BGC0000264: resistomycin biosynthetic gene cluster from Streptomyces resistomycificus
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Location: 1 - 16,662 nt. (total: 16,662 nt).
This entry is originally from NCBI GenBank AJ585192.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000264
Short description resistomycin biosynthetic gene cluster from Streptomyces resistomycificus
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Other)
Loci NCBI GenBank: AJ585192.1
Compounds
  • resistomycin
  • resistoflavine
Species Streptomyces resistomycificus [taxonomy]
References
Chemical products information
resistomycin [synonyms: Heliomycin, Geliomycin, Croceomycin, Itamycin, Geliomitsin]
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C22H16O6
Chemical database entries
PubCHEM
ChemSpider
resistoflavine
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C22H16O7
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAE51169.1
  • remQ
 256 - 843 (-) RemQ protein
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  • CAE51170.1
  • remR
 840 - 1289 (-) RemR protein
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  • CAE51171.1
  • remF
 1536 - 1967 (+) Cyclase containing zinc
  • Scaffold biosynthesis
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  • CAE51172.1
  • remG
 1964 - 3013 (+) C-dimethyltransferse
  • Tailoring (Methylation)
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  • CAE51173.1
  • remH
 3023 - 4066 (+) RemH protein
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  • CAE51174.1
  • remA
 4069 - 5355 (+) RemA protein
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  • CAE51175.1
  • remB
 5352 - 6590 (+) RemB protein
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  • CAE51176.1
  • remD
 6569 - 6997 (+) RemD protein
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  • CAE51177.1
  • remC
 7042 - 7293 (+) RemC protein
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  • CAE51178.1
  • remI
 7298 - 7750 (+) RemI protein
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  • CAE51179.1
  • remJ
 7821 - 8828 (+) RemJ protein
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  • CAE51180.1
  • remK
 8984 - 9466 (+) RemK protein
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  • CAE51181.1
  • remL
 9469 - 10299 (+) RemL protein
  • Scaffold biosynthesis
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  • CAE51182.1
  • remE
 10410 - 11687 (+) RemE protein
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  • CAE51183.1
  • remM
 11719 - 12312 (+) RemM protein
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  • CAE51184.1
  • remO
 12323 - 13522 (-) Resistomycin hydroxylase
  • Tailoring (Hydroxylation)
Activity assay
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  • CAE51185.1
  • remN
 13561 - 15108 (-) RemN protein
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  • CAE51186.1
  • remP
 15208 - 15873 (-) RemP protein
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Polyketide-specific information
Subclass Other
Starter unit Acetyl-CoA
Ketide length 10
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
remL
+
remA
+
remF
+
remI 		Synthase subclass: Type II
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: F65XGYSSLMUEJC2Q4T3BLCPS, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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