CDS             complement(25246..25494)
                     /NRPS_PKS="Domain: ACP (13-81). E-value: 2.2e-11. Score:
                     35.8. Matches aSDomain: nrpspksdomains_ravC1_ACP.1"
                     /codon_start=1
                     /db_xref="GOA:D1H0K3"
                     /db_xref="InterPro:IPR006163"
                     /db_xref="InterPro:IPR009081"
                     /db_xref="UniProtKB/TrEMBL:D1H0K3"
                     /function="putative role in ravidomycin biosynthesis"
                     /gene="ravC1"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1129:acyl carrier protein (Score: 107.9; E-value:
                     3.4e-33)"
                     /gene_functions="biosynthetic-additional (t2pks) ACP
                     (Score: 113.2; E-value: 1e-35)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative acyl carrier protein"
                     /protein_id="CBH32812.1"
                     /sec_met_domain="PP-binding (E-value: 6.9e-11, bitscore:
                     33.8, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTGTFTLTELKRILVDAAGADESVDLDGDILDTFFSDLGYDSLA
                     LLETAAVVSREYGVELVDDAVTAITTPRGFIELVNAA"
     aSDomain        complement(25252..25455)
                     /aSDomain="ACP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ravC1_ACP.1"
                     /evalue="2.20E-11"
                     /label="ravC1_ACP.1"
                     /locus_tag="ravC1"
                     /protein_end="81"
                     /protein_start="13"
                     /score="35.8"
                     /tool="antismash"
                     /translation="ILVDAAGADESVDLDGDILDTFFSDLGYDSLALLETAAVVSREYG
                     VELVDDAVTAITTPRGFIELVNA"
     gene            complement(25510..25836)
                     /gene="ravG"
     CDS             complement(25510..25836)
                     /codon_start=1
                     /db_xref="GOA:D1H0K4"
                     /db_xref="InterPro:IPR006765"
                     /db_xref="InterPro:IPR011008"
                     /db_xref="UniProtKB/TrEMBL:D1H0K4"
                     /function="putative role in ravidomycin biosynthesis"
                     /gene="ravG"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1225:Polyketide synthesis cyclase (Score: 154.1;
                     E-value: 1.8e-47)"
                     /gene_functions="biosynthetic-additional (t2pks) CYC
                     C4-C17/C2-C19 (Score: 189.1; E-value: 1.8e-58)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative cyclase"
                     /protein_id="CBH32813.1"
                     /transl_table=11
                     /translation="MHSTLIVARLRPGSVDDVSELFGAFDRTDMPERMGTLRRQLFSYQ
                     GLYFHLQDFADDDGGERISQARSHPLFVGISDDLKQHITAYDPDTWRSPADAMAQRFYH
                     WQQD"
     gene            complement(25959..27470)
                     /gene="ravOI"
     CDS             complement(25959..27470)
                     /codon_start=1
                     /db_xref="GOA:D1H0K5"
                     /db_xref="InterPro:IPR002938"
                     /db_xref="InterPro:IPR003042"
                     /db_xref="UniProtKB/TrEMBL:D1H0K5"
                     /function="putative oxygenase involved in ravidomycin
                     biosynthesis"
                     /gene="ravOI"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050:monooxygenase FAD-binding (Score: 539.1; E-value:
                     1.9e-163)"
                     /gene_functions="biosynthetic-additional (t2pks) OXY
                     (Score: 563.6; E-value: 8.7e-172)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative monooxygenase"
                     /protein_id="CBH32814.1"
                     /transl_table=11
                     /translation="MNATHATGDAPVIVVGAGPTGLMLAGELRLGGAEVIVLDRLAEPV
                     TESRGLGFTARATEVFDQRGLLDRFADAEISAKGHFGGIPMDYSVLPGGHFGVRNVEQS
                     ETEAVLTAWPVELGADLRRGHQVTAIAQNDDGVVVSATDPDGPVTMRCSYLVGADGGRS
                     TVRQAAGIDFPGQDATCEMFLADVAGADIRPRFIGERVAGGMVMAARLSDGLDRVIVCE
                     RGTAPGERTAPPSYEEVAAAWKRLTGEDIGHGEARWVSSFTDASRIVTAYRRGRVLLAG
                     DAAHIHLPAGGQGLSVGVQDAVNLGWKLAAVVTGRAGDALLDTYHQERHPVGERVLTNT
                     RAQGILYLSGTEVDPLRAVLGELMADDEVLKRLAGMVSGLDVQYDTGGGEHPLLGRRLP
                     PCDLRTDDGTTTGSRLLHSARGLLLTLDGATGLRGAAAPWADRVDVVTASVLGEGTDAQ
                     LDGVRALLVRPDGHVVWVAPDGGDLTTALARWFGDPGDEPMPAAA"
     gene            complement(27467..28036)
                     /gene="ravH"
     CDS             complement(27467..28036)
                     /codon_start=1
                     /db_xref="InterPro:IPR005025"
                     /db_xref="UniProtKB/TrEMBL:D1H0K6"
                     /function="putative role in ravidomycin biosynthesis"
                     /gene="ravH"
                     /product="putative NADPH-dependent FMN reductase"
                     /protein_id="CBH32815.1"
                     /transl_table=11
                     /translation="MTRIGIILGSTRPQRNGGAVAEWVHDIAVRRGDAEYELVDIAELA
                     LPLLDEPIPPLAGMYQHPHTLAWAERIARLDGFVFVTPEYNHSVPGALKNAIDYLFAEW
                     NDKAAGFVGYGPVGAVRAVEHLRLVMAELQVATVRAQVALTFDADFVDRSEFRPTAEKA
                     ELVGSVLDQVVAWSQALEPVRRKAAS"
     gene            complement(28100..28423)
                     /gene="ravV"
     CDS             complement(28100..28423)
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:D1H0K7"
                     /gene="ravV"
                     /product="hypothetical protein"
                     /protein_id="CBH32816.1"
                     /transl_table=11
                     /translation="MKYTAFLGVRFEPEWFLLEPAERDRFEAENVFPILGKHAATLDIR
                     PFRASGFSTRHTDFFLVGFDDVAQYHAFVEDLRESPLAARRYVTVTDNAIGIEQPFGAD
                     DSA"
     gene            28696..29181
                     /gene="ravX4"
     CDS             28696..29181
                     /codon_start=1
                     /db_xref="InterPro:IPR011991"
                     /db_xref="UniProtKB/TrEMBL:D1H0K8"
                     /function="putative regulatory role in ravidomycin
                     biosynthesis"
                     /gene="ravX4"
                     /product="putative regulatory protein"
                     /protein_id="CBH32817.1"
                     /transl_table=11
                     /translation="MAAQGGRIVDELRSWGANYTEFTRRFAAQLGLHSTDAAALVEILY
                     AEDQGQPLSLARLSERVSLTSGATTALVDRLEKAGHIVRTRGEHSDRRVVTLRSGPEIG
                     KAATEFFTPFAGRMTTMMSAYPPELIGQFEEFLKDMRRTLTALLAEEYRENRPRERG"
     gene            complement(29198..29983)
                     /gene="ravF"
     CDS             complement(29198..29983)
                     /NRPS_PKS="Domain: PKS_KR (7-170). E-value: 8.4e-14. Score:
