BGC0000273: steffimycin D biosynthetic gene cluster from Streptomyces steffisburgensis
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Location: 1 - 42,877 nt. (total: 42,877 nt).
This entry is originally from NCBI GenBank AM156932.1.

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core biosynthetic genes
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Gene details
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General
Compounds
Genes
Polyketide
Saccharide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000273
Short description steffimycin D biosynthetic gene cluster from Streptomyces steffisburgensis
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Anthracycline)
  • Saccharide (hybrid/tailoring)
Loci NCBI GenBank: AM156932.1
Compounds
  • steffimycin D
Species Streptomyces steffisburgensis [taxonomy]
References
Chemical products information
steffimycin D
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C28H32O12
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • CAJ42313.1
 51 - 1502 (-) putative inosine monophosphate dehydrogenase
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  • CAJ42314.1
 1602 - 1955 (-) hypothetical protein
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  • CAJ42315.1
 1980 - 3023 (-) putative transcriptional regulator
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  • CAJ42316.1
 3102 - 3788 (-) putative ribulose-phosphate 3-epimerase
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  • CAJ42317.1
  • sfrA
 3953 - 6091 (+) putative membrane protein
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  • CAJ42318.1
  • stfS
 6118 - 6378 (-) acyl carrier protein
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  • CAJ42319.1
  • stfK
 6391 - 7611 (-) chain length factor
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  • CAJ42320.1
  • stfP
 7620 - 8888 (-) ketoacyl synthase
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  • CAJ42321.1
  • stfOI
 8890 - 9225 (-) monooxygenase
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  • CAJ42322.1
  • stfT
 9351 - 10175 (-) ketoreductase
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  • CAJ42323.1
  • stfX
 10200 - 10640 (-) cyclase
  • Scaffold biosynthesis
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  • CAJ42324.1
  • stfY
 10818 - 11597 (+) cyclase
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  • CAJ42325.1
  • stfRI
 11796 - 12668 (+) SARP family regulator
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  • CAJ42326.1
  • stfRII
 12711 - 13301 (-) transcriptional regulator
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  • CAJ42327.1
  • stfQ
 13694 - 14623 (+) aromatase
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  • CAJ42328.1
  • stfMI
 14616 - 15293 (+) O-methyl transferase
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  • CAJ42329.1
  • stfC
 15424 - 15987 (-) SWIM Zn-finger
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  • CAJ42330.1
  • stfD
 15984 - 17840 (-) SNF2 related domain
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  • CAJ42331.1
  • sfrB
 17833 - 19341 (-) putative transmembrane efflux protein
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  • CAJ42332.1
  • stfRIII
 19419 - 19919 (+) putative transcriptional regulator
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  • CAJ42333.1
  • stfPI
 19995 - 21203 (+) cytochrome P450
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  • CAJ42334.1
  • stfE
 21249 - 22829 (+) dehydrogenase
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  • CAJ42335.1
  • stfOII
 22887 - 24050 (-) putative oxygenase
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  • CAJ42336.1
  • stfMII
 24068 - 25243 (-) O-methyl transferase
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  • CAJ42337.1
  • stfF
 25233 - 25574 (-) putative 5-chloromuconolactone dehalogenase
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  • CAJ42338.1
  • stfG
 25654 - 26916 (-) glycosyltransferase
  • Tailoring (Glycosylation)
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  • CAJ42339.1
  • stfPII
 26977 - 28077 (-) cytochrome P450-like
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  • CAJ42340.1
  • stfMIII
 28239 - 29417 (+) O-methyl transferase
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  • CAJ42341.1
 29583 - 33797 (-) hypothetical protein
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  • CAJ42342.1
 33847 - 34971 (-) hypothetical protein
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  • CAJ42343.1
 34976 - 36010 (-) putative trypsin-like serine protease
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  • CAJ42344.1
 36061 - 37308 (-) hypothetical protein
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  • CAJ42345.1
 37796 - 39223 (-) hypothetical Sun-family protein
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  • CAJ42346.1
 39673 - 40605 (-) putative methionyl-tRNA formyltransferase
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  • CAJ42347.1
 40935 - 41486 (+) hypothetical protein
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  • CAJ42348.1
 41608 - >42876 (-) putative primosomal protein N'
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Polyketide-specific information
Subclass Anthracycline
Starter unit Acetyl-CoA
Ketide length 10
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
stfP
+
stfS
+
stfY
+
stfQ
+
stfX 		Synthase subclass: Type II
Saccharide-specific information
Subclass hybrid/tailoring
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: IROSGRAECON7XFWB774QFHDN, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Updated bioactivity data
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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