LOCUS       BGC0000266             32634 bp    DNA     linear   BCT 26-AUG-2002
DEFINITION  Streptomyces collinus DSM2012 rubrinomycin gene cluster, complete
            sequence.
ACCESSION   BGC0000266
VERSION     BGC0000266
KEYWORDS    .
SOURCE      Streptomyces collinus
  ORGANISM  Streptomyces collinus
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
REFERENCE   1  (bases 1 to 32634)
  AUTHORS   Saito,H., Bruenker,P., Martin,R. and Minas,W.
  TITLE     Streptomyces collinus DSM2012 rubromycin biosynthesis gene cluster
  JOURNAL   Unpublished
REFERENCE   2  (bases 17848 to 24190)
  AUTHORS   Martin,R., Bailey,J.E. and Minas,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (04-AUG-2000) Institute of Biotechnology, ETH-Zuerich,
            HPT, Zuerich CH-8093, Switzerland
REFERENCE   3  (bases 1 to 32634)
  AUTHORS   Saito,H., Bruenker,P., Martin,R. and Minas,W.
  TITLE     Direct Submission
  JOURNAL   Submitted (23-AUG-2002) R & D, Anbics Management-Services AG,
            Technoparkstrasse 1, Zuerich CH-8005, Switzerland
  REMARK    Sequence update by submitter
COMMENT     ##antiSMASH-Data-START##
            Version     :: False
            Run date    :: 2025-08-15 16:47:15
            NOTE :: This is a single region extracted from a larger record!
            Orig. start :: 0
            Orig. end   :: 32634
            ##antiSMASH-Data-END##
            On Aug 26, 2002 this sequence version replaced AF293355.1.
FEATURES             Location/Qualifiers
     source          1..32634
                     /db_xref="taxon:42684"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces collinus"
                     /strain="DSM 2012"
                     /type_material="type strain of Streptomyces collinus"
     region          1..32634
                     /candidate_cluster_numbers="1"
                     /contig_edge="True"
                     /product="T2PKS"
                     /region_number="1"
                     /rules="(t2ks and t2clf)"
                     /subregion_numbers="1"
                     /tool="antismash"
     subregion       1..32634
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="PKS"
                     /subregion_number="1"
                     /tool="antismash"
     cand_cluster    1..32634
                     /candidate_cluster_number="1"
                     /contig_edge="True"
                     /detection_rules="(t2ks and t2clf)"
                     /kind="single"
                     /product="T2PKS"
                     /protoclusters="1"
                     /tool="antismash"
     protocluster    1..32634
                     /aStool="rule-based-clusters"
                     /category="PKS"
                     /contig_edge="True"
                     /core_location="[18748:21300](+)"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
                     /tool="antismash"
     proto_core      18749..21300
                     /aStool="rule-based-clusters"
                     /tool="antismash"
                     /cutoff="20000"
                     /detection_rule="(t2ks and t2clf)"
                     /neighbourhood="35000"
                     /product="T2PKS"
                     /protocluster_number="1"
     gene            768..2321
                     /gene="rubI"
                     /note="putative rubrumycin resistance gene"
     CDS             768..2321
                     /codon_start=1
                     /gene="rubI"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1138: FAD linked oxidase domain protein"
                     /gene_kind="biosynthetic-additional"
                     /product="RubI"
                     /protein_id="AAM97372.1"
                     /transl_table=11
                     /translation="MAGQRRCRVLRPAGHQAARARGVQGDRRQVRHRRLMRAAALRDRL
                     DGDLVLPDETGFALARQLQNTEYDTIEPSAVAYCASERDVALCVRHAREQGVRLHVRGG
                     GHSFNGWSTGEGLVVDLSRMNHAVAEGPVVRLGAGVQSLDALDALRSQGRQIVTGTFPT
                     VAAGGFLTGGGIGWQTRRFGLGSDRVAAARVVLADGRAVRCSPTEEPDLYWASRGGGGG
                     TFGVVTEFEVRSIDAPAMTGFETLWAYDDAVEVLTAWQEWAVDGPDELGTSLVVLPGMF
                     GPGGRPVVRVWGAHLGPDEALHEGLDELAERAGCKPLSRTVAARGGYAEVMHEALCGSK
                     SVSQCRRTGTGPEAEGHRHPYTRQSYRLTGRSATRAESAALLDAWDPALDAVGQERYLL
                     CIALGGAANRVPVSATAYAHRDARFLIGYQFACREAEADPAAPARLTALADRAAEALTP
                     LACGSYINFPSSRVGGDWETEYFGANRFRLRAVKRAYDPEDFFRHAQSIGRAPTTEVES
                     "
     gene            2318..3091
                     /gene="rubJ"
     CDS             2318..3091
                     /NRPS_PKS="Domain: PKS_KR (8-185). E-value: 9.3e-11. Score:
                     33.9. Matches aSDomain: nrpspksdomains_rubJ_PKS_KR.1"
                     /codon_start=1
                     /gene="rubJ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /note="putative polyketide ketoreductase"
                     /product="RubJ"
                     /protein_id="AAM97360.1"
                     /sec_met_domain="adh_short (E-value: 1.2e-31, bitscore:
                     100.8, seeds: 230, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MRTDLRNKVVLVTGASSGIGRATAVAYGEEGAKVAITYHSNEDGA
                     RETARLVTEAGGTALVVRYDLADERCIRDAVGRVAEEWGGIDVLVANAVVWSEAIPRPG
                     QPVPRFEDVPAKQWQEVLRTSVDAVFHTLQAVLPWMRGRPWGRIVLLGAGLADTGKAGA
                     GAYGAGKSALFGLMRSLAWELGPDGILVNMVVPGQTSTETVRAHVPPGFLEEKGKTLPS
                     GRMSAPEDVARAITFLGSAANGNTNGETLRVTGGA"
     CDS_motif       2342..2413
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rubJ_0001"
                     /evalue="2.10E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="rubJ"
                     /protein_end="32"
                     /protein_start="8"
                     /score="10.8"
                     /tool="antismash"
                     /translation="VVLVTGASSGIGRATAVAYGEEGA"
     aSDomain        2342..2872
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_rubJ_PKS_KR.1"
                     /evalue="9.30E-11"
                     /label="rubJ_PKS_KR.1"
                     /locus_tag="rubJ"
                     /protein_end="185"
                     /protein_start="8"
                     /score="33.9"
                     /tool="antismash"
                     /translation="VVLVTGASSGIGRATAVAYGEEGAKVAITYHSNEDGARETARLVT
                     EAGGTALVVRYDLADERCIRDAVGRVAEEWGGIDVLVANAVVWSEAIPRPGQPVPRFED
                     VPAKQWQEVLRTSVDAVFHTLQAVLPWMRGRPWGRIVLLGAGLADTGKAGAGAYGAGKS
                     ALFGLMRSLAWELG"
     gene            4337..5176
                     /gene="rubK"
     CDS             4337..5176
                     /codon_start=1
                     /gene="rubK"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PF07366"
                     /gene_kind="biosynthetic-additional"
                     /note="similar to SnoL"
                     /product="RubK"
                     /protein_id="AAM97361.1"
                     /sec_met_domain="PF07366 (E-value: 3.7e-39, bitscore:
                     124.2, seeds: 29, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTTVIPARQRTRNAELIRELYGTLYRERRFEEAGRFFHADCVEHD
                     PGDWRTSDRTFPALRADIDHLVAGNDRVMLFATWTGRSRSGTELRLHTAELYRLRDGRV
                     AEHWSVVDRDVLXGHGVDGGPDRSGQPAAPGLHGPHSDTERANAELVLGAYRDVFSEHR
                     LELAERYYHQDYRHHNMRTDAVPDGLDAFKAFFADNIAAFPDLVTTVDHIVAADDRVMV
                     FVTWTGTLTGAWSGGGPSGLPLEMRTCDQFRIERGKVAEHWEVVDYLALGRAGLPTP"
     gene            5227..6894
                     /gene="rubL"
     CDS             5227..6894
                     /codon_start=1
                     /gene="rubL"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000012: Monooxygenation (69% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /note="putative polyketide hydroxylase; similar to TcmG"
                     /product="RubL"
                     /protein_id="AAM97362.1"
                     /transl_table=11
                     /translation="MTSASEPSGPSGSAPVLIVGGSLVGLSTAVFLARHGVRCTLVERH
                     PGTSVHPRAVGYYPRTGELLRQAGVEDAAVREASGFATHRTRAGVTSLAGEVLFSKEEL
                     EGDDDLGDLTPSRLLLLPQDRLEPLLRDRAVELGADLRFGTELVSFAEDPEGVTAVLDD
                     GTGGTRTFRSSYLVACDGPRSTVREALKVPRQGRGVLSRHVSIAFGADLRPVLGDRRYS
                     VVHVKNPQVTGILVHDDTLTGGTLIVGYRPEDGESLEDFTDDRCAELVGAAVGAPGVEV
                     TIRSRFPWDMAEQVAESFVHGRVLLAGDAAHVVPPTGGYGANTGIADAHNLAWKLALVA
                     AGVAGPGLVETYDAERRPVAVYTAEQGSLQLALRSGTATPEQQAAVADAVTVTSGQAYR
                     STAVVGEPDGADLPVASDPRELRGAPGTRAPYVELLRGGETVSTLDLFGRDFVLLTGEH
                     GREWISAAVSASAGLGLKITARRVVPGTDAGAGTLADPDGDWSERYGGLRPEGAVLVRP
                     DGVVAWRSPGADPGGEESAVLAAVLRSVLARESRTGGK"
     gene            complement(6976..7464)
                     /gene="rubM"
     CDS             complement(6976..7464)
                     /codon_start=1
                     /gene="rubM"
                     /gene_functions="regulatory (smcogs) SMCOG1135: MarR family
                     transcriptional regulator"
                     /gene_kind="regulatory"
                     /note="putative transcriptional regulator; MarR family-like
                     transcriptional regulator"
                     /product="RubM"
                     /protein_id="AAM97363.1"
                     /transl_table=11
                     /translation="MDTSTQPPPRAADLLDAVGPAFSRLRRAQALNVEKQVSRKDFTRT
                     LVLNIVQDGPDQEGQEITVGVVGERLAVDPSVASRMVSDCISAGYLIRAASQRDGRRTI
                     LQLTPEGHETLARFRRHQRAAFERITQDWPEEERLEFARLLIKYVDSVGELQHESGSA"
     gene            7614..9170
                     /gene="rubN"
     CDS             7614..9170
                     /codon_start=1
                     /gene="rubN"
                     /gene_functions="biosynthetic-additional (MITE)
                     MITE0000013: Monooxygenation (76% identity)"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /note="putative polyketide oxygenase; similar to MtmOIV"
                     /product="RubN"
                     /protein_id="AAM97364.1"
                     /transl_table=11
                     /translation="MSQSVPPEQSERDFEITYDTDVDFDVLIVGGGPVGMLLAAELRIS
                     RVRAVVLERLPERTPHSKAFGLHARSLESLDRRGLLKRFREGARSWNNGHFAGLDEWVD