                     43.7. Matches aSDomain: nrpspksdomains_ravF_PKS_KR.1"
                     /codon_start=1
                     /db_xref="GOA:D1H0K9"
                     /db_xref="InterPro:IPR002198"
                     /db_xref="InterPro:IPR002347"
                     /db_xref="InterPro:IPR016040"
                     /db_xref="InterPro:IPR020904"
                     /db_xref="UniProtKB/TrEMBL:D1H0K9"
                     /function="putative role in ravidomycin biosynthesis"
                     /gene="ravF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001:short-chain dehydrogenase/reductase SDR (Score:
                     267.4; E-value: 2e-81)"
                     /gene_functions="biosynthetic-additional (t2pks) KR C9
                     (Score: 470.5; E-value: 3e-144)"
                     /gene_kind="biosynthetic-additional"
                     /product="putative ketoreductase"
                     /protein_id="CBH32818.1"
                     /sec_met_domain="adh_short (E-value: 2e-41, bitscore:
                     133.1, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTNGLDRTALVTGATSGIGLAVVQHLAELGHRVFFCARDADRVKQ
                     TVEELREQGHDVDGVACDVRSAQDVRAMVTAAVERYGSIDVLVNNAGTGGGGVTADLTD
                     DAWLQVIETNLNSVFYVTRDVLSVGGMRDKSRGRIVNIASTAGKQGVVLAAPYSASKHG
                     VVGFTKSLGNELAKTGITVNAVCPGYVETPMAERVRAGYARAWETTEEDILERFQAKIP
                     LGRYSTVTEVAGMVGYLVSDTAASVTSQAINVCGGLGNF"
     aSDomain        complement(29474..29962)
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_ravF_PKS_KR.1"
                     /evalue="8.40E-14"
                     /label="ravF_PKS_KR.1"
                     /locus_tag="ravF"
                     /protein_end="170"
                     /protein_start="7"
                     /score="43.7"
                     /specificity="KR activity: inactive"
                     /specificity="KR stereochemistry: C2"
                     /tool="antismash"
                     /translation="TALVTGATSGIGLAVVQHLAELGHRVFFCARDADRVKQTVEELRE
                     QGHDVDGVACDVRSAQDVRAMVTAAVERYGSIDVLVNNAGTGGGGVTADLTDDAWLQVI
                     ETNLNSVFYVTRDVLSVGGMRDKSRGRIVNIASTAGKQGVVLAAPYSASKHGVVGFTKS
                     "
     CDS_motif       complement(29693..29728)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ravF_0002"
                     /evalue="7.30E+00"
                     /label="PKSI-ER_m5"
                     /locus_tag="ravF"
                     /protein_end="97"
                     /protein_start="85"
                     /score="-0.2"
                     /tool="antismash"
                     /translation="VLVNNAGTGGGG"
     CDS_motif       complement(29888..29956)
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_ravF_0001"
                     /evalue="1.00E-06"
                     /label="PKSI-KR_m1"
                     /locus_tag="ravF"
                     /protein_end="32"
                     /protein_start="9"
                     /score="21.4"
                     /tool="antismash"
                     /translation="LVTGATSGIGLAVVQHLAELGHR"
     gene            30212..30409
                     /gene="ravX3"
     CDS             30212..30409
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:D1H0L0"
                     /gene="ravX3"
                     /product="hypothetical protein"
                     /protein_id="CBH32819.1"
                     /transl_table=11
                     /translation="MHMFFIPGRPVKPPPGPSSRRRPFNRRCRARRRRSCGPRRRPRPR
                     PRRSSRPPARSSRNGRGTPR"
     gene            complement(30581..31393)
                     /gene="ravX2"
     CDS             complement(30581..31393)
                     /codon_start=1
                     /db_xref="UniProtKB/TrEMBL:D1H0L1"
                     /gene="ravX2"
                     /product="hypothetical protein"
                     /protein_id="CBH32820.1"
                     /transl_table=11
                     /translation="MNSYEDRGEGESEDADDASTGVTGPPAPTAGGATGAGGAPAAGGT
                     PEASKVPEDLEAPENREAPENPEAPDGLQAPDTPEAPEPTDPAPDAPTGPPPPPPAGIA
                     ALTLPYQIAAAVVLGLLALAACIHLAMTFLHVAPSNTVTKEYGKQIDAWIYPEFEQNWK
                     LFAPNPLQQNIGVQVKAEVKTADGALRTTEWIDLAAEDAEAIRGNLLPSHTQQNMLRRS
                     WDFYQNTHDSQNRSTEARGPLAENYLRRLVMLRLADRDLGGEVERIQI"
     gene            31507..32484
                     /gene="ravX1"
     CDS             31507..32484
                     /codon_start=1
                     /db_xref="GOA:D1H0L2"
                     /db_xref="InterPro:IPR007814"
                     /db_xref="InterPro:IPR009078"
                     /db_xref="InterPro:IPR011881"
                     /db_xref="InterPro:IPR012347"
                     /db_xref="UniProtKB/TrEMBL:D1H0L2"
                     /gene="ravX1"
                     /product="putative phenylacetate-CoA oxygenase"
                     /protein_id="CBH32821.1"
                     /transl_table=11
                     /translation="MTTVTPDATERYEAVFDAAVAADERIEPRDWMPDAYRATLIRQMA
                     QHAHSEIIGMQPEANWISRAPSLRRKAILMAKVQDEAGHGLYLYSAAETLGVGRDELLD
                     KLHSGRQRYSSIFNYPTLTWADVGAIGWLVDGAAITNQVPLCRCSYGPYARAMVRICKE
                     ESFHQRQGYELLLTLSRGTPAQHEMAQDAVDRWWWPSLMMFGPPDDESAHSAQSMTWKI
                     KRHSNDELRQRFVDICVPQAEALGLTLPDPDLRWNEDRGHHDFGAIDWSEFQAVLKGNG
                     PCNEQRISQRRRAHEEGAWVREAAAAHAAKQARTHTDEPREATA"
     gene            32481..32801
                     /gene="ravX"
     CDS             32481..32801
                     /codon_start=1
                     /db_xref="InterPro:IPR009359"
                     /db_xref="UniProtKB/TrEMBL:D1H0L3"
                     /gene="ravX"
                     /product="putative phenylacetic acid degradation protein"
                     /protein_id="CBH32822.1"
                     /transl_table=11
                     /translation="MSSSDGTAAAAGGAKDWPLWEVFVRSRRGLSHTHAGSLHAPDAQM
                     ALRNARDLYTRRNEGVSIWVVPSTAVTASSPDEKDPFFEPAADKPYRHPTFYEIPEGVK
                     HL"
ORIGIN
        1 tcagtcgcag gtgacttcgt cgcgcggcgt gtagcgcgtc ttgaacggct cccgcttcac
       61 ttcctggccg ccgtccatga agatccgctc caccgtgacg tcgaagccct ccagcggcgt
      121 ctgcggctgg cagtccttcg tggcgccggg gcgggtgccg ggctccttga cgttggtccg
      181 cgggcccttg accgccttca cctcgtcgta cttcttcgtg ccgaggaagg tcacggtcac
      241 ctcggtgtcc gaggcgctgg tcaggatgtg gatggcgctg tcggagtcgt tcttgaaccg
      301 caggtcgagg ctgccccagg ccaccgtcgc ctcgcggccc tcggggtagc gctcgatgta
      361 gaaggagtgg gcgccgtact ccaccggctt caggccggcg aagaagaacg cgttgaacat
      421 ggtggtggcg accgtggaga cgccgccgcc ggccgccttc gtgtacttgt cgttgaggat
      481 gatgatgccg tcgacgaagc cgttctccgg cgtccgctcg ccgacggtgc cgttgaagct
