BGC0000275 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000275 (Streptomyces glaucescens)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	13,123	High	tetracenomycin C	PKS:Type II

BGC0000275 - Region 1 - T2PKS

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Location: 1 - 13,123 nt. (total: 13,123 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 13,124
Label		BGC0000275

Tailoring functions

Oxidoreductases: oxygenase

tcmG: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

Transferases: methyltransferase

tcmN: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

tcmO: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

Lyases: cyclase

tcmI: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

Ligases: synthase

tcmK: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

tcmL: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000275.4	1.00	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0000231.5	0.66	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.59	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001513.3	0.58	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0001366.5	0.57	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0000219.4	0.57	PKS, saccharide	elloramycin	Streptomyces olivaceus
BGC0000215.5	0.57	PKS	curamycin	Streptomyces cyaneus
BGC0001197.5	0.56	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000204.5	0.56	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0000221.5	0.55	PKS	erdacin	uncultured soil bacterium V167

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000275.4	1.00	PKS	tetracenomycin C	Streptomyces glaucescens
BGC0000231.5	0.66	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0000234.5	0.59	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0001513.3	0.58	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0001366.5	0.57	PKS	BE-24566B, zunyimycin A	Streptomyces sp. FJS31-2
BGC0000219.4	0.57	PKS, saccharide	elloramycin	Streptomyces olivaceus
BGC0000215.5	0.57	PKS	curamycin	Streptomyces cyaneus
BGC0001197.5	0.56	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000204.5	0.56	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0000221.5	0.55	PKS	erdacin	uncultured soil bacterium V167

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 0 to 13123
Starter unit(s):: acetyl-CoA (Score: 0.0; E-value: 0)
Malonyl elongations:: 8|9 (Score: 657.9; E-value: 1.1e-200)
Product class(es):: tetracenomycin
Product molecular weight(s):: acetyl-CoA_8: 376 Da
acetyl-CoA_9: 418 Da

tcmG: OXY (Score: 312.0; E-value: 1.8e-95)
tcmI: CYC C4-C21/C2-C23|C2-C19 (Score: 161.0; E-value: 1.7e-50)
tcmJ: CYC C5-C18 (Score: 203.5; E-value: 2.2e-63)
tcmK: KS (Score: 759.2; E-value: 2.4e-231)
tcmL: CLF 8|9 (Score: 657.9; E-value: 1.1e-200)
tcmM: ACP (Score: 89.8; E-value: 2e-28)
tcmN: CYC C9-C14 (Score: 240.4; E-value: 1.4e-74); MET C11O (Score: 546.0; E-value: 6.7e-167)
tcmO: MET C13O|C17O (Score: 433.2; E-value: 1.3e-132)
tcmP: MET carboxy_O (Score: 277.5; E-value: 1.9e-85)