BGC0000264 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000264 (Streptomyces resistomycificus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS	1	16,662	resistomycin/resistoflavine	PKS:Type II	100%

BGC0000264 - Region 1 - T2PKS

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Location: 1 - 16,662 nt. (total: 16,662 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 16,663
Label		BGC0000264

Detailed domain annotation

Selected features only

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Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000264	1.00	Polyketide	resistomycin, resistoflavine	Streptomyces resistomycificus
BGC0001197	0.28	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0000204	0.27	Polyketide	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0000231	0.26	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0001895	0.25	Polyketide	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0001782	0.24	Other	spiroindimicin A, spiroindimicin B, spiroindimicin C, spiroindimicin D, indimicin A, indimicin B, indimicin C, indimicin D, indimicin E, lynamicin A, lynamicin D, lynamicin F, lynamicin G	Streptomyces sp. SCSIO 03032
BGC0002514	0.24	Polyketide	julichrome Q6.6	Streptomyces sampsonii
BGC0000217	0.23	Polyketide	daunorubicin	Streptomyces sp.
BGC0000234	0.22	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000218	0.22	Polyketide	doxorubicin	Streptomyces peucetius

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000264	1.00	Polyketide	resistomycin, resistoflavine	Streptomyces resistomycificus
BGC0001197	0.62	Polyketide	frankiamicin	Frankia sp. EAN1pec
BGC0000204	0.60	Polyketide	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0000231	0.60	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0001895	0.58	Polyketide	huanglongmycin A, huanglongmycin B, huanglongmycin C	Streptomyces sp. CB09001
BGC0001782	0.57	Other	spiroindimicin A, spiroindimicin B, spiroindimicin C, spiroindimicin D, indimicin A, indimicin B, indimicin C, indimicin D, indimicin E, lynamicin A, lynamicin D, lynamicin F, lynamicin G	Streptomyces sp. SCSIO 03032
BGC0002514	0.57	Polyketide	julichrome Q6.6	Streptomyces sampsonii
BGC0000217	0.56	Polyketide	daunorubicin	Streptomyces sp.
BGC0000234	0.55	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000218	0.55	Polyketide	doxorubicin	Streptomyces peucetius

Similar known gene clusters from MIBiG 4.0

NRPS/PKS substrates

Type II PKS

NRPS/PKS substrate predictions

remE

PKS_AT (98..389): mal

ATSignature: Malonyl-CoA

Top 3 matches:: Malonyl-CoA: 54.2%

minowa: Malonyl-CoA

Prediction, score:

Malonyl-CoA: 74.3
inactive: 44.3
Methoxymalonyl-CoA: 36.4
Methylmalonyl-CoA: 36.1
Propionyl-CoA: 27.9
Isobutyryl-CoA: 21.3
3-Methylbutyryl-CoA: 13.5
Benzoyl-CoA: 12.0
Ethylmalonyl-CoA: 11.5
CHC-CoA: 9.5
trans-1,2-CPDA: 9.4
Acetyl-CoA: 7.6
2-Methylbutyryl-CoA: 7.2
fatty_acid: 0.0

Type II PKS gene cluster prediction details

Cluster section:: 0 to 16662
Starter unit(s):: propionyl-CoA (Score: 109.0; E-value: 6.78e-30)

remA: KS (Score: 548.1; E-value: 2.9e-167)
remB: CLF (Score: 439.5; E-value: 2.6e-134)
remC: ACP (Score: 39.8; E-value: 7.9e-13)
remE: AT (Score: 153.5; E-value: 1.6e-47); AT BAB72049.1_Aklavinone_propionyl-CoA (Score: 109.0; E-value: 6.78e-30)
remG: MET (Score: 189.9; E-value: 1.5e-58)
remH: MET (Score: 134.5; E-value: 1e-41)
remI: CYC C9-C14 (Score: 158.6; E-value: 2e-49)
remL: CYC C5-C14/C3-C16 (Score: 352.5; E-value: 3e-108)
remO: OXY (Score: 123.4; E-value: 3e-38)