                     FSTLDSAHGYALLSEQTRTERLLEERAAEFGAEIRRGHEVTAIRQDADGVEAEVAGPDG
                     TYTLRARYAVGCDGGRSLVRREAGIDFPGTGGRVTARLGDVILADRENAPMGMERTERG
                     LLFCVPLDDTYHRVSTFDFEADREPGAELTLEELTASLREIWGDDLGAHSPRWLSVFTD
                     SACQADRYREGRLLIAGDAAHTHFPVGGQGVNLGLQDAFNLGWKLAAEVHGWAPEDLLD
                     SYDRERQAPARKVLANTRAQIALMNPDPYVTPLRELFTDLMRKEQVNRHLAEMLSGVTV
                     RYAIDGPEHRLLGDFARDLELRTEDGVRPLPKYLKRGTGLLLDLTGDGQIGQVHEKWAA
                     GASWAGRLQHVRAECAEEPQLAGLLVRPDGYVAWAADRDMPEAELRESLTAAVTTWFGT
                     D"
     gene            9322..10749
                     /gene="rubO"
     CDS             9322..10749
                     /codon_start=1
                     /gene="rubO"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /note="putative polyketide O-methylase/hydroxylase;
                     putative chimeric protein"
                     /product="RubO"
                     /protein_id="AAM97365.1"
                     /transl_table=11
                     /translation="MAIRVAATLGLSDHMAAGAVTVETLAREADVDAIALGRLLGHLVN
                     AGIYRRLPDGAYEPTDLGALLRDDLPQSGRDWLRLDGPTGRGEAAVFRLLDAVRSGEPV
                     YSALYGQEFWTDVESDGALAEAFARRMAASMRWVVPELLAQGHWQSVRHVVDVGGGSGD
                     LLAAVVDATPGARGTLLDLEAPAAAAERDFTEERCTALVRAAVGVPDLPLKIESADMPA
                     WDISARVADTFATRRVFVAGDAAHVMPPTGAFGASTGIQDAYNLAWKLALVLSGTAGPG
                     LLESYDAERRPVAEETVRQAMLRFAVREGKQYQDVAAELLDETTMTFGYCYRSGAFAAE
                     EGAPDAIVEDPAHPSARPGARAPHLQLDGPEGPVSVIDLYGDGFTLLVDEAAGRWTGAV
                     EREAERLGVALKVVRIGRGTRLWDQDGSFRRRYGLLAGGAVLXRPDGFVGWRTTAGRSG
                     PVDQAAIDALRGVLDRV"
     gene            complement(10920..12497)
                     /gene="rubP"
     CDS             complement(10920..12497)
                     /codon_start=1
                     /gene="rubP"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1050: monooxygenase FAD-binding"
                     /gene_kind="biosynthetic-additional"
                     /note="putative polyketide oxygenase; simlar to TcmG"
                     /product="RubP"
                     /protein_id="AAM97366.1"
                     /transl_table=11
                     /translation="MADETTEVLIVGGSMVGLAQALFLARQGIRPVLVERHAEISAHPR
                     AQAASPRTMELLRALGLEDAVRARENPHAQYGDILQAESLTGAELGRFDGPFRFDRHEV
                     GTTGWTLIGQDRLEPVLRERAEELGADIRFATEMTEFTQDADGVTAVLRDLGDGSERTV
                     RARYLVAADGSRAPIRTSLGIGHHGQGVFGRQMNIVFHADLDPYVAGRTFFLCFVSNPA
                     VKGVLGKLGGADSDRWVLAPSLPPGADHRVYGTEDCVELVRAAVGVPDLPVTVESATSW
                     EIAAWVADRFRSGRVLLAGDSAHVMPPTGGFGGNMGIQDAHNLAWKLARVLRGQAGPGL
                     LDTYEQERAPVAEFTVDQGVIRYLQRSGLDEAAAARHRPETTVLFGHVYRSDAVLREAG
                     DDDTAVIEDPTTPTGRPGTRAPHLPLVRQGKDVALHDLLDGDFWLLAGPGGIAWQEPAA
                     ALGLSFHRVGAEESPAVVERFLARYXXEETGAVLLRPDGFIAWRAGRAEGDAGGSLXAV
                     LDAVLRRA"
     gene            12702..13148
                     /gene="rubQ"
     CDS             12702..13148
                     /codon_start=1
                     /gene="rubQ"
                     /note="similar to ORF5 of the pradamycin gene cluster in
                     Actimoadura hibisca"
                     /product="RubQ"
                     /protein_id="AAM97373.1"
                     /transl_table=11
                     /translation="MEALSVLVLTGTGLVAGVLFAVAVSVMPALIAMTPERYVSTHILL
                     GKRYDRIMPFIVTGSTAVDVGLAIRASEGPRVLFAAAAVCMAGVAVVSQTRNVPINRRV
                     KRTRPEDLGPGWRDPRPAWRDWHLVRTGLAIAGCALTAAAVVLS"
     gene            13145..13678
                     /gene="rubW"
     CDS             13145..13678
                     /codon_start=1
                     /gene="rubW"
                     /note="similar to grhN in the griseorhodin cluster of
                     Streptomyces sp. JP95"
                     /product="RubW"
                     /protein_id="AAM97367.1"
                     /transl_table=11
                     /translation="MSPVVVRELPEGPERAAADARMRELLSRPAPGPVAERLALLHFSG
                     RRSGRPYTVPAGVHTLGGALVVATGSGWRYNFAGGSPGELTWRGQRRPVRFTLVDDAER
                     SARGYLELYRRYGEEAPRRLGLAVRGAGTPALAEFREAVGRHGLSLVEVTLVTHAPAEN
                     SAPPSDAESERTPR"
     gene            13675..15546
                     /gene="rubR"
     CDS             13675..15546
                     /codon_start=1
                     /gene="rubR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) GATase_7"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) Asn_synthase"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1177: asparagine synthase (glutamine-hydrolyzing)"
                     /gene_kind="biosynthetic-additional"
                     /note="putative asn synthase"
                     /product="RubR"
                     /protein_id="AAM97368.1"
                     /sec_met_domain="GATase_7 (E-value: 1.3e-36, bitscore:
                     116.0, seeds: 307, tool: rule-based-clusters)"
                     /sec_met_domain="Asn_synthase (E-value: 2.4e-91, bitscore:
                     297.7, seeds: 78, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSGIAGWVDFERDLTPEAPTVRAMAAALAHRGPDGFGEWIEGHAA
                     LAHRRLSLIGSEHAGQPAIVESEAGSPVAVLTLDGSVTNAVELRRELAAKGHRFTGDGD
                     AEVALHAYLEWGAAFPERLEGLFALAVWDVRRQELLLVRDRLGVKPLCYFLTPSGVVFG
                     SEPKALLAHPAVRPVVDADGLRELFAHSRKPGTGVFRGTREVLPGHTMTVRAPGTGHRR
                     YWSLPARPHTDSLETTVATVRRLLSEAVATHLRADVPVGAMLSGGIDSSALTALAAHRR
                     RAEGAGLRSFSVNFSGYAENFEPHPTMRATPDAPYAALAAEHIGTEHTEILLDTAALAD
                     PGTHAAALRSQDAPSPLGDMDVSLLLFFEALRGAGITAVLSGETADEVFNGYFWAYDPG
                     HSNSTTFPWVSFERGHDAAAGGLGCSLVDRTLRKELDFMDYADQHYRDALTEVPQVAGE
                     SPAERRAREVTYLALTRWAPTHLDRADRMSMAHGVQLRPPFCDRALVEYVYNVPAELKR
                     VNGQEKSLLRAAVADLLPERVLNRPKSAYPTVQEAAYGEFVRHRFEDVAADRTAPVAPL
                     LDAEATRVALGAAAAPSGAFAWVERASMEMVLQLNTWLSEYGVELRV"
     gene            15807..17792
                     /gene="rubS"
     CDS             15807..17792
                     /codon_start=1
                     /gene="rubS"
                     /gene_functions="regulatory (smcogs) SMCOG1041:
                     transcriptional regulator, SARP family"
                     /gene_kind="regulatory"
                     /note="putative transcriptional activator"
                     /product="RubS"
                     /protein_id="AAM97369.1"
                     /transl_table=11
                     /translation="MAATHTGGSLRGNAVIEIGLLGSMRIRRNGEDVTPSAPKLRQVLA
                     LLVLNANSLVSVDQLCEELWEDHPPLSALTTLQTYIYQLRRRLLLATGQHGAAFGSRPP
                     HGCPAILTRVGGYELRLDDKQSVDAYRFDQLIEQGMAQLRTGAGEEEAARTLKAALSLW
                     QGGALVDVSTGRRLSAWSTQLEERRKSVLEQRFSLELQLGRHHTVLDELSEAFRAHPTH
                     EAFAGQLMRALHRCGRRPDALNTFRTLRSHLVEELGLEPSVQLQRLHQEVLADRGHLRG
                     PAPAKAETVSGGRRLVPXPAQLPADVGDFVGRERELDQLETFLGADRPSTGMRVVEVHG
                     PPGVGKSAFAVRAAHRLRPRFPDGQLFIDLSAVGEGSQQLADVLSACLTACGIQREKQP
                     SGLGELSRLFRTWTADRRVLVVVDDALTASQIRAVLPGGSGCAVIATNRYRAHSLSTGR
                     KIVLPALSPEESLQLYDRVAGERSRQEDPGAVQELIGLCEGLPLAIRAVAGRLTARPGW
                     SAARLASRLRGNHRMLLELPAGTQSLMTTVAASHRHLPARSRELLRLLLQRERPRWSLD
                     EVVTRLRPGSGDAETLLEYLVDVHLVQEHLTPDAELLYSVPRLTRQALILLSRGTPAGD
                     VPNGRMVGAGVVAGTGVTLMKADVRR"
     gene            17953..18324
                     /gene="rubE"
     CDS             17953..18324
                     /codon_start=1
                     /gene="rubE"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1225: Polyketide synthesis cyclase"
                     /gene_kind="biosynthetic-additional"
                     /note="rubromycin biosynthesis-related cyclase I"
                     /product="putative cyclaseI"
                     /protein_id="AAG03065.2"
                     /transl_table=11
                     /translation="MHRTLIVARMDLADAEGVAQVFADSDSTELPHLVGVSRRTLFAFH
                     NLYFHLVEADQDIAPNLYKARSHPLYEEINTRLGQFISPYDPDWREPKDAMAVPFYSWT
                     PQDGPQTRAPRSANLGGAR"
     gene            18321..18752
                     /gene="rubD"
     CDS             18321..18752
                     /codon_start=1
                     /gene="rubD"
                     /note="rubromycin biosynthesis-related cyclase II"
                     /product="putative cyclase II"
                     /protein_id="AAG03066.1"
                     /transl_table=11
                     /translation="MSAPATPKVAADEVAANTKRGGDIRVTLSPKTVGCTSGFGGVLRL
                     APGHHVTEHLHPYSEEFLHVVQGRLEMTLDGGTPVALGPGDSLLVSIGVRHRLVNTGSV
                     PAEAVFHLSPLAPRPELGHIDTEQPLDASAGNPDVGAAR"
     gene            18749..20035
                     /gene="rubA"
     CDS             18749..20035
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (9-396). E-value:
                     3e-52. Score: 169.9. Matches aSDomain:
                     nrpspksdomains_rubA_PKS_KS.1"
                     /codon_start=1
                     /gene="rubA"
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2ks"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mod_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) tra_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) hyb_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) itr_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ene_KS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1022: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /note="rubromycin beta-ketoacylsynthase alpha subunit"
                     /product="ketosynthase alpha subunit"
                     /protein_id="AAG03067.1"
                     /sec_met_domain="t2ks (E-value: 2.3e-236, bitscore: 775.1,
                     seeds: 25, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 3.8e-53, bitscore:
                     171.3, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="mod_KS (E-value: 1.5e-43, bitscore: 139.9,
                     seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="tra_KS (E-value: 3.9e-45, bitscore: 145.1,
