Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000273.1:
Cluster 1Polyketide / Saccharide142877

BGC0000273, steffimycin biosynthetic gene cluster from Streptomyces steffisburgensis. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: steffimycin
SMILES string: Copy to clipboard
Molecular formula: C28H30O13
Exact molecular mass: 575.53 Da ([M+H]+)
Molecular activity: Cytotoxic
Molecular target: DNA

Class-specific details

Biosynthetic class(es):
Polyketide / Saccharide
Polyketide subclass:
Anthracycline (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
CAJ42318.1,CAJ42320.1
Genes involved in folding/cyclization:
CAJ42323.1, CAJ42324.1, CAJ42327.1

Gene cluster description

steffimycin (BGC0000273). Gene Cluster 1. Biosynthetic class = Polyketide/Saccharide. GenBank AM156932. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Knock-out studies, Heterologous expression, Sequence-based prediction
MIxS-compliance:Unknown
Contact for this cluster:Jose A. Salas (University of Oviedo)

Literature references

1. Gullon S et al. (2006) Isolation, characterization, and heterologous expression of the biosynthesis gene cluster for the antitumor anthracycline steffimycin. Appl Environ Microbiol 72(6):4172-83. doi: 10.1128/AEM.00734-06.