BGC0000270 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000270 (Streptomyces antibioticus)

Region	Type	From	To	Most similar known cluster		Similarity
Region 1	T2PKS,aminocoumarin	1	39,428	simocyclinone D8	PKS	100%

BGC0000270 - Region 1 - T2PKS,aminocoumarin

Download region GenBank file

Download region SVG

Location: 1 - 39,428 nt. (total: 39,428 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)
aminocoumarin: (novK or novJ or novI or novH or SpcDK_cou)

Legend:

core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

reset view

zoom to selection

Gene details

Select a gene to view the details available for it

Gene overview

MIBiG

NRPS/PKS domains

MIBiG comparison

KnownClusterBlast

NRPS/PKS modules

Gene/CDS overview

Filter:

Automatically zoom to filtered/selected features

Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 39,429
Label		BGC0000270

Detailed domain annotation

Selected features only

Show module domains

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000270	1.75	Polyketide	simocyclinone D8	Streptomyces antibioticus
BGC0000231	0.78	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000867	0.72	Other	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0000866	0.70	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0001072	0.66	Polyketide, Saccharide, Other (Aminocoumarin)	simocyclinone D8	Streptomyces antibioticus
BGC0000234	0.61	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001928	0.61	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37
BGC0001723	0.61	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0001444	0.58	Other (shikimate derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0002435	0.55	Other	coformycin, aristeromycin	Micromonospora haikouensis

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000270	1.00	Polyketide	simocyclinone D8	Streptomyces antibioticus
BGC0000231	0.83	Polyketide	griseusin A, griseusin B	Streptomyces griseus
BGC0000234	0.73	Polyketide	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723	0.72	Polyketide	oviedomycin	Streptomyces antibioticus
BGC0000867	0.69	Other	polyhydroxyalkanoic acids	Ectothiorhodospira shaposhnikovii
BGC0001072	0.68	Polyketide, Saccharide, Other (Aminocoumarin)	simocyclinone D8	Streptomyces antibioticus
BGC0000866	0.68	Other	polyhydroxyalkanoate	Burkholderia sp. DSM 9242
BGC0001444	0.64	Other (shikimate derived)	caboxamycin	Streptomyces sp. NTK 937
BGC0000252	0.64	Polyketide	nonactin	Streptomyces griseus subsp. griseus
BGC0001928	0.64	Other	(2R,3S,4S)-5-fluoro-2,3,4-trihydroxypentanoic acid	Streptomyces sp. MA37

Similar known gene clusters from MIBiG 4.0

Module view

Legend

NRPS/PKS products

NRPS/PKS substrates

Type II PKS

Predicted core structure(s)

For candidate cluster 1, location 0 - 36379:

Rough prediction of core scaffold based on assumed PKS/NRPS colinearity; tailoring reactions not taken into account

Polymer prediction:: (Tyr)

Direct lookup in NORINE database: strict or relaxed

Link to NORINE database query form

NRPS/PKS substrate predictions

simL

AMP-binding (15..415): X

nrpys: Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aliphatic (Ala, Gly, Val, Leu, Ile, Abu, Ival, Ser, Thr, Hpg, Dhpg, Cys, Pro, Hpr)
Large clusters prediction:: N/A
Small clusters prediction:: N/A
Single AA prediction:: N/A

Stachelhaus prediction details:

Stachelhaus sequence:: -GAAFTVIIK
Nearest Stachelhaus code(s):
Stachelhaus code match:: 0% (weak)

simH

Search NORINE for peptide: strict or relaxed

AMP-binding (413..808): Tyr

nrpys: Tyr

SVM prediction details:

Predicted physicochemical class:: hydrophobic-aromatic (Phe, Tyr, diOH-Bz, Ph-Gly, bOH-Tyr)
Large clusters prediction:: Aromatic side chain (Phe, Trp, Ph-Gly, Tyr, bOH-Tyr)
Small clusters prediction:: Polar aromatic ring (Tyr, bOH-Tyr)
Single AA prediction:: tyr (Tyr)

Stachelhaus prediction details:

Stachelhaus sequence:: DATVVAAVCK
Nearest Stachelhaus code(s):: Phe DAWTVAAVCK (76% 8Å match); Tyr DASTVAAVCK (74% 8Å match)
Stachelhaus code match:: 80% (moderate)

AAL15617.1

AMP-binding (1..176): X

Type II PKS gene cluster prediction details

Cluster section:: 0 to 36379
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 714.3; E-value: 8.4e-218)
Product class(es):: angucycline
anthracycline
aureolic acid
tetracycline
Product molecular weight(s):: acetyl-CoA_8: 391 Da
acetyl-CoA_9: 433 Da

sim3: CLF 8|9 (Score: 714.3; E-value: 8.4e-218)
sim4: ACP (Score: 132.1; E-value: 1.3e-41)
sim5: KR C9 (Score: 487.6; E-value: 1.9e-149)
sim6: CYC C7-C12 (Score: 499.6; E-value: 6e-153)
sim7: OXY (Score: 589.4; E-value: 1.3e-179)
sim8: KR C15 (Score: 487.4; E-value: 2e-149)
sim9: KR (Score: 42.0; E-value: 2e-13)
simJ1: KR (Score: 210.4; E-value: 8.5e-65)
simJ2: KR (Score: 206.4; E-value: 1.4e-63)
simK: KR (Score: 83.2; E-value: 5.5e-26)