                     seeds: 44, tool: rule-based-clusters)"
                     /sec_met_domain="hyb_KS (E-value: 1.9e-45, bitscore: 146.1,
                     seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="itr_KS (E-value: 1.2e-51, bitscore: 166.5,
                     seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="ene_KS (E-value: 8.7e-31, bitscore: 97.6,
                     seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MTAGHRRAVITGVGAVAPGGIGRDAYWDLLTAGRTATRRISLFDP
                     AGFRSQVAAECDFDPLAAGLTPQEARRMDRAGQFAVVAAREAVADSGVELPGTDPERVG
                     ISIGSAVGCTMGLEEEYAVLSDGGRDWLVDHSYGVPHLYGYMVPSTLAVEVARQAGAEG
                     PVALISTGCTSGLDAIGHGVQLIEEGSADIVLAGATDAPLSPITSACFDAIKATTANND
                     DPEHASRPFDGQRDGFVLGEGSAVMVIEELESARRRGATVYAEILGFAGRSNAFHMTGL
                     KPDGREMAEAVRVALHRARLDPGAIDYINAHGSGTKQNDRHETAAFKRSLGQRAHEVPV
                     SSIKSMIGHSLGAIGSLEIAACALALRHQVVPPTANLSTPDPECDLDYVPVTAREHRMD
                     RVLSVGSGFGGFQTAMVLGRPHLAHGEAA"
     aSDomain        18776..19936
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_rubA_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="3.00E-52"
                     /label="rubA_PKS_KS.1"
                     /locus_tag="rubA"
                     /protein_end="396"
                     /protein_start="9"
                     /score="169.9"
                     /tool="antismash"
                     /translation="ITGVGAVAPGGIGRDAYWDLLTAGRTATRRISLFDPAGFRSQVAA
                     ECDFDPLAAGLTPQEARRMDRAGQFAVVAAREAVADSGVELPGTDPERVGISIGSAVGC
                     TMGLEEEYAVLSDGGRDWLVDHSYGVPHLYGYMVPSTLAVEVARQAGAEGPVALISTGC
                     TSGLDAIGHGVQLIEEGSADIVLAGATDAPLSPITSACFDAIKATTANNDDPEHASRPF
                     DGQRDGFVLGEGSAVMVIEELESARRRGATVYAEILGFAGRSNAFHMTGLKPDGREMAE
                     AVRVALHRARLDPGAIDYINAHGSGTKQNDRHETAAFKRSLGQRAHEVPVSSIKSMIGH
                     SLGAIGSLEIAACALALRHQVVPPTANLSTPDPECDLDYVPVTAREH"
     CDS_motif       19169..19222
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rubA_0001"
                     /evalue="4.50E-01"
                     /label="NRPS-te1"
                     /locus_tag="rubA"
                     /protein_end="158"
                     /protein_start="140"
                     /score="3.3"
                     /tool="antismash"
                     /translation="HLYGYMVPSTLAVEVARQ"
     CDS_motif       19787..19831
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rubA_0002"
                     /evalue="7.20E-02"
                     /label="NRPS-te1"
                     /locus_tag="rubA"
                     /protein_end="361"
                     /protein_start="346"
                     /score="5.8"
                     /tool="antismash"
                     /translation="IGHSLGAIGSLEIAA"
     gene            20032..21300
                     /gene="rubB"
     CDS             20032..21300
                     /NRPS_PKS="Domain: PKS_KS(Iterative-KS) (83-382). E-value:
                     9.3e-26. Score: 82.6. Matches aSDomain:
                     nrpspksdomains_rubB_PKS_KS.1"
                     /codon_start=1
                     /gene="rubB"
                     /gene_functions="biosynthetic (rule-based-clusters) T2PKS:
                     t2clf"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ketoacyl-synt"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) itr_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) mod_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) hyb_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) tra_KS"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) ene_KS"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1093: Beta-ketoacyl synthase"
                     /gene_kind="biosynthetic"
                     /note="rubromycin beta-ketoacylsynthase beta subunit; chain
                     length factor"
                     /product="ketosynthase beta subunit"
                     /protein_id="AAG03068.1"
                     /sec_met_domain="t2clf (E-value: 1.3e-178, bitscore: 584.4,
                     seeds: 26, tool: rule-based-clusters)"
                     /sec_met_domain="ketoacyl-synt (E-value: 1.6e-36, bitscore:
                     116.8, seeds: 77, tool: rule-based-clusters)"
                     /sec_met_domain="itr_KS (E-value: 6e-26, bitscore: 81.8,
                     seeds: 96, tool: rule-based-clusters)"
                     /sec_met_domain="mod_KS (E-value: 4.1e-25, bitscore: 79.1,
                     seeds: 217, tool: rule-based-clusters)"
                     /sec_met_domain="hyb_KS (E-value: 1.4e-24, bitscore: 77.3,
                     seeds: 33, tool: rule-based-clusters)"
                     /sec_met_domain="tra_KS (E-value: 3.2e-20, bitscore: 63.0,
                     seeds: 44, tool: rule-based-clusters)"
                     /sec_met_domain="ene_KS (E-value: 2.8e-18, bitscore: 56.3,
                     seeds: 19, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MSASGISPGRRGRSVVTGLGVVAPTGIGAVRHWESVLSGKSGLGR
                     ITRFDPTGYPVRVAGEVPGFHAGEQVPGRLVPQTDRFTHFALAAAEDALADAAADPATL
                     PEYEMAVVTASSSGGTEFGQHEMENLYQKGSSWVGAYQSIAWFYAATTGQVSIRHGMRG
                     PCGVICGEQAGGLDALGQSRRLLDTGSRLVLSGGTDASLCPYGLVAQLSTGRLSTEDDP
                     ARAYLPFDAAASGFVPGEGGAILVVENAEGAHARGVPAYGELLGYAAGFDPTADGTTTG
                     HSVLVSVVRRALADAGLAPGDVDVVFADASGTPAEDLAEARAITEVFGPGGVPVTAPKT
                     LTGRLYAGGAALDVATALLALSAGVVPHTAGLGRPAPGCEIDLVLDRPRQTDPRTALVL
                     ARGHGGFTSALVLGAGDRGAPGK"
     aSDomain        20281..21177
                     /aSDomain="PKS_KS"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_rubB_PKS_KS.1"
                     /domain_subtypes="Iterative-KS"
                     /evalue="9.30E-26"
                     /label="rubB_PKS_KS.1"
                     /locus_tag="rubB"
                     /protein_end="382"
                     /protein_start="83"
                     /score="82.6"
                     /tool="antismash"
                     /translation="HFALAAAEDALADAAADPATLPEYEMAVVTASSSGGTEFGQHEME
                     NLYQKGSSWVGAYQSIAWFYAATTGQVSIRHGMRGPCGVICGEQAGGLDALGQSRRLLD
                     TGSRLVLSGGTDASLCPYGLVAQLSTGRLSTEDDPARAYLPFDAAASGFVPGEGGAILV
                     VENAEGAHARGVPAYGELLGYAAGFDPTADGTTTGHSVLVSVVRRALADAGLAPGDVDV
                     VFADASGTPAEDLAEARAITEVFGPGGVPVTAPKTLTGRLYAGGAALDVATALLALSAG
                     VVPHTAGLGRPAPGCEID"
     CDS_motif       20716..20754
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rubB_0001"
                     /evalue="8.60E-04"
                     /label="PKSI-KS_m4"
                     /locus_tag="rubB"
                     /protein_end="241"
                     /protein_start="228"
                     /score="12.5"
                     /tool="antismash"
                     /translation="FDAAASGFVPGEG"
     CDS_motif       20842..20874
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rubB_0002"
                     /evalue="2.20E+00"
                     /label="PKSI-KS_m4"
                     /locus_tag="rubB"
                     /protein_end="281"
                     /protein_start="270"
                     /score="2.5"
                     /tool="antismash"
                     /translation="FDPTADGTTTG"
     gene            21339..21602
                     /gene="rubC"
     CDS             21339..21602
                     /NRPS_PKS="Domain: PKS_PP (29-82). E-value: 8.3e-15. Score:
                     46.9. Matches aSDomain: nrpspksdomains_rubC_PKS_PP.1"
                     /codon_start=1
                     /gene="rubC"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) PP-binding"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1129: acyl carrier protein"
                     /gene_kind="biosynthetic-additional"
                     /note="rubromycin acyl carrier protein"
                     /product="acyl carrier protein"
                     /protein_id="AAG03069.1"
                     /sec_met_domain="PP-binding (E-value: 3.2e-14, bitscore:
                     44.0, seeds: 164, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAEFTLDDIRRILRASGGVDEQTDLDGEHFADTSFADLGYDSLAL
                     LELVNRIEREYGIQIPDGDLSHTQTPREALTYVHARLTEARV"
     aSDomain        21426..21584
                     /aSDomain="PKS_PP"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_rubC_PKS_PP.1"
                     /evalue="8.30E-15"
                     /label="rubC_PKS_PP.1"
                     /locus_tag="rubC"
                     /protein_end="82"
                     /protein_start="29"
                     /score="46.9"
                     /tool="antismash"
                     /translation="FADTSFADLGYDSLALLELVNRIEREYGIQIPDGDLSHTQTPREA
                     LTYVHARL"
     gene            21602..22798
                     /gene="rubF"
     CDS             21602..22798
                     /NRPS_PKS="Domain: Polyketide_cyc (10-123). E-value:
                     1.6e-13. Score: 43.0. Matches aSDomain:
                     nrpspksdomains_rubF_Polyketide_cyc.1"
                     /NRPS_PKS="Domain: PKS_KR (158-327). E-value: 9.9e-13.
                     Score: 40.3. Matches aSDomain:
                     nrpspksdomains_rubF_PKS_KR.1"
                     /codon_start=1
                     /gene="rubF"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /note="putative polyketide cyclase/reductase; similar to
                     proteins found in the prodamycin gene cluster"
                     /product="RubF"
                     /protein_id="AAG03070.2"
                     /sec_met_domain="adh_short (E-value: 5.1e-33, bitscore:
                     105.3, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 4.2e-34, bitscore:
                     109.3, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MAGHTDNGIVVEAPMDLVWTMTNDVAAWPRLFNEYASAEILGRDG
                     DTVTFRLALHPDENGTVWSWVSERTPDPATRTVVARRVETGPFAHMNIRWEYEEVPGGV
                     RMRWIQDFAMKPDAPIDDAGMTARLNRNTAVQMRLIKAKVETAARAGRQLQGKRILVTG
                     GSRGIGRGIVLAAARAGADVVTCYRTPGEAVATLEEELAGTPGKHQVLRADAADATDVD
                     RLAAACEASPGGLDAVVNNAGTFRPQPYTDLGPTEWADTLQGNLTATHLVTRRTLPLLS
