BGC0000266 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000266 (Streptomyces collinus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	32,634	High	collinomycin	PKS

BGC0000266 - Region 1 - T2PKS

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Location: 1 - 32,634 nt. (total: 32,634 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 32,635
Label		BGC0000266

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxygenase

rubF: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

rubG: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

rubI: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

rubJ: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

rubL: Monooxygenation

MITE: MITE0000012Monooxygenation (identity: 69.20%)
smcogs: SMCOG1050: monooxygenase FAD-binding

rubN: Monooxygenation

MITE: MITE0000013Monooxygenation (identity: 76.70%)
smcogs: SMCOG1050: monooxygenase FAD-binding

rubO: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

rubP: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

rubU: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

Hydrolases: hydrolase

rubR: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: cyclase

rubE: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

Ligases: synthase

rubA: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

rubB: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000266.5	1.00	PKS	collinomycin	Streptomyces collinus
BGC0000231.5	0.65	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000275.4	0.61	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0000234.5	0.61	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001197.5	0.61	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000204.5	0.55	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0000215.5	0.55	PKS	curamycin	Streptomyces cyaneus
BGC0000272.3	0.54	PKS	spore pigment	Streptomyces collinus
BGC0001513.3	0.54	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0002631.2	0.53	ribosomal	Myxarylin	Pyxidicoccus fallax

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000266.5	1.00	PKS	collinomycin	Streptomyces collinus
BGC0000231.5	0.65	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000275.4	0.61	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0000234.5	0.61	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001197.5	0.61	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000204.5	0.55	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0000215.5	0.55	PKS	curamycin	Streptomyces cyaneus
BGC0000272.3	0.54	PKS	spore pigment	Streptomyces collinus
BGC0001513.3	0.54	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0002631.2	0.53	ribosomal	Myxarylin	Pyxidicoccus fallax

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 32634
Starter unit(s):: malonamyl-CoA (Score: 559.0; E-value: 0)
Malonyl elongations:: 11|12 (Score: 708.5; E-value: 4.7e-216)
Product class(es):: pentangular polyphenol
Product molecular weight(s):: malonamyl-CoA_11: 553 Da
malonamyl-CoA_12: 595 Da

rubA: KS (Score: 767.7; E-value: 6.2e-234)
rubB: CLF 11|12 (Score: 708.5; E-value: 4.7e-216)
rubC: ACP (Score: 112.7; E-value: 1.4e-35)
rubD: CYC C5-C18 (Score: 212.5; E-value: 3.8e-66)
rubE: CYC C4-C21/C2-C23|C2-C19 (Score: 182.8; E-value: 2.9e-57)
rubF: CYC C9-C14 (Score: 255.1; E-value: 4.2e-79); KR C19 (Score: 313.5; E-value: 2.4e-96)
rubG: KR C19 (Score: 426.7; E-value: 6.4e-131)
rubJ: KR (Score: 175.7; E-value: 3.3e-54)
rubL: OXY (Score: 279.8; E-value: 1.1e-85)
rubN: OXY (Score: 465.7; E-value: 4.3e-142)
rubO: MET (Score: 444.7; E-value: 4.7e-136)
rubP: OXY (Score: 294.5; E-value: 3.7e-90)
rubR: AMID (Score: 735.4; E-value: 9.7e-224); AMID CAM34350.1_Lysolipin_malonamyl-CoA (Score: 559.0; E-value: 0.0)