LOCUS       BGC0000278              5408 bp    DNA     linear   BCT 16-MAY-2001
DEFINITION  Streptomyces fradiae strain T#2717 urdamycin biosynthetic gene
            cluster, partial sequence.
ACCESSION   BGC0000278
VERSION     BGC0000278
KEYWORDS    .
SOURCE      Streptomyces fradiae
  ORGANISM  Streptomyces fradiae
            Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
            Streptomycetaceae; Streptomyces.
COMMENT     ##antiSMASH-Data-START##
            Version      :: False
            Run date     :: 2024-10-17 13:18:22
            NOTE: This is a single region extracted from a larger record!
            Orig. start  :: 0
            Orig. end    :: 5408
            ##antiSMASH-Data-END##
FEATURES             Location/Qualifiers
     source          1..5408
                     /db_xref="taxon:1906"
                     /mol_type="genomic DNA"
                     /organism="Streptomyces fradiae"
                     /strain="T#2717"
     subregion       1..5408
                     /aStool="mibig"
                     /contig_edge="True"
                     /label="PKS"
                     /subregion_number="1"
                     /tool="antismash"
     region          1..5408
                     /contig_edge="True"
                     /product="unknown"
                     /region_number="1"
                     /subregion_numbers="1"
                     /tool="antismash"
     gene            26..1066
                     /gene="urdZ3"
     CDS             26..1066
                     /codon_start=1
                     /gene="urdZ3"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score:
                     152.1; E-value: 4e-46)"
                     /gene_kind="biosynthetic-additional"
                     /product="NDP-hexose 4-ketoreductase UrdZ3"
                     /protein_id="AAF72549.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 2.1e-15, bitscore:
                     44.9, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MVVLGSGGFLGRHIGDAFAAQGARVHAVTRNSSDRTPHGAATGSR
                     TTPIDLLTTPPQEVAEFLGSVGADVVVNAAGRAWRADEAQMTAGNAELVLRLVTALEQV
                     PGPPIRLVQLGSVHEYGAGAPNTGTGEEHEPTPVTAYGRTKLLGTQTVLRAAQDRTVEG
                     VVLRLANVIGAGVPEGSLFGRVAAHLAAAARAESRGEKAAELRLPPLAAARDVVDARDA
                     ADAVVAAATTVGVAGRVINVGRGEAVGTRELIDRMVRLSGLAVPVVEETAAAMSRTDVD
                     WQRLDVSRARRLLGWRPRRSLDASLRDLLAAALPSSSTRLGGVPDVASRRAPLDAPTTA
                     PVDERK"
     gene            1069..2373
                     /gene="urdQ"
     CDS             1069..2373
                     /codon_start=1
                     /gene="urdQ"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) DegT_DnrJ_EryC1"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1056:DegT/DnrJ/EryC1/StrS aminotransferase (Score:
                     376.5; E-value: 2.5e-114)"
                     /gene_kind="biosynthetic-additional"
                     /product="NDP-hexose 3,4-dehydratase UrdQ"
                     /protein_id="AAF72550.1"
                     /sec_met_domain="DegT_DnrJ_EryC1 (E-value: 7.5e-103,
                     bitscore: 332.9, seeds: 38, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MGDRKELVLEEVRTYHRDVSPDQEFIPGTTEIWPSGAVLDESDRV
                     ALVEAALDMRIAAGTSSRKFESAFARRLKRRKAHLTNSGSSANLLAVSALTSHVLEDRR
                     LRPGDEVITVAAGFPTTVNPILQNGLVPVFVDVDLPTYNATAERVAQAIGPKTRAIIIA