                     AGSSVVNIGSTVAFIGMAGGVHYTAVKSALVGMTRSLARELGPRGIRVNTVSPGRIATE
                     ALDELPPEEAERQRATFASFTALGRLGTVDDIARTVLFLISDHAGYVTGQNIHVDGCV"
     aSDomain        21632..21970
                     /aSDomain="Polyketide_cyc"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_rubF_Polyketide_cyc.1"
                     /domain_subtypes="Polyketide_cyc"
                     /evalue="1.60E-13"
                     /label="rubF_Polyketide_cyc.1"
                     /locus_tag="rubF"
                     /protein_end="123"
                     /protein_start="10"
                     /score="43.0"
                     /tool="antismash"
                     /translation="VEAPMDLVWTMTNDVAAWPRLFNEYASAEILGRDGDTVTFRLALH
                     PDENGTVWSWVSERTPDPATRTVVARRVETGPFAHMNIRWEYEEVPGGVRMRWIQDFAM
                     KPDAPIDDA"
     aSModule        21632..22582
                     /domains="nrpspksdomains_rubF_Polyketide_cyc.1"
                     /domains="nrpspksdomains_rubF_PKS_KR.1"
                     /incomplete
                     /locus_tags="rubF"
                     /tool="antismash"
                     /type="pks"
     aSDomain        22076..22582
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_rubF_PKS_KR.1"
                     /evalue="9.90E-13"
                     /label="rubF_PKS_KR.1"
                     /locus_tag="rubF"
                     /protein_end="327"
                     /protein_start="158"
                     /score="40.3"
                     /tool="antismash"
                     /translation="ILVTGGSRGIGRGIVLAAARAGADVVTCYRTPGEAVATLEEELAG
                     TPGKHQVLRADAADATDVDRLAAACEASPGGLDAVVNNAGTFRPQPYTDLGPTEWADTL
                     QGNLTATHLVTRRTLPLLSAGSSVVNIGSTVAFIGMAGGVHYTAVKSALVGMTRSLARE
                     LGPRGI"
     CDS_motif       22079..22144
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rubF_0001"
                     /evalue="1.80E-02"
                     /label="PKSI-KR_m1"
                     /locus_tag="rubF"
                     /protein_end="181"
                     /protein_start="159"
                     /score="7.8"
                     /tool="antismash"
                     /translation="LVTGGSRGIGRGIVLAAARAGA"
     gene            22829..23578
                     /gene="rubG"
     CDS             22829..23578
                     /NRPS_PKS="Domain: PKS_KR (9-178). E-value: 1.7e-16. Score:
                     52.6. Matches aSDomain: nrpspksdomains_rubG_PKS_KR.1"
                     /codon_start=1
                     /gene="rubG"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) adh_short_C2"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1001: short-chain dehydrogenase/reductase SDR"
                     /gene_kind="biosynthetic-additional"
                     /note="rubromycin biosynthesis-related putative reductase"
                     /product="putative reductase"
                     /protein_id="AAG03071.1"
                     /sec_met_domain="adh_short (E-value: 2.1e-36, bitscore:
                     116.3, seeds: 230, tool: rule-based-clusters)"
                     /sec_met_domain="adh_short_C2 (E-value: 4.3e-41, bitscore:
                     132.1, seeds: 47, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MELALHGRKLLITGGTRGIGRGIVLAAARAGADVLTCYRQESEAV
                     DSLTAALKETAGDHHVIRADVGDTAEADRLVGEAKDRFGRLDGVVNNAGVISHIPFGEL
                     PADEWSRILDTNLTAAYRIIHQALPLLGTGSSVVNIGSRGAAAGIPLRAHYTAAKAAMI
                     GLTRSLAKELGPKGIRVNVVAPGVIETEAFADMPAERAAGLRATYSQKTALARLGTVEE
                     LAGPVLFLLSDAAAYITGETLNVDGGI"
     aSDomain        22856..23362
                     /aSDomain="PKS_KR"
                     /aSTool="nrps_pks_domains"
                     /database="nrpspksdomains.hmm"
                     /detection="hmmscan"
                     /domain_id="nrpspksdomains_rubG_PKS_KR.1"
                     /evalue="1.70E-16"
                     /label="rubG_PKS_KR.1"
                     /locus_tag="rubG"
                     /protein_end="178"
                     /protein_start="9"
                     /score="52.6"
                     /tool="antismash"
                     /translation="LLITGGTRGIGRGIVLAAARAGADVLTCYRQESEAVDSLTAALKE
                     TAGDHHVIRADVGDTAEADRLVGEAKDRFGRLDGVVNNAGVISHIPFGELPADEWSRIL
                     DTNLTAAYRIIHQALPLLGTGSSVVNIGSRGAAAGIPLRAHYTAAKAAMIGLTRSLAKE
                     LGPKGI"
     CDS_motif       22859..22924
                     /aSTool="nrps_pks_domains"
                     /database="abmotifs"
                     /detection="hmmscan"
                     /domain_id="nrpspksmotif_rubG_0001"
                     /evalue="2.40E-03"
                     /label="PKSI-KR_m1"
                     /locus_tag="rubG"
                     /protein_end="32"
                     /protein_start="10"
                     /score="10.6"
                     /tool="antismash"
                     /translation="LITGGTRGIGRGIVLAAARAGA"
     gene            23580..23906
                     /gene="rubH"
     CDS             23580..23906
                     /codon_start=1
                     /gene="rubH"
                     /note="rubromycin biosynthesis-related protein of unknown
                     function"
                     /product="hypthetical protein"
                     /protein_id="AAG03072.1"
                     /transl_table=11
                     /translation="MPEPTEKVFRVMLRMQIKSGMEHEFEKVWLEVGDSVTTHPANLGQ
                     WLSRSAEEDGIYYIVSDWVDEPLFREFETSDRHLEHRQKLHPYRSGGSMTTMHVVAALA
                     GAAS"
     gene            23903..24256
                     /gene="rubT"
     CDS             23903..24256
                     /codon_start=1
                     /gene="rubT"
                     /product="RubT"
                     /protein_id="AAM97374.1"
                     /transl_table=11
                     /translation="MTGGAIEVVLYHLSDEPDLVLPAYHEASRRMAGTAGLLGNKLLHA
                     LGDPRSYVVVSRWSDWEAFTAWESGSAHKDQTAPLRPLRDTGRDRPFEIYRELASYPEG
                     RAATPTADVKEGV"
     gene            24259..25518
                     /gene="rubU"
     CDS             24259..25518
                     /codon_start=1
                     /gene="rubU"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) p450"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1007: cytochrome P450"
                     /gene_kind="biosynthetic-additional"
                     /note="putative cytochrome P-450 monoxygenase"
                     /product="RubU"
                     /protein_id="AAM97370.1"
                     /sec_met_domain="p450 (E-value: 6e-17, bitscore: 52.1,
                     seeds: 50, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MARTDAPQAAPPADLFTPAFHQNPHEALAGLRRTAPAVPVMTPNG
                     LRTWLVTGHEHARALLADPRLSKDMRVGRDLIPRNFVDPDKQREFLAESGERSQFPHVL
                     SVHMLDSDPPDHTRLRRLVGRAFTARRVESLRPRITELTDELLDAMARHERLDLMEALA
                     FPVPFTVICWLLGVPPDDRAAFRRWSNLLVSGAGTDEVREASASMITYLTELIEAKRNE
                     PADDMLTDLVHARDAGDQLSSDELISMAFLLLVAGHETTVNLIGNGALALLTHPEVREQ
                     LAADESLWPGAVEEFLRYDGPVTNATWRFTTEPVEVGSVTIPEGEFVTISIGAAGRDPD
                     RYPDPDRLDITRAHSGSVAFGHGIHHCLGAPLARLEGRIVLSRLFARLPGLRLAADPDE
                     LSWRSSLMMRGLEELPVFTA"
     CDS             25557..26396
                     /codon_start=1
                     /gene_functions="other (smcogs) SMCOG1292: hypothetical
                     protein"
                     /gene_kind="other"
                     /inference="non-experimental evidence, no additional
                     details recorded"
                     /note="Orf2"
                     /product="hypothetical protein"
                     /protein_id="AAM97375.1"
                     /transl_table=11
                     /translation="MERQDTGPAPRTTERPTWAPPEVDIDTPSIARVYDHWIGGTHNFP
                     ADRELARKVAAGNPDLPATLKANRAFLRRAVRELSALGIRQFLDIGSGIPAEGNVHDVA
                     LAAHPDSRVVYVDIDPVAVAHGRALLADEPRAAVFQGDLYKSREILEAEDTRRLIDFDR
                     PVALILAAVLHFVPDGDDPLALVRRYTERLAPGSALVISHAGAEEVPRTAPEAAEQYRG
                     AVSQVIWRDNRELAALFEDFELVTPGVVRAPLWRPEPADTPDPALAMLAGVALKPAR"
     CDS             26403..27905
                     /codon_start=1
                     /gene_functions="transport (smcogs) SMCOG1202: major
                     facilitator transporter"
                     /gene_kind="transport"
                     /note="Orf3; similar to putative peptide transporter in
                     Streptomyces coelicolor"
                     /product="putative transporter"
                     /protein_id="AAM97376.1"
                     /transl_table=11
                     /translation="MDTSLTPQDSPPATAGSAPPRAGDHRPGFGTLLAVDLWERFSFFG
                     MAAILVLYLTASEARGGMGMAPQPATAIFAAYMSLCFMAGLPGGWLADRVLGARRAVLL
                     GGVLITCGHAVLAVPVTGTLYAGLLLVVGGTGLVKPAMAAMVAGVSGDGEGRREAAFSL
                     FYMCIQVSALIAPVVTGLLAERVAWHLGFAAAAVGMTAGLIQFALGLRRYGDVGARPPR
                     PVPRPEALAMLRRAAWVTGSVGALVVLPVSRGLLPLPVVLAALGLTTITLPFWYLRSLR
                     LAHAPGTGHRRRLTGFTALMAASAAFWMIFAQSGSVLSLFAERHTDRDVLGFEVPASWF
                     QSVHPLFVLLVAPLFARLWVRAPRVDVPVKFAGALIAAGSSFLLMAVAATLAEHGPVGP
                     HWLLLVYLLYSCGEIALAPAGLALAAAVAPPGSTSRLLAVNGLFGAVGVVVGGQLFRLT
                     TVLSPATYFLLLGAFVLAVGTTIALGTPRLRTLLALRRNPGP"
     CDS             29882..31063
                     /codon_start=1
                     /note="Orf4"
                     /product="DNA methylase"
                     /protein_id="AAM97371.1"
                     /transl_table=11
                     /translation="MPVPPPGSEGHLHALVQAIGSIQRVGPLLDQCLRDLSADQAEGSR
                     YFTPDDMARLMVGAAVPRDRHRVLDPVCGSGGLLVESHRYVRENVGLDPTMSLQGKEQH
                     AHTSQVARMNFAVRGITAHVFPPGDSLADPEPEPHDIILANLPFNQRDWAPEDKTERDV
                     RRSPSPIPVDPRWPEESPSKGSANSAWIQHIAHALAPAGRAVFLMADSVANSRQPVTRS
                     VRERLLRDDLVECVIALPPRVFGHSKAPACLWVLNKDKSARPGWGARDRRRQVLFINAR
                     RAFEPVPKSRARRLGETNTTAVLATLAAWRGLSENGAAASPYDDAVGWSRSCSTREIAD
                     RESSLMPTSYVMEPPGPERDTRSRVEQLKLELTDQFQQMRALELQLLDALEEM"
ORIGIN
        1 gaattcatcg cccacgtccg gttctccggc agcggctatg tgtcgctccc ccttcccttc
