BGC0000285: flaviolin biosynthetic gene cluster from Saccharopolyspora erythraea
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Location: 1 - 11,124 nt. (total: 11,124 nt).
This entry is originally from NCBI GenBank AY078067.1.

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core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
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Gene details
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General
Compounds
Genes
Polyketide
Saccharide
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000285
Short description flaviolin biosynthetic gene cluster from Saccharopolyspora erythraea
Status Minimal annotation: no
A minimal annotation only contains information on the BGC loci and one or more linked chemical product(s)

Completeness: complete
Whether the loci encodes everything needed for the pathway producing the compound(s)
Remarks "This type III PKS containing cluster is involved in the formation of red-brown pigment/melanin, and equivalent clusters have been studied in other organisms, e.g. PMID 10476972; 11723138; 15659395; 15701630; 16291687. The PKS product THN (1,3,6,8-tetrahydroxynaphthalene) of these clusters are variously oxidized/dimerized/polymerized by the action of additional enzymes in the cluster including a cytochrome P450 monooxygenase (RppB) and a monooxygenase of the cupin domain superfamily. The products of these clusters have been shown to provide resistance to UV radiation. Flaviolin rhamnoside is believed to be a shunt metabolite, or by-product, in which flaviolin is serendipitously used as an aglycone substrate by some unidentified glycosyl transferase."
Biosynthetic class(es)
  • Polyketide (Chalcone)
  • Saccharide (oligosaccharide)
Loci NCBI GenBank: AY078067.1
Compounds
  • flaviolin
  • flaviolin rhamnoside
  • 3,3'-diflaviolin
Species Saccharopolyspora erythraea [taxonomy]
References
Chemical products information
flaviolin
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C10H6O5
Chemical database entries
PubCHEM
flaviolin rhamnoside
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C16H16O9
3,3'-diflaviolin [synonyms: flaviolin dimer]
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C20H10O10
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAL78049.1
 3 - 179 (+) ORFA
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  • AAL78050.1
 176 - 1405 (+) ORFB
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  • AAL78051.1
 1497 - 2021 (-) ORFC
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  • AAL78052.1
 2089 - 2757 (+) ORFD
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  • AAL78053.1
  • rppA
 3111 - 4214 (+) Type III PKS
  • Scaffold biosynthesis
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  • AAL78054.1
  • rppB
 4211 - 5416 (+) Cytochrome P450 monooxygenase
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  • AAL78055.1
 5452 - 5991 (+) Quinone forming monooxygenase
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  • AAL78056.1
 6672 - 7298 (+) ORFE
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  • AAL78057.1
 8156 - 11002 (-) ORFF
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Polyketide-specific information
Subclass Chalcone
Starter unit Malonyl-CoA
Ketide length 5
Cyclic? yes
Polyketide-synthases
Genes Properties Modules
rppA Synthase subclass: Type III
Saccharide-specific information
Subclass oligosaccharide
Annotation changelog
MIBiG version Submitter Notes
1.0
  • Hidden contributor (ID: SOJ5J6FNXPWDFJNGJGPS2QRA, no GDPR consent given).
  • Submitted
2.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Migrated from v1.4
3.0
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Fixed incorrect gene identifier
  • Moved complete compound to first in the list
  • Removed glycosyltransferase annotation on missing gene
3.1
  • Hidden contributor (ID: AAAAAAAAAAAAAAAAAAAAAAAA, no GDPR consent given).
  • Update chemical activity to schema version 2.11
Similar known gene clusters
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