BGC0000263 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000263 (Streptomyces ravidus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	32,801	ravidomycin	PKS	100%

BGC0000263 - Region 1 - T2PKS

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Location: 1 - 32,801 nt. (total: 32,801 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 32,802
Label		BGC0000263

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000263	1.00	Polyketide	ravidomycin	Streptomyces ravidus
BGC0000231	0.32	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0002084	0.32	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002099	0.32	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0001924	0.32	Terpene	ascofuranone	Acremonium egyptiacum
BGC0001817	0.30	Other	vancosamine	Streptomyces sp. WAC2288
BGC0002733	0.29	Other	sinapigladioside	Burkholderia gladioli
BGC0001723	0.28	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000264	0.27	Polyketide	resistomycin, resistoflavine	Streptomyces resistomycificus
BGC0000272	0.26	Polyketide	spore pigment	Streptomyces collinus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000263	1.00	Polyketide	ravidomycin	Streptomyces ravidus
BGC0000231	0.65	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0002084	0.65	RiPP	biarylitide YYH, biarylitide YFH	Planomonospora sp. ID82291
BGC0002099	0.65	RiPP	biarylite-YFH	Planomonospora sp. ID107089
BGC0001924	0.65	Terpene	ascofuranone	Acremonium egyptiacum
BGC0001817	0.64	Other	vancosamine	Streptomyces sp. WAC2288
BGC0002733	0.63	Other	sinapigladioside	Burkholderia gladioli
BGC0001723	0.61	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000264	0.60	Polyketide	resistomycin, resistoflavine	Streptomyces resistomycificus
BGC0000272	0.59	Polyketide	spore pigment	Streptomyces collinus

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

ravQ

PKS_AT (9..302): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 66.7%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 57.2
Methylmalonyl-CoA: 28.9
Methoxymalonyl-CoA: 28.3
Ethylmalonyl-CoA: 19.6
fatty_acid: 15.0
Propionyl-CoA: 14.9
CHC-CoA: 12.5
trans-1,2-CPDA: 12.4
2-Methylbutyryl-CoA: 11.2
inactive: 10.7
Benzoyl-CoA: 9.6
Acetyl-CoA: 9.5
Isobutyryl-CoA: 8.8
3-Methylbutyryl-CoA: 0.0

ravP

PKS_AT (6..297): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 62.5%; Isobutyryl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 70.2
Methylmalonyl-CoA: 38.5
Methoxymalonyl-CoA: 32.7
Propionyl-CoA: 22.1
inactive: 19.5
2-Methylbutyryl-CoA: 17.2
Isobutyryl-CoA: 13.7
CHC-CoA: 13.0
Ethylmalonyl-CoA: 12.9
Benzoyl-CoA: 11.4
trans-1,2-CPDA: 10.6
fatty_acid: 10.6
Acetyl-CoA: 9.3
3-Methylbutyryl-CoA: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 0 to 32801
Starter unit(s):: propionyl-CoA (Score: 633.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 703.9; E-value: 1.2e-214)
Product class(es):: angucycline
Product molecular weight(s):: propionyl-CoA_8: 574 Da
propionyl-CoA_9: 616 Da

ravA: KS (Score: 782.8; E-value: 1.6e-238)
ravB: CLF 8|9 (Score: 703.9; E-value: 1.2e-214)
ravC: ACP (Score: 114.4; E-value: 4.2e-36)
ravC1: ACP (Score: 113.2; E-value: 1e-35)
ravF: KR C9 (Score: 470.5; E-value: 3e-144)
ravG: CYC C4-C17/C2-C19 (Score: 189.1; E-value: 1.8e-58)
ravGT: GT (Score: 381.4; E-value: 1.5e-116)
ravK: CYC C7-C12 (Score: 462.7; E-value: 1e-141)
ravMT: MET (Score: 314.3; E-value: 2.3e-96)
ravOI: OXY (Score: 563.6; E-value: 8.7e-172)
ravOIV: OXY (Score: 488.2; E-value: 6.3e-149)
ravQ: AT (Score: 384.2; E-value: 1.2e-117); AT CBH32803.1_Ravidomycin_propionyl-CoA (Score: 633.0; E-value: 0.0)