      541 ccaggtctcg ccgggcatga tcgtcgagcc gttgatcagt tccgcggccc ggccgatgtt
      601 cttcgtgcgg tactcggcgc gctcgaaggt gctggtgtag gaggacacct gctccgtgat
      661 gcccagcttg gccacgctct cggcggtcac cttcggctgg gtctcgacgg tggccaccgc
      721 gccggtgcgg gccgcggagc cggtcttggt cagcagcggc atgaccgcgt cgccgaggct
      781 cttggcgttg acctcctggc cgggcttgcc gtcggcgacc acctcgacct tgccgccgtt
      841 cagccgcagg gtggcgtcgg tggcctcgtt cgtggccgcg gcgagttgcg gcgcgatgcg
      901 cgggtccttc agcagggccg cgccgttcag cttgggtgcc agccggtcgt ccttgccggg
      961 ggccatcgtc agatgcttgc cgagggtcga cggggagatg gtgatccggc cgctggccgt
     1021 ggtgagcgtg acggagccgg acatcgccgg gcgggcgaac tcgttcatcg cgcggtcgat
     1081 ctcggccgcg ccgatcttcg cggcggtctc cttgaccggc agggcggtgg ggccgggctt
     1141 gctgccggtg aacgccgtgc gcaccgcgtc gacggagtcg gccacgtcca gcgactggcc
     1201 gctgagcggc tccacctgct tcgcctcgcc cttggcgaag gtgatcgagc cctcgcggac
     1261 cttgcggtcg tgcttcttcg ccagctcctc aagggcggcg cgggtgcggt cctcgtcggc
     1321 gttcaccacc ggttcgacct tgccgccgcc ggaggtgaag aggttcccca cgaccgtgag
     1381 ggggtccttg tcggagcgag cggcgagcgc cgccgtctcg gcggtgtcga agctcagacc
     1441 ggccttggcc gggtcgacat tgtcagactt gtcaccaatt ttcactggca acggcgcgct
     1501 ggctatgccc tggagctgct ggtccagctt ctgcttggcg gccgattcac tcaggccccc
     1561 gatgtcgaca ccccgcacgg tggtcccctt cgggacctcg tcgcccgtca ccaggagccc
     1621 ggtgacgtac agcgccccgg ctcccaagac gacggcgcca ctcgcgacag cggcgggatg
     1681 tattcggcga cgcatggatc tcccccgaaa aatgtccgga acgacaagct ggccgggcgc
     1741 agcccggcca gggtggtcac tgctaaggac gttaccgata cctgggtaag cgaacggtaa
     1801 ataatcctac ctttcgtatt tcagtggatg gacaccgggg tctggttccg gggcgtcggg
     1861 cgggaggtcg ggcggggtct tcggggcgat ggtgagcggg agttcgtacg tggtgaagga
     1921 ccggccgtcg ggggtggtcg agcccccgcg ggccagccag ccgtgccgct cgtagtacgg
     1981 gccggcgccg ccctccccgg tgagcgtgac gaggcagacg cgggcgcacc cggcctcggc
     2041 ggcgtccgcg acgaaccgtg cgatgagggc ggcgccgagg ccgagcgagc gggcccgggc
     2101 cgccactgcc acgtacgcga ggaccgcggt ggggccggcg ggctcggggg cgggctcggc
     2161 cccggcgtcc ggcaccggcg gtgcgggtgg ctccgtcgac ggcgccgcgc ggcgccccgg
     2221 ggcgagggtg cgggcgtacc gccccgctcg cgtccgcagg aagtgccctg cgacacgggg
     2281 gcgcacggcg agcgagagcg cgccgcgcgc ggccagcgag agccggtggg agcgcagcac
     2341 gtgggcccgg tggcccggcg ggtcgagggc gccgagcaga tagccggccg gccccaggtc
     2401 cgtctccgct aggtagccgc gcgcgtacgg attgttcagg tacgtgccgc agtacgcggt
     2461 caagaaggcg ggtccgaggc gtgcgaagaa gccgtcaggg aaatgcgtca ggtgctccgc
     2521 gacgacgtgc ggcaggtcgt ccgcggtcat cgtgcgcacg gcggtgggcg ctgcggcgcg
     2581 cccggcgtcc gcggcggcgc gggagcgtgc ggcggggacg gggaggcggg gcggggcggc
     2641 cccgagggca gggctgggga gcgcggctgc gcgctggtcg gcatccacgt tccgcaaact
     2701 actacactgc gtagaagttt agtggatctg aggtaggaga ttgaacgcga ggagggtggt
     2761 tggacgcgag gcggacgagg ccgccggact cagcgccgcg ccgcggcgcc tgcgggccgc
     2821 ccgaggcggc gggggcgtca gtcgcgcctc tgcccctcgt cgacggccgg cgtcgccgcg
     2881 gcgctcgaag cgcccgaagt gccctttctg cggtggaagt cggcgtacag gtcggcgggc
     2941 cacagcggcg cctggagggc gacctccaac aggaagacgg tgcgcacgtc caccagcccc
     3001 gcgcccgtga ggatgcgccg gaccgtggga tgggtggtgc ccgtacgggc ggccagcgcg
     3061 cgggcgctga ggctgcgggc ccgcatcagc gcccgcaggc tgcgggccag cgcctggccg
     3121 gcgtgggcgg tgggcggtgc gtcggccgtc agcgggccgt cgggccaggt gccgctctcg
     3181 gtgtacgacg ccggcggggc gtcgacgggg ttgcgcatgg cgtactcctt ccggaacgtt
     3241 catttgccgg ctgccgcgcg agaacggccg gccccctccc cgcggaagga aaggggaccg
     3301 gccgtcaccg cggcggactc agtcgcgccg cacggccacc acgtgccaca ccggcatcgt
     3361 ggccttgccg aactcgtcca gttcgagacc gggcaggctg tccgcgtcga cgtcccggtc
     3421 cgggtactcg gcccgggtca tctcgacgac gtcggccgcg ccgagcgaac tcgcgtacgt
     3481 ggcctcctcg acggacacca cgtcccacac gccgcccacc acctcgcgca ggctccgcgc
     3541 gctgtgccgg tgcggaccgg ggaacggcgc cggcagctcc tcggcgaagg agaagatgtg
     3601 cagccgcgcg cccggtcggg ccgcccggtg cagcgcctcc aggtagcgca cccggtcgtc
     3661 ctcggcgagc gagtggtagc aggcgctgtc cacgaccgtg tcgaagcggc cgtcgaagcc
     3721 ggtcagccgg gtcgcgtcgg tgacggcgaa ctccacctcc acgcccttgg ccgaggcccg
     3781 ggcgctcgcc tcgtccaccg cgatctgcga cacgtcgacc gcggtgaccc ggtggccctg
     3841 ggaggccagg aaggcggcgt tgtcgcccag gccgcagccc acgtcgagca cgtcgcccgt
     3901 gatcagcccg gccttgtggg cgtccaccag cgcgggctgc ggacggccga tgtcccaggg
     3961 ctggaccggg ggagcgtcct ggtcgccctg atacatgctc acgaagtcgt atcggtccgg
     4021 gatgtggtca gcggcgaagg acacgttctg ctccggaatc tgggggtggg ggcggtcggc
     4081 ggaccctgcg tcgtcggcgg gcgggcgcac cgacatcgcg tggtggaaca cgtcacgcgg
     4141 gtcgtaggcg gccttcaccc gctgcagcgc cgggtagttg tccttgtagt acagctcgtg
     4201 ccagggcacg ccggaggtgt tctccgcggg gtcggtcagg tcgacgtccg ggtagttgat
     4261 gtacgacccg tccgccacct cgccggagac gggcgcgccg ccggtcgacg cgaacagctc
     4321 ccggtacagc ccgcgcaccc aggcgatgtg cccctcgtcc tccgcggggt cgtgccaggc
     4381 ggcggagtac gcggccttga tcaccgagtc gcgctgggcg gacgcggtgt cgccgggcgc
     4441 gaccgcgttg atggcgccgc cgtagctgtt gagcatcatc agcgactcgc gcccgaagta
     4501 gtcctcctgg tggaaccacc ggtacagcgc ggcgatctgc tcgtccgagt gcaccccgcg
     4561 caggtacgcg gccttcgcct tgttgcgggc gcccagcacc ggaccggagt cgccctggcc
     4621 catgtagcgc acgccggtca gccagggcag ccggtggcgg aagacgaagg ggctgacgcc
     4681 ggtgccctct tcgacggctg ccaggaactc gtccaacagc gcgtcggcgc ccgactccgg
     4741 gtcgtcgcag ccgttcgggc cctcggtggc atcggcggcg ttggctatct gaacgtacat
     4801 cgtcagatca ccgccggagc ggtgtcgcac ccacagcgag gcgaagaggc gcgcgaaccg
     4861 ggagtcgggc gcgctgttcg ccacgtgcca cgccatgaag ttgcgcacga gccgggtgaa
     4921 cgccgcctgg tcgcagctct cccacgacca cgccaccatc gcggtcagca gcgacgacgg
     4981 cgccttgggc aacaactgct ccggggccgg ccccccgtcc ccgggcgagc gcagccaaaa
     5041 gcgcgtcacg atgccgaagt tgccgccgcc gccaccggtg tgcgcccacc acagctcgcg
     5101 gtgcgggtcg tcctcctcac gggtggcgac cacggtgcac acccggccgt cggcgtcgac
     5161 gtggacgacc tcgaccgcgt acaggtggtc cgcgaccagg ccgtgcagcc ggcccagcgg
     5221 accgtatccg ccgcccgtca cgtgcccgcc catgcccact gcggtgcaca cgcccgcggg
     5281 cacggtcacg ccccagttgc ggtacagctc cttgtagacc tggcccacgt tggcgcccgc
     5341 cgccacggcg aaggcgcccc gttccgcgtc gtacgacacc tccgacatca gcgacatgtc
     5401 gatgacgacc tcgacggccg ggtcggcgac gaacgcctcc ccgcagtggc cgccgctgcg
     5461 cacggccacc cgcttgccct ccgccagggc cgcccccagc gcgtcggcga cctgctcggc
     5521 ggtgcggacg agcacgacgc ggtcgggctc gccggtgaag cggtagttgt cgccgcggac
     5581 gaactcggcg tagcgccggt cggtgggcag gaccaccacc gggtccggca cggaggactc
     5641 cacggtcact gcgcacccgc cgcatcgtcc gcggccgagc gggagaagac gacctcgtac
     5701 gtgttcgacg agcgcgaggt cagcagcggg cgggcggcgg cgcgcatcga gcgcgagtcc
     5761 gccggccgct cctcctccgg caggttgtgg aacgcctcgt acgccgcccg gctctcccac
     5821 tgcgcgtagt tgacgacgaa gtcgccctcc agaccgcgca ggatcgaatg ggagcggtag
     5881 ccggcgacgc cctccatcca cgggtcgggc ttggcgaaca ggtccaccag gcgcgcctgg
