BGC0000279 - 1 region(s) - antiSMASH results

Identified secondary metabolite regions using strictness 'relaxed'

BGC0000279 (Streptomyces flavogriseus)

Region	Type	From	To	Similarity Confidence	Most similar known cluster
Region 1	T2PKS	1	52,255	High	xantholipin	PKS

BGC0000279 - Region 1 - T2PKS

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Location: 1 - 52,255 nt. (total: 52,255 nt) Show pHMM detection rules used

Region on contig edge.

T2PKS: (t2ks and t2clf)

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core biosynthetic genes

additional biosynthetic genes

transport-related genes

regulatory genes

other genes

resistance

TTA codons

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Gene details

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Gene overview

MIBiG

Tailoring

MIBiG comparison

KnownClusterBlast

NRPS/PKS domains

Gene/CDS overview

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Identifier	Product	Length		Function	Sequence		NCBI Blast	Filter details
		NT	AA		NT	AA

External annotation

Name		MIBiG
Version		4.0alpha

Type		Subregion
Location		1 - 52,256
Label		BGC0000279

Tailoring functions

Oxidoreductases: dehydrogenase oxidoreductase oxygenase

xanO2: cytochrome P450

smcogs: SMCOG1007: cytochrome P450

xanO4: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

xanO5: monooxygenase FAD-binding

smcogs: SMCOG1050: monooxygenase FAD-binding

xanS1: 3-hydroxyisobutyrate dehydrogenase

smcogs: SMCOG1100: 3-hydroxyisobutyrate dehydrogenase

xanS2: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

xanZ1: oxidoreductase

smcogs: SMCOG1083: oxidoreductase

xanZ2: aldo/keto reductase family oxidoreductase

smcogs: SMCOG1039: aldo/keto reductase family oxidoreductase

xanZ3: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

xanZ4: short-chain dehydrogenase/reductase SDR

smcogs: SMCOG1001: short-chain dehydrogenase/reductase SDR

Transferases: carboxylase glycosyltransferase halogenase kinase methyltransferase transferase

xanB1: acetyl-CoA carboxylase biotin carboxylase

smcogs: SMCOG1090: acetyl-CoA carboxylase biotin carboxylase

xanB3: acetyl-CoA carboxylase, carboxyl transferase,

smcogs: SMCOG1059: acetyl-CoA carboxylase, carboxyl transferase,

xanG: glycosyltransferase, MGT family

smcogs: SMCOG1062: glycosyltransferase, MGT family

xanH: flavin-dependent cycline orsellinic halogenase

halogenases: flavin-dependent cycline orsellinic halogenase
MITE: MITE0000024Halogenation (identity: 100.00%)
smcogs: SMCOG1119: halogenase

xanM1: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

xanM2: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

xanM3: O-methyltransferase

smcogs: SMCOG1042: O-methyltransferase

xanY4: PfkB domain protein

smcogs: SMCOG1276: PfkB domain protein

Hydrolases: hydrolase

xanA: asparagine synthase (glutamine-hydrolyzing)

smcogs: SMCOG1177: asparagine synthase (glutamine-hydrolyzing)

Lyases: cyclase

xanC1: cyclase/dehydrase

smcogs: SMCOG1128: cyclase/dehydrase

xanC3: Polyketide synthesis cyclase

smcogs: SMCOG1225: Polyketide synthesis cyclase

Ligases: synthase

xanE: Beta-ketoacyl synthase

smcogs: SMCOG1093: Beta-ketoacyl synthase

xanF: Beta-ketoacyl synthase

smcogs: SMCOG1022: Beta-ketoacyl synthase

Translocases: transport

xanU: MMPL domain-containing transport protein

smcogs: SMCOG1035: MMPL domain-containing transport protein

Similar gene clusters

Analysis type:

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000279.5	0.97	PKS	xantholipin	Streptomyces flavogriseus
BGC0002608.2	0.77	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0002341.2	0.76	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0000231.5	0.65	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001197.5	0.63	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000234.5	0.62	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000272.3	0.56	PKS	spore pigment	Streptomyces collinus
BGC0000204.5	0.55	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0001513.3	0.55	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0000248.5	0.55	PKS	α naphtocyclinoic acid, fogacin	Streptomyces arenae DSM 40737

Reference	Similarity score	Type	Compound(s)	Organism
BGC0000279.5	1.00	PKS	xantholipin	Streptomyces flavogriseus
BGC0002608.2	0.77	NRPS, PKS	ochratoxin A	Aspergillus steynii
BGC0002341.2	0.76	other (other)	3,5-dibromo-p-anisic acid	Planctomycetales bacterium 10988
BGC0000231.5	0.65	PKS	griseusin A, griseusin B	Streptomyces griseus
BGC0001197.5	0.63	PKS	frankiamicin	Frankia sp. EAN1pec
BGC0000234.5	0.62	PKS	jadomycin	Streptomyces venezuelae ATCC 10712
BGC0000272.3	0.56	PKS	spore pigment	Streptomyces collinus
BGC0000204.5	0.56	PKS	benastatin A, benastatin B, BE-43767, TAN1532B	Streptomyces sp. A2991200
BGC0001513.3	0.55	PKS	anthrabenzoxocinone	Actinobacteria bacterium
BGC0000248.5	0.55	PKS	α naphtocyclinoic acid, fogacin	Streptomyces arenae DSM 40737

Similar known clusters from MIBiG 4.0

Detailed domain annotation

Selected features only

Show module domains

Type II PKS

Type II PKS gene cluster prediction details

Cluster section:: 10016 to 52255
Starter unit(s):: malonamyl-CoA (Score: 878.0; E-value: 0)
Malonyl elongations:: 11|12 (Score: 737.4; E-value: 7.7e-225)
Product class(es):: pentangular polyphenol
Product molecular weight(s):: malonamyl-CoA_11: 799 Da
malonamyl-CoA_12: 841 Da

xanA: AMID (Score: 983.7; E-value: 6.7e-299); AMID CAM34350.1_Lysolipin_malonamyl-CoA (Score: 878.0; E-value: 0.0)
xanC1: CYC C9-C14 (Score: 259.5; E-value: 1.8e-80)
xanC2: CYC C5-C18 (Score: 225.8; E-value: 3e-70)
xanC3: CYC C4-C21/C2-C23|C2-C19 (Score: 178.7; E-value: 5.7e-56)
xanD: ACP (Score: 105.6; E-value: 2.3e-33)
xanE: CLF 11|12 (Score: 737.4; E-value: 7.7e-225)
xanF: KS (Score: 766.1; E-value: 2e-233)
xanG: GT (Score: 347.9; E-value: 2.3e-106)
xanH: HAL (Score: 750.0; E-value: 2.1e-228)
xanM1: MET C13O|C17O (Score: 483.1; E-value: 8.5e-148)
xanM2: MET C13O|C17O (Score: 505.7; E-value: 1.1e-154)
xanM3: MET C13O|C17O (Score: 454.2; E-value: 5.1e-139)
xanO3: OXY (Score: 33.7; E-value: 5e-11)
xanO4: OXY (Score: 313.3; E-value: 7.5e-96)
xanO5: OXY (Score: 289.9; E-value: 9.1e-89)
xanS2: KR (Score: 129.0; E-value: 5.6e-40)
xanZ3: KR C19 (Score: 427.1; E-value: 4.7e-131)
xanZ4: KR C11 (Score: 447.8; E-value: 2.1e-137)