       61 gacggcggcg tggaaatggc cgtccgcgcc gcctgacgga tgcgcggcgc ccgagggatc
      121 cgcgccgccc gacggaaacg ccccgcctga cgaatccgcg cacgcatcct ctaggagtgc
      181 cgtgtcccct cgtccgttcg acccggagtt cctgcccgag ggacaccccg acaagaaccc
      241 cgtcccaccc cgcggcaccg cctcgcgcgc cctgtggcga gggctggttc gctacctcct
      301 gctgccggcg taccgcgcgc tggtggccct cggatcggtg cacgtggcag cgctctggca
      361 tccggagttc gggcccgcgg tcagccggcc gccgcaggag ccgccgagct acaggacgtt
      421 tcgagcgggt cttgagagcg ggccggaagc ctggccggga catccccacc ccccagttcc
      481 cagagagaat cgaggagatc tgtcatgagc gacgcgcggc tggtcggcac ctggaccacg
      541 cagctggacg acgacggcaa ggcggtcccc ggactcgtct gcttctcggc ggacggcacg
      601 gtcgtctcca cccagctcaa cacgaagaac atcggcctgg gcacctggcg ctccacgggc
      661 ccgcacagct tcgagtacgg cttccacatc ctggcggccg accccgaggg caaccacgtg
      721 ggggaggcac atgtccgggt gtcgggcgag ttcgtctcgg acacggagtg gcagggcaac
      781 ggcggtgccg agttcttcga cccgcagggc accaagctgc gcgggcacgc ggggtccaag
      841 gtgaccgccg gcaagttcgg catcgacgac tgatgcgggc ggcggcgctg cgggaccggc
      901 tcgacgggga cctggttctg ccggacgaga cgggcttcgc tctggcccgg cagctgcaga
      961 acaccgagta cgacacgatc gagccgtcgg ccgtcgcgta ctgcgcctcc gagcgggatg
     1021 tcgcgctgtg cgtgcggcac gcccgggagc agggggtgcg gctgcacgtc cggggcggcg
     1081 gacacagctt caacggctgg tcgaccggtg aggggctggt cgtcgacctg tcccggatga
     1141 accacgccgt cgccgagggg cccgtggtgc ggctgggggc gggcgtccag tccctggacg
     1201 cgctggacgc cctgcggtcc caggggcggc agatcgtcac cgggacgttt cccacggtcg
     1261 ccgcgggcgg atttctgacc ggcggcggga tcggctggca gacgcgcagg ttcgggctgg
     1321 gcagcgaccg ggtcgcggcc gcgcgcgtcg tgctcgcgga cggcagggcc gtccgctgct
     1381 cgcccaccga ggaacccgat ctgtactggg cctcgcgcgg cgggggcggc ggcaccttcg
     1441 gggtggtcac ggagttcgag gtgcggtcga tcgacgcgcc cgccatgacc ggcttcgaga
     1501 cgctgtgggc gtacgacgac gctgtggagg tgctgacggc ctggcaggag tgggccgtgg
     1561 acggccccga cgagctcggc acctctctgg tcgtgctgcc gggcatgttc gggcccggcg
     1621 ggcgccccgt ggtccgggtc tggggggcgc acctgggtcc ggacgaggcc ctgcacgagg
     1681 gtctggacga actggcggag cgggccgggt gcaagccgct gagcaggacc gtcgccgcgc
     1741 ggggcgggta tgccgaggtg atgcacgagg cgctgtgcgg ctcgaagtcg gtgtcccagt
     1801 gccgtcgtac gggaaccggg cccgaggccg aggggcaccg ccacccgtac acccggcaga
     1861 gctaccggct caccggccgg tccgcgaccc gggcggaatc ggcggcactg ctcgatgcct
     1921 gggatcccgc actcgacgcg gtgggccagg agcgctatct gctgtgcatc gcgctgggcg
     1981 gagcggcgaa ccgggtgccg gtcagcgcca ccgcctacgc gcaccgggac gcccggttcc
     2041 tgatcggcta tcagttcgcc tgccgtgagg cggaggcgga cccggcggcg ccggcgcggc
     2101 tgaccgcgct ggcggaccgt gccgccgagg cactcacgcc gctcgcttgc ggctcgtaca
     2161 tcaacttccc cagctcgcgg gtgggcgggg actgggagac ggagtacttc ggcgcgaacc
     2221 ggttccggct gcgcgccgtg aagcgggcct acgaccccga ggacttcttc cggcacgcgc
     2281 agagcatcgg ccgtgccccg acgaccgagg tggagtcatg aggacggatc tgcggaacaa
     2341 ggtcgtactg gtcaccggcg cctcctcggg catcggccgg gcgacggccg tggcgtacgg
     2401 ggaggagggg gccaaggtcg cgatcacgta ccacagcaat gaggacgggg cccgggagac
     2461 ggcccggctg gtgaccgagg cgggcgggac tgcgctggtg gtgcgctacg acctcgcgga
     2521 cgagcggtgc atacgggacg ccgtggggcg ggtcgccgag gagtggggcg gcatcgacgt
     2581 gttggtggcc aacgcggtgg tctggagcga ggcgatcccg cggcccgggc agccggtgcc
     2641 gcgcttcgag gacgtgccgg ccaagcagtg gcaggaggtg ctgcgtacgt ccgtcgacgc
     2701 cgtgttccac acgctgcagg cggtcctgcc gtggatgcgc ggacggccgt ggggccggat
     2761 cgtgctgctc ggcgcgggcc tggcggacac cggcaaggcc ggggcggggg cctacggcgc
     2821 gggcaagtcc gcgctcttcg ggctgatgcg cagcctggcc tgggagctgg ggcccgacgg
     2881 gatcctggtc aacatggtcg tgccgggcca gaccagcacc gagaccgtgc gggcgcacgt
     2941 gcccccgggc tttttggagg agaagggcaa gaccttgccg tcgggccgga tgtccgcgcc
     3001 cgaggacgtg gcccgggcca tcaccttcct gggctcggcc gccaacggca acaccaacgg
     3061 cgagacgctc cgcgtgacgg gcggcgcctg acgggtccgg ccggcgtccg ctcacggtac
     3121 ggccccgccg ctctccggga accccggagc gcggcggggc ccgccccgtt cccgcctcct
     3181 ctttccgccc ccgttcctgg ccggcgcacg cgcgcggtgt cgagttgtcc tcgacgatgt
     3241 ttcgagaggc ccgggccacc gtgtggggca tggagattcg tagcctcgac ggcgatgagc
     3301 cggcgaccat tgccgcgttg cttcccggat tccgggacac catgagcctg gaactgcccg
     3361 gtgatccacc ggtgacggag gccctgctgg cgcggctgtt ccagcggcgg cacgggacgg
     3421 aacggatcgt gctggccgcg tacgacggcg gcaccccggc cggtgtgctg aagctggggc
     3481 tcgatctggg agatccgagc gggccgggac acggttcgct gtgggttttc ccggggttcc
     3541 ggcgacgcgg tgccgggcgg gcgctggtgg ctgcggggct ggtggcgctg cgggagcgcg
     3601 ggcgggagct gctgctggcc gacgctcccc gggcggcggg cggcgagcgg ttcgcggcgg
     3661 agctcggagc cgacctcatc ggcgagagcg tgcgccatcg gctccgcccg gccgggcccg
     3721 ctcgcgcggc gctggaggcg gccgcaaccc ggccggtgcc cggttaccgg ctggtggcgt
     3781 ggcaggggcc ctgccccgac gacctggtgg agtcctacgc ccgggcctgg agcgccctgg
     3841 aggagcgggt caacggccag gccaggatcc ggcgtccctc cgccgacgac gtacgggcgc
     3901 gggaggccga ggcggagcgg gccgggcatg tgccccacgt ggtggcggca ctgcccgagc
     3961 acggtacgtc gatcgtcgcg tacgccacct tgttcgtgcg caacagcccg atggcggacg
     4021 tcggcgagac gctggtgctg cccaagcacc ggcggcgtgg tctcgccacc tggctgaagg
     4081 gcgaactgct gctcggggcc gcccgggaga acaaccggct cgcgctgatc caggtcttca
     4141 acgacaccgc cgacaccgct gtggtcgcgc tcaaccggaa gctcggcttc gaggccgact
     4201 cgtactggtc gacgtacgcg ctcaaggcct gagcggccgg ccccgccccg atccggtccc
     4261 gcatccgttt ccccggtgcc cgatccccgg tgcccgaccc ccgacccccg atcaagagcc
     4321 gagccgagag gaacccatga ccaccgtgat ccccgccagg cagcgcacgc gcaacgccga
     4381 gctgatccgc gagctgtacg ggacgctcta tcgtgagcgc cgcttcgagg aggcgggtcg
     4441 cttcttccat gccgactgcg tcgagcacga cccgggcgac tggcggacat cggaccgtac
     4501 gttcccggcg ctgcgcgccg acatcgacca cctggtggcc ggcaacgacc gggtgatgct
     4561 cttcgcgacc tggaccggac gctcccgctc gggtaccgaa ctccggttgc ataccgctga
     4621 gttgtaccgc ctgcgggacg gtagggtcgc cgagcactgg agcgtggtgg accgcgacgt
     4681 gctcntcggg cacggtgtgg acggcggacc ggaccggagc ggtcagccgg ctgccccggg
     4741 tctgcacggc ccgcacagcg acaccgagcg ggccaacgcg gagctggtgc tcggcgcgta
     4801 ccgcgacgtc ttcagcgagc accggctgga gctggccgag cgctactacc accaggacta
     4861 ccggcaccac aacatgcgta cggacgcggt gccggacggg ctcgacgcgt tcaaggcgtt
     4921 cttcgccgac aacatcgccg ccttccccga cctggtcacc accgtggacc acatcgtcgc
     4981 cgccgacgac cgggtgatgg tcttcgtcac ctggaccggc acgctcaccg gcgcgtggag
     5041 cggaggcggg ccctccgggc tgcctctgga gatgcgcacc tgcgaccagt tccggatcga
     5101 acgcgggaag gtcgccgagc actgggaggt cgtggactac ctggccctgg ggcgggccgg
     5161 gctgccgacc ccgtgagcag gaccgacgcc gttccgaaag ccgacatccg agagagggac
     5221 cccgcgatga cctccgcttc cgaaccttcc ggcccttccg gcagcgcacc cgtactgatc
     5281 gtcggcggca gcctcgtcgg cctgtccacc gccgtgttcc tcgcccggca cggggtccgc
     5341 tgcactctgg tggagcgcca tccgggcacg tccgtccatc cgagggccgt cgggtactac
     5401 ccccggaccg gcgaactgct gcggcaggcc ggggtcgagg acgccgccgt gcgggaggcg
     5461 tccgggttcg ccacgcatcg cacccgtgcc ggggtgacct cgctggccgg cgaggtgctg
     5521 ttcagcaagg aggagctgga gggcgatgac gatctgggcg acctcacgcc gtcccggctg
     5581 cttctgctgc cgcaggaccg gctggagccg ctgctgcggg accgtgcggt ggagctcggg
     5641 gccgacctcc ggttcggcac ggaactggtg tccttcgcgg aggacccgga gggggtcacc
     5701 gccgtcctcg acgacggcac cggcggcacc cgtaccttcc gcagctccta cctggtggcc
     5761 tgcgacgggc cgcgcagcac cgtccgggag gcgctgaagg tgccccggca ggggcgcggg
     5821 gtgctgtccc gccatgtgag catcgcgttc ggcgcggatc tgcgcccggt gctgggggac
     5881 cgccgctaca gcgtggtcca tgtgaagaac ccccaggtca cgggcattct cgtgcatgac
     5941 gacaccttga ccgggggcac gctcatcgtc gggtaccggc ccgaggacgg cgagagcctg
     6001 gaggacttca ccgacgaccg ctgcgccgag ctggtggggg ccgcggtggg agcgccgggg
     6061 gtcgaggtga cgatccgctc gcgcttcccc tgggacatgg cggagcaggt ggccgagagc
     6121 ttcgtgcacg gcagggtgct gctcgccggg gacgcggctc acgtggtccc gcccacgggg
     6181 ggctacggcg ccaacaccgg tatcgccgac gcccacaacc tcgcctggaa gctcgccctg
     6241 gtggccgcgg gcgtcgcagg gcccggcctc gtggagacgt acgacgccga gcggcggccc
     6301 gtggcggtct acacggccga gcagggatcc ctccagctcg cactgcgttc cggcaccgcc
     6361 accccggagc agcaggccgc cgtcgcggac gcggtgacgg tgacgtcggg gcaggcgtac
     6421 cgctccacgg cggtggtggg ggagccggac ggcgcggatc tcccggtcgc ctccgatccg
     6481 cgggaactgc gcggggcgcc gggcacccgg gcgccgtatg tggagctgct gcggggcggt
     6541 gaaacggtgt ccacgctcga cctcttcggg cgggacttcg tcctgctgac cggagagcac
     6601 ggccgtgagt ggatctcggc ggccgtctcc gcctccgccg gactgggcct gaagatcacc
     6661 gcccgccggg tggtgccggg tacggacgcc ggggcgggca ccctggccga cccggacggc
     6721 gactggtccg agcgctacgg cggtctgcgc ccggaagggg ctgtcctggt caggccggac
     6781 ggtgtcgtcg cgtggcggtc gccgggcgcc gacccgggag gcgaggagag cgcggtgctg
     6841 gcagcggtgc tgcggagtgt cctcgcgcga gagtcccgca cgggcgggaa gtagcgggcc
     6901 gaggtccgtg gcggccgccg ccgcgggcct ctgccgtgcg gagcgccggg ccgcccaccc
     6961 ggccagggca cagggtcagg cagaacccga ctcgtgctgc aactcgccta cggagtcgac
     7021 gtacttgatg agcaggcggg cgaattcgag ccgctcctcc tccggccagt cctgagtgat
     7081 gcgctcgaag gccgcacgct ggtggcgccg gaagcgggcg agcgtctcgt gcccctccgg
     7141 ggtgagctgc aggatcgtac ggcggccgtc gcgctgcgag gccgcacgga tcagatagcc
     7201 ggcggagatg cagtcggaga ccatccggct ggccacggag gggtcgacgg cgagccgctc
     7261 gcccacgaca ccgacggtga tctcctgacc ctcctggtcg ggcccgtcct ggacgatgtt
     7321 gaggaccagc gtcctggtga agtccttgcg ggacacctgc ttctccacgt tcagcgcctg
     7381 cgcacgccgc agccgggaga aggcggggcc gacggcgtcg agcagatccg ctgcccgggg
     7441 cgggggctga gtcgaagtgt ccatgtccgc attctaagcg agttgattac ggcagacgag
     7501 catctgtatg ctctcaatcg actgcatgac ataaagcata tacctgtgag cgaacatata
     7561 tcgccacaac tctcgcgcac tttcgacgca cacatccacc gagggggaac cccatgtccc
     7621 agtccgtgcc acccgagcag tccgaacgcg acttcgagat cacctacgac accgacgtcg
     7681 acttcgacgt gctgatcgtc ggcggcggtc ccgtcggcat gctgctcgcc gcggagctcc
     7741 ggatctcccg cgtccgggcg gtcgtactcg aacggctgcc cgagcgcacc ccgcactcca
     7801 aggccttcgg gctgcatgcc cgctccctgg aatccctcga ccggcgcggc ctgctcaagc
     7861 ggttccgcga gggagcccgg tcctggaaca acggccactt cgcgggcctc gacgagtggg
     7921 tcgacttctc caccctcgac agcgcgcacg gctacgccct gctctccgag cagaccagga
     7981 ccgagcgact gctggaggag cgtgccgccg agttcggcgc cgagatccga cgcggtcacg
     8041 aggtcaccgc gatacgccag gacgccgacg gcgtcgaggc cgaggtcgcc ggccccgacg
     8101 gcacctacac cctgcgcgcc cggtacgccg tgggctgcga cggcggtcgc agcctggtcc
