BGC0000274: tetarimycin A biosynthetic gene cluster from uncultured bacterium
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Location: 1 - 34,510 nt. (total: 34,510 nt).
This entry is originally from NCBI GenBank JX843821.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
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Gene details
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General
Compounds
Genes
Polyketide
History
NRPS/PKS domains
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000274
Short description tetarimycin A biosynthetic gene cluster from uncultured bacterium
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Biosynthetic class(es)
  • Polyketide (Anthracycline)
Loci NCBI GenBank: JX843821.1
Compounds
  • tetarimycin A
  • tetarimycin B
Species uncultured bacterium [taxonomy]
References
Chemical products information
tetarimycin A
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C21H16O6
Chemical database entries
NPAtlas
tetarimycin B
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C21H22O6
Chemical database entries
NPAtlas
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AFY23013.1
 1 - 567 (-) transcriptional regulator
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  • AFY23014.1
 603 - 1346 (-) hypothetical protein
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  • AFY23015.1
 1300 - 2109 (-) hypothetical protein
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  • AFY23016.1
 2184 - 3359 (-) L-carnitine dehydratase
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  • AFY23017.1
 3356 - 4507 (-) isovaleryl-CoA dehydrogenase
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  • AFY23018.1
 4780 - 5850 (+) unknown
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  • AFY23019.1
 5862 - 6881 (+) cellulose-binding family protein
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  • AFY23020.1
 6907 - 8376 (-) betaine aldehyde dehydrogenase
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  • AFY23021.1
 8421 - 9137 (-) methyltransferase
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  • AFY23022.1
 9305 - 10219 (+) AraC family transcriptional regulator
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  • AFY23023.1
 10284 - 11435 (+) hydrolase
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  • AFY23024.1
 11770 - 12234 (-) short-chain dehydrogenase/reductase SDR
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  • AFY23025.1
 12568 - 13569 (-) putative N-methyltransferase
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  • AFY23026.1
 13566 - 14051 (-) putative phenazine biosynthesis protein EsmA1
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  • AFY23027.1
 14073 - 14384 (-) putative phenazine biosynthesis protein EsmH1
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  • AFY23028.1
 14406 - 15026 (-) phenazine biosynthesis protein PhzD
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  • AFY23029.1
 15231 - 15437 (-) XRE family transcriptional regulator
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  • AFY23030.1
 15437 - 15916 (-) hypothetical protein
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  • AFY23032.1
 16135 - 17955 (+) TamA
  • Transport
Sequence-based prediction
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  • AFY23031.1
 17969 - 18181 (-) 30S ribosomal protein S1
  • Unknown
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  • AFY23033.1
 18223 - 19086 (-) TamB
  • Tailoring (Oxidation)
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  • AFY23034.1
 19086 - 20123 (-) TamC
  • Tailoring (Reduction)
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  • AFY23035.1
 20209 - 20778 (+) TamD
  • Regulation
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  • AFY23036.1
 20859 - 21479 (-) TamE
  • Tailoring (Reduction)
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  • AFY23037.1
 21503 - 22918 (-) TamF
  • Tailoring (Oxidation)
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  • AFY23038.1
 23088 - 23522 (-) TamG
  • Scaffold biosynthesis
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  • AFY23039.1
 23564 - 24388 (-) TamH
  • Scaffold biosynthesis
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  • AFY23040.1
 24437 - 26308 (+) TamI
  • Regulation
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  • AFY23041.1
 26357 - 26794 (-) TamJ
  • Activation / processing
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  • AFY23042.1
 26791 - 27024 (-) TamK
  • Scaffold biosynthesis
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  • AFY23043.1
 27021 - 28247 (-) TamL
  • Scaffold biosynthesis
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  • AFY23044.1
 28247 - 29503 (-) TamM
  • Scaffold biosynthesis
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  • AFY23045.1
 29516 - 30274 (-) TamN
  • Tailoring (Reduction)
Sequence-based prediction
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  • AFY23046.1
 30258 - 31313 (-) TamO
  • Tailoring (Methylation)
Sequence-based prediction
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  • AFY23047.1
 31360 - 34431 (-) TamP
  • Regulation
Sequence-based prediction
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Polyketide-specific information
Subclass Anthracycline
Starter unit Acetyl-CoA
Ketide length 20
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
AFY23042.1
+
AFY23038.1
+
AFY23039.1 		Synthase subclass: Type II
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: V5OJFE3GCDVKSA62LSGPW5E6, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
  • Updated compound(s) information (NPAtlas curation)
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Removed gene names of 'No gene ID'
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Detailed domain annotation
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