Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000267.1:
Cluster 1Polyketide / Saccharide136648

BGC0000267, saquayamycin Z / galtamycin B biosynthetic gene cluster from Micromonospora sp. Tu. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Saquayamycin Z
Molecular formula: C73H102O29
Exact molecular mass: 1465.63952 Da ([M+Na]+)
Molecular activity: Cytotoxic

Class-specific details

Biosynthetic class(es):
Polyketide / Saccharide
Polyketide subclass:
Angucycline (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
ACP19353.1
Genes involved in folding/cyclization:
ACP19352.1, ACP19357.1

Saccharide subclass:
oligosaccharide
Glycosyltransferases:
ACP19370.1:
Specificity: D-olivose
Evidence for specificity: Knock-out construct
ACP19363.1:
Specificity: L-rhodinose
Evidence for specificity: Knock-out construct
ACP19364.1:
Specificity: D-olivose
Evidence for specificity: Knock-out construct
ACP19365.1:
Specificity: Unknown
Evidence for specificity: Unknown
ACP19361.1:
Specificity: L-Rhodinose
Evidence for specificity: Knock-out construct
ACP19375.1:
Specificity: 2-deoxy-L-fucose
Evidence for specificity: Knock-out construct

Gene cluster description

saquayamycin Z / galtamycin B (BGC0000267). Gene Cluster 1. Biosynthetic class = Polyketide/Saccharide. GenBank FJ670504, positions 1126-35081. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies
MIxS-compliance:Unknown
Contact for this cluster:Andriy Luzhetskyy (Helmholtz Institute for Pharmaceutical Sciences Saarland)

Literature references

1. Erb A et al. (2009) Cloning and sequencing of the biosynthetic gene cluster for saquayamycin Z and galtamycin B and the elucidation of the assembly of their saccharide chains. Chembiochem 10(8):1392-401. doi: 10.1002/cbic.200900054.