     5941 ttcgcctcct cgacgcccat gatcacgatg acggtgaagt cgtcgcggtc cggggagatc
     6001 tcgatccgct ccagctcagg gtggaggtgg gtggcgacga cctcggtctt caacaggtgc
     6061 acggaggtgg tcagatcggt gaagtacgga acggtgttgt gcttgaagct ctcgccctcg
     6121 tagcggtccc gcaggtcctc gacgctgcgc cactggatgt agttggcggc gcacggctgg
     6181 tcgatgccgc cgtgcagcgt ggaggagcgc cagccggggt agttggcgcc ctggatgatg
     6241 ccctgcatcg tgtccagcag ggtcgtctgg tcctcgcggg tgcgggtgtc gaacaggttg
     6301 aagacggtca gcgagccgtt gtccggcgtg atgaagggca tctggacgtc tctttcgtct
     6361 ctggcatctc tagcgtctcg gggatcgctg ggagcgctgg gattgcagag ctcccgggga
     6421 tcgcggaggt ctccgggagc tcgggacctc ggggctgcgg atcgcgggtc aggcccggac
     6481 ggcttcgacc acgctgtgca ggcccgcccc gacgatccgg gtcagccgca gcccggcgcg
     6541 gtcgaagagg tcggcgaact cggcctcggt gcgctgctgg ccgccgcaga gcaccagcat
     6601 gttcaggtcc atcagcgaga ccgtcgggtt gggccgggcg ccgtccgtca tcacggcctc
     6661 caccagcagc acccgcccgc cgtcgccgag cgcggcacgg cagttggcga ggatcttcag
     6721 ggagctctcg tcgtcccagt cgtgcagcac gttggagagc aggtacgcgt caccggccgg
     6781 cggcaccgag gagaagaagt cgccgccgat gatctccacg cggtccgcga ccccgctccg
     6841 cgcgaagttc tgccgggcct cggagaccac ctcgggctgg tcgtacagca cgccccgggt
     6901 cttcggattg gccttcagga ccgcggacag cagcgcgccg cgcccgccgg ccacgtccac
     6961 cagggtcccg atgtcgccga agtcgaacgc gtccacgacg ggcgcgatga gctgccggga
     7021 cgcctccgtc atggcgtcgt tgaagacccc ggagacgtcc gtgtggtccc gcatgaagtc
     7081 ccacacgtcc tggccgtgca tccgctcgaa ggccggtgcg ccggtgcgca cgctgtcggc
     7141 gagcccggcc caggtggcgc ggtcggcggt gagcccgacc cagcgggcga agttgcgcat
     7201 ggaggtcggc gagtcgctgc gcagggcctc gccgacctcg gtgagggcga acacccggcc
     7261 ggcgcgctcc tcgaagaggc cgacgtccgt gcccgcccgc agcagtcggt agagcgtggg
     7321 cgggtgggcg tccacggcgt cggcgatctc gtccgaggtc cggggcccgc cggcgagggc
     7381 gtcggcgatg ccgagctcgg ccgccgcgct gacggccgcg gccatccagc tggcggtggc
     7441 gagctggagc acccggacgg acggcggcag ctggggagga ggggtcatgg cgcgcggttc
     7501 cctttcggtc gcggtcgggt gggagtgctg gggtggaacg gggtgaggag cggtgcggtg
     7561 cggtgaggag cggtgctggt gaggggcggt gcggtgcggt gccgggtggg cggctcagac
     7621 cgcggcgcgc accgcttcga tgacgtacga gacgtccgca tcgctcagat gggggcccat
     7681 cggcaggctc agcacctgcg ccgcgatggc ctccgcgcgt gggaacgcac ccgccggcca
     7741 gcgcttctcg tcggcgtacg cgggggagag gtggaccggc acggggtagt ggatcagggt
     7801 gcccaccccc gcgtcggtca ggctccgctg caccgcgtcc cggtcgtcgc agcacacgac
     7861 gtacaggtgc caggagggct cggcgccctc gggcacggcc gtaggccgca gcccgggcag
     7921 gtccgcgaag gcggcccggt agcgctcggc gatctcggcc cgtcgggcgt tccagcggtc
     7981 caggtgcggg agcttggccc gcagcaccgc tgcgtgcagc tcgtccagcc tggagttggt
     8041 ggacttcagc tcgtggtggt acttgcggcg cgagccgtag ttgcgcagca gccgcagcct
     8101 ctcggccagt tcggcgtcgt cggtgaggat gccgccgccg tcgccgagcg cccccaggtt
     8161 cttcccgggg tagaagctga acgcggtcgc ggtcgcgagc ccgccgccgc cgacccgggt
     8221 gccgttcagc cgtgcgccgt gggcctgcgc cgcgtcgtcg atcagcgcga gcccgtgccg
     8281 gtccgcgacc cgccgcagcg cgggcaggtc cgccggctgc ccgtacaggt gtacgggcat
     8341 gacggcccgg gtcgcgggcg tgaccgccgc ctcgacggcg gccggatcca gcaggtgggt
     8401 gtccgggtcg acctcgacgg gcaccacgtc ggcgccggtc tccgacaccg cgagccaggt
     8461 ggcgatgtag gtggcactgg gcaccacgac ctcgtcgccg gggccgatgt ccagcgcccg
     8521 cagcgcgagt tccagcgcgt cgcagccggt ggcgacgctc acgcagtgcg cggcgccgca
     8581 gtaggcggcg tactcctcct cgaaggcgcg cacctcctcg ccgagcacga accacccgga
     8641 gtccacgacg cggtggtacg cggcgtccaa ctcggcccgg atctcggtgt gcggcccctt
     8701 caggtccaga taggggacct tcatgggcgc gctccggcat ccgcgaggaa ctcgtcgtag
     8761 cggcggtagt agtcggcctc gtcgtagtgc tcggaggcca ggaccagcgc gatggcgccc
     8821 tcggagaagt tcaccaggct gttccacacc atcgggccga tgtacaggcc ctgcccgggg
     8881 tcgtcgagcc ggcagacggc ggtgtcgacg gtgtcgtcca cggcgacgtc gaaactgccg
     8941 ttgatcggga tgacgaactg ctccagattg cggtgggcgt ggtcaccgcg caccgacgac
     9001 gtcggcaggt cgtacaggta gaacagccgc ttgaccggga agccgatgtc cttggcgccc
     9061 tcgacgacgg ccaactggcc gcgcgggtcc ccgatcgtct ggagcttcat cagcgcgcac
     9121 gggcggacct tgccgacccg gctgacgtcg gtcccggcgg tcgtgccggt cgcggcggtc
     9181 gtgtcggtca tcgcggtccc ccgtcggtcg tctcgggcgc gacgccgagg aagagcccgc
     9241 ggcccgaagg cccgtccttg aggaactcga ccgcgaagcc ggcccgctcg aaggcgtcct
     9301 cgtactgctc gcgggtgaag agcgagagca cgtgcaggtc ggagaagcgg cgcacgccgt
     9361 tgacgggctc cgccacggtg tactcgacgg tcatccggct ggtgctcccg gcccgcacgg
     9421 tgtgcgagac ccgggcgatg gtgcggccgt cgacctccac caggctgctg ccgacgtagc
     9481 cgtcgaggaa cgtctccggg aaccaccacg gctcgacgag cgcgaccccg ccgggcgcga
     9541 cgtgcgcccg gaaggtgcgc agggtccgcc gcaggtcctc gaccgacttc agatagccga
     9601 cggagctgaa caggcaggtg acggcggaga accgacggct gaggttgaag gagcgcatgt
     9661 cgtcctggtg gacggcgacg ccggggagtt ggcgggtcgc cagggtgtgc atccacggcg
     9721 acagctccac cccctcgacg tggtcgaccg agccgcgcag cgccgcgagg tgcgcgccgg
     9781 tgccgcaggc cacgtcgagc aggctggtga tctcggggcg ccgggtgcgc aggacggcga
     9841 ggaaggcgtc cgcctcggcg gcgtagtcac ggccccggcc gcggtagatc gcgtcgtaga
     9901 cgtcggcgtg ttcggcgccg tacgcctgct cgacgtcggc gggcgtggga ggcgtgccgg
     9961 gctggctcac cgagagggtg ctcatccgcg caccagtcct tccaggtcct tcaccacgtc
    10021 gttcggggtg ggcagggagt tgagctcgtc ggcgaggacc cgggcctgct ggccgtagct
    10081 cccgtcggac aggaccttgc ggcaggcttc gaaggtgccg tcgggggagc cctcctcgcg
    10141 gtgcagcacg acggcggagc cctgctgctg caacagggcc agcgacggct cgaaggcgac
    10201 gaactggttg agcaccacct gcgggatgcc ggcggacatg gcgttcagcg cggtcagccc
    10261 gccgctgtgc acgatgccgt cgcaggtgcg cagcaggaac tccagcggca cccagccggc
    10321 gcggacctgc gggaagcgct cgcgcagctt ctccgtcgcg gcctcgttcg ccgcgaccac
    10381 gatctcggcg tccaggtcca cgagccggga cagcagggcg cacaggtgct cgaagatctg
    10441 cggcatggcg gtacggaagc tgccgtaggt gacgcagatc cgggggcgct cgcccttggt
    10501 gtacatccac ggctccagcg accgctggcg gttgccgggc acccagcgca tggggcggcc
    10561 gggcgtcgcg aacgacggga ggaggctcgg cgggcagatg tccaagaaca tgtccggggc
    10621 gggcagttcg gccaggccca gccgctccag ctcgggggcg agctcttcgg cggcgtactg
    10681 ctcggcgccg ccgaagtgca gccagtccca cgcctggcgg acgtgcggga cgccgaggtg
    10741 ggccgcgacg agcccggcgg cgtgcgcgtc ggtgccgccg atgacgaggt cggggcgcca
    10801 gtgccgggtc agttcgagga gtccgtcgag gctgacggcg gcctgccggc cgaaccaacg
    10861 gcccacgtaa ggcagttcct ggtcgggcga ccaggggaac tcgatcgggc cgccggggcg
    10921 gtccagctgc ttgatgctct cggtggtgtg ctcggtgacc acggccaccg gaggcagccc
    10981 gatcgcctcg atgctggagg tcaactcgtc gaaggaggcg accaggatct cgtgcccggc
    11041 gttgcgcacc gccgtggcga gcggggcgag ggcgaagacg cccgcggggc tggttcccgc
    11101 tgcgatgaac aggactttca tggcttctcc gtagggtcgg ggccgtcgtc cgggcagggc
    11161 gcagcgccgg cccgcggtga ggacgcgggt cggtcggggc accgggtgac cgggggcgaa
    11221 cgggatgcgg gacgcggatt gcgggacgcg tgcgggaagg agccgagccg tgcgctcgaa