                     HALGNPFEVAEMAQLAEEHDLFLIEDNCDAVGSTYDGQLTGTFGDLTTVSFYPAHHLTM
                     GEGGCVLTSNLSLARIVESLRDWGRDCWCEPGENDRCLKRFKYQMGTLPAGYDHKYIFS
                     HVGYNLKATDIQAALGLTQLAKLDDFIEARQRNWRRLREGLDGVPGLLLPEPTPRSQPS
                     WFGFVITVAPDAPFSRAELVDFLEDRKIGTRRLFAGNLTRHPAYIDQPHRIVGELTNSD
                     LVTEQTFWIGVYPALTDEMLDYVTASIKEFVAARG"
     gene            2414..3157
                     /gene="urdR"
     CDS             2414..3157
                     /codon_start=1
                     /gene="urdR"
                     /gene_functions="biosynthetic-additional
                     (rule-based-clusters) RmlD_sub_bind"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1010:NAD-dependent epimerase/dehydratase (Score: 86.1;
                     E-value: 4.9e-26)"
                     /gene_kind="biosynthetic-additional"
                     /product="NDP-hexose 4-ketoreductase UrdR"
                     /protein_id="AAF72551.1"
                     /sec_met_domain="RmlD_sub_bind (E-value: 4e-11, bitscore:
                     30.9, seeds: 37, tool: rule-based-clusters)"
                     /transl_table=11
                     /translation="MDIVGNGFLARNLRPLAERHPDTVALAAGVSWASGTSDADFAREA
                     ALLRDTAKQCAATGRRLLFFSTAATGMYGLAEGPGREDTPVTPCTPYGAHKLALEELLR
                     DSGADHVILRLGHLVGPDQPEHQLLPTLVRHLREGAVRIHRGAARDLIDVSDVVTIVDC
                     LLGLDLKAETVNVASGYAVPVKDIVELLRRRLGVEARYEFQDAGGQHVISIEKLRALVP
                     QVQDMGFGPDYYRRILSDFTSAVRI"
     gene            3196..4605
                     /gene="urdS"
     CDS             3196..4605
                     /codon_start=1
                     /gene="urdS"
                     /product="NDP-hexose 2,3-dehydratase UrdS"
                     /protein_id="AAF72552.1"
                     /transl_table=11
                     /translation="MLSESLLAVAQPRAADNTCDRIGLSAATADGRHLRTSDFGDWLAG
                     RGRANEFRVDRVPFAALDGWAFDEATGNLVHRSGRFFTVEGLHVTELDAPYGDGPYADW
                     HQPIIKQPEVGILGILVKEFDGVLHFLMQAKMEPGNPNLLQLSPTVQATRSNYTKAHHG
                     ADVKYIEHFVGPTRGHIIADVLQSEHGSWFYRKSNRNMIVEAVGDVPLHDDFCWLTLGQ
                     ISTLMHQDNVVNMDSRTVLSCLPYADTRSRALLSDTQLLSWITEERSRHDVRVERVPLG
                     SLPGWRRGESTIEHEAGRYFKVVAVAVQAGSREVTGWTQPLFEPVGLGVTAFLTRAFDG
                     VPHVLVHARVEAGFLDTIELGPTVQYTPGNYAHLDEKNRPLFLDTVLRAPSDRIRYEAV
                     HSEEGGRFLNAESRYLIVDTDETEAPQNPPSGYAWVTPAQLTSLVRHGHYVNVQGRTLL
                     ACLNAMAVNSR"
     gene            4602..>5408
                     /gene="urdT"
     CDS             4602..>5408
                     /codon_start=1
                     /gene="urdT"
                     /gene_functions="biosynthetic-additional (smcogs)
                     SMCOG1079:oxidoreductase (Score: 167.8; E-value: 6.6e-51)"
                     /gene_kind="biosynthetic-additional"
                     /product="oxidoreductase UrdT"
                     /protein_id="AAF72553.1"
                     /transl_table=11
                     /translation="MSRPVGIGVIGCADIAVRRMLPAFATGPETEVVAVASRTLGKAER
                     VAERFGCRAVQGYAALLELEKVQAVYIPLPAALHAEWVRKAALRGQSTCWPRNPSRPTP
                     LRTEQLLKLARYRGLALMENVMFVHHSRHEAVRRLVDEGAIGELRGLQSAFTIPAPADD
                     DIRYAPELGGGALPDVGVYPLRAALHFLGPGLEVVGAHLASGPGRHVETSGAALLRTPA
                     GVTAQVIFGMEHTYRSTYYLLGGDGRLTVERAFTPSADFIPVIPVPP"
