BGC0000264 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000264 (Streptomyces resistomycificus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	16,662	High	resistomycin/resistoflavine	PKS:Type II

BGC0000264 - Region 1 - T2PKS

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Location: 1 - 16,662 nt. (total: 16,662 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 16,663
Label		BGC0000264

Tailoring functions

Oxidoreductases: oxygenase

remO: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: acylase kinase methyltransferase

remE: malonyl CoA-acyl carrier protein transacylase

smcogs: SMCOG1021: malonyl CoA-acyl carrier protein transacylase

remG: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

remH: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

remJ: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

Lyases: cyclase

remI: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

remA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

remB: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000264.5	1.00	PKS	resistomycin, resistoflavine	Streptomyces resistomycificus
BGC0001257.3	0.64	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.64	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata
BGC0001160.5	0.61	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000231.5	0.60	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.55	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000272.3	0.55	PKS	spore pigment	Streptomyces collinus

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000264.5	1.00	PKS	resistomycin, resistoflavine	Streptomyces resistomycificus
BGC0001257.3	0.64	PKS	1,3,6,8-tetrahydroxynaphthalene	Nodulisporium sp. ATCC74245
BGC0002154.2	0.64	PKS	1,3,5,8-tetrahydroxynapthalene, 1-(alpha-l-(2-O-methyl)-6-deoxymannopyranosyloxy)-3,6,8-trimethoxynaphthalene	Pyricularia oryzae 70-15
BGC0000107.3	0.63	PKS	naphthopyrone	Aspergillus nidulans FGSC A4
BGC0001254.3	0.61	PKS	ACT-Toxin II	Alternaria alternata
BGC0001160.5	0.61	PKS	1-nonadecene, (14Z)-1,14-nonadecadiene	Synechococcus sp. PCC 7002
BGC0001164.3	0.60	PKS	1-heptadecene	Cyanothece sp. PCC 7822
BGC0000231.5	0.60	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.55	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000272.3	0.55	PKS	spore pigment	Streptomyces collinus

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

remE: mal

PKS_AT (98..389): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 74.3
inactive: 44.3
Methoxymalonyl-CoA: 36.4
Methylmalonyl-CoA: 36.1
Propionyl-CoA: 27.9
Isobutyryl-CoA: 21.3
3-Methylbutyryl-CoA: 13.5
Benzoyl-CoA: 12.0
Ethylmalonyl-CoA: 11.5
CHC-CoA: 9.5
trans-1,2-CPDA: 9.4
Acetyl-CoA: 7.6
2-Methylbutyryl-CoA: 7.2
fatty_acid: 0.0

Link to PARAS substrate predictor

Type II PKS gene cluster prediction details

Cluster section:: 0 to 16662
Starter unit(s):: propionyl-CoA (Score: 109.0; E-value: 6.78e-30)

remA: KS (Score: 548.1; E-value: 2.9e-167)
remB: CLF (Score: 439.5; E-value: 2.6e-134)
remC: ACP (Score: 39.8; E-value: 7.9e-13)
remE: AT (Score: 153.5; E-value: 1.6e-47); AT BAB72049.1_Aklavinone_propionyl-CoA (Score: 109.0; E-value: 6.78e-30)
remG: MET (Score: 189.9; E-value: 1.5e-58)
remH: MET (Score: 134.5; E-value: 1e-41)
remI: CYC C9-C14 (Score: 158.6; E-value: 2e-49)
remL: CYC C5-C14/C3-C16 (Score: 352.5; E-value: 3e-108)
remO: OXY (Score: 123.4; E-value: 3e-38)