Genomic loci for this biosynthetic pathway

Cluster Type From To
The following clusters are from record BGC0000280.1:
Cluster 1Polyketide16033

BGC0000280, 2,4-Diacetylphloroglucinol biosynthetic gene cluster from Pseudomonas fluorescens. Locus 1. Full MIBiG entry.

Chemical compounds

Compound: 2,4-diacetylphloroglucinol
PubChem ID: 16547
SMILES string: Copy to clipboard
Molecular formula: C10H10O5
Average molecular mass: 210.185 Da
Molecular activity: Antifungal
Molecular target: Mitochondria

Class-specific details

Biosynthetic class(es):
Polyketide
Polyketide subclass:
Polyphenol (cyclic)
Polyketide synthase subclass:
Type III
Starter unit:
Acetyl-CoA
Polyketide synthase / ketosynthase-encoding genes:

Gene cluster description

2,4-Diacetylphloroglucinol (BGC0000280). Gene Cluster 1. Biosynthetic class = Polyketide. GenBank AF497760. Click on genes for more information.

Legend:

biosynthetic genes
transport-related genes
regulatory genes
other genes

Homologous known gene clusters

General MIBiG information on this cluster

Complete gene cluster sequence?incomplete
Evidence for cluster-compound connection:Knock-out studies, Gene expression correlated with compound production
MIxS-compliance:Unknown
Contact for this cluster:Fergal O'Gara (BIOMERIT Research Centre, School of Microbiology, University College Cork)

Literature references

1. Abbas A et al. (2004) The putative permease PhlE of Pseudomonas fluorescens F113 has a role in 2,4-diacetylphloroglucinol resistance and in general stress tolerance. Microbiology 150(Pt 7):2443-50. doi: 10.1099/mic.0.27033-0.
2. Abbas A et al. (2002) Characterization of interactions between the transcriptional repressor PhlF and its binding site at the phlA promoter in Pseudomonas fluorescens F113. J Bacteriol 184(11):3008-16.
3. Delany I et al. (2000) Regulation of production of the antifungal metabolite 2,4-diacetylphloroglucinol in Pseudomonas fluorescens F113: genetic analysis of phlF as a transcriptional repressor. Microbiology 146 ( Pt 2):537-43. doi: 10.1099/00221287-146-2-537.
4. Abbas A et al. (2004) The putative permease PhlE of Pseudomonas fluorescens F113 has a role in 2,4-diacetylphloroglucinol resistance and in general stress tolerance. Microbiology 150(Pt 7):2443-50. doi: 10.1099/mic.0.27033-0.
5. Moynihan JA et al. (2009) Evolutionary history of the phl gene cluster in the plant-associated bacterium Pseudomonas fluorescens. Appl Environ Microbiol 75(7):2122-31. doi: 10.1128/AEM.02052-08. Epub
6. Troppens DM et al. (2013) The bacterial secondary metabolite 2,4-diacetylphloroglucinol impairs mitochondrial function and affects calcium homeostasis in Neurospora crassa. Fungal Genet Biol 56:135-46. doi: 10.1016/j.fgb.2013.04.006. Epub 2013