BGC0000264: resistomycin biosynthetic gene cluster from Streptomyces resistomycificus
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Location: 1 - 16,662 nt. (total: 16,662 nt).
This entry is originally from NCBI GenBank AJ585192.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Biosynthesis
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000264
Short description resistomycin biosynthetic gene cluster from Streptomyces resistomycificus
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • PKS (Type II)
Loci
AJ585192.1
via Heterologous expression
Compounds
  • resistomycin
  • resistoflavine
Species Streptomyces resistomycificus [taxonomy]
References
Chemical products information
resistomycin Evidence:
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C22H16O6
Chemical database entries
PubCHEM
ChemSpider
resistoflavine Evidence:
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C22H16O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAE51169.1
  • remQ
 256 - 843 (-) RemQ protein
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    • CAE51170.1
    • remR
    		 840 - 1289 (-) RemR protein
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      • CAE51171.1
      • remF
      		 1536 - 1967 (+) Cyclase containing zinc
      • Scaffold biosynthesis
      • Knock-out
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      • CAE51172.1
      • remG
      		 1964 - 3013 (+) C-dimethyltransferse
      • Tailoring
      • Knock-out
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      • CAE51173.1
      • remH
      		 3023 - 4066 (+) RemH protein
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        • CAE51174.1
        • remA
        		 4069 - 5355 (+) RemA protein
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          • CAE51175.1
          • remB
          		 5352 - 6590 (+) RemB protein
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            • CAE51176.1
            • remD
            		 6569 - 6997 (+) RemD protein
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              • CAE51177.1
              • remC
              		 7042 - 7293 (+) RemC protein
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                • CAE51178.1
                • remI
                		 7298 - 7750 (+) RemI protein
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                  • CAE51179.1
                  • remJ
                  		 7821 - 8828 (+) RemJ protein
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                    • CAE51180.1
                    • remK
                    		 8984 - 9466 (+) RemK protein
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                      • CAE51181.1
                      • remL
                      		 9469 - 10299 (+) RemL protein
                      • Scaffold biosynthesis
                      • Knock-out
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                      • CAE51182.1
                      • remE
                      		 10410 - 11687 (+) RemE protein
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                        • CAE51183.1
                        • remM
                        		 11719 - 12312 (+) RemM protein
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                          • CAE51184.1
                          • remO
                          		 12323 - 13522 (-) Resistomycin hydroxylase
                          • Tailoring
                          • Knock-out Other in vivo study Activity assay
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                          • CAE51185.1
                          • remN
                          		 13561 - 15108 (-) RemN protein
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                            • CAE51186.1
                            • remP
                            		 15208 - 15873 (-) RemP protein
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                              Biosynthesis information
                              Annotation changelog

                              Entry version: 4

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-10-07
                              Update chemical activity to schema version 2.11
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 3

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2022-09-15
                              Updated bioactivity data
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 2

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2019-10-16
                              Migrated from v1.4
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              2019-10-16
                              Updated compound(s) information (NPAtlas curation)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                              Entry version: 1

                              Date
                              Changes
                              Submitters
                              Reviewers
                              2015-06-12
                              Submitted
                              • (ID: F65XGYSSLMUEJC2Q4T3BLCPS)
                              • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                              Detailed domain annotation
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