ORIGIN
        1 gcgtcacaag gcggccgcgc tgtcgatggt cgtcctggga agcggcggtt ttctggggcg
       61 ccacatcggc gacgccttcg ccgcgcaggg agcgcgggtg cacgccgtga cccggaacag
      121 ctcggaccgt actccccacg gcgccgcgac cgggtcccgc acgacaccca tcgacctgct
      181 gacgacccca ccgcaggagg tcgccgagtt cctcggctcg gtcggcgccg atgtcgtcgt
      241 caacgccgcc ggccgggcct ggcgggccga cgaggcccag atgaccgcgg gcaacgccga
      301 actggtcctg cgcctcgtca ccgccctcga gcaagtgccc ggcccgccga tccggctggt
      361 gcagctcggc agcgtccacg agtacggggc gggcgcgccg aacaccggca ccggtgagga
      421 gcacgagccc accccggtga ccgcctacgg acgcaccaag ctcctcggga cgcagaccgt
      481 cctgcgcgcc gcgcaggacc gcactgtcga gggcgtcgtg ctccggctcg ccaacgtcat
      541 cggtgcgggc gttccggagg gcagcctgtt cggcagggtc gccgcgcacc tcgcggcggc
      601 cgcgcgcgcc gagtcccggg gggagaaggc cgccgagctg cgccttccgc cactggccgc
      661 ggcgcgcgac gtcgtcgacg cgcgtgacgc cgccgacgcg gtggtggccg ccgccaccac
      721 ggtcggtgtc gccggacggg tgatcaacgt ggggcgcggc gaggcggtcg ggacacgcga
      781 gctgatcgac cggatggtcc ggctcagcgg cctggccgtc ccggtcgtgg aagagaccgc
      841 cgcggcgatg tcacgcacgg acgtggactg gcagcggctg gatgtgtccc gcgcgcgtcg
      901 gctgctgggc tggcggccgc gccgcagcct cgatgcctcg ctgcgcgacc ttctcgcggc
      961 ggccctgccg tcatcctcga cacgcctcgg cggcgtcccg gacgtcgcat cccgccgcgc
     1021 accactcgac gctccgacca ccgcgccggt tgacgaaagg aagtgaccat gggtgaccgc
     1081 aaggaactgg tgctggaaga ggtccgcacg tatcaccggg atgtctcgcc cgaccaggag
     1141 ttcatcccgg gaaccaccga gatctggccg tccggcgcgg tgctggacga gtccgaccgc
     1201 gtggccttgg tcgaggccgc cctcgacatg cgcatcgccg cgggaacgag ttcccggaag
     1261 ttcgaatccg cctttgctcg acggctcaag cggcgcaagg cccatctcac caactccggt
     1321 tcgtccgcga acctgctcgc cgtgtcggca ctcacctcgc acgtcctgga ggatcgaagg
     1381 ctgaggccgg gcgacgaggt gatcacggtg gccgccggct tccccaccac cgtgaacccg
     1441 atcctgcaga acggcctggt cccggtgttc gtggacgtgg accttcccac ctacaacgcc
     1501 accgccgagc gggtggccca ggcgatcggc cccaagaccc gggcgatcat catcgcccat
     1561 gcgctgggca acccgttcga ggtggccgag atggcccagc tcgccgagga gcacgacctg
     1621 ttcctgatcg aggacaactg cgacgcggtg ggctccacct acgacggaca gctcacgggc
     1681 accttcggcg acctgaccac ggtcagtttc tatccggcgc accatctgac catgggggag
     1741 ggcgggtgcg tcctgacctc caacctcagc ctcgcccgca tcgtggagtc actgcgtgac
     1801 tggggccggg actgctggtg cgaaccgggc gagaacgaca ggtgcctcaa gcgcttcaag
     1861 taccagatgg gcaccctccc cgccggatac gaccacaagt acattttctc gcacgtcggt
     1921 tacaacctga aggccaccga catacaggcg gccctcggcc tgacgcagct cgccaagctg
     1981 gacgacttca tcgaagcccg tcagcgcaac tggcgtcgtc tgcgcgaagg gctcgacggc
     2041 gtaccgggcc tgctgttgcc ggagcccacg ccgcgttccc agccgagctg gttcggcttc
     2101 gtgatcaccg tcgcccccga cgcacccttc agccgggccg agttggtcga cttcctggag
     2161 gaccggaaga tcggcactcg acgcttgttc gccggcaacc tcaccaggca cccggcctac
     2221 atcgaccagc cgcaccgcat cgtcggcgag ctcaccaaca gcgacctcgt caccgagcag
     2281 accttctgga tcggcgtcta tcccgcgctc accgacgaaa tgctcgatta cgtgaccgcc
     2341 tcgatcaagg agttcgtcgc cgcacgtggc taggtccgaa tgtgtcaccc catcacagag
     2401 atcaggacga cgcatggaca ttgtgggaaa tggattcctg gcgcggaacc tgcggccgct
     2461 ggccgaacgg catcccgata ccgtggccct cgccgccggt gtctcatggg cgagcggtac
     2521 ctccgatgcc gacttcgccc gggaagccgc actcctgcga gacaccgcca agcagtgcgc
     2581 ggccaccgga cgacgactgc tgttcttctc gaccgctgcc acgggcatgt acggcctggc
     2641 ggagggaccc ggccgagagg acacgccagt gacgccgtgc accccgtacg gcgcgcacaa