    11281 gggcgcgggg cggaaggcgg ggcggacgcc gggtgagggt cgggtccggg cggcgctcaa
    11341 agcgggaacg ggcctcggag gcacagcagt tccacgatgg acgcaatctt cttcacggct
    11401 ggtcgcggtg tcaaggggga gtcggcgcgg cccttcgggg agtcggtgcg ctccgtccac
    11461 ggcgccgcgc gccgactcac cgaagggccg cgccgggccg tgccgactcc cggaggactg
    11521 ttgacaagcg gtccagggag caattagctt tatcgtgaag atacctcaga gtggagataa
    11581 tctccgtctg agtgggcgac ccggtcggcc ggttcaaacc cccgtagccg accggccggg
    11641 tccttcgccc atcgccgccg acggcgtgcg aaattcagtg ccggtgtgtg cactatgaat
    11701 gcccctggta aatcaacatt ccaccccggc agcaattccg ggcgcagtga taagaaagcc
    11761 tggacagtcc cgtcggcgtg tgcctaggct ttatcgccgg tgcatcaccc atgaccaagc
    11821 ctgctgttcc gtccccggta tgaagttcgg gcggtatacg gcatgaggct tcggccggaa
    11881 tctgggagaa aaatgccgtc gcacaagtcc gccatcgaag gccgttacgg cgtccgcagt
    11941 gaattcccgg cgcgaggtgg ccgccagtga aggccctcgt cctgtccggc ggcgccggca
    12001 ctcggctccg ccccctcacc cacacctccg ccaagcagtt ggttcccgtc gccaacaagc
    12061 ccgtgctgtt ctacgggctc gaagccatcg ccgaagcggg catccgcgag gtcggcatca
    12121 tcgtcggcga caccgcggac gagattcgcg acgcggtggg cgacggctcc aaattcggaa
    12181 tcgacgtcac ctacattccc caggagctcc ccctcgggct cgcccacgcg gtgctgatcg
    12241 cccgggactt cctcggggac gacgacttcg tgatgtacct cggcgacaat ttcatcgtcg
    12301 gcggcatcgc ggacctcgtg cagggcttcc gcgacgaccg cccggacgcc cagatcctgc
    12361 tgacccgggt gtcggacccc tcggtcttcg gcgtcgccga actcgacgcg gccggggagg
    12421 tggtccggct ggaggagaag ccccagtgcc ccaggagcga cctggccctc gtcggcgtct
    12481 acctgttcac ctccgcggtc cacgaggcgg tccgcgcgat ccagccctcc ctgcgcggcg
    12541 agttggagat cacccacgcc atccagtggc tcatcgaccg cggctaccgg gtgcgctcca
    12601 ccaccatctc cggctactgg aaggacaccg gcaacgtcat cgacatgctg gaggtcaacc
    12661 ggtccgtgct ggagaccatg gagccgtgga tcgagggcag cgtcgacgag gagagccaac
    12721 tgatcggccg ggtgaccgtg gaggccggcg cgcaggtgct ccgttcgcgg atcgtcggac
    12781 cggcgatcat cgggcgctcc accgtgatca gcgactcgta cgtcggggcg tacacctccg
    12841 tgtcggaggg ctgccggata gagaacagcg agatcgagtt ctccatcgtg ctgcgcgact
    12901 cctcgatcaa gggggtgcga cgggtggagg cttcgctcat cgggcgcagc gtgaccgtcg
    12961 cgcccgcccc cgccgtcccg cacgcccacc gactgatcct cggcgaccac agcaaggtgc
    13021 agatctcctc atgacctcga cacacatcct ggtgaccggc ggcgcgggct tcatcggctc
    13081 gacctacgtg cgcacgctcc tcgggccgga cggccccggt gacgtgaagg tcaccgtcct
    13141 cgaccgactg acctacgccg gcaacccggc caacctcgac ccggtgcgcg agcaccccgc
    13201 cttcgggttc gtccggggcg acatcaccga cagcgcgctg gtggggatgt tgatggcccg
    13261 ggtcgaccag gtcgtgaact tcgcggccga gtcccacgtg gaccggtccc tcgcgtcgtc
    13321 ggctcccttc gtgcgcacca acgtggtcgg cacccaggtc ctgttggacg ccgcactcca
    13381 ggcaggcgtg cgcaccttcg tccagatatc gaccgacgag gtgtacggct ccatcgccga
    13441 gggctcgtgg tcggaagagc gaccgctcgc gcccaattcc ccctactcgg ccagcaaggc
    13501 cgcggccgat ctgctcgcgc tgagctacca ccgcagccac ggattggacg tgcgggtcac
    13561 ccgctgttcc aacaactacg gctcccacca gtacccggaa aagatcattc cgctgtttgt
    13621 gaccaatctg ctggacggga agaaggttcc cctctacggt gacgggcgca acgtccgtga
    13681 ctggctgcac gtggacgatc atgtgcaggg tgtcgagctg gtgcgcaccg cgggtcgccc
    13741 gggcgaggtc tacaacatcg ggggaggcac ggagctgacc aaccgtgagc tcgcggatct
    13801 cctggtcacg gcgtgcgacg ccgacgggga cagcgtggag tacgtcgccg accgcaaagg
    13861 tcacgaccgg cggtactcag tcgactgtac taagatccgc accgagctgg gataccggcc
    13921 cgtccggaac ttgaccgccg gattggctga aactgttgct tggtatcggg ggaaccgcaa
    13981 gtggtgggag ccgttgaagg agcgcgcgat ggtgtgagac cgtccgcatc gcgcgccggc
    14041 gcgccgttgg gtgcgcactc atctcacccg cttaaccgca gggtaagcgg gacttcaatc
    14101 cgtgcacagg gaaacttgtc cctgcccaaa cggaccctca gaggctaagc tcgtgaccga
    14161 ctggcgttgc cattggcgcg ctgcaggaca ctcgcgttca cctctggagg gaaagtgatt
    14221 aaggttctgc tcgcccaaga cggccgtatg gtacgggggg catttctcgc gcttctggcg
    14281 caggagaacg acatcgtcgt cgtcgccgaa ttagcggcgg gacgcgagtt ggtgccggct
    14341 gcacgccgtt ttgagccgga cgtcgcggtg gtcgacatcg atacgccggg acacgatgac
    14401 ctgtcgtcta ttcaacaaat tcatgaggag ttgccgcaga cgcggacgct cattctgaca
    14461 agtacgtggc ggccgacgat cgtacggcgg gccctcgaca tccaggtggg tggattcctg
    14521 gtcaaggaat ccccacctga gaaactcgtc agcaccataa gggagttggc ggcggggctg
    14581 cgggtcatcg acttcgacct cgccgtttcg gcgtggcagt caccgccgcc gccactgacg
    14641 gagcgtcaac tggagatcct gcggctggcg gcggccggcg acggcgtgcc cgagatcgcg
    14701 gcccggctcc atctgtcgcc gggcacggtc cgcaactatc tgagctcggt caccaccaag
    14761 ctcaatgcgc gcacccggat ggacgcggtc cgcatcgcgg ctgacgcggg ctggctgtga
    14821 ccctccctct tccggctcta acgcggccgg ggtggtcccg aggtggctgg aacacctatg
    14881 gtccccgccc cggccctcgt atgttcacgg ccggtcggca aggccgccga ggcgggggcg
    14941 gccgacgtct gccggggctc cgcagggcgc ttcacgggct cgtcgcccgg gcttcagaag
    15001 gtgttttcca gtcagtcacg aacggtgctt cccctgtgct gacggtgatt catgcaggtg
    15061 agcggtgatg ggcgacgctt cctgagtgtc atgttcgcgc cggcttcggt catcacgtga
    15121 ttgacgcacg cggccatgtg agttcttcac gaagcacatg ggttttccat aatgtgttga
    15181 tgatgaagac actcccccgt ggagtcttgc tgccctacgg tggtgggaaa ccagtcgagt
    15241 tgtctggctg aacaaggggg atctggcgcg actatgcgaa gcccgtcatg gaaccactgc
    15301 cgcgctccga aagtcacggt cggttgcaca gccgagggag gcaccaccct gtgcgactgc
    15361 tgcaaggacg aactgttcaa caccctcggg gagctacccg cgctgtactt ggcgtgtgag
    15421 gtcgccctcg ggggatcgcg tacggtccag gaaagggtgt ccggcggcgc cggacggcgt
    15481 gacctgccgt tcaacgagaa cgtcgccgaa gtgcgctccc gggtccgggc cgtactggcc
    15541 tcctggtcgg ccctggtggt cgaggagcgg gaggtcgagg cgcccgagcg gcgcgtggcg
    15601 ccgatggcgc gcttctgcca ggagaacgtg gactggctgg ccgagcactg ggcggccggg
    15661 gacgtgttgg aggagctgcg ggccctcacc cggctcgccc gcaaggccac cgagaccgac
    15721 cgggtgcgcg tcgtgcccct cggggcctgc gtccgcgaag gctgctcggg caagttgcgg
    15781 gccgtggtca aggcgccggg cccggacgcg aagccgtcgg agatccggtg cagcgcggat
    15841 gcgacccacg cgtgggggcc ggacgagtgg gccgcgctcc gctcggacgc ccagggccgc
    15901 accgccaacc cgcgcgcctg gtacacggtc gtggacatca aggcgctgtg gaacctgccg
    15961 aacggcagca tctaccgact cgccaaccag aacgaatggc gtcggcggaa ggtcgcggga
    16021 cgcgtgtact accacgctgg ggacgtgacc gcggcgctgc ggggctgacc tgacgcagcg
    16081 cccgcgccgg tgagcgtgcg gggcgccgcc cggcggggcg gacgccccgt acgtgcgcgc
    16141 gcgcccgcac gtacgggggg ccgcgtcacc ggtgacgacg gcgacgacgg tgggggaagc
    16201 ccgggacagg ggctcccccc accgctcacg acgccggctg cgccaccgac ccgcccaact
    16261 ggtcgaccgc cgccgtccac acgggccagg gctcacgcga ggcgggcgcc agcagcggta
    16321 cgaccgggct gtggcccgca cgtaccgaag ggtgacggcg cgccagggtc gccagcgccc
    16381 ccgcgggggc ggcgtcgacc acggtgtgcg ccgcgccgtc caacacggtg cacagcgccg
    16441 gccagaactg caccggcagc gccatctgtt cggcccagaa gtcgggtcgc accgcttccc
    16501 gctccgacac cggacgaccg gtgcgggtgg acacgatcgg gatccgcggc gggctcagca
    16561 cctcgtccgc gacggcggcg cagaaccggt ccgccgcccg gcgcatcgcc ggcgcgtgcc
    16621 acggctccag cgcccgtacc cggcgcgccg tcagcccttc atcgcgcaag tggcgttcgg