     8161 gccgggaggc cggcatcgac ttccccggca ccggcggccg ggtcactgcc cggctcggcg
     8221 acgtgatcct cgccgaccga gagaacgccc ccatgggcat ggagcgcacc gaacgcggcc
     8281 tgctgttctg cgtgccgctg gacgacacct accaccgggt ctccaccttc gacttcgagg
     8341 ccgaccgcga gcccggggcg gaactcaccc tggaggagct gaccgccagc ctgcgcgaga
     8401 tctggggcga cgacctcggt gcgcactcgc cgcgctggct ctccgtcttc accgactccg
     8461 cctgccaggc ggaccgctac cgcgagggcc ggctgctgat cgcgggcgat gccgcccaca
     8521 cccacttccc cgtcggcggg cagggcgtca acctcggtct ccaggacgcc ttcaacctcg
     8581 gctggaagct cgccgccgag gtgcacggct gggctcccga ggacctgctc gacagctacg
     8641 accgcgaacg ccaggcgccg gcccgcaagg tgctggccaa cacccgcgcg cagatcgcgc
     8701 tgatgaaccc ggacccctac gtcaccccgc tgcgcgagct cttcaccgac ctcatgcgca
     8761 aggagcaggt gaaccggcac ctcgccgaga tgctcagcgg cgtcaccgtc cgctacgcga
     8821 tcgacggtcc cgaacaccgg ctgctcggcg acttcgcccg cgacctggaa ctgaggaccg
     8881 aggacggcgt caggccgctc cccaagtacc tgaagcgcgg caccggtctg ctgctcgacc
     8941 tgaccggcga cgggcagatc gggcaggtcc acgagaagtg ggccgcgggc gcctcctggg
     9001 ccggccggct ccagcacgtc cgggccgagt gcgccgagga gccgcagctg gccggtctgc
     9061 tggtccgccc cgacggctat gtcgcctggg ccgcggaccg ggacatgccg gaggcggagc
     9121 tgcgcgaatc gctgaccgcg gccgtcacca cctggttcgg caccgactga cgcaggaccg
     9181 gcgagggccg gaggggcacg cccctccggc cggcacgaca gctactccaa ccccccacac
     9241 cgcttgtgca cgtgagagga cgacgtgagc aatcccccct ggtcgcagga gttactggag
     9301 aagagcgacc tgatcacccc catggccatc agagtggccg ccaccctcgg actctcggac
     9361 cacatggccg ccggagcggt cacggtcgag acgctggccc gcgaggcgga cgtggacgcg
     9421 atcgccctgg gccgtctcct cggtcacctg gtgaacgccg ggatctaccg ccggctcccc
     9481 gacggggcct acgaaccgac ggacctcggc gccctgttgc gcgacgacct cccccagtcg
     9541 ggccgtgact ggctccgcct ggacggcccc accggccggg gcgaggcggc ggtgttccgc
     9601 ctgctcgatg ccgtgcgctc cggcgaaccc gtctactccg ccctgtacgg gcaggagttc
     9661 tggacggacg tcgagtcgga cggcgcgctc gccgaggcct tcgcccggcg gatggcggcg
     9721 agtatgcgct gggtcgtccc cgagctgctg gcccagggcc actggcagtc cgtacggcac
     9781 gtcgtcgacg tgggtggcgg aagcggtgac ctgctcgcgg ccgtggtcga cgccaccccg
     9841 ggcgcgcggg gcacgctgct cgacctggag gcgcccgccg ccgcggccga gcgggacttc
     9901 accgaggagc gctgcaccgc cctggtgcgc gccgcggtcg gggtgcccga cctgccgctg
     9961 aagatcgagt cggcggacat gcccgcgtgg gacatctccg cgagggtggc ggacaccttc
    10021 gcgacccgcc gggtgttcgt cgccggggac gccgcccatg tgatgccgcc gaccggggcg
    10081 ttcggcgcca gcaccggtat ccaggacgcg tacaacctgg cctggaagtt ggccctggtg
    10141 ctctccggca cggcgggtcc cggactcctg gagagctacg acgccgagcg gcggccggtg
    10201 gccgaggaga ccgtccggca ggcgatgctg cggttcgcgg tgcgggaggg caagcagtac
    10261 caggacgtcg ccgcggagct gctggacgag acgaccatga cgttcgggta ctgctaccgc
    10321 tccggggcct tcgccgcgga ggagggggcg ccggacgcca tcgtcgagga ccccgcgcac
    10381 ccctcggcgc ggcccggggc gcgggcaccg cacctccaac tcgacgggcc ggaaggaccg
    10441 gtttcggtca tcgacctgta cggcgacgga ttcacgctgc tggtcgacga ggcggcggga
    10501 cggtggaccg gggcggtgga gcgggaggcc gagcggttgg gtgtcgcgct gaaggtcgta
    10561 cggatcggac gcgggacgcg gctgtgggac caggacgggt ccttccggcg gcggtacggg
    10621 ctgctggccg ggggcgcggt tntgntacgg cccgacgggt tcgtggggtg gcgtacgacc
    10681 gcggggcgca gcgggcccgt cgaccaggcg gcgatcgacg cgctgcgggg ggtgctggac
    10741 cgggtctagg cgcgacgcgc cgcatgggcg cgccgcgcgc cccatgaagc ggccgcggtg
    10801 ctccttcccg gagcaccgcg gccgtcctgt gcacgcgcag cgtgcgtcaa ggggtgcggg
    10861 ggaccgcgcg acacgccacg ccgacgccgc ggccgcccgg acacccacga gccgaacgct
    10921 cacgcacgcc gcaacaccgc gtcgagcacc gccngcagcg acccgccggc atcaccctcc
    10981 gcccgaccgg cacgccacgc gatgaacccg tccggccgga gcagcaccgc accggtctcc
    11041 tcgangcngt agcgggcgag gaaccgttcg acgaccgcgg gggactcctc ggcgcccacc
    11101 cggtggaagg acaggccgag cgcggccgcc ggctcctgcc aggcgatgcc gccggggccg
    11161 gcgaggagcc agaagtcgcc gtcgaggagg tcgtggaggg cgacgtcctt gccctggcgg
    11221 accaggggga ggtggggagc gcgggtgccg gggcggccgg tgggcgtcgt cgggtcctcg
    11281 atcacggcgg tgtcgtcgtc cccggcctcg cggaggacgg cgtccgaccg gtacacgtgg
    11341 ccgaacagca ccgtggtctc gggccggtgc cgggccgcgg ccgcctcgtc gaggccgctg
    11401 cgctggaggt agcggatgac gccctggtcg acggtgaact cggcgaccgg ggcccgctcc
    11461 tgctcgtagg tgtccagcag gccggggccc gcctgtccgc gcagcacccg cgcgagcttc
    11521 caggccaggt tgtgcgcgtc ctggatgccc atgttgccgc cgaagccccc ggtgggcggc
    11581 atgacgtggg cgctgtcgcc ggccagcagc acgcgtccgg agcggaagcg gtccgcgacc
    11641 caggcggcga tctcccagct cgtcgcggac tccaccgtga ccggcagatc gggcacgccc
    11701 accgcggccc ggaccagctc cacgcagtcc tcggtgccgt agacgcggtg gtcggccccg
    11761 ggcggcaggc tcggcgcgag cacccagcgg tcggagtccg cgccgccgag cttgccgagc
    11821 acgcccttga cggccgggtt gctgacgaag cagaggaaga aggtgcgccc cgccacgtag
    11881 gggtcgaggt cggcgtggaa gacgatgttc atctgccggc cgaacacgcc ctgcccgtga
    11941 tggccgatgc cgagcgaggt gcggatcggc gcccgtgagc cgtcggccgc gaccaggtac
    12001 cgcgcccgta cggtccgctc cgagccgtcg cccaggtcgc gcaggacggc cgtgacgccg
    12061 tccgcgtcct gggtgaactc cgtcatctcc gtggcgaacc ggatgtccgc gccgagttcc
    12121 tcggcccgct cccgcagcac cggttcgagg cggtcctgcc cgatcagtgt ccagccggtg
    12181 gtgccgacct cgtgccggtc gaagcggaac ggcccgtcga accgcccgag ttccgccccg
    12241 gtgagggact cggcctggag gatgtcgccg tactgggcgt gcgggttctc ccgtgcccgt
    12301 accgcgtcct ccaggccgag cgcgcgcagc agctccatgg tccgcgggct cgcggcctgc
    12361 gcccgggggt gcgccgagat ctcggcgtgc cgttccacca gcaccggccg gatgccctgc
    12421 cgggcgagga acagggcctg ggcgagcccc accatgctgc cgcccacgat gagtacttcg
    12481 gtcgtctcgt ccgccatacc ggctcctcga agggtgtgga ttgcgttcgg tttcgggggg
    12541 ccgatgcaac acccgacgcc tcgaaccggg ctcgcggcgc gggcgagcgg aaccggtgcg
    12601 gagcgacgcg ctcccagtcg gattcgagtg ccgtgcgagg accggctgac agtttcggac
    12661 caggcccgaa gtacacggct cgaaggagga cggaagcggt ggtggaggct ttgagtgtgc
    12721 tggtgctcac gggcaccggc ctggtggcgg gggtgctctt cgcggtcgcg gtgagcgtga
    12781 tgcccgcgct gatcgcgatg accccggagc ggtacgtgtc cacgcacatc ctgctcggca
    12841 agcgctacga ccggatcatg ccgttcatcg tcaccggctc cacggccgtg gacgtagggc
    12901 tcgcgatacg ggcgtcggag ggcccccggg tgctgttcgc ggccgccgcg gtctgcatgg
    12961 cgggggtggc cgtggtgtcg cagacccgga acgtgccgat caaccggcgg gtcaagcgga
    13021 cccggcccga ggacctgggc cctggctggc gggacccgcg cccggcctgg cgggactggc
    13081 atctggtgcg caccggcctc gcgatcgcgg gctgcgcgct gaccgccgct gcggtggtgc
    13141 tgtcatgagc cccgtcgtcg tacgcgaact gccggagggc ccggagcgag cggcggccga
    13201 tgcccggatg cgggagctgc tgtcccgtcc cgcgcccggc ccggtggccg agcggctcgc
    13261 gctgctgcac ttcagcggcc ggcgcagcgg gcggccgtac accgtgcccg ccggggtgca
    13321 caccctcggt ggcgcgctgg tggtggcgac cggcagcggc tggcggtaca acttcgcggg
    13381 cggctcgccg ggcgagctga cctggcgcgg acagcggcgg ccggtgcggt tcacgctggt
    13441 cgacgacgcg gagcgcagcg cgcgcggcta tctggagctg taccgccgct acggggagga
    13501 ggccccgcgc cggctcggac tggcggtgcg cggtgcgggg acgcccgcac tcgccgagtt
    13561 ccgggaggcg gtcggccggc acgggctctc cctggtggag gtcaccctcg tcacccacgc
    13621 cccggcggag aacagcgcac ccccatcaga cgcagagagc gaaaggacgc cacgatgagc
    13681 ggaatcgccg gctgggtgga cttcgaacgg gacctgacac cggaggcccc caccgtacgg
    13741 gcgatggcgg cggcgctcgc gcaccgcggc ccggacggct tcggtgagtg gatcgagggc
    13801 catgccgcac tggcccaccg gcggctctcc ctgatcggct ccgagcacgc ggggcagccg
    13861 gccatcgtgg agtcggaggc cgggagcccg gtggccgtgc tgaccctgga cgggagcgtc
    13921 accaacgcgg tggagctgcg ccgcgaactg gcggcgaagg ggcaccggtt caccggggac
    13981 ggtgacgcgg aggtggcgct gcacgcctac ctggagtggg gtgccgcgtt ccccgagcgg
    14041 ctggagggcc tgttcgcgct ggccgtgtgg gacgtgcggc ggcaggaact gctgctggtc
    14101 cgcgaccggt tgggggtgaa gccgctgtgc tacttcctga cgccgtccgg tgtggtcttc
    14161 ggctccgagc ccaaggcgct gctggcccat ccggcggtcc ggccggtggt cgacgccgac
    14221 gggctgcggg agctgttcgc gcacagccgc aagccgggca ccggggtgtt ccggggcacg
    14281 cgcgaggtgc tgcccggcca cacgatgacc gtgcgggcgc cgggcaccgg ccaccgccgc
    14341 tactggtcgc tgcccgcccg cccgcacacc gacagcctgg agaccaccgt cgccaccgtg
    14401 cgccggctgc tgtcggaggc ggtcgccacg catctgcgtg cggacgtgcc ggtcggcgcg
    14461 atgctctccg gcgggatcga ctccagcgcg ctgaccgcgc tcgcggccca ccggcggcgg
    14521 gccgaggggg ccggcctccg gtcgttctcg gtgaacttct ccggctacgc ggagaacttc
    14581 gagccgcacc cgaccatgcg cgccaccccc gacgccccct acgcggctct cgccgccgag
    14641 cacatcggga ccgagcacac cgagatcctg ctggacacgg cggcgctcgc cgatccgggg
    14701 acgcacgccg ccgctctgcg cagccaggac gcgccctcgc cgctcggtga catggacgtc
    14761 tcgctgctgc tgttcttcga ggcgctgcgc ggcgcgggga tcaccgcggt gctctccggg
    14821 gagaccgcgg acgaggtgtt caacggctac ttctgggcgt acgacccggg ccacagcaac
    14881 tccacgacct tcccgtgggt ctccttcgag cgcgggcacg acgccgccgc gggcggtctc
    14941 ggctgctcgc tggtggaccg tacgctccgc aaggagctgg acttcatgga ctacgccgac
    15001 cagcactacc gcgacgcgct caccgaggtc ccgcaggtgg ccggcgagag tcctgccgag
    15061 cgcagggcgc gcgaggtcac gtatctggcg ctgacccggt gggccccgac ccatctggac
    15121 cgggccgacc ggatgagcat ggcgcacggg gtgcaactgc gcccgccgtt ctgcgaccgg
    15181 gcgctggtgg agtacgtcta caacgtcccg gccgagttga agcgcgtgaa cggccaggag
    15241 aagagcctgc tgcgggccgc ggtcgccgat ctgctgccgg agcgggtgct caaccggccc
    15301 aagagcgcct atccgaccgt gcaggaggcg gcgtacggcg agttcgtgcg ccaccgcttc
    15361 gaggacgtgg ccgcggaccg cacggcgccg gtcgccccgc tgctggacgc cgaggcgacc
    15421 cgggtggccc ttggtgcggc ggctgctccc agcggtgcct tcgcgtgggt ggaacgggcg
    15481 agcatggaga tggtgcttca gctgaacacg tggctctcgg agtacggggt cgagctgcgg
    15541 gtgtgagagt gccggaggcc accgcccgcg cagaaatgtg ctccttgtca tccatgtgtg
    15601 cgaagcatag gatgcggacg agatagagaa tgggaatgcg gcattcggtt tcgactcgca
    15661 tcgccgggtg ctcgcagggt tattgctggt ttcaacttct ttttcggcga aacgtaattc
    15721 ccgagtaaag gggaggcaat ttttccgccc cttcgagcga atgatgtttc gcccaaaaat
    15781 aagtgacgca ggaaggtgaa taaccgatgg ccgccaccca cacaggcggc tcactcaggg
    15841 ggaatgcagt gatagagatc ggtctgctgg gctccatgcg aatacgcagg aacggggagg
    15901 acgtcacacc gtccgccccc aaactgcgtc aggtgctggc cctgctggtg ctcaatgcca
    15961 actcgctggt cagtgtggac cagctgtgcg aggagctgtg ggaggaccac ccgccgctca
    16021 gcgcgctgac caccttgcaa acctacattt atcaactgcg ccgcagactg ctgctggcca
    16081 ccggccagca cggcgcggct ttcggctccc gtccaccgca cggctgcccc gcaatcctga
    16141 ccagggtcgg cggctatgaa ctgcgcctgg acgacaagca gtcggtggac gcctaccggt
    16201 tcgaccagct catagaacag ggcatggcac aactccgcac cggcgcgggg gaggaagagg
    16261 cggcccgcac cctcaaggcg gccctttccc tgtggcaggg cggagccctg gtcgacgtca
