BGC0000269: SF2575 biosynthetic gene cluster from Streptomyces sp. SF2575
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Location: 1 - 53,273 nt. (total: 53,273 nt).
This entry is originally from NCBI GenBank GQ409537.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
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resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000269
Short description SF2575 biosynthetic gene cluster from Streptomyces sp. SF2575
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Tetracycline)
  • Saccharide (hybrid/tailoring)
Loci NCBI GenBank: GQ409537.1
Compounds
  • SF2575
Species Streptomyces sp. SF2575 [taxonomy]
References
Chemical products information
SF2575
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C40H43N1O15
Chemical database entries
PubCHEM
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • ADE34480.1
 50 - 1327 (+) cysteine desulferase
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  • ADE34481.1
 1344 - 1808 (+) SUF system FeS assembly protein
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  • ADE34482.1
 1805 - 2143 (+) hypothetical protein
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  • ADE34483.1
  • ssfO2
 2224 - 3879 (-) ssfO2
  • Tailoring (Hydroxylation)
Other in vivo study
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  • ADE34484.1
  • ssfM4
 4053 - 5084 (+) ssfM4
  • Tailoring (Methylation)
Other in vivo study
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  • ADE34485.1
  • ssfV
 5087 - 6079 (+) ssfV
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  • ADE34486.1
  • ssfY4
 6217 - 6588 (-) ssfY4
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  • ADE34487.1
  • ssfM3
 6827 - 7876 (+) ssfM3
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  • ADE34488.1
  • ssfY3
 7873 - 8748 (+) ssfY3
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  • ADE34489.1
  • ssfY2
 8817 - 9749 (+) ssfY2
  • Scaffold biosynthesis
Other in vivo study
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  • ADE34490.1
  • ssfY1
 9830 - 10774 (-) ssfY1
  • Scaffold biosynthesis
Other in vivo study
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  • ADE34491.1
  • ssfU
 10815 - 11600 (-) ssfU
  • Tailoring (Reduction)
Other in vivo study
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  • ADE34492.1
  • ssfS5
 11711 - 12715 (+) ssfS5
  • Precursor biosynthesis
Sequence-based prediction
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  • ADE34493.1
  • ssfL2
 12718 - 14319 (+) ssfL2
  • Scaffold biosynthesis
Other in vivo study
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  • ADE34494.1
  • ssfX3
 14417 - 15514 (-) ssfX3
  • Tailoring (Acylation)
Activity assay
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  • ADE34495.1
  • ssfL1
 15623 - 17254 (-) ssfL1
  • Precursor biosynthesis
Activity assay
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  • ADE34496.1
  • ssfX2
 17303 - 18319 (-) ssfX2
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  • ADE34497.1
  • ssfQ
 18406 - 19614 (-) ssfQ
  • Precursor biosynthesis
Sequence-based prediction
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  • ADE34498.1
  • ssfM2
 19848 - 20843 (-) ssfM2
  • Tailoring (Methylation)
Sequence-based prediction
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  • ADE34499.1
  • ssfO1
 20880 - 22424 (-) ssfO1
  • Tailoring (Hydroxylation)
Sequence-based prediction
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  • ADE34500.1
  • ssfP
 22528 - 23382 (+) ssfP
  • Tailoring (Hydroxylation)
Sequence-based prediction
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  • ADE34501.1
  • ssfR
 23407 - 25044 (-) ssfR
  • Transport
Sequence-based prediction
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  • ADE34502.1
  • ssfT2
 25137 - 25766 (+) ssfT2
  • Regulation
Sequence-based prediction
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  • ADE34503.1
  • ssfN
 26113 - 26991 (+) ssfN
  • Precursor biosynthesis
Sequence-based prediction
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  • ADE34504.1
  • ssfK
 27008 - 27748 (+) ssfK
  • Precursor biosynthesis
Sequence-based prediction
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  • ADE34505.1
  • ssfJ
 27739 - 28533 (+) ssfJ
  • Precursor biosynthesis
Sequence-based prediction
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  • ADE34506.1
  • ssfI
 28569 - 29816 (-) ssfI
  • Precursor biosynthesis
Sequence-based prediction
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  • ADE34507.1
  • ssfH
 30132 - 31457 (-) ssfH
  • Precursor biosynthesis
Sequence-based prediction
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  • ADE34508.1
  • ssfM1
 31776 - 32774 (-) ssfM1
  • Tailoring (Methylation)
Sequence-based prediction
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  • ADE34509.1
  • ssfG
 33010 - 34029 (+) ssfG
  • Tailoring (Acylation)
Sequence-based prediction
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  • ADE34510.1
  • ssfS3
 34103 - 35506 (+) ssfS3
  • Precursor biosynthesis
Sequence-based prediction
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  • ADE34511.1
  • ssfS4
 35503 - 36438 (+) ssfS4
  • Precursor biosynthesis
Sequence-based prediction
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  • ADE34512.1
  • ssfS6
 36669 - 37820 (-) ssfS6
  • Tailoring (Acylation)
Activity assay
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  • ADE34525.1
  • ssfF
 38005 - 38976 (+) ssfF
  • Tailoring (Reduction)
Sequence-based prediction
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  • ADE34513.1
  • ssfE
 39023 - 40654 (+) ssfE
  • Precursor biosynthesis
Sequence-based prediction
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  • ADE34514.1
  • ssfX1
 40698 - 40919 (+) ssfX1
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  • ADE34515.1
  • ssfS1
 41065 - 42132 (+) ssfS1
  • Precursor biosynthesis
Sequence-based prediction
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  • ADE34516.1
  • ssfS2
 42129 - 43112 (+) ssfS2
  • Precursor biosynthesis
Sequence-based prediction
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  • ADE34517.1
  • ssfT1
 43176 - 43988 (-) ssfT1
  • Regulation
Sequence-based prediction
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  • ADE34518.1
  • ssfA
 44931 - 46205 (+) ssfA
  • Scaffold biosynthesis
Other in vivo study
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  • ADE34519.1
  • ssfB
 46202 - 47440 (+) ssfB
  • Scaffold biosynthesis
Other in vivo study
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  • ADE34520.1
  • ssfC
 47491 - 47748 (+) ssfC
  • Scaffold biosynthesis
Other in vivo study
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  • ADE34521.1
  • ssfD
 47938 - 49791 (+) ssfD
  • Precursor biosynthesis
Other in vivo study
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  • ADE34522.1
 49988 - 51838 (+) hypothetical protein
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  • ADE34523.1
 51841 - 52236 (-) hypothetical protein
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  • ADE34524.1
 52287 - 53255 (+) AraC family transcriptional regulator
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Polyketide-specific information
Subclass Tetracycline
Starter unit Malonamyl-CoA
Ketide length 9
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
ssfL2
+
ssfA
+
ssfY2
+
ssfY1 		Synthase subclass: Type II
Saccharide-specific information
Subclass hybrid/tailoring
Sugar-encoding genes
  • ssfS1, ssfS2, ssfS3, ssfS4, ssfS5
Glycosyltransferases
ssfS6
Specificity: D-olivose
Evidence:
  • Activity assay
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: BMUFDHMMOLZWQLUNJMQED2GP, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Added version number to gene accession
  • Removed gene names of 'No gene ID'
  • Corrected gene identifiers
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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