    16681 ccgcggtcag cgccggctcg gggcccgcga gcacggtttg cgcgggcccg ttgtgcgcgc
    16741 cgagcgccac gcccgcgcac ccgtccccgg cccgcacccg ttccaacacc ggctccggcg
    16801 cccccgcgac ggccagcatg ccgccggcgg gggcctgcga gagcgccgcg cagcgcgccg
    16861 cgaggatccg ggccgccgcg gcgggcgaga acactcccgc tagcgtcgcg gcggccaact
    16921 cgcccacgct gtgcccgacc agtacggccg gccgcacgcc gcgggccgcc agcgcctccc
    16981 cgatgccgta cccgatcagg aacagcaggg gttgcgcggt gacgccccgg tcggcgggcg
    17041 cgccgtcgac ccgcccgagc cacgtcctgc gcacctccgc cccccacgcc cccagcgcgt
    17101 gcaggaactc gtcggcgacc gcggtgaacc gcggctcgcg ccggtacagc tccacggcca
    17161 tgccgacgtg ctggaagccc tgccccggca ggagcagggc gatcggggac gccctcaccg
    17221 gaccagcgcc ccgggggagc gcaccgcacc cagcgccgcc acggcctggg ccaggcgcgg
    17281 tgcgtcattg gtgcggtacg tcgtcgagtc gggggagatc cgctgacaca gcttgctcag
    17341 cgccttgccg gggccgacct ccacgaaccg gtcgaccccg aagtccgtca gggcgcgcac
    17401 ggtgtccgcc cacagcaccc ggctggtgaa ctgccggcgc aggcactcgg cggcctgtcg
    17461 ggcgtcgagc accggggcgg cggtcagggc cgagtagacc gggaccaccg gatcccgcag
    17521 gtcgagcccg tcgatcgcgc gcccgaactc ctcctcgatg cccgacagga ggctgcagtg
    17581 cgccggcccg cccacgtcca gggtgagcac ccgctcggcg cccgcctcgt ccgcgtactt
    17641 gagcagcgcc gccacaccgg cgagcccgcc ggagaccacg atctgccggt cctcgttcag
    17701 attggcgatc tccacgacct cacccgtgtc ggcggcggca cggacgcaca actcctccac
    17761 cccggcgacc gggacgccga tcacgacgcc caggcacccg ggcacggtgc ggttcaccga
    17821 gtccatcagc tctccgcgca gtcggaccag gcgcagcccg tcccgcaggt cgagcacccc
    17881 ggccgcgacc atcgcggcga actcgcccag gctgtgcccg gtcaccacgt cggggacgac
    17941 gccgtgaccg cgcagcacct catgggccac gacgctggtc aggaacaccg cgggctgggt
    18001 gacgggcatc gcccgcaact cctgcgccgg cccctcccaa cacagccgcg tcagcgggat
    18061 tcccaggatc tcgtcggcga cccggtagtg ggattcgatc aggtcgggcc ggtccgcgac
    18121 gaggtcacga cccatcccga cgcgctgcga cccctgtccc gggaagacga aggcggtcga
    18181 actcatcccg ggcgtcaccc ccttcttttc cgtgttcttg cgtgacttct tccaacaagg
    18241 cctcgtgcac ggcgtcggcc cgggcggcgc tcaggcgaac ctgagcgccg cgatgggaca
    18301 ggtgtgcacg gcgctgagcg ccgccgcacg ctggtcctcc ggtacgtccc cggccaccag
    18361 cacgttcgcg tggccgtcgt cgagcaagag cagctcgggc gcctccgcct cgcacagccc
    18421 gtacccctcg caccggtcga ggtcgacgga gatccgcagc cggccggtct gctcgtcggc
    18481 cgtggtcacg tgtgcagcgt gaccggcagc gaggcgatgc cgcggatggt gttgtgcagc
    18541 cgccaggtcg gctcgccgac ctcgatggaa cggaccttcg tcgacagcgc cttgagcagg
    18601 ctgtggccct ccaaccggga cagcgcctgc cccacgcagc cgtggatgcc gtggccgaag
    18661 ccgacgtgct gcgccaccgc acggcggtgg atgtcgaagg cgtccggctc cgtccagtgc
    18721 cgctcgtcgc ggttggccga gccgtacagc agcagcacgc gcatccccgg ctccagcgac
    18781 accccgccga gctcccgctc gcgggtcacc agccgggtga agccgcgcag cggcgactcg
    18841 atgcggatga tctcgttgaa cgcccgcggg atgtgcgact cgtccgcgcg gatctcctcc
    18901 cactgctcct ggtgcgtgcc cagcagccac agcatgctgg agagcgcgct gacggaggtg
    18961 tccatcgacg gggcgaggaa gtcgccgagc agccccggca gcaggtactc ctcgatcttg
    19021 ccgtccttcg cgtcggtcac caactgctcg ccccaactcc cgggccgcag attgccgggc
    19081 accgacatcc gcgccaggaa ctcggacatc tccttcagca gcgggaagcc cgacatggtg
    19141 cgctggttga gcgggccgaa ggcgttgaag ccggcggtcg cccactccaa caggcgctcc
    19201 ttgccctcgt ccaccggcca gcccagcagg tcgggcacca cggccagcgg gaacgcctgc
    19261 gcgaagtcgg tgaccgcgtc gaaggtaccc ttctcgatca gctggtcgac cagggtgttc
    19321 gcccagccct cgatgtagtc gtggaactcc tccagcgcct tcggcttcag gtggcgggcc
    19381 accaggccgc gcacgtagtc gtggtacggc gggtcactgg tgaagctgga ccccttctgc
    19441 gccttgttga gcgtctccgt caggcccacg cccgacgccg acgagaaggt ggtgtggtcg
    19501 tgcagggcgt cgtagacctc gcggtagcgc gccaccgcgt agacctcgtg cgcctccagc
    19561 cacaccaccg ggcccaggtc gcgcagtcgc cggtagtcct cgtacgggga gaggatcgac
    19621 gcgtcggtgt acgggtcgat gtcgctgcgg ggtatggtgc cggtcgccat ggtgctccgt
    19681 ctccttgggt tcttcgggtc agccgcgcgg cgcgggggcc gacagctggg cattgaccac
    19741 gccgaccagg tcgcgcgggg tctcgacgtc ggcgaacgcc gtgtcctcga actccagccc
    19801 gtactcgcga ccgatgcggc tgccggtctc cagcagcgcc agggagtcgt accccaggtc
    19861 gtcgaagctc gcgtcgagga tgtcgccgtc caactcggcg gtggcgccgg cgccctcccg
    19921 caggatgcgc ttgaggtcgt cgatcgagaa gctgctcatg ttccgctcct tcgtggcggt
    19981 cgtgctgcgc cggggcgtgt ctgacagatc gggctgacgg cggcgctcac gccgcctgca
    20041 ccacgacggc cgagttgaag ccgccgtgac cgcgcgcgag gacgaccgcg gtgcgcacgt
    20101 cggccttccg cggttcgccg gtgaccaggt cgatgccgta ctccgcggcg cccgtgacgt
    20161 gcagcgtcgg cgggatcacg ccgtcccgga tcgccagcag cgcggtcgcc acgtccagcg
    20221 cggcggcgcc cgcggtgagc cggcccgtca tcgtcttcgg ggccgtcacc ggcaccccgc
    20281 cgcggccgaa gacctcgccc agcgcatcgg cctcgatgcg gtccagctcg gggacggcgg
    20341 cgccgtccgc gaagaccacg tccacctcgt cgggccgcac cccggcgtcc tccaacgcca
    20401 gcgtcagcgc ccggcgcagc ccaggctcgc gcccgctgcc cggccgcgga tccatcgtgg
    20461 agccgtatcc gctgatcagc ccgtggatcc gggcgccgcg ctcccgcgcc gacgccacgt
    20521 cctccaccac caggtgcgcc ccgccctcgc ccggcacgtg cccgcgggcc cgggcgtcga
    20581 agggcaggta cgcgcactcc ggatcctgtg acgtgctcat ccggtcgccc gccatctgcg
    20641 ccacccagcc ccaggggcac agcgaaccgt ccaccccgcc cgagaccacc agccgggtgc
    20701 ccttgcggat ctgccgacgg ctctgggcca gtgcgtccaa cccgccggcc tggtcgctga
    20761 cgacgacccc gctggggccg cgcatgccgt gccggatcga gatctggccg gagttcaccg
    20821 cgtagaacca ggcgtacgac tggtacgcgc tgacgtactt cgggccctcg cgccagaggt
    20881 tctccaactc ccgctggccg aactcgaagc cgcccgcgga gctggcggtg atcacgccgg
    20941 ccgcgaagtc cggcaggtcc tgcggctcga ccccggcgtc gtccagggcc cactgcgccg
    21001 cggccagcga cagccgcgtc atgtggtcgg tctgcgggac gagcctgctc ggcaggtgct
    21061 cggccgggtc gaagtcgatc tcgccggcga gtttcgccgg atagccggag gcgtcgaagc
    21121 ggcgcagcgg cccgatgccg ctgcgcccct ccagggtcgc ccgccagtac tcctcggtgc
    21181 cctgcccgtt gggggcgatg gctccgacgc cggtgacagc cacggccgtc atgcggcact
    21241 cctctcggga cgggacagga ccatggcgct ctggaagccg ccgaagccgc tgccgaccgt
    21301 gaggacccgg tcggtgggcc agtcacgggc ggtcaggggc acgtagtcca ggtcgagttc
    21361 tgggtcctgc tggtgcaggt tcgcggtggg cggcaccacg ttgtgccgga tggcgagcgc
    21421 ggaggcggcg atctcgatgg agccgatcgc gcccagggag tggcccacca tcgacttgat
    21481 ggagctcacc ggcacccggt aggcgtgcgc gcccagactg gccttgaagg cggccgtctc
    21541 gtgccggtcg ttctgcttgg tgccggagcc gtgcgcattg acgtagtcga cgtcctgggg
    21601 cgcgaaccgg ctctcgtcca gcgcggcggt gatcgccgcg gccatctcgg cgccgtcggc
    21661 gcgcagcccg gtcatgtggt acgcgttgct gcgcgtggcg tacccggtga cctcggcgta
    21721 cacggtcgcg ccgcggcgcc gggccgactc gtactcctcc agcacgaaca ccgcggagcc
    21781 ctcgccgagc acgaagccgt tgcgggtgct gtcgtagggg cgggaggcgt gctccgggtc
    21841 gtcgttgtgg accgtggtgg ccttgatggc gtcgaagcag gcgaccgtga tgggggagat
    21901 cggggcgtcg gtggccccgg tgaccatcac gtcggcgctg ccctcgcgga tcagctccac
    21961 ggcgtgcccg acggcgtcga tgccggaggt gcagccggtg gagaccaccg tggcgggccc
    22021 ctcggcgccg accgcccagg ccacttcggt ggcgaaggag ctcggcacga ggtagtcgta