    16321 gcaccggacg ccggctgtcg gcctggtcga cccagttgga ggaacgccgt aagagcgtcc
    16381 tggagcaacg tttctccctg gagctccaac tcggccgtca ccacaccgtc ctggacgaac
    16441 tgtcggaggc cttccgggcc caccccaccc acgaggcgtt cgccggccaa ctgatgcggg
    16501 ccctgcaccg ctgcggccgc cgcccggacg ccctcaacac cttccgcacc ctgcgcagcc
    16561 atctcgtcga ggaactcggc ctggaaccct ccgtgcagct ccagcggctc caccaggagg
    16621 tgctcgcgga ccgcggccac ctccgagggc ccgccccggc caaggccgag accgtgtcgg
    16681 gcggacgccg gctcgtgccg nggccggccc agctccccgc cgacgtcggt gacttcgtcg
    16741 ggcgggaacg cgaactcgac cagctggaga ccttcctcgg cgcggaccgg cccagcaccg
    16801 gcatgcgcgt ggtggaggtg cacggcccgc ccggggtcgg gaagagcgcc ttcgccgtgc
    16861 gtgccgcgca ccggctgcgc ccgcgcttcc cggacggaca gctcttcatc gacctgtccg
    16921 ccgtcggcga gggctcccag caactcgcgg acgtgctctc ggcctgcctc accgcctgcg
    16981 gcatccagcg cgagaagcag cccagcgggc tcggcgagct cagcaggctc ttccgcacct
    17041 ggaccgccga ccgccgggtg ctggtcgtgg tcgacgacgc cctcaccgcc tcccagatcc
    17101 gcgccgtcct gccgggcggc tccggctgcg cggtgatcgc caccaaccgc taccgcgcgc
    17161 acagcctgtc caccggccgc aagatcgtgc tcccggccct gtccccggag gagtccctcc
    17221 agctctacga ccgggtcgcc ggggagcgct cccggcagga ggaccccggg gcggtgcagg
    17281 agctgatagg gctgtgcgag gggctgcccc tggcgatcag ggccgtggcc ggccggctca
    17341 ccgcgcggcc cggctggtcg gcggcccggc tggcgtcgcg gctgcgcggc aaccaccgga
    17401 tgctgctcga actgcccgcc ggtacccagt cgctgatgac caccgtggcc gcgagccacc
    17461 ggcatctgcc cgcccgctca cgggagttgc tgcgcctgct gctccagcgc gagcgccccc
    17521 gctggagcct cgacgaggtg gtgacacggc tgcgtcccgg cagcggagac gccgagacgc
    17581 tcctcgaata cctcgtcgac gtccacctcg tccaggagca cctgacaccg gacgccgagc
    17641 tcctgtactc cgtgccccgg ctcacccggc aggccctgat cctcctgtcg cggggcacgc
    17701 ccgcgggcga cgtaccgaac ggccggatgg tcggcgccgg tgtcgtcgcc ggcaccggcg
    17761 tcaccctgat gaaggccgac gtccgccgct agcccggccc gtccacggcc cgccgcaccc
    17821 cgggtgcggc gggccgtcgt gctgcccccg tgcgctgcac cgggtccgtc agcggttctc
    17881 caggcgcctt cgagagcgtc tcgacccccg ccgaccaggg tgaacacaga accgacaagc
    17941 cgggaggaca tcgtgcaccg aacgctgatc gtggcgagga tggacctcgc cgacgccgag
    18001 ggcgtcgcgc aggtcttcgc cgattcggac agcaccgaac tgccccatct ggtgggggtg
    18061 tcgaggcgga cgctgttcgc gttccacaac ctgtacttcc acttggtgga agccgaccag
    18121 gacatcgcgc cgaacctgta caaggcgcgc agccacccgc tctacgagga gatcaacacc
    18181 cggctcggcc agttcatctc gccgtacgac cccgactggc gcgagcccaa ggacgccatg
    18241 gccgtcccct tctactcctg gacaccccag gacggcccgc agaccagggc gccgcgctcg
    18301 gcgaacctgg gcggtgcccg atgagcgccc ccgccacccc caaggtcgcc gcggacgagg
    18361 tcgccgccaa caccaagcgc ggcggcgaca tccgcgtcac cctcagcccc aagaccgtgg
    18421 gctgcacctc gggcttcggc ggcgtgctgc ggctggcccc cggacatcac gtcaccgagc
    18481 acctccaccc gtactccgag gagttcctgc acgtcgtcca gggccggctg gagatgacgc
    18541 tggacggcgg caccccggtg gcgctcggcc ccggcgactc gctgctggtg tccatcgggg
    18601 tgcgccaccg cctggtgaac accgggtccg tgccggccga ggcggtcttc cacctctccc
    18661 cgctcgcgcc ccgccccgaa ctgggccaca tcgacaccga gcagccgctc gacgcgtccg
    18721 cgggcaaccc ggatgtgggt gcggcccgat gacagccgga caccgacgcg cggtgatcac
    18781 cggggtgggg gccgtcgcgc ccggcgggat cgggcgggac gcctactggg acctgctcac
    18841 cgccggacgc accgccaccc gccgcatcag cctgttcgac ccggccggct tccgctccca
    18901 ggtcgccgcc gagtgcgact tcgatccgct cgccgcgggg ctcacccccc aggaggcccg
    18961 ccggatggac cgggccggtc agttcgcggt cgtcgccgcc cgtgaggccg tcgcggacag
    19021 cggagtcgag ctgcccggca ccgacccgga gcgggtcggc atcagcatcg gcagcgccgt
    19081 cggctgcacc atgggcctgg aggaggagta cgcggtcctc tccgacggcg gacgcgactg
    19141 gctggtcgac cacagctacg gcgtccccca cctctacggc tacatggtgc ccagcaccct
    19201 cgccgtcgag gtggcccgcc aggcgggagc cgaggggccg gtcgcgctga tctccaccgg
    19261 ctgcacctcg ggactggacg ccatcggaca cggcgtccag ctgatcgagg agggcagcgc
    19321 cgacatcgtg ctcgccggcg ccaccgacgc cccgctgtcg ccgatcacct ccgcctgctt
    19381 cgacgccatc aaggccacca ccgccaacaa cgacgatccc gaacacgcct cccggccctt
    19441 cgacgggcag cgcgacggct tcgtcctggg cgagggctcc gccgtcatgg tgatagagga
    19501 gctggagtcg gccagacgcc gcggcgccac cgtgtacgcc gagatcctcg gtttcgcggg
    19561 ccgcagcaac gccttccaca tgaccggact caagcccgac ggccgggaga tggcggaggc
    19621 cgtccgggtc gccctgcacc gggcgcggct cgacccgggc gccatcgact acatcaacgc
    19681 ccacggctcg ggcacgaagc agaacgaccg gcacgagacc gccgcgttca agcgcagcct
    19741 gggacagcgg gcccacgagg tgccggtcag ctccatcaag tcgatgatcg ggcactcgct
    19801 cggcgccatc ggctccctgg agatcgccgc ctgcgctctc gccctgcgcc accaggtcgt
    19861 cccgccgacg gccaacctgt ccacgcccga ccccgagtgc gacctcgact acgtgccggt
    19921 gacggcccgc gagcaccgta tggaccgggt gctcagcgtc ggcagcggct tcggcggctt
    19981 ccagacggcg atggtcctgg gccggcccca cctcgcgcac ggggaggcgg catgagcgcc
    20041 tccggcatca gccccggccg gcgcggccgg tccgtggtca ccgggctcgg cgtggtcgcg
    20101 cccaccggga tcggagccgt ccggcactgg gagtcggtgc tctcggggaa gagcggcctc
    20161 ggccgcatca cccgcttcga cccgaccggc taccccgtcc gggtggcggg cgaggtcccc
    20221 ggattccacg ccggtgaaca ggtgccggga cggctcgtcc cgcagaccga ccgcttcacc
    20281 cacttcgcgc tggccgccgc cgaggacgcc ctcgcggacg ccgccgccga cccggcgacc
    20341 ctgccggagt acgagatggc ggtggtgacc gccagctcct cgggcggcac cgagttcgga
    20401 cagcacgaga tggagaacct ctaccagaag gggtcctcct gggtcggggc gtaccagtcc
    20461 atcgcctggt tctacgcggc caccaccggc caggtctcca tccggcacgg catgcgcggc
    20521 ccctgtgggg tcatctgcgg cgagcaggcc ggcggtctcg atgccctcgg ccagtcccgg
    20581 cggctgctgg acaccggctc ccggctcgtg ctcagcggtg gcaccgacgc ctcgctgtgc
    20641 ccgtacggcc tggtggcgca gctgtccacc ggccggctgt ccaccgagga cgatcccgcc
    20701 cgcgcctacc tgcccttcga cgcggccgcc tccggcttcg tcccggggga gggcggtgcc
    20761 atcctcgtcg tcgagaacgc cgagggggca cacgcccgcg gggtcccggc gtacggcgaa
    20821 ctcctcggct acgcggccgg tttcgacccc accgcggacg gcaccaccac gggccactcc
    20881 gtgctggtgt ccgtcgtgcg gcgggccctc gccgacgcag ggctcgcccc gggcgacgtc
    20941 gacgtggtct tcgccgacgc ctccggcacc cccgccgagg acctcgccga ggcccgcgcg
    21001 atcaccgagg tcttcgggcc cggcggcgtg ccggtgaccg cgccgaagac cctcaccggg
    21061 cgcctctacg cgggcggcgc cgccctggac gtggcgaccg cgctgctcgc cctgagcgcc
    21121 ggtgtcgtcc cgcacaccgc ggggctcggc cgcccggccc ccggctgcga gatcgacctc
    21181 gtcctcgacc gcccccgcca gaccgacccg cgcaccgccc tggtcctggc ccgcgggcac
    21241 ggcggcttca cctccgccct ggtcctcggc gcgggcgacc gcggcgcccc cggcaagtga
    21301 ccggcccacc atccacgacg tacgaaaggc ggctccccat ggcggagttc accctcgacg
    21361 acatccggcg gatcctgcgc gcgagcggcg gggtcgacga gcagaccgac ctggacggcg
    21421 agcacttcgc cgacacctcg ttcgccgacc tcggctacga ctccctggcc ctgctggaac
    21481 tcgtcaaccg catcgagcgc gagtacggca tccagatccc cgacggcgac ctctcgcaca
    21541 cccagacccc gcgcgaggcc ctgacctatg tccacgcccg gcttacggag gcccgcgtct
    21601 gatggcagga cacaccgaca acgggatcgt cgtcgaggca ccgatggacc tggtgtggac
    21661 gatgaccaac gacgtggccg cctggccgcg gctgttcaac gagtacgcct ccgccgagat
    21721 cctcggccgg gacggcgaca ccgtcacctt ccgcctcgcc ctgcacccgg acgagaacgg
    21781 cacggtctgg agctgggtct ccgagcgcac ccccgacccg gccacccgca ccgtcgtcgc
    21841 ccgccgggtc gagaccggcc cgttcgcgca catgaacatc cgctgggagt acgaggaggt
    21901 gcctggcggc gtacggatgc gctggatcca ggacttcgcg atgaagcccg acgccccgat
    21961 cgacgacgcc gggatgaccg cccggctcaa ccgcaacacc gccgtccaga tgcggctgat
    22021 caaggccaag gtggagaccg cggcccgggc cggccggcaa ctccagggca agcgcatcct
    22081 ggtgacgggc ggcagccgcg gcatcggcag gggcatcgtc ctcgccgcgg cccgggccgg
    22141 agccgacgtc gtcacctgct accgcacccc cggcgaggcc gtcgccacgt tggaggagga
    22201 actcgccggc acccccggca agcaccaggt gctgcgggcc gacgccgccg acgcgacgga
    22261 cgtggaccgg ctggccgccg cgtgcgaggc gagccccggc ggactggacg cggtcgtcaa
    22321 caacgccggg acgttccgcc cccagccgta caccgacctc ggacccaccg agtgggccga
    22381 caccctccag ggcaacctca cggccaccca cctggtcacc cggcgcaccc tgccgctgct
    22441 ctccgccgga tcctcggtgg tcaacatcgg ctccacggtc gccttcatcg gcatggcggg
    22501 cggcgtccac tacaccgccg tcaagtccgc actggtcggc atgacccgct cgctggcccg
    22561 ggaactcgga ccgcgcggca tccgcgtcaa caccgtctca cccggccgca tcgccaccga
    22621 ggcgctcgac gaactgcccc ccgaggaggc cgagcgccag cgcgccacct tcgcctcctt
    22681 caccgcgctc ggccggctcg gcaccgtcga cgacatcgcc cggaccgtgc tgttcctcat
    22741 cagcgaccac gccggctacg tcaccggcca gaacatccac gtcgacggct gcgtctgagc
    22801 cgcggcccca gccatgaagg gaatccccat ggaactcgca ctgcacggca ggaaactgct
    22861 catcaccggc ggcacccggg gcatcgggcg gggcatcgtc ctcgccgcgg cccgggcggg
    22921 cgccgacgtc ctcacctgct accggcagga gagcgaggcc gtcgacagcc tgaccgccgc
    22981 gctgaaggag accgccggcg accaccacgt gatccgcgcg gacgtcggtg acaccgccga
    23041 ggccgaccgc ctcgtcggcg aggccaagga ccgcttcggt cgcctcgacg gcgtggtcaa
    23101 caacgcgggc gtgatcagcc acatcccgtt cggggaactg ccggccgacg agtggtcgcg
    23161 catcctcgac accaacctca ccgcggccta ccggatcatt caccaggcgc tgccgctgct
    23221 cggcaccggc tcctcggtcg tcaacatcgg ctcgcgcgga gccgccgcgg gcataccact
    23281 gcgcgcccac tacaccgccg cgaaggccgc catgatcggg ctgacccgtt ccctcgcgaa
    23341 ggaactcggc ccgaagggca tccgggtcaa cgtggtggcc cccggcgtca tcgagaccga
    23401 ggccttcgcc gacatgcccg ccgagcgcgc cgccggactg cgcgccacct actcccagaa
    23461 gaccgccctg gcccgcctcg gcaccgtcga ggaactcgcc ggaccggtgc tgttcctgct
    23521 ctccgacgcc gccgcgtaca tcaccggcga gaccctcaac gtcgacgggg ggatctgaca
    23581 tgcccgagcc caccgagaag gtcttccggg tcatgctgcg catgcagatc aagtccggca
    23641 tggagcacga gttcgagaag gtgtggctgg aggtcggcga ctcggtcacc acccaccccg
    23701 ccaacctcgg ccagtggctg tcccgcagcg ccgaggagga cggcatctac tacatcgtca
    23761 gcgactgggt ggacgaaccg ctgttccgcg agttcgagac cagcgaccgc catctggagc
    23821 accgccagaa actgcacccc taccgcagcg gcggctccat gacgaccatg cacgtcgtcg
    23881 ccgccctggc cggcgccgcg tcgtgaccgg cggcgccatc gaggtggtgc tctaccacct
    23941 gagcgacgaa ccggacctgg tgctgcccgc gtaccacgag gccagccgcc ggatggcggg
    24001 caccgccggc ctgctcggca acaagctgtt gcacgccctc ggcgacccgc gctcctacgt
    24061 cgtggtcagc cgctggtccg actgggaggc gttcaccgcc tgggagagcg gctccgccca
    24121 caaggaccag accgcaccgc tgcgtccgct gcgcgacacc ggccgggacc ggcccttcga
    24181 gatctaccgg gagctcgcca gctacccgga gggccgggcc gccaccccca ccgccgacgt
    24241 caaggaagga gtctgagcat ggcacgcacg gacgccccgc aagcagcccc gcccgccgac
    24301 ctgttcaccc ccgccttcca ccagaacccg cacgaggcgc tggccggcct gcggcgcacc
    24361 gcgcccgccg tgcccgtcat gacacccaat ggcctgcgca cctggctggt caccggacac
    24421 gagcacgccc gggcactgct ggccgatccc cggctgagca aggacatgcg ggtcggccgg
