BGC0000285: flaviolin biosynthetic gene cluster from Saccharopolyspora erythraea
Shows the layout of the region, marking coding sequences and areas of interest. Clicking a gene will select it and show any relevant details. Clicking an area feature (e.g. a candidate cluster) will select all coding sequences within that area. Double clicking an area feature will zoom to that area. Multiple genes and area features can be selected by clicking them while holding the Ctrl key.
View antiSMASH-generated output
Download Cluster GenBank file
Download region SVG
Location: 1 - 11,124 nt. (total: 11,124 nt).
This entry is originally from NCBI GenBank AY078067.1.

Legend:

core biosynthetic genes
additional biosynthetic genes
transport-related genes
regulatory genes
other genes
resistance
TTA codons
reset zoomreset view
zoomzoom to selection
Gene details
Shows details of the most recently selected gene, including names, products, location, and other annotations.
Select a gene to view the details available for it
General
Compounds
Genes
Biosynthesis
History
KnownClusterBlast
General information about the BGC
MIBiG accession BGC0000285
Short description flaviolin biosynthetic gene cluster from Saccharopolyspora erythraea
Status Quality: questionable
The quality level of this entry.

Status: active
The status of this entry.

Completeness: complete
Whether the entry covers everything needed for the pathway producing the compound(s)
Remarks "This type III PKS containing cluster is involved in the formation of red-brown pigment/melanin, and equivalent clusters have been studied in other organisms, e.g. PMID 10476972; 11723138; 15659395; 15701630; 16291687. The PKS product THN (1,3,6,8-tetrahydroxynaphthalene) of these clusters are variously oxidized/dimerized/polymerized by the action of additional enzymes in the cluster including a cytochrome P450 monooxygenase (RppB) and a monooxygenase of the cupin domain superfamily. The products of these clusters have been shown to provide resistance to UV radiation. Flaviolin rhamnoside is believed to be a shunt metabolite, or by-product, in which flaviolin is serendipitously used as an aglycone substrate by some unidentified glycosyl transferase."
Biosynthetic class(es)
  • PKS (Type III)
  • saccharide (oligosaccharide)
Loci
AY078067.1
via Knock-out studies
Compounds
  • flaviolin
  • flaviolin rhamnoside
  • 3,3'-diflaviolin
Species Saccharopolyspora erythraea [taxonomy]
References
Chemical products information
flaviolin Evidence:
Copy SMILES
C10H6O5
Chemical database entries
PubCHEM
flaviolin rhamnoside Evidence:
Copy SMILES
C16H16O9
3,3'-diflaviolin Evidence:
Copy SMILES
C20H10O10
List of genes involved in compound(s) production
Identifiers Position Product Functions Evidence Extra
  • AAL78049.1
 3 - 179 (+) ORFA
    copy AA seq
    copy Nt seq
    • AAL78050.1
    		 176 - 1405 (+) ORFB
      copy AA seq
      copy Nt seq
      • AAL78051.1
      		 1497 - 2021 (-) ORFC
        copy AA seq
        copy Nt seq
        • AAL78052.1
        		 2089 - 2757 (+) ORFD
          copy AA seq
          copy Nt seq
          • AAL78053.1
          • rppA
          		 3111 - 4214 (+) Type III PKS
          • Scaffold biosynthesis
          • Knock-out
          copy AA seq
          copy Nt seq
          • AAL78054.1
          • rppB
          		 4211 - 5416 (+) Cytochrome P450 monooxygenase
            copy AA seq
            copy Nt seq
            • AAL78055.1
            		 5452 - 5991 (+) Quinone forming monooxygenase
              copy AA seq
              copy Nt seq
              • AAL78056.1
              		 6672 - 7298 (+) ORFE
                copy AA seq
                copy Nt seq
                • AAL78057.1
                		 8156 - 11002 (-) ORFF
                  copy AA seq
                  copy Nt seq
                  Biosynthesis information
                  Annotation changelog

                  Entry version: 4

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-10-07
                  Update chemical activity to schema version 2.11
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 3

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2022-09-15
                  Fixed incorrect gene identifier
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Moved complete compound to first in the list
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  2022-09-15
                  Removed glycosyltransferase annotation on missing gene
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 2

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2019-10-16
                  Migrated from v1.4
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)

                  Entry version: 1

                  Date
                  Changes
                  Submitters
                  Reviewers
                  2015-06-12
                  Submitted
                  • (ID: SOJ5J6FNXPWDFJNGJGPS2QRA)
                  • (ID: AAAAAAAAAAAAAAAAAAAAAAAA)
                  Similar known gene clusters from MIBiG 4.0
                  Shows clusters from the MiBIG database that are similar to the current region. Genes marked with the same colour are interrelated. White genes have no relationship.
                  Click on reference genes to show details of similarities to genes within the current region.
                  Click on an accession to open that entry in the MiBIG database.