Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000274.1:
Cluster 1Polyketide134510

BGC0000274, tetarimycin biosynthetic gene cluster from uncultured bacterium. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: Tetarimycin A
SMILES string: Copy to clipboard
Molecular formula: C21H16O6
Exact molecular mass: 364.0947 Da (None)
Molecular activity: Antibacterial

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Anthracycline (cyclic)
Polyketide synthase subclass:
Type II
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:
AFY23042.1
Genes involved in folding/cyclization:
AFY23038.1, AFY23039.1

Gene cluster description

tetarimycin (BGC0000274). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank JX843821, positions 1-34510. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?complete
Evidence for cluster-compound connection:Heterologous expression
MIxS-compliance:Unknown
Contact for this cluster:Sean Brady (The Rockefeller University)

Literature references

1. Kallifidas D et al. (2012) Tetarimycin A, an MRSA-active antibiotic identified through induced expression of environmental DNA gene clusters. J Am Chem Soc 134(48):19552-5. doi: 10.1021/ja3093828. Epub 2012 Nov