    22081 caggtgcggg gtcgcatagg cgtggtcgac gaggtgtttg gtgccgtcgt cgctgacgac
    22141 ccggtactcg tcctccaggc tggtggtggc gccgacggcg ctgccgatcg tgacgccgat
    22201 gcggtacggg tcgacctcgg gcagctccag gccgctgtcg gtgaccgcct cggcggcggc
    22261 gaccacggcg aactgcgcgg cccggtccat ccggcggatc tcctgggcgc gcagcccgtg
    22321 ctcctccggg tggaagtcga cctcggccgc gacccgcgac cggtaggggg tggggtcgaa
    22381 gtgggtcagg gtccgggtgg cggtgcgtcc ctcgctgatc agggaccaga agttcttggt
    22441 gcccacgccg cccggcgcga gcacaccgat accggtgatg accactcgcc gcctcgtcat
    22501 gatgtcctcc acagaaacga gagttcggtg atccggaagt ccggagttcc gggatggccg
    22561 ttgcccgccc tccggactcg actcggggcg gtgcggctgt tcgtgtgcgt cagtgctgtc
    22621 ggccgcgcct gcgggtcacg gtcggtcggc ggtgccgaac cagtcggtga gcgcggtgcg
    22681 cagcggggtc gtcgtgcggt cggtccacac gacgtgtccg tccggtctta cgagaacgga
    22741 agtgacggag gtgccggaag cgaagggcgc gtcgtcgggg ccggccgtgg cgcgtacggt
    22801 gcggacgcgg tcggcccaac cgtcggcgtc ggcgtcggcg tcggtcgaag ccgggccggg
    22861 cgcgaggtcg agcagcagcc cccggccgtc gcgcagcagc gcgtggacgg ttgtgccctc
    22921 gccgttcgag caggtcaggg ccaggtcggg gacgcgggat ccgagcagta gagccgggat
    22981 gtcgtcggcg ccacgcacgt cgtcacggat gttgtcacgg atgtagtcat ggccgtggta
    23041 ccggacgtcg tagcggacgt ccaggccggt cacccaggcc gcgatccggt cgcggggacc
    23101 ggggtccgac agcacctcgg cgagcacctg gcgcaccggc gcggtctgcg cgcccccgaa
    23161 catcagcatg ccctgcgcct ggacgttgtc caggacccga cgtcccaccg gatgccgctc
    23221 gtcgtggtag ctgtcgagca gcccgggcgg ggcccatccc cgcacctggg cggcgagctt
    23281 ccaacccagg ttggccgcgt cctggagccc gaggttcagg gactgaccgc ccaccggcat
    23341 gtgggcgtgg gcggcgtcgc cggccagcag gacccgaccg cgccgatagg cggcggcctg
    23401 cacccaggag tcgtcgaagg cgtcccgcca gatcggcgtc gcgcccgtga ggtcctcccc
    23461 ggtgacggtc cgccaggccg cggcgatctc ccgcagggcg ggcgggccct ggcggcggac
    23521 cggcggggcg ccgtcgaccc ggaccatcac ccgggtcacc ccgtcgggac ggcgggccga
    23581 ggcggcgaag ccccgctcca ggagctggaa ccgtcggtcg ggcacctcga tcccggtcag
    23641 gtcggcacgc agcaactcgc ggcgcgccgg gcccgattcg acggggaagc cggcgagcga
    23701 acgcacggtg ctgtgcgcgc cgtcgcagcc gacgacgtac ccggcccgca cggtgagcgg
    23761 cccgtcctcg gtgcggaagc gggcgacgac cccggcgtcg gcggcggcgt cgtcggctcc
    23821 gtcggtgtgc acgtcgcaca actcgtacaa ctcgtacccg cgcagcagcc gggcgcccgc
    23881 cgccagcgcc cgtcgggcga gcaccgcctc ggtgcggaac tgggggacct tccagtggcc
    23941 cggatacggg ctgcgcacgg cggacgcgtc gaaggacagc ccggcgaagt gcccgcgcgg
    24001 ctcggggacg agttcgtcgc cgaagtcggc cagcagcccg cgctgggcca gcacctccat
    24061 ggtgcgcgcc cccagttggg aggcgcggga ctcggtcatc ggcgcgctca ggcggtcggc
    24121 gaccaccacg tccacgcccc gctcggcgag gtcgccggcg agcagcagcc cgacgggccc
    24181 ggcgccgacg acgagcaccg cggcttcgac gtccgccggg ccggaccccg tcgccccgcc
    24241 gccggacggc ggggtcgtca agacccgccc tcgacgtggg ccttcgcgtg gttgagggtg
    24301 ctcaggctgt tggtgcccag ggcgcgccgc accgcggcgc gcgcctcggc gagcccggcc
    24361 ccctcgccca gcacctgggc gatcttcgtc tcgtcgatgg cgacggtgtg ccgcgacacg
    24421 gccagcacgc cgtcggcgtt ctcctcgaag ctccaccgac cggtgtgcag cgtcatcagc
    24481 gccggcagct tgatctgctt gtagtggatc gtgcccgcgg gccgctgaca cacccggacg
    24541 gacttcgtgg tgtggatcga gccgtcgggg gagcgggtgt ccatctccag gagctggagc
    24601 ccctcggtct cctccgtcaa gatcacgcgg gcgacgtgcg gcagccgctc ggaccacagc
    24661 tgtgcctggt cgatgaaggc gaagacgtcc gccgcggtgc cggcgatctg tagcccgtcc
    24721 tcgaacgtga agggcttctg tgcggcgtcg gggccgagct ccgccgtggt cttgagggcg
    24781 gccagctccg cgtggctgtt gcggtcgacg gcttcggcga tccactgcag ggccgccggg
    24841 tcgtcgtcca cggcgcggta gtcgtgcagc agccggaccc gacagagctc gtcgccctgc
    24901 ggctcgacga tccacgtgcc gcccatgccg gcgaccggcg ggctcgactt ctcctggcgg
    24961 aactcgatga cgccctggtc gggcaggagc cgacggatgg acgtccagcg cttcgcggcg
    25021 ccgttggcgg tcgcgcagat gcggatgcgc tcgtgctcgc cgtcctgctc cacgcgctcc
    25081 acgtgcacgc tcggcgggaa catcgccggc cagtcctcca cctcgaccag cagttggtag
    25141 acgtccttgg cgggcgcggc caccgtgatc tcgtgctcga cttcgcggac ctccggtccg
    25201 ggcatggcaa ctccgtaagg gttcaagggg tgtggggcgg ggcgctcacg ccgcgttgac
    25261 cagctcgatg aagccgcgcg gggtggtgat ggcggtgacg gcgtcgtcca ccagctccac
    25321 gccgtactcc cgggagacca cggccgcggt ctccaacagg gccagggagt cgtagcccag
    25381 gtcgctgaag aaggtgtcca ggatgtcgcc gtcgaggtcg acggactcgt cggcgccggc
    25441 ggcgtcgacg aggatgcgct tgagttcggt gagggtgaac gtgccggtgg tcatggggtc
    25501 gtcctctcgt cagtcctgct gccagtggta gaagcgctgg gccatggcgt cggccggcga
    25561 gcgccaggtg tcggggtcgt aggcggtgat gtgctgcttg aggtcgtcgc tgatcccgac
    25621 gaacagcggg tgggagcggg cctgcgagat ccgctcgccg ccgtcgtcgt ccgcgaagtc
    25681 ctggaggtgg aagtagaggc cctggtagct gaagagctgc cggcgcaggg tgcccatccg
    25741 ctcgggcatg tcggtgcggt cgaaggcgcc gaagagttcg ctgacgtcgt cgaccgagcc
    25801 cgggcggagc cgggcgacga tcagggtgct gtgcatggcg gggtcctcga tgtcgtaggt
    25861 ccgtgtccgt gtcgtaggtg cgtgcggtgc tgtgtccgcg ccccggtgcg gcggcgtgta
    25921 cacgtgtacg cagtcgggtt cgggcggggg cgcgacggtc aggccgccgc gggcatcggc
    25981 tcgtcgcccg ggtccccgaa ccaccgggcc agggccgtcg tcaggtcgcc gccgtcgggc
    26041 gccacccaga ccacgtgacc gtccggccgc accaacagcg ctcgcacgcc gtccagttgg
    26101 gcgtcggtgc cctcgccgag cacgctcgcc gtgacgacgt cgacccggtc ggcccacggc
    26161 gcagcggcgc cccggagccc ggtggcgccg tcgagggtca gcagcagtcc ccgcgcggag
    26221 tgcagcagtc ggctcccggt ggtggtcccg tcgtcggtgc gcaggtcgca cggcggcagc
    26281 cgacggccga gcagcgggtg ttcgccgccg ccggtgtcgt actgcacgtc gagcccgctg
    26341 accatgccgg ccagccgctt cagcacctcg tcgtccgcca tcagctcgcc gaggaccgcc
    26401 cgcagcgggt cgacctcggt gccgctgagg tagaggattc cctgcgcgcg ggtgttcgtc
    26461 agcacccgct cgccgaccgg gtggcgctct tggtggtacg tgtccaacag cgcgtcgccc
    26521 gcccgcccgg tgaccaccgc ggcgagcttc cagccgaggt tcaccgcgtc ctgcacgccc
    26581 acgctcagcc cctggccgcc ggccggcagg tggatgtggg cggcgtcgcc ggccagcagg
    26641 acccggccgc gccggtaggc ggtgacgatc cgcgaggcgt ccgtgaagga gctgacccaa
    26701 cgcgcctcgc cgtggccgat gtcctcgccg gtgagccgct tccaggccgc ggcgacctct
    26761 tcgtacgacg ggggagcggt acgctccccg ggcgccgtgc cgcgctcgca gacgatgacc
    26821 cggtcgagcc cgtcgctgag ccgggcggcc atcaccatgc cgccggccac ccgctcgccg
    26881 atgaagcggg gcctgatgtc cgcgccggcc acgtcggcga ggaacatctc gcaagtggcg
    26941 tcctggccgg ggaagtcgat gccggccgcc tggcgcacgg tgctgcgtcc gccgtcggcg
    27001 cccacgaggt acgagcagcg catcgtcacc ggtccgtcgg ggtcggtcgc cgagacgacg
    27061 accccgtcat cgttctgagc gatcgcggtc acctggtggc cgcggcgcag gtcggcgccg
    27121 agttcgacgg gccacgcggt gagcacggcc tcggtctccg actgttcgac gttgcgcacg
    27181 ccgaagtggc cgccgggcag gacggagtag tccatcggga tgccgccgaa gtggcccttg
    27241 gcgctgatct ccgcgtcggc gaagcggtcg aggagaccgc gttggtcgaa gacctcggtg
    27301 gcgcgggcgg tgaagccgag cccgcgggac tccgtgaccg gctcggcgag ccggtcgagg
    27361 acgatgacct cggcgccgcc gagccggagt tcgccggcga gcatcagccc cgtcggtccg
