Gene cluster description
red pigment (BGC0000285). Gene Cluster 1. Biosynthetic class = Polyketide/Saccharide. GenBank AY078067, positions 3111-5991. Click on genes for more information.
Homologous known gene clusters
General MIBiG information on this cluster
|Complete gene cluster sequence?||complete|
|Evidence for cluster-compound connection:||Knock-out studies|
|Comments:||This type III PKS containing cluster is involved in the formation of red-brown pigment/melanin, and equivalent clusters have been studied in other organisms, e.g. PMID 10476972; 11723138; 15659395; 15701630; 16291687. The PKS product THN (1,3,6,8-tetrahydroxynaphthalene) of these clusters are variously oxidized/dimerized/polymerized by the action of additional enzymes in the cluster including a cytochrome P450 monooxygenase (RppB) and a monooxygenase of the cupin domain superfamily. The products of these clusters have been shown to provide resistance to UV radiation.|
|Contact for this cluster:||Professor Barrie Wilkinson (John Innes Centre)|
1. Cortes J et al. (2002) Identification and cloning of a type III polyketide synthase required for diffusible pigment biosynthesis in Saccharopolyspora erythraea. Mol Microbiol 44(5):1213-24.