     2701 gctggcgctg gaggaactgc tgcgggactc cggtgccgac catgtgattc tcaggctcgg
     2761 gcacctcgtg gggcccgacc agcccgagca ccaactgctg cccacgctgg tgcgtcacct
     2821 acgcgaaggc gcggtgcgca ttcaccgagg cgcggcccgt gacctcatcg acgtcagcga
     2881 cgtcgtcacc attgtcgact gccttctcgg ccttgacctc aaggccgaga cggtcaacgt
     2941 ggcctccggc tacgccgttc cggtgaagga catcgtcgaa ctcctgcgcc gcaggctcgg
     3001 ggtcgaggcg cggtacgagt tccaggatgc cggtggtcag cacgtcatct ccatcgagaa
     3061 gctgcgcgca ctcgttccgc aggtccagga catgggcttc gggcccgact actaccggcg
     3121 gatcctcagt gacttcacct ccgccgtccg tatctgaccg ccgaagcccg gcgcactgaa
     3181 cacgggagcc ttctgatgct ttctgaaagc cttctcgcag tggcccagcc gcgtgcggcc
     3241 gacaacacct gtgatcgcat cgggctgtcc gcagcgaccg ccgacggtag gcacctgcgc
     3301 acgtcggatt tcggggactg gctggccgga cgcggccggg ccaacgagtt ccgggtggac
     3361 cgcgtaccgt tcgccgcact ggacggctgg gccttcgacg aggccaccgg caatctggtg
     3421 caccgcagcg gccggttctt cacagttgag ggcctgcacg tcaccgagct ggacgccccc
     3481 tacggcgacg gcccctatgc cgactggcac cagcccatca tcaagcagcc cgaggtgggc
     3541 atcctgggca tcctggtcaa ggagttcgac ggggtactgc attttctcat gcaggcaaag
     3601 atggagccgg gcaatccgaa cctgctccaa ctctcgccca cggttcaggc cactcgcagc
     3661 aactacacca aggcccacca cggagccgac gtgaagtaca tcgagcactt cgtcggtccg
     3721 acgcgcggtc acatcatcgc ggacgtactg cagtcggaac acggctcgtg gttctaccga
     3781 aagtccaacc gcaacatgat cgtggaagcc gtcggcgacg tgccgctgca cgacgacttc
     3841 tgctggctca ccctcggcca gatcagcacg ctgatgcacc aggacaacgt ggtcaacatg
     3901 gactcgcgta ccgtcctgtc ctgcctgccc tacgcggaca cccgttcgcg cgcgctgctc
     3961 tccgacaccc agttgctctc ctggatcacc gaggagcgat cgcgacacga tgtgcgggtt
     4021 gagcgggtcc cgctcgggag cctcccgggg tggcgacgcg gtgagagcac gatcgagcac
     4081 gaagcgggcc ggtacttcaa ggtcgtggcc gtggccgtgc aggccggcag ccgtgaggtg
     4141 accggctgga cccagcccct cttcgagccg gtcggcctgg gcgtcacggc cttcctcacc
     4201 cgcgcattcg atggcgttcc gcacgtgctg gttcacgccc gggtcgaggc cggtttcctc
     4261 gacaccatcg agctgggccc gaccgtccag tacaccccgg gcaattacgc ccacctggac
     4321 gagaagaacc ggccgctctt cctcgacacc gtgctgcgtg ccccgtcgga tcgcatccgc
     4381 tacgaggccg tgcactcgga ggagggcggt cgcttcctca acgccgagag ccgctacctg
     4441 atcgtcgaca ccgacgagac ggaggccccg cagaacccgc cgtcgggcta cgcctgggtc
     4501 acaccggcac aactgacctc gctggtgcga cacggccatt acgtcaatgt ccagggccgc
     4561 actctgctgg cctgcctcaa cgccatggcg gtgaacagcc gatgagccga ccggtgggga
     4621 tcggagtgat cggctgtgcc gacatcgcgg tacgccggat gctccctgct ttcgcaaccg
     4681 ggcctgagac agaggtcgtc gcggttgcca gccgcaccct gggcaaggcc gagcgggttg
     4741 ccgagcgctt cgggtgccgg gctgtccagg gctacgccgc gctcctggaa ctggagaagg
     4801 tgcaggccgt gtacataccg ctgcctgccg ctctgcacgc ggagtgggtc cgaaaggctg
     4861 cgctgcgcgg gcaaagcacg tgctggccga gaaacccctc acgcccgacc ccgctgcgca
     4921 ctgagcagct gctgaagctg gcccggtacc gcgggctggc cctgatggag aacgtcatgt
     4981 tcgtccatca ttctcgccat gaggcggttc ggcggctggt cgacgagggc gcgatcggtg
     5041 aactgcgcgg tctgcagtcg gcattcacca ttccggctcc ggccgacgac gacatccggt
     5101 acgccccgga gctcggcggc ggcgcgctcc cggacgtcgg cgtctatccg ctccgcgccg
     5161 ccttgcactt cctcggcccg gggctggaag tcgtcggagc acatctcgcg agtggacccg
     5221 gcagacacgt cgagacctcg ggcgcggccc tgctgcgtac acctgcgggc gtcacggcgc
     5281 aggtgatctt tggcatggag cacacgtacc gctccaccta ttatctgttg ggcggtgacg
     5341 gacggctcac cgtcgagcgg gccttcacac cgtcggccga cttcattccc gtgatccccg
     5401 tccccccg
//
