BGC0000273 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000273 (Streptomyces steffisburgensis)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	42,877	High	steffimycin D	PKS:Type II+saccharide:hybrid/tailoring

BGC0000273 - Region 1 - T2PKS

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Location: 1 - 42,877 nt. (total: 42,877 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 42,878
Label		BGC0000273

Tailoring functions

Oxidoreductases: dehydrogenase oxidase oxygenase

stfE: FAD linked oxidase domain protein

smcogs: SMCOG1138: FAD linked oxidase domain protein

stfPI: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

stfPII: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

stfT: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: formyltransferase glycosyltransferase

CAJ42346.1: methionyl-tRNA formyltransferase

smcogs: SMCOG1228: methionyl-tRNA formyltransferase

stfG: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

Lyases: cyclase

stfQ: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

Ligases: synthase

stfK: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

stfP: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: transport

sfrA: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000273.5	1.00	PKS, saccharide	steffimycin D	Streptomyces steffisburgensis
BGC0000231.5	0.67	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.61	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.59	PKS	oviedomycin	Streptomyces antibioticus
BGC0002084.4	0.57	ribosomal	biarylitide YYH	Planomonospora sp. ID82291
BGC0001197.5	0.56	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000271.5	0.56	PKS	spore pigment	Streptomyces avermitilis
BGC0001513.3	0.56	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0000275.4	0.54	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0001366.5	0.54	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000273.5	1.00	PKS, saccharide	steffimycin D	Streptomyces steffisburgensis
BGC0000231.5	0.67	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.61	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001723.5	0.59	PKS	oviedomycin	Streptomyces antibioticus
BGC0002084.4	0.57	ribosomal	biarylitide YYH	Planomonospora sp. ID82291
BGC0001197.5	0.56	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000271.5	0.56	PKS	spore pigment	Streptomyces avermitilis
BGC0001513.3	0.56	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0000275.4	0.54	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0001366.5	0.54	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 42877
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 673.4; E-value: 2.1e-205)
Product class(es):: anthracycline
aureolic acid
tetracycline
Product molecular weight(s):: acetyl-CoA_8: 574 Da
acetyl-CoA_9: 616 Da

stfG: GT (Score: 494.4; E-value: 7e-151)
stfK: CLF 8|9 (Score: 673.4; E-value: 2.1e-205)
stfMI: MET C9O (Score: 455.8; E-value: 4.7e-140)
stfMII: MET C18O (Score: 536.3; E-value: 9.8e-164)
stfMIII: MET C18O (Score: 731.9; E-value: 3.8e-223)
stfOII: OXY (Score: 55.8; E-value: 9.7e-18)
stfP: KS (Score: 782.9; E-value: 1.6e-238)
stfPI: OXY (Score: 60.6; E-value: 3.4e-19)
stfQ: CYC C7-C12 (Score: 360.7; E-value: 1.2e-110)
stfS: ACP (Score: 113.4; E-value: 8.4e-36)
stfT: KR C17 (Score: 483.1; E-value: 4.2e-148)
stfX: CYC C1-C18|C2-C19 (Score: 216.4; E-value: 3e-67)
stfY: CYC C5-C14/C3-C16 (Score: 456.1; E-value: 7.7e-140)