    24481 gacctcattc cgcggaactt cgtcgatccc gacaagcagc gggagttcct cgcggagtcg
    24541 ggggagcgca gccagttccc gcacgtcctc agcgtgcaca tgctggacag cgacccgccg
    24601 gaccacaccc ggctgcgccg gctcgtcggc cgggccttca ccgcgcgacg ggtcgagtcc
    24661 ctgcggccgc gcatcaccga actcaccgac gaactgctgg acgccatggc ccggcacgag
    24721 cggctggacc tcatggaggc cctggccttc cccgtgccgt tcacggtcat ctgctggctg
    24781 ctcggcgtcc ccccggacga ccgggccgcg ttccgccgct ggtccaacct gctcgtctcc
    24841 ggcgcgggca ccgacgaggt acgcgaggcc agcgcgtcga tgatcacgta cctgacggag
    24901 ctgatcgagg ccaagcggaa cgagccggcc gacgacatgc tcaccgacct ggtgcacgcc
    24961 cgggacgccg gcgaccagct gtcgtccgac gagctgatct ccatggcgtt cctgctgctg
    25021 gtggccggcc acgagaccac ggtcaacctc atcggcaacg gcgccctggc cctgctcacc
    25081 caccccgagg tgcgcgagca gctcgcggcg gacgagtcgc tgtggcccgg ggccgtggag
    25141 gagttcctcc gctacgacgg cccggtcacc aacgccacct ggcgcttcac caccgaaccc
    25201 gtcgaggtcg gctccgtcac catccccgag ggcgagttcg tgaccatctc gatcggcgcc
    25261 gccggccggg acccggaccg ctaccccgac ccggaccgcc tggacatcac ccgcgcccac
    25321 tccggctcgg tcgccttcgg ccatggcatc caccactgcc tgggcgcccc gctcgcccgg
    25381 ctggagggcc ggatcgtcct cagccgtctg ttcgcgcgcc ttcccgggct gcggctcgcc
    25441 gcggacccgg acgaactgag ctggcgcagc agcctgatga tgcgcggcct cgaagaactc
    25501 ccggtgttca cggcgtgacc gccgaccccg ccccgcccct actggaggag acacccgtgg
    25561 aacgtcagga caccggaccc gcaccccgca ccaccgaacg ccccacctgg gccccgcccg
    25621 aggtcgacat cgacaccccg agcatcgccc gggtctacga ccactggatc ggcggcaccc
    25681 acaacttccc ggcggaccgg gaactcgccc gcaaggtcgc ggccggcaac ccggacctcc
    25741 cggccaccct caaggcaaac cgcgccttcc tgcgccgcgc ggtacgcgag ctgtccgcgc
    25801 tcggcatacg gcagttcctc gacatcggct ccggcatccc ggccgagggc aacgtgcacg
    25861 acgtggccct cgccgcccac ccggacagca gggtcgttta cgtcgacatc gacccggtgg
    25921 ccgtcgcgca cggtcgggcg ctgctcgccg acgaacctcg ggcggccgtc ttccagggcg
    25981 acctgtacaa gtcccgggag atcctggagg cggaggacac ccgtcggctg atcgacttcg
    26041 accggccggt cgcgctgatc ctcgccgccg tactgcactt cgtcccggac ggcgacgatc
    26101 cgctcgctct ggtgcgccgg tacaccgagc ggctggcacc cggcagcgcc ctggtgatct
    26161 cgcacgccgg cgcggaggag gtcccgagga cggcgccgga ggcggccgag cagtaccggg
    26221 gcgcggtgag ccaggtgatc tggcgcgaca accgggaact tgccgcgctg ttcgaggact
    26281 tcgagcttgt gacgcccggt gtggtccggg ccccgctgtg gcgccccgaa ccggccgaca
    26341 cccccgaccc ggcgctcgcg atgctggccg gagtggcact caaaccggct cggtgacctc
    26401 cggtggacac gtccctcacc ccacaggact ccccgccggc caccgcgggc tccgcacctc
    26461 cgcgggccgg tgaccacagg cccggcttcg gcacactgct cgcggtcgac ctgtgggagc
    26521 ggttcagctt cttcggcatg gcggcgatcc tggtcctcta cctgaccgct tccgaggcgc
    26581 gcggcggcat gggcatggcg ccgcagccgg ccaccgcgat cttcgcggcg tacatgtcgc
    26641 tctgcttcat ggccggcctg cccggcggct ggctcgccga ccgggtgctg ggtgcgcgcc
    26701 gggccgtgct gctcggcggt gtgctgatca cctgcggcca cgcggtactg gcggttccgg
    26761 tgacgggcac gctctacgcc ggtctgctgc tggtcgtcgg ggggacgggc ctggtcaagc
    26821 cggccatggc ggcgatggtc gcgggggtca gcggggacgg ggagggccgc cgcgaggcgg
    26881 ccttctcgct cttctacatg tgcatccagg tcagcgcgct catcgccccc gtggtcaccg
    26941 ggctgctcgc cgagcgcgtc gcctggcacc tcggcttcgc ggcggccgcc gtcggcatga
    27001 cggcgggact gatccagttc gccctgggcc tgcgccggta cggggacgtc ggcgcgcgtc
    27061 cgccccgccc ggtgccgcgc cccgaggccc tcgcgatgct ccggcgcgcc gcgtgggtca
    27121 cggggtcggt gggcgcgctg gtggtgctgc cggtgtcccg cggactgctg cctcttcccg
    27181 tggtgctcgc cgccctcggc ctgacgacca tcaccctccc gttctggtac ctgaggtcac
    27241 tccgcctggc ccacgcgccg ggcacgggcc acaggcgccg gctgaccggc ttcaccgcgc
    27301 tgatggcggc gtcggccgcc ttctggatga tcttcgcgca gagcggttcg gtgctcagcc
    27361 tcttcgccga gcgtcacacc gaccgggatg tgctcggttt cgaggtcccc gcgagttggt
    27421 tccagtcggt gcacccgctc ttcgtcctgc tggtcgcccc gctcttcgcc cggctctggg
    27481 tacgggcgcc gcgggtggac gtgccggtca agttcgcggg cgcgctgatc gcggcaggct
    27541 ccagctttct gctgatggcg gtcgcggcca cgctcgccga gcacggcccg gtcggcccgc
    27601 actggctgct gctggtctac ctgctgtact cctgcggcga gatcgcactc gccccggcgg
    27661 gcctggcact cgccgcggcg gtggccccac ccggcagcac cagccgcctg ctcgcggtga
    27721 acggcctgtt cggcgcggtg ggagtggtcg tgggaggcca gctgttccgg ctgacgacgg
    27781 tgctgtcgcc ggcgacgtac ttcctgctgc tcggcgcctt cgtactggca gtcggcacaa
    27841 ccatcgccct cggcaccccg cgcctacgca cactcctcgc cctccggagg aaccccggcc
    27901 cctgaacccc gaaaaccaca cagggacccg acccgcactg cggatcaggt ccctgatgtg
    27961 ttctcaaact gtcggggtgg cgggatttga acccacgacc tcttcgtccc gaatgaggtt
    28021 cgaatgggct cgtgatcggc ggagatcagt atcggtgctg gtcagaggct tgctgtgggg
    28081 cgggctcgca tggcttcggt gggcctctgt tggaagatca tctcccagat ttcttcctgc
    28141 gcactgggcg cagagtggtg cggttgccgc ggcaagtttg cgtatcaggt gaggctcttg
    28201 cggcgcgcgc gcagggagta ggtcgtcggc ccgcccggcc tgccgctctt cgaccagcca
    28261 ccgctcgtcg cgatgaccca gccctgctgc tccttcatct gcgcggcgaa ggcacggcgg
    28321 tcgttgatgg agcagccgca ggtgagggtg acgtcgatgt cgaggtactg gctgcgaggg
    28381 ttgtcgttgc cgtacgggtc cttgatccat tcgaccttgt ggatgtggtc cttcaggccc
    28441 gttcgctctt cgtcatgctt gatcccaagt gccttggcga actcgtccag gtcgtcgatc
    28501 tcgaagaggt cgctcgacca ctggccgggc cagacggcga acagccggga ctctccggcg
    28561 accgcgcgct cgtaggcggc gcgctggtcc ccgtgcgtca cggtcccatc cccgtggacc
    28621 tcgatatagc acgttgtact tgaggtgtac gggaagtctc tgccggttgc ggccgcgctt
    28681 cgtggtttca ttggcccccc aatgtggttc tacggcaaag cactttgttc gatcccagtg
    28741 aacaacaggt cggcattgcc agggtgccat ctcgtgaaag gtgctcaggg cgcgttgtcg
    28801 accagagcgc cgttggtgag gcgaaggcga cggacctcac ggagcgtcct tcaagcggat
    28861 gtgcgccagc cactgcgtgt tccctgctgc tcgacggtat cgacacaggc cccggggctc
    28921 gtgctacccg agcccgcccc ggcgtgacag ttgatcggta atctccgacc ctgcgtcgga
    28981 ccgcgtcacc tcgtccttgt acttcttgtc gccatcgccc ttcgggtgca ctacggccgt
    29041 cttggtgatc acggaacggc atcggcgagg tgccctgggc cccatccctg cgcagagcgt
    29101 ccactgatcc gggtcaaggc tcttcgtctg cctgttcggg gcgtgagttg agggcccaga
    29161 tgccccctta cgtcgactcg ctgtctcaaa tcccaaacga cgtgcactcg acgaaagtgc
    29221 tcgaacctcg ggcgcgcgtc tagagaaacc ccaaacggcg tgcacccagc ggtgcgtggc
    29281 cttcgccttc tactgtcctt cctgaagcca gggatcaccg gctcactcgt ccgctgggag
    29341 atcccccgac ctcaggaagg aaccaagtcg tgcagttgag gctgatgtac gtgatcaccg
    29401 cggtcctcgc ggcgcttgtc gccgctcttg tcggcagcgt cgtgaccgtt gtcgagggag
    29461 ggcgtcccac ggcggccttc aagactggag cattgacctt cgccggctcc ttgacgctcc
    29521 ttatggtggt catgggggcc ctgggggtgg tgggctcgtg agcgacatga gtgcccttgg
    29581 aggacacgtg caggccggga gtgcctcctc gctcgacgag gttctcgcga aggtgcgccg
    29641 acaccgcatg catctctcgc ggctgatgaa cgctcacgac gcgacccgcc tcgttctagg
    29701 gttgctgtac ctgagcagga aggcgcacgc cgagcccggc accggcgtac cgacatgggc
    29761 gtggttgatg gggcagccgg cagggcgcgg ctcgggagtc cgcgctgccg tgagcaagtg
    29821 tctgagccac tggcttcccg caaccgacga acagggttct gacgcgggca cgaggagcct
    29881 gatgcccgtt ccgccccctg gttccgaagg acacctgcac gctctcgtcc aggccatcgg
    29941 ttccatccag cgggtcgggc ccctgctcga ccagtgcctc cgtgacctct cggcggacca
    30001 ggctgagggc agccgctact tcacgccgga tgacatggcg cgtctcatgg ttggtgcggc
    30061 cgtcccccgt gacaggcaca gagtgctgga cccggtctgc ggttcaggag gactgctcgt
    30121 cgagagccac cgctacgtcc gcgaaaacgt cgggctggac ccgaccatgt ctttgcaggg
    30181 aaaggagcag cacgcccata cctcacaggt ggcccgcatg aacttcgcgg tacgtgggat
    30241 cacggctcac gtcttcccgc ccggggacag cctcgcggat cccgaaccgg agccccacga
    30301 catcatcctg gccaacctcc ccttcaacca gcgcgactgg gcacccgagg acaagacgga
    30361 gcgggacgtc cgccggtcgc cttccccgat cccggtcgat cccaggtggc cggaggagtc
    30421 tccgtccaaa ggatccgcca actccgcgtg gattcagcac atcgcgcacg cgctggctcc
    30481 ggccggacgt gccgtcttcc tgatggccga cagcgtggcc aacagcagac agcccgtcac
    30541 ccgaagcgtt cgcgagcgcc tcctgcgtga cgatctcgtc gaatgcgtga tcgctctgcc
    30601 acctcgcgtg ttcggtcact ccaaagcccc cgcctgtctg tgggtgctca acaaggacaa
    30661 gagcgctcgc cccggctggg gtgcccggga ccgccgtcgg caggtgctgt tcatcaacgc
    30721 gcggcgagct ttcgaaccgg tcccgaagtc gagagcgcgg aggctgggcg agacgaacac
    30781 gacagcggtc ctggccacct tggcggcctg gcgtggcctc tccgagaacg gtgctgcggc
    30841 ctcgccgtac gacgacgccg tcggctggtc ccgaagctgc tccaccaggg agatcgccga
    30901 ccgcgagtcc agtctgatgc cgacctcgta cgtcatggag cctcctggcc cagagcggga
    30961 cacacggagc cgggtcgagc agctcaagct cgaactaacc gatcagttcc agcagatgcg
    31021 cgccctggag ctccaattgc tggacgcctt ggaggagatg tgatggaagc caatgccgac
    31081 caggcctact cgggtaatgc ggcttggcag acgacctcca tcaaccatga gcgggtccac
    31141 gggcgtattt acaccacttc cggtttcctc gacgaagcgg ctgccgctca gacggcagga
    31201 gtcgtcagct cgacgttcgt ccagggcggc aggatcctct cgcccagggc cgatgagtgc
    31261 cggcccggcg aatccccgcc tagccgggca atcctcagag agggcgacct ggccgtcgta
    31321 ctcgtccgac gggtgggcga ttccgcgctg gtcaccgccg agcacgcggg atgtacagcg
    31381 accaggtcga tcggcatcat ccgcgctgaa ccgcacatag tgcggtggct gcgtatctgg
    31441 ctgcagacac cgacggcgaa ggctcgtatc gacgaggacg tgacggcaca tgtcgagccc
    31501 accatcagcc tcgacaccct ccaccgcatg ctgtttccac tgcctccgcc agacgtcatc
    31561 aacgcgtacc accgagcctt cggcctcatc gacgagatga ccgccctcta ccaggaaacc
    31621 gcccgcaagg cggtggaact ggtcgacgcc ctccatgacg actgggcggc gacgattccg
    31681 ccgtgggagg cacggcccct cgcgaaagtc gccaagtcgg agacgggcaa aggttccgaa
    31741 cgctcgattc ccccgttgcc cacagaaccc accaccgacg taaccgatgc agtcgcccct
    31801 aaagatctct acgacctccc cgtgccccat gtccagaggt tccgtctgag cagtccggcg
    31861 aacgacggcg aggcacatcc tcccggcacc ttgatgctga gcacccgctc cgacggtgca
    31921 cacatcgctg tgccgagccg accggcaaca ccactcagag gcgtcgtggc cgtacgacct
    31981 gctgaggacg aagacggttg gtggctgctc cacgaactca ggagcaggag cagcgacatc
    32041 gcgcggctgg cgcagggcca gaacgggcgg gaaatctcgg cccgcgccct caagcgcctg
    32101 gaggtcacct ggccggaccg gttcacgcgc accgatttcc acgcgatggc cgatcccctg
    32161 cacaccgcgg cgcgactcct gatcgccaag atcgcgacgc tgcacaccct gcgggacgcg
    32221 ctcctgcgcg acatctcagc gaaagccggc gtcctccggg aacctgcaac gatggcgtga
    32281 ccagctgaga ccctcaggtc cctcaccgct tcggcggccc atcaatgccc atcgctcgcg
    32341 tcaccacggg ctactgctcg cagtgtggtg gccgcggtcc gaccaagccg aggtccgtca
    32401 ggacttgctg agccagttcg aaaggctggt tgcgggggcc gtgggggacg gggacggcag
    32461 attcgcatgt tcgagggcta cgccggcacc agcgactccg gcttccgcga tgaggtcgaa
    32521 gccgagcaag ccctcgcccg tggccagttg ctcgccgagc tgggtgccga cgaagaccga
    32581 ccgacgctgg ctgggccggc cggggccgag gccgaagccc ggctcgccga attc
//