    27421 gcgccgacca cgatgacggg ggcgtcgccc gtcgcatggg tcgcgttcat gacgccgcct
    27481 tgcgacgcac gggctccagc gcctggctcc aggccacgac ctggtcgagc acgctgccga
    27541 ccaactccgc cttctcggcg gtggggcgga actcgctgcg gtccacgaag tcggcgtcga
    27601 aggtgagggc cacctgcgcc cgtacggtcg cgacctggag ttcggccatc accaggcgca
    27661 ggtgctcgac ggcgcggacg gcgccgacgg gaccgtaccc gacgaagccc gcggccttgt
    27721 cgttccactc ggcgaacagg tagtcgatgg cgttcttcaa cgcgccgggc accgagtggt
    27781 tgtactcggg ggtcacgaag acgaagccgt ccaggcgcgc gatccgctcc gcccaggcca
    27841 gggtgtgcgg gtgctggtac atcccggcca acggcggaat gggctcgtcc agcaggggca
    27901 gcgccagctc ggcgatgtcc acgagctcgt actcggcgtc gccgcggcgg acggcgatgt
    27961 cgtgcaccca ctcggcgacg gcgccgccgt tgcgctgggg ccgggtgctg ccgaggatga
    28021 tgccgattct cgtcatggtc gctccggtgt cgagttgagg agttcgatcc ccgatgacgg
    28081 gcgcgtcacc gggtcgtggt cacgcgctgt catcggcccc gaacggctgc tcgatgccga
    28141 tggcgttgtc cgtgacggtc acgtaccggc gggccgccag cggggactcc cgcaggtcct
    28201 cgacgaaggc gtggtactgc gccacgtcgt cgaagcccac gaggaagaag tccgtgtggc
    28261 gggtggagaa gccggaggcc cggaagggac ggatgtcgag ggtcgccgcg tgcttgccga
    28321 ggatcgggaa tacgttctcg gcttcgaatc ggtcgcgctc ggccggctcc agcaggaacc
    28381 attcgggctc gaaccgaacc ccgagaaatg ccgtgtactt catgtgctga tctccttccg
    28441 ggaagtgctg ggggttgctg aggtgtacgg agggcgaggg ggcactcggg gcgaaggcga
    28501 tgaaaggtgg gcaatctgcc cgatcgaagc cagagctcgg ccgtgctcac ccacatctgt
    28561 ggcgccggcc cggggagatc gctttgccgt tgagttgtat cgccgtgata tatcctgatg
    28621 gaaaaggaac cgcaggaatt tcgacgtgcg gtgctgacga ggagcgaacg gatggaagag
    28681 cccgacaccg cgcagatggc ggcgcaaggg ggccgcatcg tggacgagtt gcgttcctgg
    28741 ggggccaact acacggaatt cacccggcgc tttgccgccc aattgggcct gcattccacg
    28801 gacgccgccg ccctggtgga gatcctgtac gcggaggacc agggccagcc gctctcgctg
    28861 gcccggctga gcgagcgcgt ctccctcacc tcgggcgcga ccaccgccct ggtggaccgg
    28921 ctggagaagg cgggccacat cgtgcggacc cgcggtgagc actccgaccg ccgggtggtg
    28981 acgctgcgta gcggaccgga gatcggcaag gccgccaccg aattcttcac gccgttcgca
    29041 ggccggatga ccaccatgat gtcggcctat ccgcccgaac tcatcggaca gttcgaggag
    29101 ttcctgaagg acatgcgccg cacgctcacc gcgctgctgg ccgaggagta ccgggagaac
    29161 cggccccgcg agcgcggatg aggcgaccgg agcgggctca gaagttgccg agtccgccgc
    29221 agacgttgat ggcctgcgac gtcaccgacg cggccgtgtc gctcaccagg tagcccacca
    29281 tgccggcgac ctcggtcacc gtcgagtagc ggcccagcgg gatcttcgcc tggaaccgct
    29341 ccaggatgtc ctcctccgtg gtctcccacg cccgtgcgta cccggcgcgc acccgctccg
    29401 ccatcggcgt ctcgacgtag ccggggcaga ccgcgttgac cgtgatcccg gtcttcgcca
    29461 actcgttgcc cagggacttg gtgaagccca ccacgccgtg cttggacgcc gagtacggag
    29521 ccgccagcac cacgccctgc ttgcccgcgg tggaggcgat gttgacgatg cggccccggc
    29581 tcttgtcccg catgccgccc accgagagca cgtcccgggt cacgtagaag acgctgttga
    29641 ggttggtctc gatcacctgg agccaggcgt cgtccgtgag gtcagcggtc accccgccgc
    29701 caccggtgcc cgcgttgttg accagcacgt cgatgctgcc gtaccgctcg accgccgcgg
    29761 tcaccatggc ccgtacgtcc tgcgcggagc gcacgtcgca ggcgacgccg tccacgtcgt
    29821 ggccctgctc ccgcaactcc tccacggtct gcttgacccg gtcggcgtcc cgggcgcaga
    29881 agaagacccg gtgcccgagc tcggccaggt gctggacgac ggccagcccg atgccgctgg
    29941 tcgcccccgt caccaaggcg gtcctgtcga ggccgttcgt catggtccgt ccccaatccc
    30001 gcgccgcggt cccgctcggc cgtcggcgcg cacgaagaag cggcccggac gtggccggac
    30061 cgctgagaag tcgctcgctg agaagtcgct tgttgtgaag tcgtctggcg tgaagtcgcc
    30121 cactgtggaa ggtcgttgct ccgacgtcgt ctgcgtccgg tcagcgggcg gggcctaggg
    30181 cctgcccgct gggcacaacc tttccaatgt gatgcatatg ttcttcatcc caggtcggcc
    30241 tgtcaagccc cctccggggc cgagcagtcg aaggcgcccc ttcaaccgcc gctgccgcgc
    30301 acgtcggagg cggtcttgtg gaccgcggcg acgaccgcgt ccacgtcctc gtcggtcatc
    30361 gcggccccca gcccgatcgt cacggaacgg ccgaggaacc cctcgctgat ccggttgcgc
    30421 tccggacgct cccactcctt gccccacggg gtgcgcccct cccgcaccgc ccggtgcgtg
    30481 gacaccgtct gcccctggta gagggtgtac gccgggacgc ccgccgcccg gagccccgcg
    30541 acgaacccgc gggccgtcag ccgggagtcc agcaacagcg tcagatctgt atgcgctcca
    30601 cctcgccccc gaggtcgcgg tccgcgaggc gcagcatcac gagccgccgc aggtagttct
    30661 cggcgagggg gccgcgggcc tcggtggagc ggttctggct gtcgtgcgtg ttctggtaga
    30721 agtcccagct gcggcgcagc atgttctgct gcgtgtggct ggggagcagg ttgccgcgga
    30781 tcgcttcggc gtcctcggcg gccaggtcga tccactcggt cgtccgcagc gcgccgtccg
    30841 ccgtcttgac ctcggccttc acctggacgc cgatgttctg ctggagcggg ttgggggcga
    30901 agagcttcca gttctgctcg aactcggggt agatccaggc gtcgatctgc ttgccgtact
    30961 ccttcgtcac ggtgttggag ggcgcgacgt gcagaaacgt catggcgagg tggatgcagg
    31021 cggcgagcgc gagcaggccg aggacgactg cggcggcgat ctggtacggg agcgtgagcg
    31081 cggctatgcc ggcggggggc gggggcgggg ggccggtcgg ggcgtcgggc gccgggtcgg
    31141 tcggctcggg cgcctcgggg gtgtcaggag cctgaagacc gtcgggagcc tcggggttct
    31201 cgggagcctc gcggttctca ggggcttcga ggtcctcagg gactttggac gcctcgggag
    31261 tcccaccagc cgctggagcc ccgccggctc cggtagcccc tcctgcggtc ggggccggtg
    31321 ggccggtcac tccagtggac gcatcgtccg cgtcctcgct ctcgccctcg ccccggtcct
    31381 cgtaggagtt catcccgccc cgatccagtc cggccagcct cggttatcca cagggttgac
    31441 accttaaggg ccggcgactc accattgaag tcaatgaacc gaacgatcgg tcggtagggg
    31501 gtccggatga cgacagtgac gccagatgcg acggagaggt acgaggcggt cttcgacgcg
    31561 gccgtggccg cggacgagcg catcgagccg cgcgactgga tgccggacgc ctaccgtgcg
    31621 accttgatcc gtcagatggc gcagcacgcc cattcggaga tcatcggcat gcagcccgag
    31681 gcgaattgga tcagccgcgc accctcgctg cggcgcaagg cgatcctgat ggccaaggtc
    31741 caggacgaag ccgggcacgg cctctatctg tacagcgctg cggagacctt gggcgtcggc
    31801 cgcgacgagc tcctcgacaa gctccactcc ggccgccagc ggtattcctc gatcttcaac
    31861 tatccgacgc tgacctgggc ggacgtcggc gccatcggct ggctcgtgga cggcgccgcg
    31921 attacgaacc aggtgccgct ctgccgctgt tcctacggcc cgtacgcccg cgcgatggtc
    31981 cgcatctgca aggaggagtc cttccaccag cgccaggggt acgagctgct gctgaccctg
    32041 tcccggggca cccccgcgca gcacgagatg gcgcaggacg cggtggaccg ctggtggtgg
    32101 ccgtcgctga tgatgttcgg cccgcccgac gacgagtcgg cccactcggc gcagtccatg
    32161 acctggaaga tcaagcgtca ctccaatgac gagttgcgcc agcgcttcgt ggacatctgc
    32221 gtcccgcagg ccgaggccct cggcctcacc ctccccgacc ccgacctgcg gtggaacgaa
    32281 gaccgtggcc accatgactt cggcgcgatc gactggtcgg agttccaggc cgtcctcaag
    32341 ggcaacggcc cgtgtaacga gcagcggata tcccagcgcc gccgggcgca cgaggagggc
    32401 gcctgggtgc gggaggccgc cgcggcgcac gccgccaagc aggcgcgcac gcacaccgac
    32461 gagccgcggg aggccacggc atgagcagtt ccgacggcac ggcagccgct gcgggcgggg
    32521 cgaaggactg gccgctgtgg gaggtcttcg tccgttcgcg gcggggcctg tcccacaccc
    32581 acgccggcag cctgcacgcc cccgacgccc agatggccct gcgcaacgcc cgggacctgt
    32641 acacccggcg caatgagggc gtgtccatct gggtcgtgcc ctcgaccgcc gtcaccgcct
    32701 cgtcgccgga cgagaaggac cccttcttcg agcccgccgc cgacaagccc tatcgccatc
    32761 cgacgttcta cgagatcccg gagggggtga agcacctgtg a
//
